Phenotypic screen of early-developing larvae of the blood fluke, schistosoma mansoni, using RNA interference. by M M Mourão, Nathalie Dinguirard, Glória R Franco, Timothy P Yoshino

“…Although RNAi holds great promise as a functional genomics tool for larval schistosomes, our finding of potential off-target or nonspecific effects of some dsRNA treatments and variable efficiencies in specific gene knockdown indicate a critical need for gene-specific testing and optimization as an essential part of experimental design, execution and data interpretation.…”
Get full text

Distinctive Gait Variations and Neuroimaging Correlates in Alzheimer's Disease and Cerebral Small Vessel Disease by Xia Zhou, Wen‐Wen Yin, Chao‐Juan Huang, Si‐Lu Sun, Zhi‐Wei Li, Ming‐Xu Li, Meng‐Meng Ren, Ya‐Ting Tang, Jia‐Bin Yin, Wen‐Hui Zheng, Chao Zhang, Yu Song, Ke Wan, Yue Sun, Xiao‐Qun Zhu, Zhong‐Wu Sun

“…Gait metrics included the timed up and go (TUG) test, dual‐task TUG (DTUG) test, Berg balance scale (BBS), dual‐task cost (DTC), step length, gait speed, cadence and coefficient of variation of gait. The relationships among structural and perfusion variations, gait metrics and cognitive function were examined. …”
Get full text

Steady-State Dynamical Response of a Strongly Nonlinear System with Impact and Coulomb Friction Subjected to Gaussian White Noise Excitation by Guidong Yang, Dongmei Huang, Wei Li, Meng Su

“…The Zhuravlev nonsmooth transformation of the state variables combined with the Dirac delta function is utilized to simplify the original system to one without velocity jump. …”
Get full text

Exploring the nexus of many-body theories through neural network techniques: the tangent model by Senwei Liang, Karol Kowalski, Chao Yang, Nicholas P Bauman

“…The NN representation not only allows us to evaluate the effective interactions efficiently for various geometrical configurations of chemical systems corresponding to various levels of complexity of the underlying wave functions, but also reveals that the bare and effective interactions are related by a tangent function of some latent variables. …”
Get full text

Biotinylated fusion protein-streptavidin-peroxidase complex based non-competitive magnetic immunoassay for rapid detection of organophosphorus pesticides by Ruirui Shi, Jiangke Li, Wenli Yu, Tengfei Yin, Haiyan Lin, Juan Liu, Wenyu Cui

Get full text

Neutral Mode Dominates the Forced Global and Regional Surface Temperature Response in the Past and Future by Fukai Liu, Jian Lu, L. Ruby Leung

“…Abstract Using a large suite of Green's function perturbation experiments, we construct the emergent dynamical operator for surface temperature and extract the most excitable mode. …”
Get full text

Modeling Overall Survival in Patients With Pancreatic Cancer From a Pooled Analysis of Phase II Trials by Eva Rahman Kabir, Faruque Azam, Tanisha Tabassum Sayka Khan, Hasina Yasmin, Namara Mariam Chowdhury, Syeda Maliha Ahmed, Baejid Hossain Sagar, Nasrin Ahmed Tahrim

“…The relationship between predictors and OS was explored by a gamma generalized linear model (GLM) with a log‐link function and compared with linear models. Results The Spearman rank correlation coefficient between PFS/TTP and OS was 0.88 (95% confidence interval [CI] 0.85–0.89; p < 0.0001; n = 610) and between ORR and OS was 0.58 (0.52–0.64; p < 0.0001; n = 514). …”
Get full text

Sensitivity analysis of melting heat transfer in Williamson fluid by Aliya Batool, Zakir Hussain, Dilawar Hussain

“…The model is simplified to ordinary differential equations by introducing similarity variables and tackled by bvp4c Matlab function. The significant variables on flow model are identified by Response Surface Method (RSM). …”
Get full text

qDESH: a method to quantify disproportionately enlarged subarachnoid space hydrocephalus by Sofia Behndig, Afroditi Lalou, Jan Axelsson, Jenny Larsson, Anders Wåhlin, Pavel Ryska, Ondrej Slezak, Katrine Riklund, Jan Zizka, Jan Malm, Anders Eklund

Get full text

Optimized Blade Design of Counter-Rotating-Type Pump-Turbine Unit Operating in Pump and Turbine Modes by Jin-Woo Kim, Jun-Won Suh, Young-Seok Choi, Kyoung-Yong Lee, Toshiaki Kanemoto, Jin-Hyuk Kim

“…The pump and turbine mode efficiencies of the unit were selected as the objective functions and they combined into a single specific objective function with the weighting factors. …”
Get full text

Radar-equivalent snowpack: reducing the number of snow layers while retaining their microwave properties and bulk snow mass by J. Meloche, N. R. Leroux, B. Montpetit, V. Vionnet, C. Derksen

“…A reduction in the mathematical complexity of SWE retrieval cost functions and a reduction in computation of up to 80 % can be gained by using fewer layers in the SWE retrieval.…”
Get full text

Developing a novel hybrid model based on GRU deep neural network and Whale optimization algorithm for precise forecasting of river’s streamflow by Amin Gharehbaghi, Redvan Ghasemlounia, Farshad Ahmadi, Rasoul Mirabbasi, Ali Torabi Haghighi

“…The Pearson’s correlation coefficient (PCC) and Cosine Amplitude Sensitivity (CAS) as feature (input) selection process determine the only precipitation (P m ) as the most effective input variable among a list of on-site potential climate time series parameters recorded in the study area. …”
Get full text

TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1 by Christina Funk, Nadja Uhlig, Zsolt Ruzsics, Florentin Baur, Matthias Peindl, Sarah Nietzer, Karina Epting, Gabriele Vacun, Gudrun Dandekar, Catherine Botteron, Christian Werno, Thomas Grunwald, Susanne M. Bailer

“…Viruses are able to efficiently penetrate cells, multiply, and eventually kill infected cells, release tumor antigens, and activate the immune system. …”
Get full text

An assessment of the likely impact of strain-related phenotypic plasticity on hominin fossil species identification by M. Collard, S.J. Lycett

“…We divided the measurements into three groups: measurements of features subject to high masticatory strain, measurements of features subject to low-to-moderate masticatory strain, and measurements of features that do not remodel and therefore are not prone to strain-related phenotypic plasticity. Next, we used the coefficient of variation and ANOVA to investigate whether masticatory strain is a cause of variability. …”
Get full text

Why is Multi-Business Forestry Needed to Overcome the Low Performance of Forestry Governance and Food Security in Indonesia? by Suryanto Suryanto, Dodik Ridho Nurrochmat, Suria Darma Tarigan, Iskandar Zulkarnaen Siregar, Ishak Yassir, Mangarah Silalahi, Irdika Mansur, Rhett D. Harisson, Agus Wahyudi, Lutfy Abdulah

“…Results showed that CLD formulated in 280 sub-models in a total of 4,764 decision variables with an error deviation of 6.4%. The SM Mb-F simulation on two sample concession units produces a projected increase in wood supply, employment, and state revenue, plus the provision of new functions such as food, NTFP, and environmental services. …”
Get full text

IrrigApp: An Online Tool for Determining Crop Water Use and Evaluating Irrigation Scheduling Options by José O. Payero

“…., county, crop, soil type, start date, end date, irrigation applications, and irrigation efficiency). IrrigApp calculates daily crop evapotranspiration (ETc) and conducts a daily soil water balance to estimate several daily and seasonal variables, such as ETc under dryland and irrigated conditions, soil water content in the crop root zone, and water losses by runoff and deep percolation. …”
Get full text

Optimizing Load Frequency Control of Multi-Area Power Renewable and Thermal Systems Using Advanced Proportional–Integral–Derivative Controllers and Catch Fish Algorithm by Saleh A. Alnefaie, Abdulaziz Alkuhayli, Abdullah M. Al-Shaalan

“…Additionally, by contrasting the performance of the PID, PI, cascaded PI(PDN), and FOPID, PI(1+DD) controllers, the efficiency of the CFA is confirmed. Additionally, a sensitivity analysis that considers simultaneous modifications of the frequency bias coefficient (B) and speed regulation (R) within a range of ±25% validates the efficacy and dependability of the suggested CFA-tuned PI(1+DD). …”
Get full text

Emerging Role of Mesenchymal Stromal Cell and Exosome Therapies in Treating Cognitive Impairment by Vick Key Tew, Muttiah Barathan, Fazlina Nordin, Jia Xian Law, Min Hwei Ng

“…Cognitive aging, characterized by the gradual decline in cognitive functions such as memory, attention, and problem-solving, significantly impacts daily life. …”
Get full text

Decellularized adipose-derived matrix from Superficial layers of abdominal adipose tissue exhibits superior capacity of adipogenesis compared to deep layers by Xiaomu Ma, Qiang Yue, Su Fu, Chunjun Liu, Jie Luan

“…These findings not only deepen our comprehension of the structural and functional heterogeneity of adipose tissues but also become one of the reason for the large variability between batches of DAM products, providing guidance for constructing more efficient and stable bio-scaffolds.…”
Get full text

Revolutionizing Lung Segmentation with Machine Learning: A Critical Review of Techniques in Medical Imaging by Momina Aisha, Moazma Ijaz, Nimra Tariq, Sehar Anjum, Sidra Siddiqui, Usman Hashmi

“…Techniques such as X-rays, Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET) play essential roles in identifying the physical and functional aspects of the lungs. Manual lung segmentation by radiologists, while adjustable, is time-consuming and subject to variability. …”
Get full text