Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy by Muthuganesh Muthuvel, Muthuganesh Muthuvel, Thamizhselvi Ganapathy, Trent Spencer, Sunil S. Raikar, Saravanabhavan Thangavel, Alok Srivastava, Alok Srivastava, Alok Srivastava, Sunil Martin

“…CARs are modular synthetic antigen receptors integrating the single-chain variable fragment (scFv) of an immunoglobulin molecule to the TCR signaling. …”
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A Fusion Method Based on Physical Modes and Satellite Remote Sensing for 3D Ocean State Reconstruction by Yingxiang Hong, Xuan Wang, Bin Wang, Wei Li, Guijun Han

“…This study developed an operational-oriented lightweight framework for three-dimensional ocean state reconstruction by integrating multi-source observations through a computationally efficient multivariate empirical orthogonal function (MEOF) method. …”
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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…The DL model exhibited high accuracy in tissue quantification and TP53 status prediction, outperforming traditional methods in terms of precision and efficiency. DL-based approaches offer significant promise for enhancing biomarker testing and precision oncology by reducing intra- and inter-observer variability, but further validation is required to optimize their integration into real-world clinical workflows. …”
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Numerical examination of the chemically reactive MHD flow of hybrid nanofluids over a two-dimensional stretching surface with the Cattaneo–Christov model and slip conditions by Algehyne Ebrahem A., Alamrani Fahad Maqbul, Seada M. M., Saeed Anwar, Bognár Gabriella

“…As main outcomes of the work, it is revealed that the increasing magnetic parameter enhances the skin friction of hybrid nanofluids; however, a reverse influence is noticed in the velocity curve. …”
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Precision optimization of reactive squeezing flow in stratified fluids: A response surface exploration by Anum Shafiq, Tabassum Naz Sindhu, Muhammad Ahmad Iqbal

“…The Nusselt number, Sherwood number, and skin friction coefficient are computed numerically for various parameter settings. …”
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Cost-effective process design for methanol synthesis from carbon dioxide hydrogenation by Sheng-Zhong Huang, Chih-Yao Lin, Chianghui Wang, Akhmat Fauzan Saputra, Henggar Yudha Hananto, Nicolas Justin Sutanto, Anggit Raksajati, Vincentius Surya Kurnia Adi

“…Accordingly, this research introduces an optimization framework capable of handling diverse process configurations, operating variables, and their interactions. This approach enables effective optimization using total annual cost (TAC) as the objective function and significantly enhances process design efficiency. …”
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Multi-Objective Optimal Design of 200 kW Permanent Magnet Synchronous Motor Based on NSGA-II by Chengxu Sun, Qi Li, Tao Fan, Xuhui Wen, Ye Li, Hongyang Li

“…Interior permanent magnet synchronous motors (IPMSMs) are widely applied as drive motors in electric vehicles because they have the advantages of high power density, high efficiency, and excellent dynamic performance. This paper introduces a framework for multi-objective optimization, tailored for the demands of V-Shaped IPMSMs, which involves high-dimensional variables. …”
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Accurate prediction of clinical stroke scales and improved biomarkers of motor impairment from robotic measurements. by Dimitris K Agrafiotis, Eric Yang, Gary S Littman, Geert Byttebier, Laura Dipietro, Allitia DiBernardo, Juan C Chavez, Avrielle Rykman, Kate McArthur, Karim Hajjar, Kennedy R Lees, Bruce T Volpe, Michael Krams, Hermano I Krebs

“…<h4>Objective</h4>One of the greatest challenges in clinical trial design is dealing with the subjectivity and variability introduced by human raters when measuring clinical end-points. …”
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COVID-19 recovery: benefits of multidisciplinary respiratory rehabilitation by Wim Janssens, Greet Hermans, Rik Gosselink, Daniel Langer, Thierry Troosters, Hilde Beyens, Stephanie Everaerts, Arne Heyns, Natalie Lorent

“…Impressive results on physical recovery were determined after 6 weeks and 3 months, with significant improvement of lung function, muscle force and exercise capacity variables. …”
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Signatures of Rapidly Rotating Stars with Chemically Homogeneous Evolution in the First Galaxies by Boyuan Liu, Yves Sibony, Georges Meynet, Volker Bromm

“…We find that the rest-frame UV luminosity of star-forming galaxies can be significantly enhanced by a factor of  ∼3−6 when CHE stars above a minimum initial mass of ${m}_{\star ,\min }^{\mathrm{CHE}}\sim 2-10\,{M}_{\odot }$ account for more than half of the total stellar mass following a Salpeter initial mass function. As a result, the UV luminosity functions observed at z  ∼ 12−16 can be reproduced with less extreme values of star formation efficiency and UV luminosity stochastic variability. …”
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Codesign of Transmit Waveform and Receive Filter with Similarity Constraints for FDA-MIMO Radar by Qiping Zhang, Jinfeng Hu, Xin Tai, Yongfeng Zuo, Huiyong Li, Kai Zhong, Chaohai Li

“…Finally, the Riemannian limited-memory Broyden–Fletcher–Goldfarb–Shanno (RL-BFGS) algorithm is employed to optimize the variables in parallel. Simulation results demonstrate that our method achieves a 0.6 dB improvement in SINR compared to existing methods while maintaining competitive computational efficiency. …”
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ANALYTICAL SOLUTIONS OF NON-LINEAR HEAT CONDUCTION PROBLEMS by V. A. Bondarev

“…An example of calculations in the case of variable coefficients of thermal conductivity and radiative heating transfer on the boundaries is considered in the paper. …”
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Unsupervised selective labeling for semi-supervised industrial defect detection by Jian Ge, Qin Qin, Shaojing Song, Jinhua Jiang, Zhiwei Shen

“…This has motivated a shift towards semi-supervised learning (SSL), which leverages labeled and unlabeled data to improve learning efficiency and reduce annotation costs. This work proposes the unsupervised spectral clustering labeling (USCL) method to optimize SSL for industrial challenges like defect variability, rarity, and complex distributions. …”
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Robust Optimization Research of Cyber–Physical Power System Considering Wind Power Uncertainty and Coupled Relationship by Jiuling Dong, Zilong Song, Yuanshuo Zheng, Jingtang Luo, Min Zhang, Xiaolong Yang, Hongbing Ma

“…Furthermore, the deterministic power balance constraints are relaxed into inequality constraints that account for wind power forecasting errors through fuzzy variables. The lower-level model focuses on minimizing traffic load shedding by establishing a topology–function-constrained information network traffic model based on the maximum flow principle in graph theory, thereby improving the efficiency of network flow transmission. …”
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Retrieval of carbon and inorganic phosphorus during hydrothermal carbonization: ANN and RSM modeling by Abolfazl Shokri, Mohammad Amin Larki, Ahad Ghaemi

“…Next, Multilayer Perceptron (MLP) and Radial Basis Function (RBF) were used to compare the results and improve the model fit. …”
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Support vector regression model for the prediction of buildings’ maximum seismic response based on real monitoring data by Dongwang Tao, Shizhe Fang, Haixu Liu, Jianqi Lu, Jiang Wang, Qiang Ma

“…Our results demonstrate that SVR-MDR model outperform other machine learning models such as kernel ridge regression and decision tree models, and SVR-MDR and RSVR-MDR models outperform conventional loglinear regression and multinomial models, because SVR can map the complex nonlinear function of multiple variables and consider the available information of buildings especially the fundamental frequency. …”
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Accurate Sugarcane Detection and Row Fitting Using SugarRow-YOLO and Clustering-Based Spline Methods for Autonomous Agricultural Operations by Guiqing Deng, Fangyue Zhou, Huan Dong, Zhihao Xu, Yanzhou Li

“…This model introduces the WTConv convolutional modules to expand the sensory field and improve computational efficiency, adopts the iRMB inverted residual block attention mechanism to enhance the modeling capability of crop spatial structure, and uses the UIOU loss function to effectively mitigate the misdetection and omission problem in the region of dense and overlapping targets. …”
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Biomechanical Analysis of <i>Camellia oleifera</i> Branches for Optimized Vibratory Harvesting by Rui Pan, Ziping Wan, Mingliang Wu, Shikui Lu, Lewei Tang

“…The nonlinear least squares method, based on the hyperbolic tangent function, was employed to fit the bending load–deflection curves of the branches. …”
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Randomization-Driven Hybrid Deep Learning for Diabetic Retinopathy Detection by A. M. Mutawa, G. R. Hemalakshmi, N. B. Prakash, M. Murugappan

“…Timely identification is crucial for efficient intervention, as untreated diabetic retinopathy can progress to irreversible vision loss. …”
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Exploring Machine Learning Models for Vault Safety in ICL Implantation: A Comparative Analysis of Regression and Classification Models by Qing Zhang, Qi Li, Zhilong Yu, Ruibo Yang, Emmanuel Eric Pazo, Yue Huang, Hui Liu, Chen Zhang, Salissou Moutari, Shaozhen Zhao

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