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Estudio comparativo de las funciones ejecutivas entre pacientes con enfermedad de Parkinson y pacientes con enfermedad degenerativa cerebelosa Comparison study of executive functio...
Published 2006-09-01“…On the other hand the PD group showed a selective increase of non perseverative errors, without reaching significant between group difference. CONCLUSION: The CD group appears to have greater deficits in EF with a pattern of prefrontal dysfunction.…”
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Interstitial fluid transport in linea alba is involved in acupuncture-induced attenuation of ovarian hypofunction in aged rats
Published 2025-05-01“…Our study not only provides a mechanistic basis for the clinical efficacy of acupuncture in treating ovarian disorders but also identifies ISF dynamics as a novel therapeutic target in age-related ovarian dysfunction.…”
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Clinical outcomes of the tunica albuginea plication for patients with Peyronie’s disease: a bicentric retrospective analysis
Published 2025-05-01“…Patients with complex curvature patterns had a higher risk of reoperation. Conclusions Plication surgery is an effective and safe option for treating penile curvature in Peyronie’s disease, particularly in patients with more severe deformities. …”
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Agomelatine: A review for general practitioners
Published 2012-06-01“…Agomelatine is a melatonin 1 (MT1) and melatonin 2 (MT2) receptor agonist and serotonin (5-hydroxytryptamine) 2C (5-HT2C) receptor antagonist. It is effective in treating moderate-to-severe depression, alleviating the symptoms of anxiety, and restoring the disrupted sleep patterns that often result from this potentially devastating disease. …”
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Atrioventricular Conduction Abnormalities in Multisystem Inflammatory Syndrome in Children
Published 2021-01-01“…Cardiac manifestations in multisystem inflammatory syndrome in children (MIS-C) can include coronary artery aneurysms, left ventricular systolic dysfunction, and electrocardiographic disturbances. …”
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Transvertebral magnetic neuromodulation for the treatment of overactive bladder: 6 months follow-up
Published 2020-12-01“…The most common type of lower urinary tract dysfunction is an overactive bladder (OAB). Today there is a need to search for new effective methods of treating this disease.Purpose of the study. …”
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Disseminated intravascular coagulation
Published 2025-06-01“…Conversely, these pathogenic pathways and DIC synergistically contribute to organ dysfunction, leading to poor prognoses. Effective DIC management requires treating the underlying condition, along with substitution therapies and, in some cases, antifibrinolytics. …”
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Health status and disability in persons with spinal cord injuries in South Africa and Kenya
Published 2024-09-01“…Results: In both countries, sexual dysfunction (55% – 57%), pain (48% – 49%), spasticity (41% – 42%) and bladder dysfunction (27% – 60%) emerged as the predominant secondary medical complications, with sexual dysfunction and pain showing overlap. …”
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Acupuncture treatment for functional gastrointestinal disorders: Identification of major acupoints using network analysis
Published 2023-09-01“…These findings could be applied in future acupuncture research on therapy for gastrointestinal system dysfunction. They may also help bridge the gap between the traditional meridian theory, which assumes that there is a link between diseases/symptoms and the specific body region being treated, and real-world clinical evidence.…”
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A Case Report on the Thyroid and Eye Connection: A Deep Dive into Evaluation and Treatment Strategies
Published 2025-06-01“…Among individuals diagnosed with TAO, about 90% have Graves’ hyperthyroidism, while a smaller percentage may have primary hypothyroidism, Hashimoto’s thyroiditis, or normal thyroid function. These patterns emphasise the importance of recognising thyroid dysfunction in orbitopathy management which includes treating the underlying thyroid dysfunction, using corticosteroids to reduce inflammation, and applying artificial tears for symptomatic relief. …”
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Impairment of neuronal activity in the dorsolateral prefrontal cortex occurs early in parkinsonism
Published 2025-01-01“…Little is known, however, regarding how neuronal activity in the executive control network of the brain changes in the parkinsonian condition.ObjectiveInvestigate the impact of parkinsonism on neuronal activity in the dorsolateral prefrontal cortex (DLPFC), a key region in executive control, during a go/nogo reaching task.MethodsUsing a within-subject design, single and multi-unit neuronal activity was recorded in the DLPFC of a nonhuman primate (n = 1) before and after the induction of mild parkinsonism using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).ResultsCoincident with development of mild parkinsonian motor signs, there was a marked reduction in the percentage of DLPFC cells with significant task-related firing rate modulation during go and nogo conditions.ConclusionThese results suggest that DLPFC dysfunction may occur early in parkinsonism and contribute to cognitive impairments and disrupted executive function often observed in PD patients.…”
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The Effect of Audible Joint Manipulation Sounds in the Upper Cervical Spine on Brain Wave and Autonomic Nervous System Activity
Published 2025-01-01“…Background: High-velocity, low-amplitude (HVLA) manipulation is a common manual therapy technique used for treating pain and musculoskeletal dysfunction. An audible manipulation sound is commonly experienced by patients who undergo HVLA manipulation; however, there is little known about the effects and clinical relevance of the audible manipulation sound on cortical output and the autonomic nervous system. …”
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Rectal spacer use and overall long-term healthcare costs: payer perspective
Published 2025-08-01“…However, total insurer paid costs over the following 4 years post-RT were significantly lower for RS patients by $8,095 ($52,345 vs. $60,440, p=0.011). Similar patterns were observed when examining costs related to bowel, sexual, or urinary dysfunction separately.ConclusionsPatients with RS use undergoing PCa RT had significantly lower long-term overall healthcare costs despite incurring higher initial costs prior to and during RT, suggesting that upfront investment in RS may be offset by long-term savings for insurers.…”
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Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands
Published 2025-12-01“…Additionally, culture supernatant of irradiated cultured SG epithelial cells contained damaged associated molecular pattern (DAMP)/senescence-associated secretory phenotype (SASP) factors. …”
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Targeted discovery of gut microbiome-remodeling compounds for the treatment of systemic inflammatory response syndrome
Published 2024-10-01“…By quantifying their impact on microbial structure and clustering their regulatory patterns, we devised multiple gut microbiome remodeling compound (GMRC) cocktails. …”
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Budesonide promotes airway epithelial barrier integrity following double-stranded RNA challenge.
Published 2021-01-01“…Respiratory viruses are responsible for a large fraction of asthma exacerbations, and are particularly potent at disrupting epithelial barrier function through pattern recognition receptor engagement leading to tight junction dysfunction. …”
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Clinical manifestations, histopathological changes and quality of life in patients with advanced knee osteoarthritis caused by age, trauma, obesity and their combination
Published 2021-09-01“…The methodological basis for differential approach to treating different categories of OA patients was developed.…”
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