Developments in the study of the role of lactate metabolism in the genesis and progression of thyroid cancer by Lei Shi, Lei Shi, Lei Shi, Xuyang Zhong, Jiafeng Liu, Yong Ying, Zibing Liao, Jin Liu, Liwen Zhao, Jianing Zhong, Jianing Zhong, Xiangtai Zeng, Xiangtai Zeng

“…We systematically dissect the multifaceted regulatory circuits governing lactate metabolism by integrating three pivotal dimensions: (i) canonical signaling cascades; (ii) tumor-microenvironmental variables, most notably hypoxia and acidosis; and (iii) the emerging epigenetic paradigm of lactylation, which dynamically reprograms the catalytic efficiency of rate-limiting enzymes and reshapes the transcriptional landscape of metabolic genes, thereby precisely coordinating lactate homeostasis. …”
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Load frequency control in isolated island city microgrids using deep graph reinforcement learning considering extensive scenarios by Ping He, Xiongwei Huang, Ruobing He, Linkun Yuan

“…Demonstrated effectively in China Southern Grid’s island microgrid setup, LE-LFC emerges as an advanced solution for modern grid variability, offering superior robustness, adaptability, and learning speed, thus enabling flexible and efficient energy system management.…”
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Evaluation of the efficacy of hydrated sodium calcium aluminosilicate at mitigating the negative impact of aflatoxicosis on nutrient digestibility and other production- and health-... by Ahmed Ali Saleh, Rashed A. Alhotan, Mohammed A.A. Al-Badwi, Elsayed Osman Hussein, Livio Galosi, Giuseppe Crescenzo, Mahmoud Alagawany, Walied Abdo, Sara Mahmoud Omar, Claudia Zizzadoro

“…Importantly, not all types of aluminosilicates have the same decontaminating efficiency; thus, a full characterization of the protective properties of each single material would assist in selecting the most appropriate binder. …”
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Hybrid Approach of Finite Element Method, Kigring Metamodel, and Multiobjective Genetic Algorithm for Computational Optimization of a Flexure Elbow Joint for Upper-Limb Assistive D... by Duc Nam Nguyen, Thanh-Phong Dao, Ngoc Le Chau, Van Anh Dang

“…The optimization problem considers three design variables and two objective functions. An efficient hybrid optimization approach of central composite design (CDD), finite element method (FEM), Kigring metamodel, and multiobjective genetic algorithm (MOGA) is developed. …”
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A differential diagnostic model based on immunological evaluation and routine laboratory tests: distinguishing multiple myeloma from other disorders with aberrant immunoglobulin el... by Manning Li, Sixun Jia, Han Wu, Chunyi Shou, Xiaolu Song, Ye Peng, Huafang Wang, Ying Wang, Xiangmin Tong, Yirui Chen

“…Laboratory indicators, including complete blood count, biochemistry, coagulation function, and immunoglobulin markers, were collected. …”
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New Patient PROMIS Scores of Patients Presenting with Low Back Pain Predict Time to Elective Spine Surgery by Justin E. Kung, Chase Gauthier, Yianni Bakaes, Michael Spitnale, Richard A. Bidwell, David G. Edelman, Heidi C. Ventresca, J. Benjamin Jackson, Shari Cui, Gregory Grabowski

“…A chart review was conducted to collect sociodemographic variables, clinic visit details, and PROMIS domain scores (PF [Physical Function], PI [Pain Interference], Depression, and Global Health―Physical and Global Health―Mental). …”
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Optimization Design of Fast Neutron Target Station Beam Extraction Based on Genetic Algorithm by QIN Ziqian1, 2, 3, TAN Xinjian2, 3, ZHANG Xiaodong2, 3, PAN Qingquan1, LIU Xiao2, 3

“…Therefore, the aforementioned parameters are used as variables, and the three important indicators are taken as the objective function. …”
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‘‘Practices and factors affecting on-site medical equipment maintenance at Wau Teaching Hospital, South Sudan’’ by Natale Massimino Ucin, Manassé Nimpagaritse, Shital Mahindra Maru, Mulatedzi Makhado, Shiferaw Mitiku Tebeka

“…Abstract Background of the study Along with developments in the clinical domain, medical equipment is becoming more sophisticated, and it needs to function at peak efficiency. In this case, hospitals should priorities the prompt and effective maintenance of life-saving equipment. …”
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Effect of Central Motor and Neuromuscular Impairments on Front Crawl Body Roll Characteristics of Para Swimmers by Yu-Hsien Lee, Dawn Nicola O’Dowd, Luke Hogarth, Brendan Burkett, Carl Payton

“…CMNI swimmers were divided into three upper-limb [mild (n = 9), moderate (n = 9), severe (n = 9)] and three lower-limb function subgroups [bilateral (n = 2), unilateral (n = 6), without kick (n = 19)] based on their Froude efficiency (a measure of how effectively upper limbs contribute to propulsion) and the number of lower limbs actively kicking during trials, respectively. …”
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Sensitivity analysis of melting heat transfer in Williamson fluid by Aliya Batool, Zakir Hussain, Dilawar Hussain

“…The model is simplified to ordinary differential equations by introducing similarity variables and tackled by bvp4c Matlab function. The significant variables on flow model are identified by Response Surface Method (RSM). …”
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A Semantic Generalization of Shannon’s Information Theory and Applications by Chenguang Lu

“…The improvements in machine learning methods involve multi-label learning and classification, maximum mutual information classification, mixture models, and solving latent variables. Furthermore, insights from statistical physics are discussed: Shannon information is similar to free energy; semantic information to free energy in local equilibrium systems; and information efficiency to the efficiency of free energy in performing work. …”
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The Effect of Hydraulic Partitioning on Prediction the Rate of Bed Load Transport in Gravel-bed Rivers using Support Vector Machine by Kiyoumars Roushangar, Mohammad Hosseini, Saman Shahnazi

“…After optimization of parameters for kernel function, the bed load transport rate was predicted and obtained results from different models were investigated in terms of correlation coefficient (R), Root mean square error (RMSE) and Nash-Sutcliffe (NSE). in order to assess the capability of SVM in quantification of bed load under varied hydraulic conditions, Froude number (Fr) and bed slope of channel (S0) were selected as a parameters describing the hydraulic conditions and median diameter of the sediment particles (D50) and shear Reynolds number (Re*) were considered as a representative of sediment characteristic. …”
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Impact of pulmonary rehabilitation in sleep in COPD patients measured by actigraphy. by Suman B Thapamagar, Kathleen Ellstrom, James D Anholm, Ramiz A Fargo, Nagamani Dandamudi

“…Paired comparisons (t-test or Wilcoxon-signed-rank test) were performed before and after PR data on all variables.<h4>Methods</h4>This retrospective study of COPD patients undergoing PR utilized actigraphy watch recordings before and after 8-weeks of PR to assess changes in sleep variables including total time in bed (TBT), total sleep time (TST), sleep onset latency (SOL), sleep efficiency (SE), wakefulness after sleep onset (WASO) and total nocturnal awakenings. …”
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ITER NBI operational window and power availability constraints due to shine-through losses by P. Vincenzi, M. Schneider, P. Veltri, J.F. Artaud, A. Loarte, S. Nicolici, C. Poggi, A.R. Polevoi, A. Snicker

“…We then present a new heuristic formula which permits the calculation of the ST fraction and the minimum plasma density that permits ITER NBI operations as a function of global variables. This allows for establishing operational limits for Hydrogen and Deuterium NBI in Hydrogen, Deuterium, and Deuterium–Tritium plasmas. …”
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The effects of IT capability and distribution competence on business performance of retailers in Omnichannel by Anh T.D. Nguyen

“…To maintain the effectiveness of business operations, increase customer value and enhance competitive advantage, retailers should generate the efficiency of IT and distribution functions. Contribution: Omnichannel is a relatively new channel in Vietnam. …”
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Manufacturing of Rotational Toroidal Shells in Coin Minting by Luís M. Alves, Paulo Alexandrino, Sónia Pereira

“…Through finite element modeling and experimentation, key process variables were identified, ensuring sound hollow toroidal shells with efficient rotation.…”
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Contribution of entropy analysis on three-dimensional Prandtl model under Hall and ion slip effects with generalized mass and heat fluxes via OHAM by Sana Akbar, Muhammad Sohail, Syed Tehseen Abbas, Abha Singh

“…This article also examined the combined impacts of thermal conductivity change together with variable mass diffusion co-efficient within the heat and mass transport in the occurrence of Prandtl fluid. …”
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同轴全铰链双输出脉冲发生机构尺度综合与优化 by 杜力, 邹昌平, 冯俊, 向成宣, 黄茂林

“…In order to enhance the efficiency,stability and simplify the structure of the mechanism,the dimension synthesis of the full hinge coaxial two-output function generator is performed by using group-synthesis scheme and regarding the six-bar mechanism as the parallel mechanism of a set of basic four-bar mechanism and a set of equivalent four-bar mechanism.Firstly,a basic four-bar mechanism synthetic model is established and solved based on two position synthesis and equal instantaneous transmission ratio.Then the dimensional parameters of an equivalent four-bar mechanism（a five-bar loop） is solved by using equivalent principle of a variable link-length four-bar mechanism based on the basic four-bar mechanism.By this scheme,the dimensional synthesis of high order of motion parameter can be solved with good results,and the results show that the pulse data of the full hinge coaxial two-output function generator is only six percent.…”
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Developing a machine learning model for fast economic optimization of solar power plants using the hybrid method of firefly and genetic algorithms, case study: optimizing solar the... by Ali Omidkar, Razieh Es'haghian, Hua Song

“…The objective functions were to optimize the exergy efficiency and the heat cost. …”
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The Relationship between Optimism and Mindfulness with Cognitive Performance in Older Adults by Sanaz Ghannadi, Morteza Tarkhan

“…Furthermore, 34% of the variance in cognitive function was explained by optimism and mindfulness.Conclusion: Therefore, based on the findings of the present study, it can be concluded that optimism and mindfulness are important variables in predicting cognitive function (p < 0.05).…”
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