Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells by Xiaofei Wei, Lin Shen, Chang Liu, Cheng Zhang, Min Tao, Jian Li, Xicheng Wang, Ting He, Fei Dai, Changsong Qi, Mingyang Ma, Yanping Ding, Xinan Lu, Dongqun Liu

“…An antigen-sensitive and long-lasting CAR-T cell targeting GUCY2C was investigated in this study.Methods Using constructed tumor cell lines with various GUCY2C expression densities, we screened out an antigen-sensitive single chain variable fragment (scFv) that enabled CAR-T cells to efficiently eradicate the GUCY2C lowly expressed tumor cells. …”
Get full text

Nonlinearity Estimation and Compensation for Accurate PMSM Modeling and Voltage Prediction by Beichen Ding, Yuting Lu, Chunyan Lai, Weiwen Peng, Kaide Huang, Guodong Feng

“…Specifically, the offsets to the base model are modeled using nonlinear functions with variable coefficients to compensate saturation and core loss effect, which can achieve better accuracy without changing the model structure. …”
Get full text

An Effective AFNIS-MPPT-Based Method for Optimizing Hybrid Energy Harvesting Systems by Muhammad Saqib, Ghulam Sarwar Kaloi, Mehr Gul, Muhammad Shahzad Nazir, Mohsin Ali Koondhar, Lutfi Albasha, Faisal Alsaif

“…The increasing global demand for renewable energy, particularly from solar and wind sources, highlights the need for sophisticated control strategies to optimize power generation efficiency. Maximum Power Point Tracking (MPPT) techniques are essential for improving the performance of Hybrid Renewable Energy Systems by maximizing power extraction from variable sources. …”
Get full text

Study of the possibility of controlling the production of low-molecular-weight heparin preparations by domestic test systems (review) by A. L. Berkovsky, E. V. Sergeeva, A. V. Suvorov

“…The data on the wide clinical use of low-molecular-weight heparin (LMWH) preparations are presented, necessitating the need for efficient and high-quality production of appropriate pharmaceuticals. …”
Get full text

A United Probabilistic Approach to Minimising the Sum of Absolute Values by Changyong Feng, Honghong Liu, Ethan Poon, Ge Feng

“…Methodology: The sum of absolute values can be standardized so that the sum of the coefficients equals 1. In this case, the sum of absolute values takes the form 𝐸𝐸|𝑋𝑋−𝑎𝑎|, where 𝑋𝑋 is a random variable. …”
Get full text

The role of housing price mediation in transferring the effect of heterogeneous behavior of investors in the housing sector on Iran's economic growth by Aliakbar Gholizadeh, Shahla Samadipour

“…The housing price is also a variable of economic growth function transfer with a threshold equal to 0.0266 percent The estimated coefficients of the first and second regimes indicate the asymmetric behavior of investors on housing prices. …”
Get full text

Digital Twin Control Method of Machine Tool Feed Rate Based on Fuzzy Neural Network by YIN Jia, BAI Lele, TIAN Hui, WU Shijie, Hou Guijin, TANG Yuyang, LIU Hongguang, ZHANG Jun

“…The role of the digital twin in the cutting process is to connect machine tools with the developed digital monitoring system so that the machine tools can realize condition monitoring and adaptive optimization in the process of complex parts machining, and improve the machining accuracy and efficiency of parts. In the current milling process of aviation parts, considering many factors such as deformation, roughness, and tool wear, process engineers always set conservative parameters based on experience, resulting in low machining efficiency, and an inability to adaptively adjust the cutting parameters according to the cutting trajectory and machine load. …”
Get full text

Changes in life satisfaction over six years in the general population: A longitudinal study with the Satisfaction With Life Scale (SWLS). by Andreas Hinz, Anja Mehnert-Theuerkauf, Heide Glaesmer, Matthias L Schroeter, Ana N Tibubos, Katja Petrowski, Michael Friedrich

“…However, the knowledge about long-term changes in life satisfaction and the associations between such changes and changes in other variables of physical and mental health is limited.…”
Get full text

Combined analysis of 16S rRNA gene sequencing data reveals core vaginal bacteria across livestock species by Lucille C. Jonas, Lucille C. Jonas, Curtis R. Youngs, Stephan Schmitz-Esser, Stephan Schmitz-Esser

“…Recent publications have uncovered a high degree of variability of the livestock vaginal microbiota, making it difficult to focus functional research on individual microorganisms. …”
Get full text

Economic and environmental power dispatch for energy management systems applied to microgrids with wind energy resources and battery energy storage systems by Jhon Montano, John E. Candelo-Becerra, Cristian Escudero-Quintero, Juan Pablo Guzmán

“…These algorithms are integrated into the objective functions and evaluated using a 24-hour power flow that incorporates a strict penalty scheme to satisfy the operational constraints. …”
Get full text

How Life Experience Shapes Cognitive Control Strategies: The Case of Air Traffic Control Training. by Sandra Arbula, Mariagrazia Capizzi, Nicoletta Lombardo, Antonino Vallesi

“…For instance, different reliance on proactive versus reactive control strategies could explain inter-individual variability. In particular, specific life experiences, like a highly demanding training for future Air Traffic Controllers (ATCs), could modulate cognitive control functions. …”
Get full text

THE STRUCTURE OF HAPPINESS REPRESENTATION FOR RUSSIAN AND AMERICAN REPRESENTATIVES by S. Yu. Zhdanova, A. V. Pecherkina, A. A. Strokanov

“…Statistical analysis of the data was based on the use of the coefficient of φ-angular Fisher transform, correlation coefficient φ, and cluster analysis.Results and scientific novelty. …”
Get full text

Development of a High-Cell-Density Production Process for a Biotherapeutic Yeast, <i>Saccharomyces cerevisiae</i> var. <i>boulardii</i>, for Use as a Human Probiotic by Ghaneshree Moonsamy, Sarisha Singh, Yrielle Roets-Dlamini, Koketso Kenneth Baikgaki, Santosh Omrajah Ramchuran

“…Once the optimised batch was validated in the replicate batches, the statistical analysis indicated a high level of reproducibility, with low variability across key performance indicators such as biomass concentration (unit), CFU production (CFU.mL⁻¹), and substrate utilization efficiency (g.g⁻¹). …”
Get full text

A Comparative Study of Deep Reinforcement Learning Algorithms for Urban Autonomous Driving: Addressing the Geographic and Regulatory Challenges in CARLA by Yechan Park, Woomin Jun, Sungjin Lee

“…To evaluate the adaptability of each algorithm to geographical variability and complex traffic laws, scenario-specific reward and penalty functions were carefully designed and incorporated. …”
Get full text

Handwritten Words Image Character Extraction Adaptive Algorithm Based on the Multi-branch Structure by GUO Xiaojing, ZHAO Xiaoyuan, ZOU Songlin

“…The improved model comprises four functional components. The innovation of this study lies in several aspects. …”
Get full text

Ultrasonographic Nomograms of Foetal Fourth Ventricle Biometry and its Correlation with Transcerebellar Diameter and Gestational Age among Normal Foetuses: A Cross-sectional Study by N Padmalatha, Paarthipan, Parthasarathy, Francis Nanda Prakash Monteiro

“…Regression analysis was performed to determine the equation of the linear fitted function with each of the independent variables (GA, TCD). …”
Get full text

A Fusion Strategy for High-Accuracy Multilayer Soil Moisture Downscaling and Mapping by Xu Zhang, Xin Liu, Xiang Zhang, Aminjon Gulakhmadov, Jiefeng Wu, Xihui Gu, Won-Ho Nam, Panda Rabindra Kumar, Veber Afonso Figueiredo Costa, Mahlatse Kganyago, Berhanu Keno Terfa, Wenying Du, Chao Wang, Peng Wang, Jing Yuan, Nengcheng Chen

“…Soil moisture (SM) is a critical factor influencing plant growth, agricultural yield, ecosystem functions, and water resource management. Existing SM products, such as SMAP, ERA5, and ESA-CCI, provide daily SM data. …”
Get full text

Eco-engineered remediation: Microbial and rhizosphere-based strategies for heavy metal detoxification by Arun Karnwal, Gaurav Kumar, Alaa El Din Mahmoud, Joydeep Dutta, Rattandeep Singh, Abdel Rahman Mohammad Said Al-Tawaha, Tabarak Malik

“…Moreover, a detailed understanding of plant–microbe interactions and the role of secondary metabolite signalling in the rhizosphere is essential to improve remediation efficiency. Future strategies should prioritize the application of functional genomics, developing bioinoculants tailored to specific environmental conditions, and implementing robust ecological risk assessments for GEMs. …”
Get full text

Generating Electricity with Hydraulically Amplified Self-Healing Electrostatic (HASEL) Transducers by Isabel Hess, Stephen Chamot, Blake Boren, Patrick Musgrave

“…This study identifies hydraulically amplified self-healing electrostatic (HASEL) transducers as electricity generators, contrary to their conventional role as actuators. HASELs are soft, variable-capacitance transducers inspired by biological muscles which were developed to mimic the flexibility and functionality of natural muscle tissues. …”
Get full text

A computationally lightweight model for ensemble forecasting of environmental hazards: General TAMSAT-ALERT v1.2.1 by E. Black, E. Black, J. Ellis, R. I. Maidment, R. I. Maidment, R. I. Maidment

“…The model presented here, General TAMSAT-ALERT, represents a significant scientific and functional advance on previous implementations. Notably, General TAMSAT-ALERT is applicable to any variable for which time series data are available. …”
Get full text