Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition by Mie K. Jakobsen, Sofie Traynor, Aaraby Y. Nielsen, Christina Dahl, Mette Staehr, Simon T. Jakobsen, Maria S. Madsen, Rasmus Siersbaek, Mikkel G. Terp, Josefine B. Jensen, Christina B. Pedersen, Anup Shrestha, Jonathan R. Brewer, Pascal H. G. Duijf, Odd L. Gammelgaard, Henrik J. Ditzel, Alexei F. Kirkin, Per Guldberg, Morten F. Gjerstorff

“…Results We show that breast cancer tumors and cell cultures exhibit a highly heterogenous response to DNA methyltransferase inhibitors, persisting even under high drug concentrations and efficient DNA methyltransferase depletion. The observed variability in response to DNA methyltransferase inhibitors was independent of cancer-associated aberrations and clonal genetic diversity. …”
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Dual-Stream Enhanced Deep Network for Transmission Near-Infrared Dorsal Hand Vein Age Estimation with Attention Mechanisms by Zhenghua Shu, Zhihua Xie, Xiaowei Zou

“…Simultaneously, another deep residual network is leveraged to strengthen the representation ability on subtle dorsal vein textures. Moreover, variable activation functions and pooling layers are integrated into the respective streams to enhance the nonlinearity modeling of the dual-stream model. …”
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Nonlinearity Estimation and Compensation for Accurate PMSM Modeling and Voltage Prediction by Beichen Ding, Yuting Lu, Chunyan Lai, Weiwen Peng, Kaide Huang, Guodong Feng

“…Specifically, the offsets to the base model are modeled using nonlinear functions with variable coefficients to compensate saturation and core loss effect, which can achieve better accuracy without changing the model structure. …”
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Numerical Simulation of Folding Tail Aeroelasticity Based on the CFD/CSD Coupling Method by Di Zhou, Weitao Lu, Jiangpeng Wu, Tongqing Guo, Binbin Lv, Hongtao Guo, Hongya Xia

“…The aeroelastic coupling was achieved through successive iterations of CFD and CSD computations in the time domain. An adaptive multi-functional morphing aircraft allowing tail fold motion was selected to be studied. …”
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Supply chain management and optimization in transportation logistics by Saoussen Krichen

“…SCM can also be seen as the process of optimizing a set of decisions that generate cost-effective solutions which provide efficient plans for acting on numerous levels while considering all decision-making standpoints. …”
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An enhanced buck-boost converter for photovoltaic diagnosis application: Accurate MPP tracker and I-V tracer by Yassine Chouay, Mohammed Ouassaid

“…In normal operation, the converter is controlled by neural network (NN) controller to efficiently extract maximum power point (MPP). However, in the event of a system failure, the converter automatically transitions to variable load mode to capture different points on the current-voltage (I-V) curve. …”
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Seasonal and diurnal freeze–thaw dynamics of a rock glacier and their impacts on mixing and solute transport by C. Louis, L. J. S. Halloran, C. Roques

“…<p>Rock glaciers play a vital role in the hydrological functioning of many alpine catchments. Here, we investigate seasonal and daily freeze–thaw cycles of the previously undocumented Canfinal rock glacier (RG) located in the Val d'Ursé catchment (Bernina Range, Switzerland) and the RG's influence on the dynamics of the hydrogeological system. …”
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Development of data-driven machine learning models and their potential role in predicting dengue outbreak by Bushra Mazhar, Nazish Mazhar Ali, Farkhanda Manzoor, Muhammad Kamran Khan, Muhammad Nasir, Muhammad Ramzan

“…This involves gathering data on various climatic factors, including temperature, rainfall, relative humidity, and wind speed, along with monthly records of dengue cases. The study functions as an efficient warning system, enabling the anticipation of dengue outbreaks. …”
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Two Weighted Fuzzy Goal Programming Methods to Solve Multiobjective Goal Programming Problem by Mousumi Gupta, Debasish Bhattacharjee

“…Here, the relative weights represent the relative importance of the objective functions. The proposed methods involve one additional goal constraint by introducing only underdeviation variables to the fuzzy operator λ (resp., 1-λ), which is more efficient than some well-known existing methods such as those proposed by Zimmermann, Hannan, Tiwari, and Mohamed. …”
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Symbolic Framework for Evaluation of NOMA Modulation Impairments Based on Irregular Constellation Diagrams by Nenad Stefanovic, Vladimir Mladenovic, Borisa Jovanovic, Ron Dabora, Asutosh Kar

“…This work presents a new symbolic framework approach for simulating signal processing functions in SDR transmit–receive paths in a dynamic NOMA downlink use case. …”
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Rapid global fitting of large fluorescence lifetime imaging microscopy datasets. by Sean C Warren, Anca Margineanu, Dominic Alibhai, Douglas J Kelly, Clifford Talbot, Yuriy Alexandrov, Ian Munro, Matilda Katan, Chris Dunsby, Paul M W French

“…This approach is often considered to be prohibitively slow and/or computationally expensive but we present here a computationally efficient global analysis algorithm for the analysis of time-correlated single photon counting (TCSPC) or time-gated FLIM data based on variable projection. …”
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Empowering small-scale industries food safety: Designing fuzzy controlled pulse electric field pasteurization by Ika Noer Syamsiana, Mohammad Wildan Fikri Amrullah, Muhammad Akhlis Rizza, Wahyu Aulia Nurwicaksana, Zakiyah Irfin, Ratna Ika Putri, Cahya Rahmad

“…The objective is to develop a more efficient and economical alternative solution for milk preservation. …”
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ASSESSING THE FARMERS’ SATISFACTION WITH THE PARTICIPATORY COCONUT PLANTING PROJECT (PCPP) USING REGRESSION ANALYSIS by Leomarich F. CASINILLO

“…The data were summarized through descriptive calculations and determine the association of variables with the aid of regression analysis. Results of the study have depicted that coconut farmers, on average, are satisfied with the different functions of PCPP in regard to their farming activities. …”
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DC algorithm for estimation of sparse Gaussian graphical models. by Tomokaze Shiratori, Yuichi Takano

“…Specifically, we convert the cardinality constraint into an equivalent constraint based on the largest-K norm, and reformulate the resultant constrained optimization problem into an unconstrained penalty form with a DC (difference of convex functions) representation. To solve this problem efficiently, we design a DC algorithm in which the graphical lasso algorithm is repeatedly executed to solve convex optimization subproblems. …”
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Fault Estimation for Semi-Markov Jump Neural Networks Based on the Extended State Method by Lihong Rong, Yuexin Pan, Zhimin Tong

“…To alleviate network congestion and optimize communication resources, the Round-Robin protocol is adopted to schedule data transmission efficiently. By constructing a Lyapunov–Krasovskii functional and applying the discrete Wirtinger inequality, sufficient conditions are derived to ensure the mean square exponential stability and dissipative performance of the system. …”
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Agricultural Waste–Derived Biochar for Antibiotics Removal in Aqueous Environment: A Comprehensive Outlook by Varalakshmi Varatharajan, Karthik V., Selvakumar Periyasamy

“…The key elements influencing antibiotic adsorption on biochar, including surface chemistry, pyrolysis conditions, and environmental variables, were discussed in detail. This review focuses specifically on the functional modification of the biochar, the mechanism involved in antibiotic adsorption, and the scalability of this process. …”
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Finite Difference/Fractional Pertrov–Galerkin Spectral Method for Linear Time-Space Fractional Reaction–Diffusion Equation by Mahmoud A. Zaky

“…The Pertrov–Galerkin spectral method is adapted using non-smooth generalized basis functions to discretize the spatial variable, and the L1 scheme on a non-uniform graded mesh is used to approximate the Caputo fractional derivative. …”
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Tumor-Associated Macrophages as Key Modulators of Disease Progression in Diffuse Large B-Cell Lymphoma by Corina Joldes, Laura Jimbu, Oana Mesaros, Mihnea Zdrenghea, Bogdan Fetica

“…Response to immunotherapy relies on the availability, functionality, and efficacy of the host’s immune effector mechanisms. …”
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A Comparative Study in Fuzzy Control Systems for Cruise Control Vehicles by Adnan Shaout, Malek I El Amr

“…However, these systems are very complex and require an accurate model, which is difficult to achieve due to complex and variable road conditions. Therefore, reaching level 5 autonomous driving, which refers to a fully automated vehicle capable of performing all driving functions, will eventually require fuzzy logic inference to help incorporate human-like thinking into the vehicle. …”
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The study of socio economic factors’ influence on the capacity dynamics of the pharmaceutical market in contracting conditions by А. А. Kotvitska, V. H. Kostiuk

“…For the effective functioning of pharmaceutical companies in the current economic conditions it is necessary to carry out product policy aimed to expanding the range of medicines that are most popular. …”
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