Development of smart samplers and their comparison to dried serum spots for the analysis of growth hormone releasing hormone analogs using LCHRMS/MS by Christina Johannsen, Anna Kha Tu Nguyen, Sasha Shabani, Inger Oulie, Siri Dørum, Yvette Dehnes, Leon Reubsaet, Trine Grønhaug Halvorsen

“…Smart samplers combine sampling and sample preparation in one tool; in this study smart samplers were developed using divinyl sulfone functionalized paper to immobilize antibodies for selective analyte capture. …”
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Reference Intervals for Echocardiography Parameters of Children Living in the Arkhangelsk Region and a Digital Application for Their Assessment by Aleksey A Karyakin, Igor’ S. Chub, Ol’ga E. Karyakina, Andrey M. Grjibovski, Aleksey V. Artemov, Ul’yana R. Zakharchenko

“…Reference intervals of echocardiography parameters were determined using body surface area as the dependent variable. The values were automatically calculated in our digital application that allows one to increase the accuracy and efficiency of interpretation of cardiac ultrasound parameters. …”
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Performance Analysis and Computational Interface for <italic>X &#x2013; R</italic> Intuitionistic Fuzzy Control Chart by Amanda Dos Santos Mendes, Tulio S. Almeida, Marcela A. G. Machado, Paloma Maria Silva Rocha Rizol

“…This work showed that intuitionistic fuzzy control charts are efficient at detecting special causes, and that the computer interface developed is capable of performing the proposed functions.…”
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Optimized Dual-Battery System with Intelligent Auto-Switching for Reliable Soil Nutrient Monitoring in Remote IoT Applications by Doan Perdana, Pascal Lorenz, Bagus Aditya

“…Implementing the DLB–PAO algorithm elevates the average reliability to 91.7% over 120 h, whereas the DLB–GA algorithm achieves near-perfect reliability (99.9%) for over 170 h, exhibiting minimal variability (standard deviation: 0.9%). The integration of intelligent auto-switching mechanisms and metaheuristic optimisation algorithms demonstrates a marked enhancement in both reliability and energy efficiency for soil nutrient monitoring systems. …”
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Expanding a Health Technology Solution to Address Therapist Challenges in Implementing Homework With Adult Clients: Mixed Methods Study by Brian E Bunnell, Kaitlyn R Schuler, Julia Ivanova, Lea Flynn, Janelle F Barrera, Jasmine Niazi, Dylan Turner, Brandon M Welch

“… BackgroundHomework is implemented with variable effectiveness in real-world therapy settings, indicating a need for innovative solutions to homework challenges. …”
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Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…Using productivity as a standard is useful for calculating efficiency, and can guide efforts to allocate resources optimally. …”
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Mechatronic system for running-in and testing of mechanical transmissions in mining shovels by Sergey I. Malafeev, Alevtina A. Malafeeva, Vladimir I. Konyashin, Andrey A. Novgorodov

“…The mechanical transmissions of the hoist and drag winches, as well as the crowd mechanisms of mining shovels, operate under highly variable and shock cyclic loads. These severe operating conditions impose stringent quality requirements on both the manufacturing and assembly of such transmissions. …”
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Systematic Evaluation of Isolation Techniques and Freeze‐Thaw Effects on Plasma Extracellular Vesicle Heterogeneity and Subpopulation Profiling by Xueqi Li, Xiangyu Li, Lingjun Tong, Liqiao Hu, Yanfen Hong, Ruoyu Zhou, Zonghong Li, Ming Dong, Junjie Hou, Tao Xu, Wen Zhong

“…However, standardizing blood‐derived EV isolation remains challenging due to the heterogeneity of EV populations and variability among isolation techniques. In this study, we systematically evaluated three distinct EV isolation methods, including asymmetrical flow field‐flow fractionation (AF4), size‐exclusion chromatography (SEC) and automated centrifugal microfluidic disc system combined with functionalized membranes (Exo‐CMDS), to compare their efficiency in isolating EVs from both freshly frozen and freeze‐thawed plasma samples. …”
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Structural network topologies are associated with deep brain stimulation outcomes in Meige syndrome by Bin Liu, Zhiqi Mao, Xinyuan Yan, Hang Yang, Junpeng Xu, Zhebin Feng, Yanyang Zhang, Xinguang Yu

“…However, the DBS efficacy varies across MS patients and the factors contributing to the variable responses remain enigmatic. We aim to explain the difference in DBS efficacy from a network perspective. …”
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Investigating the influence of soil organic carbon on pore structure within aggregates by Jingjing Liu, Yu Tian, Chiara Pasut, Mark Farrell, Shenggao Lu

“…The results revealed that the hydrogen peroxide treatment variably reduced organic carbon in soil aggregates, with Cambisol samples showing a higher removal efficiency (38.58–63.31%) compared to Ultisol samples (27.33–45.74%). …”
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Comparative Genomics of Rhamnolipid Synthesis and Monoaromatic Hydrocarbon Tolerance Genes in Environmental Pseudomonas aeruginosa strains [version 2; peer review: 2 approved] by Sandro B. Martel-Torres, Camila Castillo-Vilcahuaman, ROGER A. PALOMINO HUARCAYA, Susana M. Gutiérrez Moreno, Fernando A. Merino Rafael

“…The BTEX (benzene, toluene, ethylbenzene, and xylene) are toxic hydrocarbons requiring efficient microbial degradation for bioremediation. …”
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FVPNet: A Fuzzy Visual Positioning Perception Network for Small Object Segmentation in Remote Sensing Images by Yu Yan, Jindong Xu, Qianpeng Chong, Guangyi Wei, Zhixiang Wang

“…Furthermore, grayscale variability intensifies boundary uncertainty, complicating accurate segmentation. …”
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Optimizing Load Frequency Control of Multi-Area Power Renewable and Thermal Systems Using Advanced Proportional–Integral–Derivative Controllers and Catch Fish Algorithm by Saleh A. Alnefaie, Abdulaziz Alkuhayli, Abdullah M. Al-Shaalan

“…Renewable energy sources (RESs) are increasingly combined into the power system due to market liberalization and environmental and economic benefits, but their weather-dependent variability causes power production and demand mismatches, leading to issues like frequency and regional power transmission fluctuations. …”
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End-to-End Stroke Imaging Analysis Using Effective Connectivity and Interpretable Artificial Intelligence by Wojciech Ciezobka, Joan Falco-Roget, Cemal Koba, Alessandro Crimi

“…The goal of this pipeline is to define an efficient brain representation for connectivity in stroke data derived from magnetic resonance imaging. …”
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Analisis Penerimaan Learning Management System Institut Teknologi Garut Menggunakan Technology Acceptance Model by Asri Mulyani, Dede Kurniadi, Mita Hidayani Putri

“…It is hoped that the results of this research can be used as a reference for developers to continue to optimize the functionality of the Learning Management System so that it can be used optimally. …”
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Recent Advances in Vitamin E TPGS-Based Organic Nanocarriers for Enhancing the Oral Bioavailability of Active Compounds: A Systematic Review by Chee Ning Wong, Siew-Keah Lee, Yang Mooi Lim, Shi-Bing Yang, Yik-Ling Chew, Ang-Lim Chua, Kai Bin Liew

“…Despite using the same excipient, variability in particle size, zeta potential, and encapsulation efficiency among nanocarriers indicates the need for tailored formulations. …”
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Synergistic co-metabolism enhancing the crude oil degradation by Acinetobacter oleivorans DR1 and its metabolic potential by Lairenjam Paikhomba Singha, Renuka Kumari, Keisam Malabika Singha, Piyush Pandey, Pratyoosh Shukla

“…ABSTRACT Bacterial degradation of hydrocarbons during co-metabolism with glucose often resulted in variable degradation efficiency. This study explored the mechanistic understanding of the metabolic response during co-metabolism in Acinetobacter oleivorans DR1 using a metabolomics approach. …”
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Application of multi-objective neural network algorithm in industrial polymerization reactors for reducing energy cost and maximising productivity by Fakhrony Sholahudin Rohman, Sharifah Rafidah Wan Alwi, Dinie Muhammad, Ashraf Azmi, Zainuddin Abd Manan, Jeng Shiun Lim, Hong An Er, Siti Nor Azreen Ahmad Termizi

“…Optimization on an industrial scale is a complex task that involves fine-tuning the performance of large-scale systems and applications to make them more efficient and effective. This process can be challenging due to the increasing volume of work, growing system complexity, and the need to maintain optimal performance. …”
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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…The DL model exhibited high accuracy in tissue quantification and TP53 status prediction, outperforming traditional methods in terms of precision and efficiency. DL-based approaches offer significant promise for enhancing biomarker testing and precision oncology by reducing intra- and inter-observer variability, but further validation is required to optimize their integration into real-world clinical workflows. …”
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