Effects of ADMA upon gene expression: an insight into the pathophysiological significance of raised plasma ADMA. by Caroline L Smith, Shelagh Anthony, Mike Hubank, James M Leiper, Patrick Vallance

“…We detected specific patterns of changes that identify pathways involved in processes relevant to cardiovascular risk and pulmonary hypertension. …”
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Appropriateness of Antiplatelet Therapy and Proton Pump Inhibitor Prescribing in End-Stage Kidney Disease: A Retrospective Quality Investigation Study by Michael Che, Sumaiya Ahmed, Ryan Chan, Ayub Akbari, Deborah Zimmerman

“…Overall, it appears that prescribing patterns of DAPT and PPI at our center are unlikely to be a major contributor to the known increased risk of gastrointestinal bleeding in patients treated with hemodialysis. …”
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Significance of host antimicrobial peptides in the pathogenesis and treatment of acne vulgaris by Agata Lesiak, Paulina Paprocka, Urszula Wnorowska, Angelika Mańkowska, Grzegorz Król, Katarzyna Głuszek, Ewelina Piktel, Jakub Spałek, Jakub Spałek, Sławomir Okła, Sławomir Okła, Krzysztof Fiedoruk, Bonita Durnaś, Bonita Durnaś, Robert Bucki

“…We hypothesized that the increased expression of AMPs and their patterns in AV act as a compensatory mechanism to protect the skin with an impaired permeability barrier. …”
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Gradient changes in bioprosthetic valve thrombosis: duration of anticoagulation and strategies to improve detection by Vuyisile T Nkomo, Alexander C Egbe, Heidi M Connolly, Patricia A Pellikka, Sorin V Pislaru, Filip Ionescu, Hartzell V Schaff, Ioana Petrescu, Jwan A Naser, Cristina Pislaru

“…We set forth to (1) evaluate patterns of increase in gradients prior to BPVT diagnosis and (2) characterise time-course of response to anticoagulation.Methods Patients treated with warfarin for BPVT (1999–2019) with clinically significant reduction of mean gradients (≥25%) were identified retrospectively. …”
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Temporal changes of spinal microglia in murine models of neuropathic pain: a scoping review by Simran Dhir, Simran Dhir, Hannah Derue, Hannah Derue, Alfredo Ribeiro-da-Silva, Alfredo Ribeiro-da-Silva

“…Neuropathic pain (NP) is an ineffectively treated, debilitating chronic pain disorder that is associated with maladaptive changes in the central nervous system, particularly in the spinal cord. …”
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Reliability of Scapula Clinical Assessment and Effectiveness of Scapular-Focused Exercises in a Non-Athletic Population with Shoulder Pain – a Literature Review by Maciej Olszewski, Sara Gamrot, Joanna Golec, Elżbieta Szczygieł

“…Scapular movement abnormalities have been defined as scapular dyskinesis. It is treated as a dysfunction that increases the risk of shoulder pain. …”
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Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease by Jenna L. Gollihue, Khine Zin Aung, Colin B. Rogers, Leopoldine B. Galopin, Nicholas A. Wright, Pradoldej Sompol, Erica M. Weekman, Yuriko Katsumata, Josh M. Morganti, Christopher M. Norris

“…Abstract Hyperhomocysteinemia (HHcy)-inducing diets recapitulate cerebral small vessel disease phenotypes in mice including cerebrovascular pathology/dysfunction, neuroinflammation, synaptic deficits, and cognitive decline. …”
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The crossroads of anxiety: distinct neurophysiological maps for different symptomatic groups by Gerez M, Suarez E, Serrano C, Castanedo L, Tello A

“…Addressing the underlying dysfunctions should improve treatment response. By its own nature, neurophysiology can be the best tool to address dysfunctional processes.Purpose: To search for neurophysiological dysfunctions and differences among panic disorder (PD), agoraphobia-social-specific phobia, obsessive–compulsive disorder (OCD) and generalized anxiety disorder.Methods: A sample population of 192 unmedicated patients and 30 aged-matched controls partook in this study. …”
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Neck and mind: exploring emotion processing in cervical dystonia by Federico Carbone, Marina Peball, Philipp Ellmerer, Beatrice Heim, Wolfgang Nachbauer, Elisabetta Indelicato, Matthias Amprosi, Philipp Mahlknecht, Anna Hussl, Anna Hotter, Roberta Granata, Klaus Seppi, Klaus Seppi, Atbin Djamshidian, Sylvia Boesch

“…ObjectiveA wide range of non-motor symptoms such as pain, mood disorders, insomnia, and executive dysfunction may occur in focal dystonia. Little is known, however, about emotional processing. …”
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Long-term Patient-reported Functional Outcome after Pelvic Ring Injuries: Analysis using Two Different Types of Outcome Scores by Sameer Aggarwal, Lav Mehta, Sandeep Patel, Vishal Kumar, Prasoon Kumar

“…Patient’s demographic profile, mode and pattern of injury, associated injuries, management, and complications were recorded. …”
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Adherence to clinical guidelines for the evaluation and management of eosinophilic esophagitis among gastroenterologists in the Arab countries by Abdulrahman Al-Hussaini, Abdulrahman Al-Hussaini, Abdulrahman Al-Hussaini, Jaber Alrashidi, Mohamad Miqdady, Rana Bitar, Isamme AlFayyad

“…BackgroundThe practice patterns of eosinophilic esophagitis (EoE) remain poorly characterized. …”
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Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…The analyses of LV-adjusted metrics also show that atrophic patterns observed in the hippocampus, thalamus and pallidum were strongly correlated with HAND(especially dysfunction in executive function) and clinical markers (i.e., CD4/CD8 ratio).ConclusionWe conclude that models that control for individual variability in intracranial and ventricular volumes have the potential to minimize discrepancies and variations in structural reports of HIV, improving the diagnostic power of identified patterns and fostering greater consistency across research studies. …”
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Organ-system-based subclassification of preeclampsia using machine learning predicts pregnancy outcomes by Yanhong Xu, Yizheng Zu, Xiaosi Lu, Yiping Wang, Jiaying Zheng, Xia Xu, Jianying Yan

“…Conclusions Machine learning identified distinct PE subclasses based on organ system dysfunction patterns, each demonstrating unique pregnancy outcomes. …”
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Case Report: A 55 kg retroperitoneal liposarcoma by Ren Yingzheng, An Junjie, Wang Guifei, Yang Yang, Dong Long, Jiang Linlin, Fang Zhiqiang, Bi Xiaogang, Dong Yonghong

“…The peak value of the abdominal circumference reached 165 cm. Abdominal and pelvic CT examination indicated that there was a huge mass with mixed density in the abdominal and pelvic cavity, which contained lipid, calcification, and soft tissue density shadows. …”
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Clinical and Laboratory Features, Treatment and Prognosis in Children with Guillian-Barre Syndrome by N. A. Suponeva, A. K. Shakaryan, A. V. Rakhteenko, M. A. Piradov, I. V. Mitrofanova, M. I. Prytkova, I. Ya. Leont’ieva, S. V. Shakhgildyan, N. S. Morozova

“…Cranial nerve dysfunction at nadir was observed in a greater percentage of patients (51%) compared to that of 23% cases at the onset, with the facial palsy increasing from 10 to 32% and the bulbar palsy from 12 to 19%. …”
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Identification of a multiple DAMP scavenger mimicking the DAMP-binding site of TLR4 to ameliorate lethal sepsis by Takuya Murao, Gaifeng Ma, Atsushi Murao, Alok Jha, Jingsong Li, Yongchan Lee, Mian Zhou, Ping Wang, Ping Wang, Monowar Aziz, Monowar Aziz

“…Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. …”
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C-Reactive Protein and Cytokines in Polytrauma by E. K Gumanenko, N. S Nemchenko, V. V. Boyarintsev, S. V. Gavrilin, D. A. Vologzhanin, A. A. Rud

“…CRP inhibition of the anti-inflammatory properties of IL-4 causes an uncontrolled systemic inflammatory response. The pattern of relationships of IL-4, TNF-a, IFN-y, and CRP should be borne in mind when posttraumatic sepsis is treated.…”
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Clinical features of non-compaction cardiomyopathy across age groups: a retrospective study of 415 patients by Ying Li, Jimei Chen, Min Qiu, Miao Tian, Ziqin Zhou, Ruyue Zhang, Jiazichao Tu, Linjiang Han, Shuheng Zhou, Xinming Li, Jian Zhuang, Shusheng Wen

“…A significant correlation was observed between both LVESD and LVEDD measurements and MR area in patients with NCM (p<0.05).Conclusion Patients with NCM with concomitant MR consistently exhibited left ventricular dilatation and systolic dysfunction across all age groups. Significant age-related variations were observed in clinical presentations, arrhythmia patterns and the prevalence of congenital and valvular heart disease. …”
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Voluntary Activity Wheel Running Improves Hyperammonaemia‐Induced Skeletal Muscle Molecular and Metabolic Perturbations in Mice by Annette Bellar, Avinash Kumar, Khaviyaa Chandramohan, Saurabh Mishra, Muaz Alsabbagh‐Alchirazi, Artem Astafev, Pugazhendhi Kannan, Amy Attaway, Roman Kondratov, Thomas Jaramillo, Lopa Mishra, Takhar Kasumov, Nicole Welch, Srinivasan Dasarathy

“…Wheel runs were measured, and weekly average rotations, distance, and circadian patterns were analysed. Indirect calorimetry was performed pre‐ and post‐intervention. …”
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Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis by Menglin Liu, Jingmin Gu, Chenchen Zhao, Jinxia Li, Fanrong Kong, Xinyu Du, Dandan Qi, Enzhu Li, Jie Gao, Xiliang Du, Yuxiang Song, Guowen Liu, Wenwen Gao, Xinwei Li, Lin Lei

“…Necroptosis, a form of programmed cell death associated with cellular lysis, releases damage-associated molecular patterns (DAMP) into injured tissues, thereby amplifying inflammatory responses and tissue damage. …”
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