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Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells
Published 2024-10-01“…An antigen-sensitive and long-lasting CAR-T cell targeting GUCY2C was investigated in this study.Methods Using constructed tumor cell lines with various GUCY2C expression densities, we screened out an antigen-sensitive single chain variable fragment (scFv) that enabled CAR-T cells to efficiently eradicate the GUCY2C lowly expressed tumor cells. …”
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1263
Improved representation of soil moisture processes through incorporation of cosmic-ray neutron count measurements in a large-scale hydrologic model
Published 2024-12-01“…<p>Profound knowledge of soil moisture and its variability plays a crucial role in hydrological modelling to support agricultural management, flood and drought monitoring and forecasting, and groundwater recharge estimation. …”
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1264
RNAtango: Analysing and comparing RNA 3D structures via torsional angles.
Published 2024-10-01“…It supports researchers in accurately assessing structural similarities, which contributes to the precision and efficiency of RNA modeling.…”
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Flexible imputation toolkit for electronic health records
Published 2025-05-01“…Pympute’s core algorithm, Flexible, intelligently selects the optimal imputation method for each variable based on its characteristics. Pympute offers a comprehensive suite of functionalities. …”
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Neighborhood competition improves biomass estimation for Scots pine (Pinus sylvestris L.) but not Pyrenean oak (Quercus pyrenaica Willd.) in young mixed forest stands
Published 2025-08-01“…Therefore, accurate biomass estimation is essential for understanding ecosystem functioning and informing forest management strategies to mitigate climate change. …”
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1267
Shape Accuracy Improvement of the Flange Turning Process in Aluminum Aerosol Can Production
Published 2024-12-01“…These findings support more efficient production processes for aluminum aerosol bottles.…”
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1268
KNOT OPTIMIZATION FOR BI-RESPONSE SPLINE NONPARAMETRIC REGRESSION WITH GENERALIZED CROSS-VALIDATION (GCV)
Published 2025-01-01“…Nonparametric regression is a statistical method used to model relationships between variables without making strong assumptions about the functional form of the relationship. …”
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1269
Development of Speech Therapy Application for Children with Stuttering (STACS)
Published 2025-09-01“…Conclusion: Most parents found this prototype app easy to use, efficient in training their children, and highly functional. …”
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Analysis of Hydrological and Meteorological Conditions in the Southern Baltic Sea for the Purpose of Using LNG as Bunkering Fuel
Published 2025-06-01“…The southern Baltic Sea is characterized by highly variable weather conditions, particularly in autumn and winter, when storms, strong westerly winds, and temporary sea ice formation disrupt maritime operations. …”
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Effects of electron beam irradiation on microbial loads, physicochemical properties, stability of active ingredients, and antioxidant activity in Angelica sinensis Radix
Published 2025-10-01“…As the demand for safe, wholesome, and high-quality food continues to rise, more research is being done on innovative food processing technologies that maximize efficiency while reducing negative effects on food quality. …”
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Optimal selection of satellite XCO<sub>2</sub> images for urban CO<sub>2</sub> emission monitoring
Published 2025-01-01“…Despite such efficient filtering, the accuracy of the estimates corresponding to the former group of images varies widely from city to city.…”
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Human saliva exerts strong type-dependent effects on adenovirus infectivity
Published 2025-06-01“…All human Ads used were replication-competent and expressed a GLN cassette containing a green-fluorescent protein, nano-luciferase, and neomycin resistance. Loss-of-function experiments were conducted by immunoprecipitation or enzymatic digestion of specific saliva components to decipher related mechanisms.ResultsTemporal and inter-individual variability in saliva samples were observed, validating the use of a saliva pool to represent the population. …”
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Order assignment mechanism based on hierarchical decomposition and element matching
Published 2025-06-01“…This integrates and coordinates operational tasks, ensures no resource conflicts, and provides alternatives for responding to battlefield variables. The approach employs a planning network model to illustrate the logical interrelationships among operations. …”
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The Analysis of the Effective Factors on Urban Blight in District 3, Region 12, Tehran City
Published 2019-09-01“…Moreover, a factor analysis was employed to reduce the number of independent variables and identify the urban blight dimensions. …”
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Smart technique for calculating fault current model parameters using short circuit current measurements
Published 2025-08-01“…The difference concept can be utilized to obtain precise mathematical formulas for evaluating the parameters of the fault current model. This is for efficient implementation of multiple functions that include digital protective relay, fault locator, digital filter, CT saturation detector and compensator. …”
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Development of a Data‐Driven Lightning Scheme for Implementation in Global Climate Models
Published 2025-02-01“…Abstract This study proposes a new lightning scheme applicable at the global scale, predicting lightning rates from climatic variables. Using satellite lightning records spanning a period of 29 years, we apply machine learning methods to derive a functional relationship between lightning and climate reanalysis data. …”
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Exploring the Impact of School-Based Physical and Perceived Environments on Students’ Physical Activity During Recess: A Case Study of Four Schools in Xi’an, China
Published 2024-10-01“…The study’s results confirmed previous findings from a social–ecological perspective and provide a comprehensive assessment framework that includes the spatial organization/spatial quality of the school and the perceived variables of safety, comfort, aesthetics, accessibility and functionality. …”
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Dimensions-Reduced Volterra Digital Pre-Distortion Based On Orthogonal Basis for Band-Limited Nonlinear Opto-Electronic Components
Published 2019-01-01“…Here, we propose the use of orthogonal polynomial basis functions for efficient DPD implementation. The orthogonal basis enables the estimation of each coefficient separately, which provides a significant computational gain. …”
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Three Decades of Land Cover Dynamics in a Boreal Coastal Basin: A Multisensor Spectral Index and Machine Learning Approach Using Landsat Data and GB-SAR Data
Published 2025-01-01“…Boreal coastal habitats, with their complex hydrological, ecological, and geological functions, play a pivotal role in regulating regional climate, supporting biodiversity, and sustaining local communities. …”
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