Optimization of PLGA-Doxorubicin Hybrid Nanoparticles using Design of Experiments: Synthesis, Characterization, and Applications by Adina TURCU-STIOLICA, Andrei BITA, Maria Viorica CIOCILTEU

“… Background and Aim: Poly (lactic-co-glycolic acid) (PLGA) exhibits a range of advantageous properties, including tunable particle sizes, stability, biodegradability, and the potential for surface functionalization. These characteristics have established PLGA as a widely utilized material in drug delivery systems. …”
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Changes in white matter predict efficacy of repetitive transcranial magnetic stimulation in Parkinson's disease by Jinying Han, Lingling Lv, Xin Chen, Mengqi Wang, Lili Hu, Fengbo Xing, Pingping Liu, Liuzhenxiong Yu, Ziye Zhao, Jinmei Sun, Tingting Liu, Jingjing Cheng, Minhao Zhu, Manman Gao, Gongjun Ji, Rong Ye, Kai Wang, Panpan Hu

“…Conclusion: Baseline WM function may serve as a biomarker for predicting motor response to cTBS.…”
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Application of Post-Occupancy Evaluation in the Design of Collegiatae Educational Space: (Case study: Faculty of Arts and Architecture, Islamic Azad University-Tehran South Branch) by Reza Naghdbishi, Zeinab Gohari

“…This process led to the development of structural equations, path coefficient models, and factor loadings for the conceptual model.…”
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Assessment of upper limb motor control: establishing normative benchmarks for clinical applications by Pablo Martín-Sierra, Cristina Sanchez, Eloy Urendes, Rafael Raya

“…A combination of clinical functional scales with the quantitative metrics presented here is expected to enable better evaluation of motor control. …”
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Evaluating Machine Learning Models for Predicting Hardness of AlCoCrCuFeNi High-Entropy Alloys by Uma Maheshwera Reddy Paturi, Muhammad Ishtiaq, Pasupuleti Lakshmi Narayana, Anoop Kumar Maurya, Seong-Woo Choi, Nagireddy Gari Subba Reddy

“…This study evaluates the predictive capabilities of various machine learning (ML) algorithms for estimating the hardness of AlCoCrCuFeNi high-entropy alloys (HEAs) based on their compositional variables. Among the ML methods explored, a backpropagation neural network (BPNN) model with a sigmoid activation function exhibited superior predictive accuracy compared to other algorithms. …”
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Meristic and morphometric comparison of an undescribed sucker of the Río Culiacán (Catostomus sp.) and Yaqui sucker (Catostomus bernardini) (Catostomidae, Teleostei) from the Sierr... by Gorgonio Ruiz-Campos, Sergio Sánchez-Gonzáles, Richard L. Mayden, Alejandro Varela-Romero

“…Likewise, the discrimination was associated with the lowest values for predorsal distance, soft posterior ocular margin to occiput, and number of anal rays. The standardized coefficients for canonical variables 1 and 2 accounted 82.6% of the total variation. …”
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Estimativa das temperaturas máximas e mínimas do ar para a região do Circuito das Frutas, SP Estimation of maximum and minimum air temperatures for the "Circuito das Frutas" region... by Ludmila Bardin, Mário J. Pedro Júnior, Jener F. L. de Moraes

“…The obtained correlation coefficients varied from 0.91 to 0.96 and 0.71 to 0.94 of the maximum and minimum air temperature, respectively. …”
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Exploring restoration efforts from a social lens: statistical models reveal relationships between salmon habitat restoration efforts and ecological and social characteristics of th... by Brittany D King, Robert Fonner

“…Among the social explanatory variables, the percentage of non-Hispanic white residents in a subwatershed was the most prominent predictor of the number of restoration worksites across models, producing positive and statistically significant estimated coefficients in the instream, riparian, and total worksite models. …”
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Drug Release Analysis and Optimization for Drug-Eluting Stents by Hongxia Li, Yihao Zhang, Bao Zhu, Jinying Wu, Xicheng Wang

“…The diffusion coefficients and the coating thickness are selected as design variables. …”
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Concurrent Validity of Wearable Nanocomposite Strain Sensor With Two-Dimensional Goniometer and Its Reliability for Monitoring Knee Active Range of Motion in Multiple Participants by Han-Byeol Choi, Yongjun Kim, Ji Young Lim, Seonghee Kim, Sang Yul Yang, Kihyeon Kim, Hyouk Ryeol Choi, Seunghyun Baik, Ji Hye Hwang

“…The range of motion (ROM) of joints in the human body is essential for movement and functional performance. Real-time monitoring of joint angles is crucial for confirming pathologic biomechanics, providing feedback during rehabilitation, and evaluating the treatment efficacy. …”
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Reconstructing Equatorial Electron Flux Measurements From Low‐Earth‐Orbit: A Conjunction Based Framework by D. L. Stumbaugh, J. Bortnik, S. G. Claudepierre

“…For each conjunction, we fit the equatorial pitch angle distribution (PAD) parameterized by the function JD=C⋅sinNα. The resulting conjunction data set contains the POES electron flux measurements, L and magnetic local time coordinates, geomagnetic activity Auroral Electrojet index, and C and N coefficients from the PAD fit for each conjunction. …”
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RP-18 HPLC Analysis of Drugs’ Ability to Cross the Blood-Brain Barrier by Anna W. Sobańska, Adam Hekner, Elżbieta Brzezińska

“…On the other hand, discriminant function analyses involving log k and (log k)/PSA as discriminating variables separated the CNS+ and CNS− compounds with the success rate ca. 90%. …”
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Solving Linear Programming Problems by Reducing to the Form with an Obvious Answer by Gleb D. Stepanov

“…From the coefficients of the mentioned functionals, a matrix is formed, which is called the LPP matrix. …”
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Path model explaining the association between fear of falling and health-related quality of life in (pre-)frail older adults by Tjard Sattler, Sophie Gottschalk, Hans-Helmut König, Tobias Braun, Gisela Büchele, Michael Denkinger, Tim Fleiner, Corinna Nerz, Kilian Rapp, Martina Schäufele, Christian Werner, Judith Dams

“…Unlike previous studies that examined only few mediating variables, this study aimed to develop a more comprehensive path model explaining the association between FoF and HrQoL. …”
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Deep learning algorithm on H&E whole slide images to characterize TP53 alterations frequency and spatial distribution in breast cancer by Chiara Frascarelli, Konstantinos Venetis, Antonio Marra, Eltjona Mane, Mariia Ivanova, Giulia Cursano, Francesca Maria Porta, Alberto Concardi, Arnaud Gerard Michel Ceol, Annarosa Farina, Carmen Criscitiello, Giuseppe Curigliano, Elena Guerini-Rocco, Nicola Fusco

“…Traditional ancillary methods like immunohistochemistry (IHC) to assess TP53 functionality face pre- and post-analytical challenges. …”
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Thermoelastic damping in piezothermoelastic nanobeam resonators under the strain gradient theory with micro-inertia and non-fourier heat conduction by Olha Hrytsyna, Maryan Hrytsyna

“…To account for small-scale effects, the Helmholtz free energy density is defined as a function of the strain tensor, strain gradient tensor, electric field vector, and temperature field, considering these parameters as independent state variables. …”
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Effectiveness of eHealth for Medication Adherence in Renal Transplant Recipients: Systematic Review and Meta-Analysis by Lili Zhou, Ke Cheng, Linbin Chen, Xinyi Hou, Jingjing Wan

“…Primary outcomes included adherence measured by self-reported questionnaires, electronic monitoring devices, tacrolimus trough levels, intrapatient variability of tacrolimus concentrations, and the proportion of patients achieving a tacrolimus coefficient of variation <40%. …”
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A Systematic Review on Insights to Community Medicine and Clinical Research: Competency Training in Medical and Dental Education by Madeeha Minhas, Bilal Masood, Muhammad Hassaan Saeed, Amna Iqbal Butt, Fareed Ud Din Ahmad Chishti, Fatima Ali

“…The certainty of evidence showed moderate results for communication skills and patient satisfaction, and low to moderate results for the readiness in clinical trials and cultural competence due to variability in study design. Discussion: Effective competency training curricula substantially enhanced the functioning of healthcare systems and results for patients. …”
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Impact of Body Image Perception on Behavioral Outcomes in Chinese Adolescent and Young Adult Survivors of Sarcoma by Yihui Wei, Chung Tin Ma, Michael Can Heng Li, Keary Rui Zhou, Herbert Ho Fung Loong, Kwok Chuen Wong, Chi Kong Li, Yin Ting Cheung

“…The significant risk factors associated with body image dissatisfaction were being female (standardized coefficient estimate [Est] = 0.21, SE = 0.10; p = 0.047), surgery treatment (Est = 0.19, SE = 0.09; p = 0.046), and worse family functioning (Est = 0.27, SE = 0.10, p = 0.013). …”
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A multi-objective robust possibilistic programming approach to designing sustainable and reliable closed-loop supply chain network (case study: aluminum industry) by Sajad Amirian, Maghsoud Amiri, Mohammad Taghi Taghavifard

“…The mathematical model developed in this research is of mixed integer linear programming type, which is implemented in GAMS software to solve it and find Pareto optimal solutions.Findings: The accuracy of the overall performance of the proposed model has been evaluated with four examples (based on the coefficients of the objective functions) from a case study in the aluminium industry. …”
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