Development of smart samplers and their comparison to dried serum spots for the analysis of growth hormone releasing hormone analogs using LCHRMS/MS by Christina Johannsen, Anna Kha Tu Nguyen, Sasha Shabani, Inger Oulie, Siri Dørum, Yvette Dehnes, Leon Reubsaet, Trine Grønhaug Halvorsen

“…Smart samplers combine sampling and sample preparation in one tool; in this study smart samplers were developed using divinyl sulfone functionalized paper to immobilize antibodies for selective analyte capture. …”
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Reference Intervals for Echocardiography Parameters of Children Living in the Arkhangelsk Region and a Digital Application for Their Assessment by Aleksey A Karyakin, Igor’ S. Chub, Ol’ga E. Karyakina, Andrey M. Grjibovski, Aleksey V. Artemov, Ul’yana R. Zakharchenko

“…Reference intervals of echocardiography parameters were determined using body surface area as the dependent variable. The values were automatically calculated in our digital application that allows one to increase the accuracy and efficiency of interpretation of cardiac ultrasound parameters. …”
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Optimized Dual-Battery System with Intelligent Auto-Switching for Reliable Soil Nutrient Monitoring in Remote IoT Applications by Doan Perdana, Pascal Lorenz, Bagus Aditya

“…Implementing the DLB–PAO algorithm elevates the average reliability to 91.7% over 120 h, whereas the DLB–GA algorithm achieves near-perfect reliability (99.9%) for over 170 h, exhibiting minimal variability (standard deviation: 0.9%). The integration of intelligent auto-switching mechanisms and metaheuristic optimisation algorithms demonstrates a marked enhancement in both reliability and energy efficiency for soil nutrient monitoring systems. …”
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Expanding a Health Technology Solution to Address Therapist Challenges in Implementing Homework With Adult Clients: Mixed Methods Study by Brian E Bunnell, Kaitlyn R Schuler, Julia Ivanova, Lea Flynn, Janelle F Barrera, Jasmine Niazi, Dylan Turner, Brandon M Welch

“… BackgroundHomework is implemented with variable effectiveness in real-world therapy settings, indicating a need for innovative solutions to homework challenges. …”
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Impact of IgG subclass on monoclonal antibody developability by Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano, Yiqing Feng

“…We thus conducted a systematic study of 12 mAbs derived from three sets of unrelated variable regions, each cloned into IgG1, an IgG1 variant with diminished effector functions, IgG2, and a stabilized IgG4 variant with further reduced FcγR interaction, to evaluate the impact of IgG subclass on manufacturability and high concentration stability in a common formulation buffer matrix. …”
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Time-varying MVAR algorithms for directed connectivity analysis: Critical comparison in simulations and benchmark EEG data. by Mattia F Pagnotta, Gijs Plomp

“…Results from numerical simulations and from benchmark EEG recordings showed that: i) across a broad range of model orders all algorithms correctly reproduced patterns of interactions; ii) signal downsampling degraded connectivity estimation accuracy for most algorithms, although in some cases downsampling was shown to reduce variability in the estimates by lowering the number of parameters in the model; iii) single-trial modeling followed by averaging showed optimal performance with larger adaptation coefficients than previously suggested, and showed slower adaptation speeds than multi-trial modeling. …”
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Women with more severe degrees of temporomandibular disorder exhibit an increase in temperature over the temporomandibular joint by Almir Vieira Dibai-Filho, Ana Cláudia de Souza Costa, Amanda Carine Packer, Ester Moreira de Castro, Delaine Rodrigues-Bigaton

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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…Using productivity as a standard is useful for calculating efficiency, and can guide efforts to allocate resources optimally. …”
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The Effect of Working Capital on Investment: Evidence from the Tehran Stock Exchange by Ali Ebrahimnejad, Ali Zakizade, Fardin Razmjooei

“…The inclusion of working capital variables reveals higher cash flow coefficients, indicating that conventional models systematically underestimate internal financing's contribution to investment. …”
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Changes in white matter predict efficacy of repetitive transcranial magnetic stimulation in Parkinson's disease by Jinying Han, Lingling Lv, Xin Chen, Mengqi Wang, Lili Hu, Fengbo Xing, Pingping Liu, Liuzhenxiong Yu, Ziye Zhao, Jinmei Sun, Tingting Liu, Jingjing Cheng, Minhao Zhu, Manman Gao, Gongjun Ji, Rong Ye, Kai Wang, Panpan Hu

“…Conclusion: Baseline WM function may serve as a biomarker for predicting motor response to cTBS.…”
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Improvement of Calculation Technique for Flexible Orthotropic Plates on Elastic Base. Part 1: Calculation Theory by O. V. Kozunova

“…In nonlinear calculations, when finding the variable (secant) stiffness for the Zhemochkin section,  at each iteration, the “stiffness – curvature” dependence is used for each of the X and Y directions, approximated by a nonlinear function, the nature of the dependence of which graphically indicates the nonlinear-elastic operation of the orthotropic plate and its deformation taking into account crack formation and crack opening. …”
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Assessment of upper limb motor control: establishing normative benchmarks for clinical applications by Pablo Martín-Sierra, Cristina Sanchez, Eloy Urendes, Rafael Raya

“…A combination of clinical functional scales with the quantitative metrics presented here is expected to enable better evaluation of motor control. …”
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Mechatronic system for running-in and testing of mechanical transmissions in mining shovels by Sergey I. Malafeev, Alevtina A. Malafeeva, Vladimir I. Konyashin, Andrey A. Novgorodov

“…The mechanical transmissions of the hoist and drag winches, as well as the crowd mechanisms of mining shovels, operate under highly variable and shock cyclic loads. These severe operating conditions impose stringent quality requirements on both the manufacturing and assembly of such transmissions. …”
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Four-Dimensional Path Planning Methodology for Collaborative Robots Application in Industry 5.0 by Ilias Chouridis, Gabriel Mansour, Vasileios Papageorgiou, Michel Theodor Mansour, Apostolos Tsagaris

“…The safety value of dynamic obstacles, the coefficients of the importance of the terms of the agent’s distance to the ending point, and the safety value of dynamic obstacles were introduced in the objective function. …”
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Systematic Evaluation of Isolation Techniques and Freeze‐Thaw Effects on Plasma Extracellular Vesicle Heterogeneity and Subpopulation Profiling by Xueqi Li, Xiangyu Li, Lingjun Tong, Liqiao Hu, Yanfen Hong, Ruoyu Zhou, Zonghong Li, Ming Dong, Junjie Hou, Tao Xu, Wen Zhong

“…However, standardizing blood‐derived EV isolation remains challenging due to the heterogeneity of EV populations and variability among isolation techniques. In this study, we systematically evaluated three distinct EV isolation methods, including asymmetrical flow field‐flow fractionation (AF4), size‐exclusion chromatography (SEC) and automated centrifugal microfluidic disc system combined with functionalized membranes (Exo‐CMDS), to compare their efficiency in isolating EVs from both freshly frozen and freeze‐thawed plasma samples. …”
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Linear Interpolation on a Euclidean Ball in Rⁿ by Mikhail V. Nevskii, Alexey Yu. Ukhalov

“…We mean by \(C(B)\) the space of continuous functions \(f:B\to{\mathbb R}\) with the norm \(\|f\|_{C(B)}:=\max_{x\in B}|f(x)|\) and by \(\Pi_1\left({\mathbb R}^n\right)\) the set of polynomials in \(n\) variables of degree \(\leq 1\), i.e. linear functions on \({\mathbb R}^n\). …”
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Investigating the influence of soil organic carbon on pore structure within aggregates by Jingjing Liu, Yu Tian, Chiara Pasut, Mark Farrell, Shenggao Lu

“…The results revealed that the hydrogen peroxide treatment variably reduced organic carbon in soil aggregates, with Cambisol samples showing a higher removal efficiency (38.58–63.31%) compared to Ultisol samples (27.33–45.74%). …”
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Estimativa das temperaturas máximas e mínimas do ar para a região do Circuito das Frutas, SP Estimation of maximum and minimum air temperatures for the "Circuito das Frutas" region... by Ludmila Bardin, Mário J. Pedro Júnior, Jener F. L. de Moraes

“…Also, maps with the spacial variability of the maximum and minimum mean monthly and annual temperatures are presented for the region.…”
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Comparative Genomics of Rhamnolipid Synthesis and Monoaromatic Hydrocarbon Tolerance Genes in Environmental Pseudomonas aeruginosa strains [version 2; peer review: 2 approved] by Sandro B. Martel-Torres, Camila Castillo-Vilcahuaman, ROGER A. PALOMINO HUARCAYA, Susana M. Gutiérrez Moreno, Fernando A. Merino Rafael

“…The BTEX (benzene, toluene, ethylbenzene, and xylene) are toxic hydrocarbons requiring efficient microbial degradation for bioremediation. …”
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Convergence analysis of option drift rate inverse problem based on degenerate parabolic equation by Miao-miao Song, Zui-cha Deng, Xiang Li, Qiu Cui

“…In this paper, we study the convergence of the inverse drift rate problem of option pricing based on degenerate parabolic equations, aiming to recover the stock price drift rate function by known option market prices. Unlike the classical inverse parabolic equation problem, the article transforms the original problem into an inverse problem with principal coefficients of the degenerate parabolic equation over a bounded region by variable substitution, thus avoiding the error introduced by artificial truncation. …”
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