Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Key points Insights into the heterogeneity and transcriptional patterns of sarcoma cells may explain the challenges in treating primary cardiac angiosarcoma (PCAS) using the current therapeutic modalities. …”
Get full text

Comparative effect of dietary fortification of raw and roasted seeds of pumpkin (Cucurbita pepo L) on fertility biomolecules in cisplatin-induced spermatotoxic rats by Seun Funmilola Akomolafe, Mary Aderonke Bola Ogundare, Ibikunle Akinlua, Oluwadamilare Oluwaseun Ajayi, Elijah Olalekan Odesanmi, Olusola Bolaji Adewale

“…However, studies have shown that dietary pattern plays a pivotal role in the protection of chemotherapy-induced testicular damage, and till date no report on the comparative effect of raw and roasted pumpkin seeds against chemotherapy-induced male infertility and reproductive dysfunction. …”
Get full text

Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients by Koji Imoto, Motoyuki Kohjima, Tomonobu Hioki, Tomoyuki Kurashige, Miho Kurokawa, Shigeki Tashiro, Hideo Suzuki, Akifumi Kuwano, Masatake Tanaka, Seiji Okada, Masaki Kato, Yoshihiro Ogawa

“…Methods. Among 387 patients treated with ICIs, those who developed drug-induced liver injury were investigated. …”
Get full text

The prevalence and correlates of low sexual functioning in women on hemodialysis: A multinational, cross-sectional study. by Valeria Saglimbene, Patrizia Natale, Suetonia Palmer, Marco Scardapane, Jonathan C Craig, Marinella Ruospo, Letizia Gargano, Giuseppe Lucisano, Marietta Török, Eduardo Celia, Rubén Gelfman, Anna Bednarek-Skublewska, Jan Dulawa, Paul Stroumza, Miguel Leal, Domingo Del Castillo, Angelo Marco Murgo, Staffan Schon, Charlotta Wollheim, Jörgen Hegbrant, Giovanni F M Strippoli

“…The aim of this study was to assess prevalence and correlates of the individual domains of sexual functioning in women treated with hemodialysis. We recruited, into this multinational cross-sectional study, women treated with long-term hemodialysis (Collaborative Working Group on Depression and Sexual dysfunction in Hemodialysis study). …”
Get full text

Clinical, pathogenetic and prognostic value of diabetic retinopathy’s progression after phacoemulsification in patients with the essential hypertension by N. S. Khodjaev, V. V. Chernikh, K. E. Kuntysheva

“…All identified laboratory patterns were confirmed by the parallel dynamic prospective ophthalmic studies that demonstrated a higher incidence of vascular disorders after phacoemulsification in patients with diabetic retinopathy and hypertension who were not taking ACE inhibitors. …”
Get full text

Social-demographic factors and nursing diagnosis in patients with kidney transplant by Ana Luisa Brandão de Carvalho Lira, Marcos Venícios de Oliveira Lopes, Lúcia de Fátima da Silva, Thelma Leite de Araujo

“…Ten diagnosis presented frequency above the 75th percentile: risk of Infection; disturbed sensory perception; visual; hearing; Sleep pattern disturbance; Imbalanced nutrition; fatigue; sexual dysfunction; disturbed sensory perception: acute pain, more than body requirements; The nursing diagnosis study contributes to increasing the knowledge of realty of these patients, which is a necessary step for the establishment of nursing assistance to the renal transplanted, as well as for the direction of outcomes to be reached aiming the improvement of life quality.  …”
Get full text

Features of functional state restoration among military personnel after traumatic brain injury combined with acubarotrauma by A. V. Shvets, Yu. V. Podolian, M. I. Holinko

“…A discriminant model allows to reliably (P < 0.001) determine patterns of informative characteristics of functional state in patients with concussion and those who additionally had acubarotrauma on admission to the hospital. …”
Get full text

Sexual Motivation (Desire): Problems with Current Preclinical and Clinical Evaluations of Treatment Effects and a Solution by Anders Ågmo

“…There has been an extensive search for efficient pharmacological treatment of female sexual interest/arousal disorder and other sexual dysfunctions. However, available treatments have met limited success, except for the drugs used for treating erectile deficiency. …”
Get full text

Family Life Experiences of Children After Divorce: A Qualitative Research Parental Alienation by Sümeyra Ceylan Dolanbay, Aslıhan Aykara

“…The findings indicate that dysfunctional interaction patterns within the family witnessed prior to the before divorce period are related to the grounding of alienation experiences. …”
Get full text

How to Apply the Sequential Correction Technique to Treatment of Congenital Cervicothoracic Scoliosis: A Technical Note and Case Series by Saihu Mao, Kai Sun, Song Li, Jie Zhou, Hongda Bao, Benlong Shi, Xu Sun, Zhen Liu, Yong Qiu, Zezhang Zhu

“…ABSTRACT Objective Hemivertebrae in the cervicothoracic junction in the pediatric population are treated conventionally with a two‐rod instrumentation pattern. …”
Get full text

Age-Specific Clinical and Laboratory Features and Renal Involvement in Children with MIS-C: A Single Tertiary Centre Experience from Vojvodina by Borko Milanović, Vesna Stojanović, Gordana Vijatov-Ðurić, Marijana Savin, Andrea Ðuretić, Jelena Kesić, Nenad Barišić, Ognjen Ležakov, Ivana Vorgučin, Gordana Vilotijević-Dautović, Katarina Koprivšek

“…<i>Conclusions</i>: There are pronounced age-related differences in the clinical presentation of MIS-C, with distinct immune and clinical patterns suggesting developmental influences on disease expression and outcomes. …”
Get full text

Enhanced beta power emerges from simulated parkinsonian primary motor cortex by Donald W. Doherty, Liqiang Chen, Yoland Smith, Thomas Wichmann, Hong-Yuan Chu, William W. Lytton

“…Dysfunction in PT5B neurons, the final-common-pathway to brainstem and spinal cord, provides a new target to treat PD motor symptoms.…”
Get full text

Synergistic Effects of Low-Frequency Ultrasound and Therapeutic Agents on Endothelial and Renal Cells: Emphasis on Cell Functionality, Oxidative Stress, and Inflammatory Markers by Ieva Čiapienė, Joris Vėžys, Vaiva Lesauskaitė, Indrė Matulevičiūtė, Ugnė Meškauskaitė, Vilius Skipskis, Arvydas Strazdauskas, Sonata Trumbeckaitė, Algimantas Bubulis, Vytautas Jūrėnas, Vytautas Ostaševičius, Vytenis Tamakauskas, Vacis Tatarūnas

“…Endothelial dysfunction contributes to CMD, impairing vascular tone and increasing inflammation. …”
Get full text

Oral High-Dose Thiamine Improves the Symptoms of Chronic Cluster Headache by Costantini Antonio, Tiberi Massimo, Zarletti Gianpaolo, Pala Maria Immacolata, Trevi Erika

“…Cluster headache is a rare painful primary disorder occurring in either episodic or chronic patterns. Several authors found that the hypothalamus, the brain region regulating endocrine function and autonomic system, is involved in the pathophysiology of cluster headache. …”
Get full text

Activated PRDM1-CREBBP contributes to preeclampsia by regulating apoptosis and invasion of the human trophoblast cells by Xuan Zhang, Lei Sun

“…High-throughput mRNA sequencing (RNA-seq) was performed to analyze the gene expression patterns in placentas from patients with early-onset PE (EOPE). …”
Get full text

Global frequency, diagnosis, and treatment of hereditary angioedema with normal C1 inhibitor by Markus Magerl, MD, Marc A. Riedl, MD, MS, Luisa Karla Arruda, MD, PhD, Andrea Bauer, MD, MPH, Alejandro Berardi, MD, Jonathan A. Bernstein, MD, Laurence Bouillet, MD, PhD, Matthew Buckland, PhD, Thomas Buttgereit, MD, Danny M. Cohn, MD, PhD, Timothy Craig, DO, Roberta F. Criado, MD, PhD, Aurélie Du-Thanh, MD, PhD, Olivier Fain, MD, Margarida Gonçalo, MD, PhD, Jens Greve, MD, Anete Sevciovic Grumach, MD, PhD, Mar Guilarte, MD, PhD, Constance Katelaris, MD, PhD, Tamar Kinaciyan, MD, Elena A. Latysheva, MD, Ramon Lleonart, MD, Oscar Calderón Llosa, MD, Eli Mansour, MD, PhD, Vesna Grivcheva-Panovska, MD, PhD, Claudio Parisi, MD, Nelson Augusto Rosario Filho, MD, PhD, Amélia Spínola Santos, MD, Petra Staubach, MD, Anna Valerieva, MD, PhD, Solange Oliveira Rodrigues Valle, MD, PhD, Sherry Danese, MBA, Julie Ulloa, Paul K. Audhya, MD, MBA, Marcus Maurer, MD

“…Objective: This study sought to describe the global frequency, diagnostic pathway, and current treatment patterns of HAE-nC1INH. Methods: Board-certified HAE-treating physicians from accredited Angioedema Centers of Reference and Excellence (ACAREs) were invited to complete a 27-item online survey between December 2022 and April 2023. …”
Get full text

Mucormycosis in COVID-19 patients: A cross-sectional study at IGIMS, Patna by Tajwar Yasmeen, Nidhi Prasad, Vikash Kumar, Setu Sinha, Shishir Kumar, Sanjay Kumar

“…Methodology: This cross-sectional study included all treated mucormycosis cases with prior COVID-19 infection. …”
Get full text

Multiple kernel learning captures a systems-level functional connectivity biomarker signature in amyotrophic lateral sclerosis. by Tomer Fekete, Neta Zach, Lilianne R Mujica-Parodi, Martin R Turner

“…Intra- as well as inter-motor functional networks in the 0.03-0.06 Hz frequency band were derived from 40 patients and 30 healthy controls of similar age, and used as features for pattern detection, employing multiple kernel learning. …”
Get full text

Syntactic Analysis of Spatial Structure Characteristics of Traditional Villages Along the Yellow River in Western Shanxi Province by Chenge GAO, Fang WANG

“…This research explores the intrinsic connections between the spatial form and structure of traditional village settlements and between relevant cognitive and behavioral patterns, and explains the generation and evolution of landscape patterns, in an effort to enhance the understanding of the integration and centripetal degree of local and overall spatial functions within the village domain, the perceptibility of the spatial system, the consistency of behavioral experiences among residents and visitors, and the potential of local spaces to contribute to the overall spatial construction.MethodsThis research uses cluster sampling to select 33 national-level traditional villages in the four counties along the Yellow River in Lyuliang City, Shanxi Province, located on the eastern side of the Jin-Shaan Gorge in the middle reaches of the Yellow River. …”
Get full text

Chemogenetic tools for modulation of spatial learning in dopamine transporter deficient rats by Arina A. Gromova, Arina A. Gromova, Taisiia S. Shemiakova, Mikhail G. Khotin, Evgeniia N. Petrunina, Anastasia D. Belskaya, Raul R. Gainetdinov, Raul R. Gainetdinov, Natalia P. Kurzina, Anna B. Volnova, Anna B. Volnova

“…Variables such as the distance traveled, time taken to reach the goal box, number of errors and the perseverative patterns of activity were analyzed.ResultsNorepinephrine release from the LC to the PFC reduced hyperactive behavioral patterns in rats lacking the dopamine transporter (DAT-KO rats) with spontaneously elevated dopamine transmission. …”
Get full text