Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells by Xiaofei Wei, Lin Shen, Chang Liu, Cheng Zhang, Min Tao, Jian Li, Xicheng Wang, Ting He, Fei Dai, Changsong Qi, Mingyang Ma, Yanping Ding, Xinan Lu, Dongqun Liu

“…An antigen-sensitive and long-lasting CAR-T cell targeting GUCY2C was investigated in this study.Methods Using constructed tumor cell lines with various GUCY2C expression densities, we screened out an antigen-sensitive single chain variable fragment (scFv) that enabled CAR-T cells to efficiently eradicate the GUCY2C lowly expressed tumor cells. …”
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RAMAS-Net: a module-optimized convolutional network model for aortic valve stenosis recognition in echocardiography by Yejia Gan, Wanzhong Huang, Yan Deng, Xiaoying Xie, Yuanyuan Gu, Yaozhuang Zhou, Qian Zhang, Maosheng Zhang, Yangchun Liu

“…IntroductionAortic stenosis (AS) is a valvular heart disease that obstructs normal blood flow from the left ventricle to the aorta due to pathological changes in the valve, leading to impaired cardiac function. Echocardiography is a key diagnostic tool for AS; however, its accuracy is influenced by inter-observer variability, operator experience, and image quality, which can result in misdiagnosis. …”
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Post-thaw dimethyl sulfoxide reduction in autologous peripheral blood progenitor cell suspensions by Miroslava Jandová, Pavel Měřička, Jiří Gregor, Miriam Lánská, Aleš Bezrouk, Dana Čížková, Jakub Radocha

“…Background and objectives: Dimethyl sulfoxide has become the most common cryoprotectant used for cryopreservation of hematopoietic progenitor cells because of its efficiency, regardless of its potentially toxic side effects. …”
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Multi-objective optimal scheduling of cascade reservoirs in complex basin systems: Case study of the Jinsha River-Yalong River confluence basin in China by Zhaocai Wang, Zhihua Zhu, Hualong Luan, Tunhua Wu

“…Benchmark function tests demonstrate that IMOSSA outperforms others in terms of optimization capability and stability. …”
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Shunt active power filter using model predictive control with stability guarantee by Jhon Pérez-Ramírez, Diego Montoya-Acevedo, Walter Gil-González, Oscar Danilo Montoya, Carlos Restrepo

“…The cost function exhibits convex characteristics, ensuring a unique control law. …”
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The MiBlend Randomized Trial: Investigating Genetic Polymorphisms in Personalized Responses to Fruit and Vegetable Interventions for Chronic Disease Prevention by Julia N. DeBenedictis, Na Xu, Theo M. de Kok, Simone G. van Breda

“…As with most dietary intervention studies, inter-individual variability was observed in the responses, which might be the consequence of genetic differences. …”
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Safety Assessment of Loop Closing in Active Distribution Networks Based on Probabilistic Power Flow by Wenchao Cai, Yuan Gao, Xiping Zhang, Qin Si, Jiaoxin Jia, Bingzhen Li

“…By modeling DGs and loads as random variables, their cumulants are efficiently obtained through LHS. …”
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Comparing the Effect of Beractant (Beraksurf™) with That of Poractant Alfa (Curosurf®) on the Need for Intermittent Positive Pressure Ventilation in Neonatal Respiratory Distress S... by Yosra Khazani, Sirous Fathi Manesh, Elnaz Shaseb, Parvin Sarbakhsh

“…Performing appropriate adjusted analysis leads to a more interpretable and efficient estimation of treatment effects. Semiparametric adjustment approach modifies the estimating equations solved by the marginal treatment effect estimator by adding an augmentation function, which makes use of the baseline covariates and estimate the unbiased marginal treatment effect with improved precision. …”
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Computational studies reveal structural characterization and novel families of Puccinia striiformis f. sp. tritici effectors. by Raheel Asghar, Nan Wu, Noman Ali, Yulei Wang, Mahinur Akkaya

“…However, due to the lack of an efficient genetic transformation system in Pst, progress in effector function studies has been slow. …”
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Numerical Investigation and Optimization of Transpiration Cooling Plate Structures with Combined Particle Diameter by Dan Wang, Yaxin Liu, Xiang Zhang, Mingliang Kong, Hanchao Liu

“…An optimization analysis of CPD−PS is conducted using response surface methodology (RSM), and the influence of design variables on the objective function (<i>η</i>_ave and <i>p</i>) is analyzed. …”
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Sustainable PV-hydrogen-storage microgrid energy management using a hierarchical economic model predictive control framework by Xinyu Guo, Faying Gu, Hongxu Liu, Yongcheng Yu, Runjie Li, Juan Wang

“…First, a precise nonlinear model of the PHS microgrid is established and the logic variables are introduced to capture the hydrogen devices’ short-term properties, i.e., the start-up/shut-down of electrolyzers and fuel cells. …”
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Grid-connected PV inverter system control optimization using Grey Wolf optimized PID controller by Monika Gupta, P. M. Tiwari, R. K. Viral, Ashish Shrivastava, Basem Abu Zneid, Iryna Hunko

“…Conventional controllers such as P and PI are widely used in PV applications due to their simplicity, but they exhibit notable limitations in dynamic environments, including increased Total Harmonic Distortion (THD), slower transient response, and poor voltage regulation—particularly under variable irradiance conditions. The proposed GWO-PID method overcomes these limitations by leveraging the GWO algorithm’s global search capability to dynamically optimize the PID gains (Kp, Ki, Kd) based on a composite fitness function that minimizes Mean Squared Error (MSE) and THD. …”
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KERNEL DETERMINATION PROBLEM FOR ONE PARABOLIC EQUATION WITH MEMORY by Durdimurod K. Durdiev, Javlon Z. Nuriddinov

“…This paper studies the inverse problem of determining a multidimensional kernel function of an integral term which depends on the time variable \(t\) and \((n-1)\)-dimensional space variable \(x'= \left(x_1,\ldots, x_ {n-1}\right)\) in the \(n\)-dimensional diffusion equation with a time-variable coefficient at the Laplacian of a direct problem solution. …”
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Enhancing Urban Heat Island Analysis Through Multisensor Data Fusion and GRU-Based Deep Learning Approaches for Climate Modeling by Ning Tang, Muhammad Farhan, Pir Mohammad, M. Abdullah-Al-Wadud, Saddam Hussain, Umair Hamza, Rana Muhammad Zulqarnain, Nazih Yacer Rebouh

“…The adopted approach emphasizes vegetation&#x0027;s crucial function in reducing UHI&#x0027;s effects and offers valuable insights for urban planning and measures to mitigate climate change.…”
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Developing data driven framework to model earthquake induced liquefaction potential of granular terrain by machine learning classification models by Kennedy C. Onyelowe, Viroon Kamchoom, Tammineni Gnananandarao, Krishna P. Arunachalam

“…The high precision and Phi Correlation Coefficient further affirm the reliability and accuracy of the model’s predictions. …”
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Development of a Plant-Based Beverage with Tarwi (<i>Lupinus mutabilis</i>) Milk, Polysaccharides from Cushuro (<i>Nostoc sphaericum</i>), and Blueberry Extract by Santos Calderón, Renzo Bañón

“…The response variables were protein (%) content and viscosity coefficient (mPa·s). …”
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Two‐dimensional echocardiographic right heart ratios for assessment of right heart size in dogs: Reference intervals and reproducibility by Jacqueline N. Sankisov, Lance C. Visser, Kate E. Davis, June A. Boon, Evan S. Ross, Abigail C. Laws

“…Conclusions and Clinical Importance Reference intervals for simple body weight‐independent right heart ratios are available to help detect abnormalities of right heart size and function. Reproducibility coefficients might be useful to help identify meaningful changes in right heart size during serial evaluations.…”
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Fully Parametric Optimization Designs of Wing Components by Zhendong Hu, Ju Qiu, Fa Zhang

“…The changing tendencies of the thickness of wing skins and the cross-section areas of the wing beams are fitted to continuous polynomial functions, whose coefficients are designed as variables, which is a different engineering approach from the size variants of the thickness and the area in the traditional optimization. …”
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The impact of energy poverty on the health capital of middle-aged and older adult residents in rural China by Cuiting Yu, Tianrun Li, Qin Wan

“…Endogeneity was addressed using instrumental variables and propensity score matching.ResultsThe findings indicate that energy poverty has a significant negative impact on health capital, with a regression coefficient of −0.221(p&lt;0.01), lowering self-rated health levels. …”
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The Relationship Between Biometric Features of Trees and the Intensity of Birch Sap Leakage in Various Forest Sites by Szczepan Kopeć, Paweł Staniszewski, Robert Tomusiak, Maciej Bilek, Dariusz Zastocki, Tadeusz Moskalik

“…Research on the utility value of birch sap and the influence of a number of factors on its efficiency and quality has been carried out in many research centers, but so far, there are not many studies on the variability of such parameters as a function of time, taking into account the entire period of sap leakage. …”
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