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Genetically surface-modified Escherichia coli outer membrane vesicles targeting MUC1 antigen in cancer cells
Published 2024-12-01“…In conclusion, this rapid and efficient bio-ligation system facilitates the display of functional scFv on OMV surfaces, offering a promising approach for targeted delivery to MUC1-expressing cancer cells.…”
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743
Exploring the optimal lower blood pressure boundary during endovascular thrombectomy in patients with large vessel occlusion
Published 2025-03-01“…No significant relationship was observed between DBP and functional outcomes. Patients with higher periprocedural SBP coefficient variance exhibited a decreased rate of good functional outcomes at 3 months (aOR, 0.42, 95% CI, 0.18–0.96). …”
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744
Discriminative Validity and Reliability of the Single-Leg Squat and Single-Leg Landing Frontal Plane Kinematics in Individuals with Lower Limb Functional Deficits
Published 2025-04-01“…It is necessary to identify variables and tests with adequate reliability and with the capability to discriminate individuals with and without lower limb functional deficits. …”
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745
Different whole body HIIT protocols do not promote different muscle thickness and functional adaptations among healthy physically active subjects
Published 2025-01-01“…Morphological (ultrasound-derived muscle thickness of the vastus lateralis [MTVL]) and general fitness (muscle endurance and maximal oxygen consumption) assessments were performed at pre- and post-intervention moments.ResultsBoth training protocols elicited significant improvements in all dependent variables (p < 0.05), with no significant between-group differences.ConclusionRegardless of the training configuration, both WB-HIIT programs serve as time-efficient strategies to induce changes in muscle thickness of the vastus lateralis and functional adaptations in healthy, physically active young individuals.…”
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746
Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention
Published 2025-04-01“…Dynamic functional connectivity studies report reduced brain activity efficiency, while graph theory analyses show decreased network integration. …”
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747
Dynamic brain-heart-gut coupling during sleep: a continuous physiological signal analysis
Published 2025-05-01“…However, current research on gut function primarily focuses on gut microbiota, with a lack of systematic investigation into the macroscopic dynamic changes of gut function. …”
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748
Research of Parameterization and Optimization of Shaped-profile and Size of Circular Arc Rotor Pair for Roots Pump
Published 2018-01-01“…Then,from pitch circle radius and shape coefficient as two design variables,the minimum wrapping cube space volume of rotor pair as an objective function,the upper limit of the shape coefficient and rounded-value of center distance and the diameter ratio of the rotor and other as constraint functions. …”
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749
Research Progress of Intelligent Evaluation and Virtual Reality Based Training in Upper Limb Rehabilitation afrer Stroke
Published 2023-06-01“…Automated assessment of upper extremity motor function based on machine learning algorithms with markerless sensing techniques has focused on the Fugl-Meyer assessment of upper extremity (FMA-UE), Brunnstrom stages, and Wolf motor function test (WMFT) scales and has been proved with high-scoring accuracy and time efficiency. …”
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750
The effect of early childhood stature on later cognitive functions in Indonesian adolescents: comparation using the National growth reference and the WHO growth standard
Published 2025-06-01“…In adolescence, cognitive function were assessed. An analysis was performed to assess the associations between variables. …”
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751
Exposure-response functions of the correlated environmental exposures green space, noise, and air pollution for quantifying mortality burden in health impact assessment
Published 2025-08-01“…The studies show substantial variability in exposure levels and correlations between exposures. …”
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752
MULTI-OBJECTIVE OPTIMIZATION DESIGN FOR CUTTING MECHANISM OF ROADHEADER BASED ON IMPROVED GENETIC ALGORITHM
Published 2016-01-01“…The comprehensive performance of cutting mechanism of roadheader is decided by cutting dust,quantity of pick consumption,specific density consumption,load fluctuation and production efficiency. This paper takes motion parameters and structure parameters of cutting mechanism for design variables and optimizes multi-objective function of comprehensive performance of cutting mechanism based on the improved genetic algorithm. …”
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753
The association between TNF-receptors (TNFR1 and TNFR2) and mortality as well as kidney function decline in patients with chronic kidney disease
Published 2024-11-01“…Differences in eGFR decline in relation to plasma TNFR1 and TNFR2 were estimated by both linear and logistic regression models, with regression coefficients and odds ratios (ORs). Results: Univariate models showed significant associations between TNFR1 (n = 985) and TNFR2 (n = 988) and all-cause mortality based on 7424 person-years at risk, but in the fully adjusted models with continuous variables significant only for TNFR2 HR 1.17 (1.03–1.34), but with a borderline value for TNFR1 HR 1.15 (1.00–1.31). …”
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754
Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356× mutation in synapsin I.
Published 2013-01-01“…Given that the NMD efficiency is highly variable among individuals and cell types, we investigated also the effects of expression of the mutant protein and found that it is expressed at lower levels compared to wild-type synapsin I, forms perinuclear aggregates and is unable to reach presynaptic terminals in mature hippocampal neurons grown in culture. …”
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755
Direct methanol fuel cells parameter identification with enhanced algorithmic technique
Published 2025-04-01Get full text
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756
Influence of heavy oil components and optimal magnetic nanocatalysts on the heavy oil upgrading by microwave-assisted
Published 2025-09-01“…It indicates a slight loss in efficiency due to aggregation or degradation.…”
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757
Statistical learning-driven parameter tuning in injection molding using modified simplex method
Published 2025-09-01“…The Taguchi design of experiments and desirability function analysis were employed to establish a baseline. …”
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758
Transient decline and early recovery of noninvasive myocardial work after kidney transplantation: a prospective study
Published 2025-12-01“…NIMW parameters include global myocardial work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE).Results 1) Renal function indicators, including blood urea nitrogen, serum creatinine, and estimated glomerular filtration rate improved significantly at 10 days post-KT. …”
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759
Sensitivity Analysis of Numerical Coherency Model for Rock Sites
Published 2025-03-01“…Because of difficulties in developing an empirical coherency function from a site-specific dense array, it is seldom used in practice. …”
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760
Optimizing a Bayesian Method for Estimating the Hurst Exponent in Behavioral Sciences
Published 2025-05-01Get full text
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