Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…The analyses of LV-adjusted metrics also show that atrophic patterns observed in the hippocampus, thalamus and pallidum were strongly correlated with HAND(especially dysfunction in executive function) and clinical markers (i.e., CD4/CD8 ratio).ConclusionWe conclude that models that control for individual variability in intracranial and ventricular volumes have the potential to minimize discrepancies and variations in structural reports of HIV, improving the diagnostic power of identified patterns and fostering greater consistency across research studies. …”
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THE INFLAMMASOME DRIVES MICROVASCULAR IMPAIRMENT IN MOUSE MODELS OF INTRAVASCULAR HEMOLYSIS by PL Brito, EMFG Azevedo, LFS Gushiken, FC Leonardo, FF Costa, N Conran

“…Moreover, NLRP3 inflammasome inhibition reduced leukocyte recruitment to the venule walls of HEM mice, indicating an improvement in hemolysis-induced microvascular dysfunction. This was further corroborated by LDF, which showed improved blood perfusion in the skin of MCC950-treated HEM mice. …”
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The prevalence and correlates of low sexual functioning in women on hemodialysis: A multinational, cross-sectional study. by Valeria Saglimbene, Patrizia Natale, Suetonia Palmer, Marco Scardapane, Jonathan C Craig, Marinella Ruospo, Letizia Gargano, Giuseppe Lucisano, Marietta Török, Eduardo Celia, Rubén Gelfman, Anna Bednarek-Skublewska, Jan Dulawa, Paul Stroumza, Miguel Leal, Domingo Del Castillo, Angelo Marco Murgo, Staffan Schon, Charlotta Wollheim, Jörgen Hegbrant, Giovanni F M Strippoli

“…The aim of this study was to assess prevalence and correlates of the individual domains of sexual functioning in women treated with hemodialysis. We recruited, into this multinational cross-sectional study, women treated with long-term hemodialysis (Collaborative Working Group on Depression and Sexual dysfunction in Hemodialysis study). …”
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Clinical, pathogenetic and prognostic value of diabetic retinopathy’s progression after phacoemulsification in patients with the essential hypertension by N. S. Khodjaev, V. V. Chernikh, K. E. Kuntysheva

“…The changes in the balance of the evaluated parameters inpatients, receiving other medicines, were characterized with the increase of proangiogenic and endothelial dysfunction. It was a predictor of vascular changes. …”
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Sexual Motivation (Desire): Problems with Current Preclinical and Clinical Evaluations of Treatment Effects and a Solution by Anders Ågmo

“…There has been an extensive search for efficient pharmacological treatment of female sexual interest/arousal disorder and other sexual dysfunctions. However, available treatments have met limited success, except for the drugs used for treating erectile deficiency. …”
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Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands by Takashi I, Riho Kanai, Makoto Seki, Hideki Agata, Hideaki Kagami, Hiroshi Murata, Izumi Asahina, Simon D. Tran, Yoshinori Sumita

“…In TLR4-KO mice, onset of radiogenic SG dysfunction was markedly delayed. However, TLR2/RAGE signalings were alternatively activated, and SG function was impaired. …”
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Rectal spacer use and overall long-term healthcare costs: payer perspective by James B. Yu, Ryoko Sato, Michael R. Folkert, Samir Bhattacharyya, Emmanuel Ezekekwu, Daniel A. Hamstra

“…However, total insurer paid costs over the following 4 years post-RT were significantly lower for RS patients by $8,095 ($52,345 vs. $60,440, p=0.011). Similar patterns were observed when examining costs related to bowel, sexual, or urinary dysfunction separately.ConclusionsPatients with RS use undergoing PCa RT had significantly lower long-term overall healthcare costs despite incurring higher initial costs prior to and during RT, suggesting that upfront investment in RS may be offset by long-term savings for insurers.…”
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Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache by Costantini Antonio, Tiberi Massimo, Zarletti Gianpaolo, Pala Maria Immacolata, Trevi Erika

“…Considering the role of thiamine in brain function, in energetic metabolism, and in pain modulation, we treated a patient affected by cluster headache with oral high-dose thiamine. …”
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Activated PRDM1-CREBBP contributes to preeclampsia by regulating apoptosis and invasion of the human trophoblast cells by Xuan Zhang, Lei Sun

“…High-throughput mRNA sequencing (RNA-seq) was performed to analyze the gene expression patterns in placentas from patients with early-onset PE (EOPE). …”
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Adherence to clinical guidelines for the evaluation and management of eosinophilic esophagitis among gastroenterologists in the Arab countries by Abdulrahman Al-Hussaini, Abdulrahman Al-Hussaini, Abdulrahman Al-Hussaini, Jaber Alrashidi, Mohamad Miqdady, Rana Bitar, Isamme AlFayyad

“…BackgroundThe practice patterns of eosinophilic esophagitis (EoE) remain poorly characterized. …”
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Features of functional state restoration among military personnel after traumatic brain injury combined with acubarotrauma by A. V. Shvets, Yu. V. Podolian, M. I. Holinko

“…A discriminant model allows to reliably (P < 0.001) determine patterns of informative characteristics of functional state in patients with concussion and those who additionally had acubarotrauma on admission to the hospital. …”
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Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease by Jenna L. Gollihue, Khine Zin Aung, Colin B. Rogers, Leopoldine B. Galopin, Nicholas A. Wright, Pradoldej Sompol, Erica M. Weekman, Yuriko Katsumata, Josh M. Morganti, Christopher M. Norris

“…Abstract Hyperhomocysteinemia (HHcy)-inducing diets recapitulate cerebral small vessel disease phenotypes in mice including cerebrovascular pathology/dysfunction, neuroinflammation, synaptic deficits, and cognitive decline. …”
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The crossroads of anxiety: distinct neurophysiological maps for different symptomatic groups by Gerez M, Suarez E, Serrano C, Castanedo L, Tello A

“…Addressing the underlying dysfunctions should improve treatment response. By its own nature, neurophysiology can be the best tool to address dysfunctional processes.Purpose: To search for neurophysiological dysfunctions and differences among panic disorder (PD), agoraphobia-social-specific phobia, obsessive&amp;ndash;compulsive disorder (OCD) and generalized anxiety disorder.Methods: A sample population of 192 unmedicated patients and 30 aged-matched controls partook in this study. …”
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Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina by Borko Milanović, Vesna Stojanović, Gordana Vijatov-Ðurić, Marijana Savin, Andrea Ðuretić, Jelena Kesić, Nenad Barišić, Ognjen Ležakov, Ivana Vorgučin, Gordana Vilotijević-Dautović, Katarina Koprivšek

“…<i>Conclusions</i>: There are pronounced age-related differences in the clinical presentation of MIS-C, with distinct immune and clinical patterns suggesting developmental influences on disease expression and outcomes. …”
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Organ-system-based subclassification of preeclampsia using machine learning predicts pregnancy outcomes by Yanhong Xu, Yizheng Zu, Xiaosi Lu, Yiping Wang, Jiaying Zheng, Xia Xu, Jianying Yan

“…Conclusions Machine learning identified distinct PE subclasses based on organ system dysfunction patterns, each demonstrating unique pregnancy outcomes. …”
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Global frequency, diagnosis, and treatment of hereditary angioedema with normal C1 inhibitor by Markus Magerl, MD, Marc A. Riedl, MD, MS, Luisa Karla Arruda, MD, PhD, Andrea Bauer, MD, MPH, Alejandro Berardi, MD, Jonathan A. Bernstein, MD, Laurence Bouillet, MD, PhD, Matthew Buckland, PhD, Thomas Buttgereit, MD, Danny M. Cohn, MD, PhD, Timothy Craig, DO, Roberta F. Criado, MD, PhD, Aurélie Du-Thanh, MD, PhD, Olivier Fain, MD, Margarida Gonçalo, MD, PhD, Jens Greve, MD, Anete Sevciovic Grumach, MD, PhD, Mar Guilarte, MD, PhD, Constance Katelaris, MD, PhD, Tamar Kinaciyan, MD, Elena A. Latysheva, MD, Ramon Lleonart, MD, Oscar Calderón Llosa, MD, Eli Mansour, MD, PhD, Vesna Grivcheva-Panovska, MD, PhD, Claudio Parisi, MD, Nelson Augusto Rosario Filho, MD, PhD, Amélia Spínola Santos, MD, Petra Staubach, MD, Anna Valerieva, MD, PhD, Solange Oliveira Rodrigues Valle, MD, PhD, Sherry Danese, MBA, Julie Ulloa, Paul K. Audhya, MD, MBA, Marcus Maurer, MD

“…Objective: This study sought to describe the global frequency, diagnostic pathway, and current treatment patterns of HAE-nC1INH. Methods: Board-certified HAE-treating physicians from accredited Angioedema Centers of Reference and Excellence (ACAREs) were invited to complete a 27-item online survey between December 2022 and April 2023. …”
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Clinical manifestations, histopathological changes and quality of life in patients with advanced knee osteoarthritis caused by age, trauma, obesity and their combination by Kristina V. Korochina, Tatyana V. Chernysheva, Irina E. Korochina

“…The methodological basis for differential approach to treating different categories of OA patients was developed.…”
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Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. by Caroline L Smith, Shelagh Anthony, Mike Hubank, James M Leiper, Patrick Vallance

“…We detected specific patterns of changes that identify pathways involved in processes relevant to cardiovascular risk and pulmonary hypertension. …”
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Synergistic Effects of Low-Frequency Ultrasound and Therapeutic Agents on Endothelial and Renal Cells: Emphasis on Cell Functionality, Oxidative Stress, and Inflammatory Markers by Ieva Čiapienė, Joris Vėžys, Vaiva Lesauskaitė, Indrė Matulevičiūtė, Ugnė Meškauskaitė, Vilius Skipskis, Arvydas Strazdauskas, Sonata Trumbeckaitė, Algimantas Bubulis, Vytautas Jūrėnas, Vytautas Ostaševičius, Vytenis Tamakauskas, Vacis Tatarūnas

“…Endothelial dysfunction contributes to CMD, impairing vascular tone and increasing inflammation. …”
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Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge. by Clara Rimmer, Savas Hetelekides, Sophia I Eliseeva, Steve N Georas, Janelle M Veazey

“…Respiratory viruses are responsible for a large fraction of asthma exacerbations, and are particularly potent at disrupting epithelial barrier function through pattern recognition receptor engagement leading to tight junction dysfunction. …”
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