Assessing the Skeletal Muscle Pump During Lower Limb Counterpressure: Lags and Causality in Cardiovascular Regulation by Silvin P. Knight, Eoin Duggan, Feng Xue, Roman Romero‐Ortuno

“…The study provides a novel methodological framework for assessing skeletal muscle pump function and its impact on cardiovascular dynamics. …”
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Unraveling novel variants in the NF1 gene and investigating potential therapeutic strategies by Jianmei Huang, Ke Yang, Yaoping Wang, Xinrui Ma, Wenke Yang, Xiaodong Huo, Jie Bai, Hongjie Zhu, Jinming Wang, Yibing Lv, Shixiu Liao

“…A retrospective analysis of 49 clinical trials over the past 20 years revealed that NF1 therapies predominantly target neurofibromin’s GTPase function. Gene therapies aiming to restore neurofibromin by transducing the truncated NF1-GRD gene have been developed but faced pre-clinical challenges, including cloning capacity, transduction efficiency, and immunogenicity caused by gene delivery. …”
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Time-Jerk Optimal Robotic Trajectory Planning Under Jerk and Continuity Constraints via Convex Optimization by Chen Qian, Jianjun Yao, Yikun Zhang

“…Additionally, the objective function is improved to optimize both time and joint jerk simultaneously. …”
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Leveraging Cognitive and Speech Ecological Momentary Assessment in Individuals With Phenylketonuria: Development and Usability Study of Cognitive Fluctuations in a Rare Disease Pop... by Shifali Singh, Lisa Kluen, Katelin Curtis, Raquel Norel, Carla Agurto, Elizabeth Grinspoon, Zoe Hawks, Shawn Christ, Susan Waisbren, Guillermo Cecchi, Laura Germine

“…Similarly, to assess variability in task performance over the course of all EMAs, the coefficient of variability was computed; 28% for the task measuring sustained attention, 37% for semantic fluency, 15.8% for the task measuring executive functioning, and 17.6% for processing speed. …”
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A New Optimization Approach for Maximizing the Photovoltaic Panel Power Based on Genetic Algorithm and Lagrange Multiplier Algorithm by Mahdi M. M. El-Arini, Ahmed M. Othman, Ahmed Fathy

“…The technique which is based on objective function represents the output power of the PV panel and constraints, equality and inequality. …”
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A Three-Block Inexact Heterogeneous Alternating Direction Method of Multipliers for Elliptic PDE-Constrained Optimization Problems with a Control Gradient Penalty Term by Xiaotong Chen, Tongtong Wang, Xiaoliang Song

“…In some practical applications, it is necessary to smooth the control variables and suppress their large fluctuations, especially at the boundary. …”
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Optimization of fermentation conditions for enhanced acetylcholine and biomass production of Lactiplantibacillus plantarum AM2 using the Taguchi approach by Walid A. Lotfy, Amira M. Ali, Heba M. Abdou, Khaled M. Ghanem

“…Abstract This study aimed to optimize the fermentation conditions and medium composition for maximum acetylcholine (ACh) and biomass production by Lactiplantibacillus plantarum AM2 using the Taguchi array design, which enables efficient identification of influential variables through minimal experimental runs. …”
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Binary composite crossover genetic algorithm for locating critical slip surface by Wei Qin, Jiancheng Zhao

“…A reasonable combination of parameters for the binary composite crossover (BCC) operator in the RGA-BCC is determined through six benchmark function experiments. On this basis, the stability of five soil slopes from the literature was analysed using the RGA-BCC in combination with the Morgenstern and Price method, and the results obtained were compared with those in the published literature to demonstrate that the RGA-BCC is able to efficiently determine the CSSs of slopes and their minimum factors of safety. …”
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Optimization of Aerodynamic Design of a Winged UAV Through Genetic Algorithms and Large Eddy Simulation by Mohammad Javad Ebrahimi, Mahmoud Pasandidehfard, Ali Esmaeili, Mohammad Hossein Moghimi Esfandabadi

“…Optimization was conducted for six variables in a single stage, with 25 tests performed. …”
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Optimal tuning of multi-PID controller using improved CMOCSO algorithm by Ying Hu, Xiongyan Liu, Hao Chen

“…In this model, the parameters are designated as decision variables, the performance index serves as the objective function, and the stability constraints of the system are incorporated. …”
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Performance Investigation of Coated Carbide Tools in Milling Procedures by Paschalis Charalampous

“…The optimization of the manufacturing conditions in milling processes composes a crucial task for enhancing machining efficiency and extending the tool’s lifespan. This study presents an investigation of the cutting tool’s performance under varying machining parameters via the generation of an experimental dataset that was obtained through laboratory-controlled milling operations. …”
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Decentralized queue control with delay shifting in edge-IoT using reinforcement learning by Viacheslav Kovtun

“…Analytical expressions for key QoS indicators (delay, variability, loss, energy consumption) as functions of the shift parameter are derived, and a multi-factor reward function is constructed. …”
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Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…Although RNAi holds great promise as a functional genomics tool for larval schistosomes, our finding of potential off-target or nonspecific effects of some dsRNA treatments and variable efficiencies in specific gene knockdown indicate a critical need for gene-specific testing and optimization as an essential part of experimental design, execution and data interpretation.…”
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Analysis of value-based healthcare (VBHC) framework by incremental cost-effectiveness of surgical and therapeutic interventions: a retrospective study at tertiary private health gr... by Mona Khamis, Zainab Almoosa, Marie Santos, Engineer Diaa Kamal, Suhail Yaghmor, Muhammad Daniyal, Abbas Al Mutair

“…Additionally, ICER values were positively associated with better functional outcomes in MS and stroke patients, with mobility (b = 1.027, p = 0.003) and activity (b = 1.768, p < 0.001). …”
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A Low-Complexity Direction-of-Arrival Estimation Algorithm for Noncircular Signals via Subspace Rotation Technique by Wei Wang, Ming Zhang, Bobin Yao, Tongxing Zheng, Xiaojiao Fan

“…Then, utilizing the separation of variables and the orthogonality between the reduced-dimension noise subspace and the space spanned by the columns of the extended manifold matrix, a new one-dimensional spectral search function is derived to estimate DoAs. …”
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Elucidating Genotypic Variation in Quinoa via Multidimensional Agronomic, Physiological, and Biochemical Assessments by Samreen Nazeer, Muhammad Zubair Akram

“…The results revealed that significant variation was observed across all measured parameters, highlighting the diverse adaptive strategies and functional capacities among the tested genotypes. More specifically, genotypes Q4, Q11, Q15, and Q126 demonstrated superior agronomic potential and canopy-level physiological efficiencies, including high biomass accumulation, low infrared canopy temperatures and sustained NDVI values. …”
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Time-varying MVAR algorithms for directed connectivity analysis: Critical comparison in simulations and benchmark EEG data. by Mattia F Pagnotta, Gijs Plomp

“…Results from numerical simulations and from benchmark EEG recordings showed that: i) across a broad range of model orders all algorithms correctly reproduced patterns of interactions; ii) signal downsampling degraded connectivity estimation accuracy for most algorithms, although in some cases downsampling was shown to reduce variability in the estimates by lowering the number of parameters in the model; iii) single-trial modeling followed by averaging showed optimal performance with larger adaptation coefficients than previously suggested, and showed slower adaptation speeds than multi-trial modeling. …”
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Women with more severe degrees of temporomandibular disorder exhibit an increase in temperature over the temporomandibular joint by Almir Vieira Dibai-Filho, Ana Cláudia de Souza Costa, Amanda Carine Packer, Ester Moreira de Castro, Delaine Rodrigues-Bigaton

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EEGUnity: Open-Source Tool in Facilitating Unified EEG Datasets Toward Large-Scale EEG Model by Chengxuan Qin, Rui Yang, Wenlong You, Zhige Chen, Longsheng Zhu, Mengjie Huang, Zidong Wang

“…To tackle the challenges, this paper introduces EEGUnity, an open-source tool that incorporates modules of "EEG Parser", "Correction", "Batch Processing", and "Large Language Model Boost". Leveraging the functionality of such modules, EEGUnity facilitates the efficient management of multiple EEG datasets, such as intelligent data structure inference, data cleaning, and data unification. …”
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The Effect of Working Capital on Investment: Evidence from the Tehran Stock Exchange by Ali Ebrahimnejad, Ali Zakizade, Fardin Razmjooei

“…The inclusion of working capital variables reveals higher cash flow coefficients, indicating that conventional models systematically underestimate internal financing's contribution to investment. …”
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