Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamin... by Anna Turkiewicz, Emilia Manko, Colin J Sutherland, Ernest Diez Benavente, Susana Campino, Taane G Clark

“…Amplifications are more likely to be present in isolates with a greater accumulation of pfdhfr and pfdhps substitutions (median of 1 additional mutations; P<0.00001), and there was evidence that the frequency of pfgch1 variants may be increasing in some African populations, presumably under the pressure of SP for chemoprophylaxis and anti-folate containing antibiotics used for the treatment of bacterial infections. …”
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Determination of Microbial Properties of Freeze Dried Traditional Cheese by Tuba Büyüksırıt Bedir, Hakan Kuleaşan

“…Various technologies are currently being used for the drying of cheese and efforts are still being made to develop new methods. …”
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Global Secular Trend of Gonadal Size in Men: Review and Analysis of Publications by A. Yu. Seroukhov, A. A. Afoko, I. E. Mamaev

“…Notwithstanding the general increase in world population, there is a steady decline in birth rate. …”
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Self-sufficiency in the healthcare workforce: a system dynamics model of the domestic and foreign educated nursing and midwifery workforce in Ireland by Terence Hynes, Paul Caulfield, Peter O’Connor, John Cullinan

“…Ireland, the context for this study, currently relies heavily on foreign educated nurses and midwives to meet its demand, with Government policy moving towards a domestic recruitment model. …”
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Graded Roll‐to‐Roll Slot Die Coating for High‐Throughput Catalyst Layer Studies by George Pätzold, Maximilian Maier, Lukas Löttert, Anna T. S. Freiberg, Prof. Dr. Simon Thiele, Dr. Dominik Dworschak

“…Many of these systems are based on substrates coated with thin layers containing catalyst, ionomer or support material like carbon. …”
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Engineered extracellular vesicles for delivering functional Cas9/gRNA to eliminate hepatitis B virus cccDNA and integration by Wanjia Zeng, Liwei Zheng, Yukun Li, Jing Yang, Tianhao Mao, Jing Zhang, Yanna Liu, Jing Ning, Ting Zhang, Hongxin Huang, Xiangmei Chen, Fengmin Lu

“…Our results demonstrated that engineered EVs containing Cas9/gRNA and VSV-G can effectively reduce viral antigens and cccDNA levels in the HBV-replicating and infected cell models. …”
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Cytomegalovirus-Specific T Cells from Third-Party Donors Successfully Treated Refractory Cytomegalovirus Retinitis after Unrelated Umbilical Cord Blood Transplantation by Na Li, Guangyu Sun, Lihua Zhu, Kang Ding, Huilan Liu, Xiaoyu Zhu, Baolin Tang, Wen Yao, Xiang Wan, Liangquan Geng, Ping Qiang, Kaidi Song, Changcheng Zheng, Zimin Sun, Juan Tong

“…Umbilical cord blood (UCB) transplants (UCBTs) are becoming increasingly common in the treatment of a variety of hematologic and nonhematologic conditions. …”
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Demographic responses of hybridizing cinquefoils to changing climate in the Colorado Rocky Mountains by Kelly A. Carscadden, Daniel F. Doak, Meagan F. Oldfather, Nancy C. Emery

“…Our findings demonstrate that hybrids in this system are neither intrinsically unfit nor universally more vigorous than parents, suggesting that the demographic consequences of hybridization are context‐dependent. Our results also imply that shifts to warmer and drier conditions could have particularly negative repercussions for P. pulcherrima, which is currently the most abundant taxon in the study area, possibly as a legacy of more favorable historical climates. …”
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Is South Africa ready for point-of-care, non-sputum tests for TB diagnosis? An assessment of end-user perceptions on a novel urine test and tongue swab for TB testing by Nasiphi Mqedlana-Ntombela, Vanessa Fargnoli, Salome Charalambous, Kavindhran Velen, Sonjelle Shilton, Violet Chihota

“…Novel non-sputum sample types currently under development can increase TB testing, however there is limited knowledge on end-user perceptions on these tests. …”
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Evolution of taxis responses in virtual bacteria: non-adaptive dynamics. by Richard A Goldstein, Orkun S Soyer

“…We currently lack a full understanding of the different pathway structures and dynamics and how this integration is achieved. …”
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Safety of a change of specifications of phytosterols/phytostanols as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Helle Katrine Knutsen, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Wolfgang Gelbmann, Harry J. McArdle

“…Regarding the maximum limit of the specification parameter ‘other sterols/stanols’, the applicant asks for an increase from currently less than 3% to less than 7% to better reflect and cover the natural composition and proportions of sunflower‐based phytosterols/phytostanols, noting that the existing specifications have been established largely based on the NF when sourced from soy. …”
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Optimizing enzyme thermostability by combining multiple mutations using protein language model by Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang‐Yu Yang

“…It showed a 10.19°C increase in the melting temperature and an ~655‐fold increase in the half‐life at 58°C. …”
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Ipomoea batatas (L.) Lam. cultivation in the conditions of light culture in vitro and ex vitro by E. A. Kalashnikova, R. N. Kirakosyan, A. V. Gushchin, K. G. Abubakarov, N. N. Sleptsov, S. K. Temirbekova, A. P. Glinushkin, O. V. Meleshina, N. Ya. Rebouh, M. M. Tareeva

“…Interest in this substance is justified by its valuable properties – it is a good immunomodulator, cleanses the body of toxins, radionuclides, "bad" cholesterol, promotes the assimilation of useful trace elements necessary for human life. Inulin is contained in plants such as jerusalem artichoke, chicory, as well as in sweet potatoes, the popularity of which is increasing every year. …”
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Are interventions for environmentally sustainable dietary behaviours effective? A review by Y Ran, U M Persson, T Lindahl, M Jonell, A Brons, B Macura, J Candel, A Abu Hatab, E Röös

“…In the face of growing environmental pressures, understanding how governance can promote more sustainable dietary behaviours is increasingly critical. However, a synthesis of available intervention strategies for behavioural change is currently missing. …”
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The Association Between Traumatic Brain Injury and the Risk of Cognitive Decline: An Umbrella Systematic Review and Meta-Analysis by Ioannis Mavroudis, Dimitrios Kazis, Foivos Efstratios Petridis, Ioana-Miruna Balmus, Vasileios Papaliagkas, Alin Ciobica

“…Background: There is currently increasing interest in the implication of traumatic brain injury (TBI) as a potential risk factor for long-term neurodegenerative conditions, such as dementia and Alzheimer’s disease (AD). …”
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Morphological features of the poultry thymus by S. V. Huralska, N. V. Dyshliuk, S. S. Zaika, H. P. Hryshchuk, L. H. Yevtukh

“…Efforts to preserve the population and increase their productivity are directly related to strengthening poultry immunity and the state of their immune system. …”
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The Influence of Parameterized Shallow Convection on Trade‐Wind Clouds and Circulations in the HARMONIE‐AROME Mesoscale Model by A. C. M. Savazzi, L. Nuijens, W. deRooy, A. P. Siebesma

“…Abstract Mesoscale numerical weather prediction models currently operate at kilometer‐scale and even sub‐kilometer‐scale resolutions. …”
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Geographical accessibility of emergency neonatal care services in Ethiopia: analysis using the 2016 Ethiopian Emergency Obstetric and Neonatal Care Survey by Andrew Hayen, Getiye Dejenu Kibret, Daniel Demant

“…Addis Ababa and the Hareri regional state had full access (100% coverage) to EmNeC services within 2 hours travel time, while the Afar (15.3%) and Somali (16.3%) regional states had the lowest access.Conclusions The physical access to EmNeC services in Ethiopia is well below the universal health coverage expectations stated by the United Nations. Increasing the availability of EmNeC to health facilities where routine delivery services currently are taking place would significantly increase physical access. …”
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Clinical and laboratory assessment of the effect of hygiene products on the condition of periodontal tissues and hard tooth tissues in the treatment of caries by indirect method by I. A. Belenova, V. A. Mitronin, Z. A. Filippova, V. I. Khryachkov, M. S. Vasilyeva, N. A. Protsenko

“…According to statistics, the widespread use in modern dental practice of indirect restoration methods in the treatment of caries of the frontal group of teeth leads to an increase in the incidence of marginal periodontal disease. …”
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Efficiency and heat transport processes of low-temperature aquifer thermal energy storage systems: new insights from global sensitivity analyses by Luka Tas, Niels Hartog, Martin Bloemendal, David Simpson, Tanguy Robert, Robin Thibaut, Le Zhang, Thomas Hermans

“…Thick productive aquifer layers have been targeted first, as these are the most promising hydrogeological context for ATES. Regardless, there is currently an increasing trend to target more complex aquifers such as low-transmissivity and alluvial aquifers or fractured rock formations. …”
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