Development of smart samplers and their comparison to dried serum spots for the analysis of growth hormone releasing hormone analogs using LCHRMS/MS by Christina Johannsen, Anna Kha Tu Nguyen, Sasha Shabani, Inger Oulie, Siri Dørum, Yvette Dehnes, Leon Reubsaet, Trine Grønhaug Halvorsen

“…Smart samplers combine sampling and sample preparation in one tool; in this study smart samplers were developed using divinyl sulfone functionalized paper to immobilize antibodies for selective analyte capture. …”
Get full text

Reference Intervals for Echocardiography Parameters of Children Living in the Arkhangelsk Region and a Digital Application for Their Assessment by Aleksey A Karyakin, Igor’ S. Chub, Ol’ga E. Karyakina, Andrey M. Grjibovski, Aleksey V. Artemov, Ul’yana R. Zakharchenko

“…Reference intervals of echocardiography parameters were determined using body surface area as the dependent variable. The values were automatically calculated in our digital application that allows one to increase the accuracy and efficiency of interpretation of cardiac ultrasound parameters. …”
Get full text

FMRI insights into the neural alterations and clinical correlates in multiple sclerosis: A comprehensive overview of systematic reviews and meta-analyses by Sama Rahnemayan, Arezoo Fathalizadeh, Mehdi Behroozi, Mahnaz Talebi, Amirreza Naseri, Elham Mehdizadehfar

“…Graph theory metrics identified disrupted global efficiency and clustering in functional networks, linked to gray matter atrophy. …”
Get full text

Novel variant alters splicing of TGFB2 in family with features of Loeys-Dietz syndrome by Emily R. Gordon, Stephanie A. Felker, Stephanie A. Felker, Tanner F. Coleman, Tanner F. Coleman, Nadiya Sosonkina, Jada Pugh, Jada Pugh, Meagan E. Cochran, Meagan E. Cochran, Anna C. E. Hurst, Sara J. Cooper

“…Significant clinical variability has been noted for both related and unrelated individuals with the same pathogenic variant. …”
Get full text

Optimized Dual-Battery System with Intelligent Auto-Switching for Reliable Soil Nutrient Monitoring in Remote IoT Applications by Doan Perdana, Pascal Lorenz, Bagus Aditya

“…Implementing the DLB–PAO algorithm elevates the average reliability to 91.7% over 120 h, whereas the DLB–GA algorithm achieves near-perfect reliability (99.9%) for over 170 h, exhibiting minimal variability (standard deviation: 0.9%). The integration of intelligent auto-switching mechanisms and metaheuristic optimisation algorithms demonstrates a marked enhancement in both reliability and energy efficiency for soil nutrient monitoring systems. …”
Get full text

Expanding a Health Technology Solution to Address Therapist Challenges in Implementing Homework With Adult Clients: Mixed Methods Study by Brian E Bunnell, Kaitlyn R Schuler, Julia Ivanova, Lea Flynn, Janelle F Barrera, Jasmine Niazi, Dylan Turner, Brandon M Welch

“… BackgroundHomework is implemented with variable effectiveness in real-world therapy settings, indicating a need for innovative solutions to homework challenges. …”
Get full text

Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
Get full text

Development and Validation of Quantile Regression Forests for Prediction of Reference Quantiles in Handgrip and Chair‐Stand Test by Giulia Giordano, Luca Mastrantoni, Francesco Landi, The Lookup 8+ Study Group

“…The predictive outputs of these models may serve as surrogate biomarkers of the aging process, capturing functional decline.…”
Get full text

Deletion of genes linked to the C1-fixing gene cluster affects growth, by-products, and proteome of Clostridium autoethanogenum by Ugochi Jennifer Nwaokorie, Kristina Reinmets, Lorena Azevedo de Lima, Pratik Rajendra Pawar, Kurshedaktar Majibullah Shaikh, Audrey Harris, Michael Köpke, Kaspar Valgepea

“…However, our understanding of the functionalities of the genes involved in the C1-fixing gene cluster and its closely-linked genes is incomplete. …”
Get full text

Optimal control for high-precision repeat ground-track orbits via convex optimization by Yanchao HE, Lei ZHANG, Yijun YANG, Qian CHEN

“…The results show that the design approach enables the realization of high-precision RGT orbit designs and that the orbit control strategy is efficient.…”
Get full text

Association between TSH Values and GFR Levels in Euthyroid Cases with Metabolic Syndrome by H. Keskin, K. Cadirci, K. Gungor, T. Karaaslan, T. Usta, A. Ozkeskin, A. Musayeva, F. Yesildal, F. Isman, H. Y. Zengin

“…Partial correlation coefficients were calculated to investigate the relationship between the eGFR values and several other numerical variables while controlling for age and BMI in addition to the adjusted gender effect. …”
Get full text

Bayesian inference for peak feature extraction and prediction of material property in X-ray diffraction data by Ryo Murakami, Taisuke T. Sasaki, Hideki Yoshikawa, Yoshitaka Matsushita, Keitaro Sodeyama, Tadakatsu Ohkubo, Hiroshi Shinotsuka, Kenji Nagata

“…We challenge peak feature extraction in the situation where only the peak function profile is known a priori, without knowledge of the measurement material or crystal structure factor. …”
Get full text

MCL-SWT: Mirror Contrastive Learning with Sliding Window Transformer for Subject-Independent EEG Recognition by Qi Mao, Hongke Zhu, Wenyao Yan, Yu Zhao, Xinhong Hei, Jing Luo

“…Inspired by left/right hand motor imagery inducing event-related desynchronization (ERD) in the contralateral sensorimotor cortex, we develop a mirror contrastive loss function. It segregates feature spaces of EEG signals from contralateral ERD locations while curtailing variability in signals sharing similar ERD locations. …”
Get full text

Fast 3D localization of nano-objects in wide-field interferometric scattering microscopy via vectorial diffraction model-derived analytical fitting by Liaoliao Wei, Caroline Livan Anyi, Huakun Li, Haitao Nie, Bihan Wen, Tong Ling

“…The simplified analytic function includes a quadratically scaling amplitude term and a linearly scaling phase term, both of which change with the nano-object’s axial position. …”
Get full text

SSR loci potentially associated with high amylopectine content in maize kernel endosperm by S. I. Vakula, O. A. Orlovskaya, L. V. Khotyleva, A. V. Kilchevsky

“…As a component of functional nutrition, maize cultivars with “non-traditional” kernel composition (waxy, oilbearing, sugar, opaque, etc. phenotypic variants) are promising. …”
Get full text

Effects of bedroom environment on average heart rate during sleep in temperate regions: Winter conditions in healthy males in their twenties with average BMI by Noriaki Oota, Yasuki Yamauchi, Gota Iwase, Masaru Abuku, Yasuhiro Hiraguri

“…Additionally, it has been suggested that as the average heart rate decreases, SDNN increases, indicating favorable autonomic function. This study aimed to identify the environmental factors that most significantly affect the day-to-day variability of average heart rate during sleep (SHR) in winter. …”
Get full text

Identification and leveling of factors affecting the acceptance of excellence model in Islamic Azad University by Seyedeh Somayeh Mousavi Siah Deleh, Samad Jabbari Asl, Musa Rezvani Chaman Zamin

“…The concept of institutional excellence in higher education institutions as mentioned by Kok & McDonald (2017) refers to behavior that leads to excellence in all research, teaching and social service functions through excellence in strategy and shared values, leadership, Organizational culture. …”
Get full text

Characterization and treatment monitoring of ureagenesis disorders using stable isotopes by Gabriella Allegri, Martin Poms, Nadia Zürcher, Véronique Rüfenacht, Nicole Rimann, Déborah Mathis, Beat Thöny, Matthias Gautschi, Ralf A. Husain, Daniela Karall, Karolina Orchel-Szastak, Francesco Porta, Dominique Roland, Barbara Siri, Carlo Dionisi-Vici, René Santer, Johannes Häberle

“…Thus, the method proved to be safe and efficient to monitor UCD patients of variable severity pre- and post-therapy, being suitable as physiological endpoint for development of therapies.…”
Get full text

High expression of SOX10 is correlated with poor prognosis and immune infiltrates in skin cutaneous melanoma by Xu Sun, Yi-ming Cheng, Meng-wei Sun, Xu-dong Zhang, Xiao-yu Yu, Hai-bo Wang, Yi-fei Wang, Ning Li

“…Screening was performed by LASSO coefficients to select non-zero variables that satisfied the coefficients of lambda, and 8 genes were screened out. …”
Get full text

An Hfq-dependent post-transcriptional mechanism fine tunes RecB expression in Escherichia coli by Irina Kalita, Ira Alexandra Iosub, Lorna McLaren, Louise Goossens, Sander Granneman, Meriem El Karoui

“…This fine-tuning Hfq-mediated mechanism might have the underlying physiological function of maintaining RecB protein levels within an optimal range.…”
Get full text