Blood-based biomarkers in mild behavioral impairment: an updated overview by Efthalia Angelopoulou, Xenia Androni, Chiara Villa, Alexandros Hatzimanolis, Nikolaos Scarmeas, Sokratis Papageorgiou

“…A growing number of studies have recently begun to explore the relationship between MBI and several blood-based biomarkers associated with Alzheimer’s disease (AD) pathology, neurodegeneration, as well as systemic metabolic and inflammatory dysregulation. In this context, MBI has been associated with lower plasma Aβ42/Αβ40 ratio, higher plasma phosphorylated tau at threonine 181 (p-tau181), increased neurofilament light chain (NfL) levels, as well as disturbances in metabolic markers, including homocysteine, insulin and ferritin, suggesting a multifaceted neurobiological basis for this syndrome. …”
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The Role of Extracellular Vesicles in Aging and Age-Related Disorders by Bharathi Hassan Ganesh, Himabindu Padinjarathil, Ramya Lakshmi Rajendran, Prasanna Ramani, Prakash Gangadaran, Byeong-Cheol Ahn

“…Mitochondrial malfunction and increased oxidative stress are major contributors for the aging process. …”
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Assessment of Health-Oriented Layout and Perceived Density in High-Density Public Residential Areas: A Case Study of Shenzhen by Guangxun Cui, Menghan Wang, Yue Fan, Fei Xue, Huanhui Chen

“…The authors attempt to go beyond current regulations to propose tailored solutions for Shenzhen’s high-density context, improving spatial efficiency and residential comfort in future public housing designs. …”
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The frequent variant A57F in the GNE gene in patients from Russia has Finno-Ugric Mari origin by Dmitrii Subbotin, Sofya Ionova, Andrey Marakhonov, Elena Saifullina, Artem Borovikov, Leila Akhmadeeva, Polina Chausova, Oksana Ryzhkova, Rena Zinchenko, Sergey Kutsev, Aysylu Murtazina

“…According to our study, the estimated age of the mutation’s spread is 160.46 years (95% CI: 45.55–244.14).DiscussionBy comparing the information gathered with historical data on migration patterns in the Middle Volga region and estimating the age of the variant’s dissemination, we propose hypotheses regarding its origin and the pathways through which it spread. In the current context of increased rate of interethnic marriages, investigating the spread of common pathogenic variants from historically isolated populations is important for molecular genetic diagnosis. …”
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Registry-based surveillance of paediatric home respiratory support in Switzerland: methodology and initial findings by Sophie Guerin, Christian Bieli, Regula Corbelli, Thomas Ferry, Miriam Giaranna, Matthias Horn, Silvia Miano, Nicolas Regamey, Daniel Trachsel, Sylvain Blanchon

“…Analysis of the first year’s data in the SwissPedHRS registry showed a sixfold increase in prevalence since 2001. It also highlighted a larger spectrum of underlying medical conditions and types of sleep-disordered breathing leading to home respiratory support and important changes in home respiratory support modalities, with decreased invasive and increased non-invasive respiratory support and decreased BPAP and increased CPAP ventilation. …”
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The PRE‐registration podiatry: Accessible recruitment and employment (PREPARE) project: A commentary on the novel approach to the podiatry workforce crisis in Glasgow by Pamela Price, Paul Higgins, David Lambert, Diane M. Dickson, Ruth Barn

“…This paper explores the local context of the current workforce challenges and summarises a novel solution collaboratively developed in Glasgow. …”
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A Review of the Insider Threat, a Practitioner Perspective Within the U.K. Financial Services by Findlay Whitelaw, Jackie Riley, Nebrase Elmrabit

“…The insider threat within organisational cybersecurity continues to be of great concern globally. The current insider threat detection strategies are acknowledged as ineffective, evidenced by the increased reported events in high-profile insider threats and cyber data loss cases borne from insider and privilege misuse. …”
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Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in hypertensive patients: A prospective cross-sectional study by Sudha S, Birunthavathi M, Mythili M, Sai Sailesh Kumar Goothy

“…However, studies related to this context are sparse comparatively. Aims and Objectives: The current study explores the NLR and the PLR with hypertension as an indicator of cardiovascular risk. …”
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The Community Prevalence of Vitamin C Deficiency and Inadequacy—How Does Australia Compare With Other Nations? A Scoping Review by Danielle M. Carter, Hiep N. Le, Hai Phung

“…The prevalence of deficiency in high‐income countries is likely between 0% and 15%, with current reference ranges underestimating overall inadequacy for optimal health, by approximately 33.6%. …”
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Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology – application to amikacin by Verena Gotta, Julia Anna Bielicki, Paolo Paioni, Chantal Csajka, Dominic Stefan Bräm, Christoph Berger, Elisabeth Giger, Michael Buettcher, Klara M. Posfay-Barbe, John van den Anker, Marc Pfister

“…We aimed to demonstrate how such pharmacometric modelling and simulation can provide a scientific rationale for optimising drug doses in the context of the Swiss national dose standardisation project in paediatrics using amikacin as a case study. …”
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Effects of Ramadan on cognitive functions in young boys by Amira Miladi, Mohamed Ali Saafi, Imed Latiri

“…The study found that Ramadan fasting did not have an effect on various reaction times or on electro-physiological data, including P300 amplitude and latency. The current study, conducted with healthy children/adolescents, indicates that Ramadan fasting had no impact on various reaction times (SRT, CRT, NPRT), suggesting the preservation of information processing speed and decision-making, even in the face of increased task complexity. …”
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Sustainable Public Health Policies: Understanding Influenza Vaccination Uptake Among College Students in a Changing Society by Keren Dopelt

“…The results indicated that prior vaccination was the strongest predictor of current influenza vaccine uptake (OR = 38.7, <i>p</i> < 0.001). …”
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Innovations in the Research of the Relationship of Mental and Reproductive Health: Changes in Personality Profiles in Young Women with Pregnancy Pathology and the Reflection of Obs... by Ramazan K. MAGOMEDOV, Akhmed A. UZAYEV, Ibrahim V. NURIEV, Murajan U. MADDINOV, Radikhan Y. SHADMANOV

“…Current research in this area dictates the existence of a two-way relationship between mental and reproductive health. …”
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Assessment of the Status of <i>Cephalanthera longifolia</i> Populations in Lithuania Derived from a Single-Census Study by Laurynas Taura, Zigmantas Gudžinskas

“…Therefore, the ratio of generative to vegetative individuals reflects current habitat conditions rather than long-term population trends.…”
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Testosterone-induced erythrocytosis: addressing the challenge of metabolic syndrome and widely prescribed SGLT2-inhibitor drugs by Federica Tramontana, Azmi Mohammed, Yaasir H Mamoojee, Richard Quinton

“…Crucially, they also increase haematocrit by promoting haematopoiesis. This review focuses on the current best evidence for managing erythrocytosis, in the context of more prevalent obesity and prescriptions of testosterone and SGLT2i in this population. …”
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Data Modeling of Impact of Green-Oriented Transportation Planning and Management Measures on the Economic Development of Small- and Medium-Sized Cities by Yuan Lu, Jinyan Shao, Yifeng Yao

“…With the rapid growth of urbanization and motorization in China in recent years, the demand for transportation in people’s work and daily lives has increased. In this context, a number of issues such as urban traffic congestion, energy consumption, and environmental pollution have become increasingly severe. …”
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Good quality of life in former Buruli ulcer patients with small lesions: long-term follow-up of the BURULICO trial. by Sandor Klis, Adelita Ranchor, Richard O Phillips, Kabiru M Abass, Wilson Tuah, Susanne Loth, Kristien Velding, Tjip S van der Werf, Ymkje Stienstra

“…However, recent advances in treatment, combined with increased public health efforts have the potential to significantly improve disease outcome.…”
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Transformation of the Regional Policy of Russia and China under the Conditions of Unequal Development of Regions (1980-2020): a Comparative Historical Study by S. B. Makeeva

“…The purpose of this article is a comparative and consideration of the evolution of the regional policy of Russia and China in the context of the increasing unevenness and disproportionality of the internal regional development of the two countries in the modern period of history. …”
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Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole by Caroline Silveira Martinez, Ancheng Zheng, Qingzhong Xiao

“…In this review, we will provide an overview and discussion of the recent findings on mtROS production, its threshold for imbalance, and the subsequent dysfunction that leads to related cardiac and systemic phenotypes in the context of HFpEF. We will also focus on newly discovered cellular and molecular mechanisms underlying ROS dysregulation, current therapeutic options, and future perspectives for treating HFpEF by targeting mtROS and the associated signal molecules.…”
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Evidence of traditional Chinese medicine for treating type 2 diabetes mellitus: from molecular mechanisms to clinical efficacy by Yadong Ni, Xianglong Wu, Wenhui Yao, Yuna Zhang, Jie Chen, Xuansheng Ding

“…Context The global prevalence of type 2 diabetes mellitus (T2DM) has increased significantly in recent decades. …”
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