iPSC models of mitochondrial diseases by Sonja Heiduschka, Alessandro Prigione

“…Consequently, most mitochondrial diseases are currently untreatable. Human induced pluripotent stem cells (iPSCs) represent a promising approach for developing human model systems and assessing therapeutic avenues in a patient- and tissue-specific context. iPSCs are being increasingly used to investigate mitochondrial diseases, either for dissecting mutation-specific defects within two-dimensional (2D) or three-dimensional (3D) progenies or for unveiling the impact of potential treatment options. …”
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Enhancing digital literacy in primary education through augmented reality by Natalie Nevrelova, Lilla Korenova, Zsolt Lavicza, Nikola Bruzkova, Angelika Schmid

“…Currently, there is a need to develop digital competencies already because they are included in the new curriculum. …”
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In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington’s Disease by Luis C. Morales, Luv Modi, Saba Abbasi Dezfouli, Amarnath Praphakar Rajendran, Remant Kc, Vaibhavi Kadam, Simonetta Sipione, Hasan Uludağ

“…<b>Methods:</b> This study aims to investigate the efficacy of siRNA-containing nano-engineered lipopolymers in selectively silencing the <i>HTT</i> expression in a neuronal model expressing a chimeric protein formed by the human mutated exon 1 of the <i>HTT</i> gene, tagged with GFP. …”
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Development of an easy non‐destructive particle isolation protocol for quality control of red blood cell concentrates by Marine Ghodsi, Anne‐Sophie Cloos, Anaïs Lotens, Marine De Bueger, Patrick Van Der Smissen, Patrick Henriet, Nicolas Cellier, Christophe E. Pierreux, Tomé Najdovski, Donatienne Tyteca

“…Nevertheless, there is currently no standardized isolation protocol. In a previous publication, we developed a reproducible ultracentrifugation‐based protocol (20,000 × g protocol) that allows to classify red blood cell concentrates into three cohorts according to their vesiculation level. …”
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Selective Separation of Scandium in Acidic Water Using Carboxyl Functionalized Covalent Phosphonitrile Polymers by Yu BAI, Ayinuer WUSHUER, Lei OUYANG, Lijin HUANG, Qin SHUAI

“…As the acidity of the solution increases, the adsorption efficiency of CPF-T for Sc(III) significantly decreases, and at pH<3, the adsorption rate is below 60%. …”
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The challenges of reproducibility for research based on geodata web services by M. Cannata, M. Collombin, O. Ertz, G. Giuliani, J. Ingensand, C. Primerano, D. Strigaro

“…Additionally, we assess the currently available tools that support data versioning for databases, files and log-structured tables. …”
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Two-Hour Sea Level Oscillations in Halifax Harbour by Dan Kelley, Clark Richards, Ruby Yee, Alex Hay, Knut Klingbeil, Phillip MacAulay, Ruth Musgrave

“…We explore the nature of the oscillations as a first step towards the improvement of prediction schemes for sea level and currents in the region. This involves an analysis of the oscillations in the context of seiche and Helmholtz resonance theories and the use of a 2D numerical model to handle realistic bathymetric conditions and other complications that the simpler theories cannot address. …”
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Standardization of the Pharmaceutical Substance of the Drug LCS-1208 by E. V. Ignateva, I. V. Yartseva, Z. S. Shprakh, A. P. Bud'ko, L. V. Ektova, D. A. Kozin, V. Yu. Reshetnyak, O. V. Nesterova, E. A. Pankratova

“…Indolocarbazole derivatives are of increasing scientific interest for practical oncology. …”
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Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective by Karen Vanessa Fernandez-Muñoz, Cuauhtémoc Ángel Sánchez-Barrera, Marco Meraz-Ríos, Jose Luis Reyes, Eloy Andrés Pérez-Yépez, Maria Teresa Ortiz-Melo, Luis I. Terrazas, Monica Graciela Mendoza-Rodriguez

“…Curcumin, trimethylglycine, resveratrol, artemisinin, and some helminth-derived molecules, among others, are some natural compounds studied in the context of CRC. This review discusses the main benefits, mechanisms, advances, and dark side of conventional chemotherapeutics currently evaluated in CRC treatment. …”
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In silico identification of silent primycin biosynthetic gene clusters within the family Pseudonocardiaceae by Márk Kovács-Valasek, Csaba Fekete, Andrea Kovács-Valasek

“…In the global effort to discover or design new effective antibiotics to fight infectious diseases, the increasingly available multi-omics data with novel bioinformatics tools open up new horizons for the exploration of the genetic potential of bacteria to synthesize bioactive secondary metabolites. …”
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THE WEEKEND TOUR AS THE PROSPECTIVE TREND OF RURAL DEVELOPMENT by О. В. Чайковська, О. В. Чайковський

“…The authors of the article are convinced that the study and adopting the best practices of European countries in the context of a weekend tour will contribute to an increase in income from domestic tourism. …”
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Flavonoid intake in European adults (18 to 64 years). by Anna Vogiatzoglou, Angela A Mulligan, Marleen A H Lentjes, Robert N Luben, Jeremy P E Spencer, Hagen Schroeter, Kay-Tee Khaw, Gunter G C Kuhnle

“…For this reason, there is an increasing interest in investigating the potential health effects of these compounds. …”
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Mengkriminalisasi Greenwashing: Menjawab Tantangan Perlindungan Konsumen di Era Keberlanjutan by Zentoni, Budi Santoso, David M. L. Tobing

“…This phenomenon has grown alongside increasing public awareness of the importance of environmental sustainability. …”
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Assessing the impact of cryptocurrency usage on cybersecurity: the European Union experience by S.V., K.O.

“…Therefore, researching the impact of cryptocurrency usage on cybersecurity is currently a relevant issue. The purpose of this study is to investigate the impact of cryptocurrency usage on cybersecurity in European Union countries. …”
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Public Private Partnership in the European Union: Experiences in the UK, Germany and Austria by Ronald W. McQuaid, Walter Scherrer

“…The political context of governments differs between the UK, Germany and Austria, but each government currently has a positive view of Public private Partnership (PPP). …”
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Reporting Together: Transactional Sociability, Digital Communities and Alternate Embodiments on the Road through the Use of Waze by Regner Ramos

“…The paper seeks to fill a gap in digital spatial theory by upholding that apps are made at a fast pace to help increase their commercial value, but their development, design, and research currently lacks critical study. …”
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The evolution and scope of Article 38 of the Convention on the Rights of the Child in a globalizing world by Dawid Stadniczeńko

“…Observational method, document examination method, method of analysis and criticism of literature Results The scope of contemporary research on childhood within the context of international discourse reveals the necessity of revising the approach to children and their issues. …”
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Principles of care for adolescent girls with eating disorders and body disturbances disorders: lessons from the COVID-19 pandemic by A. A. Pichikov, Y. V. Popov, Y. A. Yakovleva, T. A. Salomatina

“…The most reasonable approaches during the pandemic are the approaches focused on the family of a teenager using, if possible, remote forms of assistance.Conclusions: Currently, there are no norms and standards in the organization of assistance to adolescents with eating disorders and body image disorders in the pandemic context. …”
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Urban human-elephant conflict in Zimbabwe: a case study of the mitigation endeavour by Aliénor Scrizzi, Sébastien Le Bel, Mike La Grange, Daniel Cornélis, Cheryl Mabika, René Czudek

“…In this context, human-elephant interactions are expected to increase. …”
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Optimizing Deep Learning Models with Improved BWO for TEC Prediction by Yi Chen, Haijun Liu, Weifeng Shan, Yuan Yao, Lili Xing, Haoran Wang, Kunpeng Zhang

“…Recently, deep learning models have become increasingly popular in TEC prediction. However, these deep learning models usually contain a large number of hyperparameters. …”
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