Applications of mutagenesis methods on affinity maturation of antibodies in vitro by LIU Yuan, LIN Manman, ZHANG Xiao, XU Chongxin, JIAO Linxia, ZHONG Jianfeng, WU Aihua, LIU Xianjin

“…In chain shuffling, a variable heavy or light chain of a specific antibody is recombined with a complementary variable domain library. …”
Get full text

Efectos de los factores de edificabilidad sobre la productividad laboral de moldajes de vigas en fundaciones The effects of buildability factors on formwork labor productivity of g... by Abdulaziz M Jarkas

“…Therefore, the objective of this research is to investigate and quantify the effects and relative influence of the following buildability factors on formwork labor efficiency of this activity: (a) variability of beam sizes; (b) beam sizes; and (c) number of joints formed at beams intersections. …”
Get full text

The Role of the Gut Microbiome in Exercise-Induced Inflammation and Recovery: A Narrative Review by Stanisław Dudek, Weronika Koziak, Aleksandra Bętkowska, Agata Kornacka, Kamila Szostak, Rafał Tomaka, Michalina Makieła, Wojciech Dudek, Anna Byra

“…While moderate exercise enhances immune function and microbial diversity, excessive training can lead to gut dysbiosis, increased intestinal permeability, and chronic inflammation. …”
Get full text

Application of multi-objective neural network algorithm in industrial polymerization reactors for reducing energy cost and maximising productivity by Fakhrony Sholahudin Rohman, Sharifah Rafidah Wan Alwi, Dinie Muhammad, Ashraf Azmi, Zainuddin Abd Manan, Jeng Shiun Lim, Hong An Er, Siti Nor Azreen Ahmad Termizi

“…Optimization on an industrial scale is a complex task that involves fine-tuning the performance of large-scale systems and applications to make them more efficient and effective. This process can be challenging due to the increasing volume of work, growing system complexity, and the need to maintain optimal performance. …”
Get full text

Intelligent Environmental Health Risk Assessment System for the Elderly in Cold Regions Based on Artificial Intelligence Integrated Development Environment by Tianheng ZHANG, Yao FU, Jian GAO, Huanran XUE

“…Physiological indicators include systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure (PP), which are measured using an Omron HEM-7136 electronic sphygmomanometer. Psychological variables are assessed using validated Chinese versions of the Profile of Mood States (POMS) and Restoration Outcome Scale (ROS) with Cronbach’s α coefficients of 0.86 and 0.82 respectively. …”
Get full text

The human gut microbiota contributes to type-2 diabetes non-resolution 5-years after Roux-en-Y gastric bypass by Jean Debédat, Tiphaine Le Roy, Lise Voland, Eugeni Belda, Rohia Alili, Solia Adriouch, Pierre Bel Lassen, Kazuyuki Kasahara, Evan Hutchison, Laurent Genser, Licia Torres, Camille Gamblin, Christine Rouault, Jean-Daniel Zucker, Nathalie Kapel, Christine Poitou, Geneviève Marcelin, Federico E. Rey, Judith Aron-Wisnewsky, Karine Clément

Get full text

SwinDAF3D: Pyramid Swin Transformers with Deep Attentive Features for Automated Finger Joint Segmentation in 3D Ultrasound Images for Rheumatoid Arthritis Assessment by Jianwei Qiu, Grigorios M. Karageorgos, Xiaorui Peng, Soumya Ghose, Zhaoyuan Yang, Aaron Dentinger, Zhanpeng Xu, Janggun Jo, Siddarth Ragupathi, Guan Xu, Nada Abdulaziz, Girish Gandikota, Xueding Wang, David Mills

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause severe joint damage and functional impairment. Ultrasound imaging has shown promise in providing real-time assessment of synovium inflammation associated with the early stages of RA. …”
Get full text

Neuro-fuzzy inference system and white shark optimization of coagulation-flocculation of aquaculture wastewater treatment by A.F. Mohamed, H. Rezk

“…During the optimization process, these controlling parameters are used as a design variable whereas the objective function required to me be a maximum is the summation of turbidity removal and salinity removal. …”
Get full text

Early Predictive Value of the Glucose‐to‐Lymphocyte Ratio for the Occurrence of Stroke‐Associated Pneumonia by Fuqiang Zhou, Liju Ma, Min Li, Haijiang Li, Heying Yang, Ye Xu, Kuankuan Dang, Fengchen Gao, Haimei Sun

“…The GLR was converted into a categorical variable for trend testing, and compared the predictive efficiency of GLR through the receiver operating characteristic (ROC) curve and Bonferroni correction analysis. …”
Get full text

The Prognostic Significance of Sleep and Circadian Rhythm for Myocardial Infarction Outcomes: Case-Control Study by Wei-Chih Chin, Pao-Hsien Chu, Lung-Sheng Wu, Kuang-Tso Lee, Chen Lin, Chien-Te Ho, Wei-Sheng Yang, I-Hang Chung, Yu-Shu Huang

“…Actigraphy was used to evaluate sleep and circadian rhythm, while HRV was monitored for 24 hours to assess autonomic nerve function. Nonparametric indicators were calculated to quantify the active-rest patterns, including interdaily stability, intradaily variability, the most active 10 consecutive hours (M10), the least active 5 consecutive hours (L5), the relative amplitude, and the actigraphic dichotomy index. …”
Get full text

Assessment of Outcomes of the Modified Stoppa Approach in the Treatment of Acetabular Fractures: A Retrospective Cohort Study by Nurgeldi Manap, Nagmet Mursalov, Mukhtar Abilmazhinov

“…Exclusion criteria: other operative approaches to pelvic bones and patients under 18 years of age. 21 patients underwent surgery with the use of modified Stoppa approach (group A) and 10 surgeries were performed using the ilioinguinal approach (group B). Efficiency was evaluated by comparison of duration of surgical procedures, amount of blood lossbetween groups, size of skin incision, quality of reduction and functional outcomes. …”
Get full text

Network Meta-Analysis of Factors Influencing the Carbon Sink Capacity of Urban Park Green Spaces by Yutong JI, Tianyi LIN, Lian LIU, Xiong LI

“…While habitat composition and planting strategies offer substantial localized benefits, their variability necessitates tailored interventions informed by specific ecological and social contexts. …”
Get full text

Randomized single-dose crossover comparative bioavailability study of two novel oral cannabidiol (CBD) formulations in healthy volunteers under fed conditions, compared to a standa... by Mehmet Nevzat Pisak, Edibe Bereket, Aydin Erenmemisoglu

“…The time to peak concentration (tmax) was shortest for the liquid (median ~ 1.0 h), followed by the capsule (2.0 h), and longest for the reference (6.0 h). Inter-individual variability in C_max and AUC was substantially lower for both novel formulations (coefficients of variation ~ 27–44%) than for the reference (> 90%). …”
Get full text

Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells by Xiaofei Wei, Lin Shen, Chang Liu, Cheng Zhang, Min Tao, Jian Li, Xicheng Wang, Ting He, Fei Dai, Changsong Qi, Mingyang Ma, Yanping Ding, Xinan Lu, Dongqun Liu

“…An antigen-sensitive and long-lasting CAR-T cell targeting GUCY2C was investigated in this study.Methods Using constructed tumor cell lines with various GUCY2C expression densities, we screened out an antigen-sensitive single chain variable fragment (scFv) that enabled CAR-T cells to efficiently eradicate the GUCY2C lowly expressed tumor cells. …”
Get full text

Preparation of Trop2-targeted chimeric antigen receptor T cells and study of their exhaustion status in vitro by LIU Xiuying, LI Xinzhan, ZHU Jingjing, ZHU Jingjing

“…Methods‍　‍The second-generation CAR plasmid was constructed based on the single-chain variable fragment (scFv) sequence of Sacituzumab Govitecan targeting Trop2. …”
Get full text

Dynamic Surrogate Optimization of Vertically Stacked Nanosheet FET Based on Gaussian Process Regression by Christofer N. Yalung, Doldet Tantraviwat

“…Source extension (<inline-formula> <tex-math notation="LaTeX">$S_{ext}$ </tex-math></inline-formula>), drain extension (<inline-formula> <tex-math notation="LaTeX">$D_{ex\mathrm {t}}$ </tex-math></inline-formula>), gate length (<inline-formula> <tex-math notation="LaTeX">$L_{g}$ </tex-math></inline-formula>), nanosheet height (NSh), nanosheet width (NSw), and number of fin (nfin) make up the input variables. In addition to applying normalization to make the weight assignment to the goal functions easier, a penalty component was incorporated to manage the <inline-formula> <tex-math notation="LaTeX">$V_{T}$ </tex-math></inline-formula>. …”
Get full text

不同种群元宝枫种仁含油率及脂肪酸组成分析与评价Analysis and evaluation of oil content in seed kernel and fatty acid composition of Acer truncatum from different populations... by 韩旻昊1，2，燕丽萍1，王因花1，任飞1，梁燕1，仲伟国1，孙超1，吴德军1 HAN Minhao1,2, YAN Liping1, WANG Yinhua1, REN Fei1, LIANG Yan1, ZHONG Weiguo1, SUN Chao1, WU Dejun1

“…The average coefficients of variation of oil content in seed kernel and various main fatty acid from Haiyang, Shandong(12.59%), Tai′an, Shandong(11.22%) and Jinan, Shandong(10.36%) were higher. …”
Get full text

The Effectiveness of Using the Reggio Emilia Approach on the Experimental Science Lesson for Third-Grade Elementary Students by Batool Sabzeh, Farangis Ghalavand, Seyedamir Ghasemtabar

“…Results of the normality test for the research variables (level 1, 2, and 3 science learning) in third-grade students indicated that all variables, both pre-test and post-test, met the assumption of normality, with significance levels greater than 0.05. …”
Get full text

Integrated transportation system planning with gravitational search algorithm approach based on fuzzy mutant controller by Alireza Hosseinzadeh Kashani, Seyed Ahmad Shayannia, Mohammad Mehdi Movahedi, Soheila Sardar

“…The efficiency of the gravity search algorithm and the mutated gravity search algorithm is better in functions F4, F7, F11, F21. …”
Get full text

Penerapan Importance Performance Analysis (IPA) pada Evaluasi Keberlanjutan Penggunaan e-filing untuk Pelaporan Pajak Perorangan by Imelda Saluza, Dewi Sartika

“…Beberapa indikator tersebut antara lain adalah Understandability (kejelasan informasi yang diberikan oleh e-filing), Contact (kontak yang dapat dihubungi), Functionality (peningkatan kualitas dan mutu pajak), Ease of Use (e-filing sulit dipelajari), Usefulness (penghematan waktu pelaporan), Service Quality, Efficiency (pengaksesan e-filing dengan gadget lain), Fulfillment (kesulitan dalam memenuhi kebutuhan pelapor). …”
Get full text