A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer by Gary Middleton, Helen L. Robbins, Peter Fletcher, Joshua Savage, Manita Mehmi, Yvonne Summers, Alastair Greystoke, Nicola Steele, Sanjay Popat, Pooja Jain, James Spicer, Judith Cave, Paul Shaw, David Gilligan, Danielle Power, Dean Fennell, Maya Bajracharya, David J. McBride, Uma Maheswari, Alexander M. Frankell, Charles Swanton, Andrew D. Beggs, Lucinda Billingham

“…Abstract There are no current stratified medicine options for STK11-deficient NSCLC. …”
Get full text

Innovating through tradition: kava-talanoa as a culturally aligned medico-behavioral therapeutic approach to amelioration of PTSD symptoms by S. Apo Aporosa, Dennis Itoga, Julia Ioane, Jan Prosser, Sione Vaka, Emily Grout, Martin J. Atkins, Mitchell A. Head, Jonathan D. Baker, Tanecia Blue, David H. Sanday, Mahonri W. Owen, Chris Murray, Karthik Sivanathan, Tua’ipulotu W. Cuthers, Anau Mesui-Henry, Mary-Jane McCarthy, James Bunn, Ifereimi Waqainabete, Helen Turner, Helen Turner, Helen Turner

“…Our core hypothesis is that, combined, kava-talanoa will outperform current standards of care in PTSD symptom management as a culturally augmented cognitive-behavioral group therapy intervention. …”
Get full text

The role of assessment of quality of life and health with the index of vital activity in patients with arterial hypertension combined with gout in the family doctor practice. by O. M. Lazarenko, A. P. Kuzmina

“…The number of studies that assess the quality of life of patients with various comorbid diseases is increasing annually. Arterial hypertension and gout is no exception. …”
Get full text

Young TPI: empowering animal-free science among the next- generation of scientists by Marta G. Valverde, Marta G. Valverde, Fatima Zohra Abarkan, Fatima Zohra Abarkan, Rebecca Van Eijden, Rebecca Van Eijden, Julia M. L. Menon, Julia M. L. Menon, Nikolas Gaio, Nikolas Gaio, Aarti Ramchandran, Aarti Ramchandran, Victoria C. De Leeuw, Victoria C. De Leeuw

“…The Dutch government has promoted initiatives such as Transitie Proefdiervrije Innovatie (TPI) to make the public aware of the current situation. However, the transition towards animal-free innovations will span over more than two generations. …”
Get full text

Intelligent beehive monitoring system based on internet of things and colony state analysis by Yiyao Zheng, Xiaoyan Cao, Shaocong Xu, Shihui Guo, Rencai Huang, Yingjiao Li, Yijie Chen, Liulin Yang, Xiaoyu Cao, Zainura Idrus, Hongting Sun

“…Moreover, our counting algorithm also achieved excellent results, with root mean square error (RMSE) of 1.3 ± 0.1, 0.2 ± 0.0, and 1.6 ± 0.1 in counting the number of bees current, entry, and out scene in an episode, respectively. …”
Get full text

Construction of medical scientific data repositories in China: analysis of survey and recommendations by Jia Song, Jia Song, Chunqiu Li, Wirapong Chansanam

“…BackgroundIn the context of global open science trends, medical open-access repositories (OARs) promote transparency in research and facilitate the sharing of scientific data. …”
Get full text

Soundscape research in wind farms: A state-of-art review by Xinyan Xu, Huan Tong, Jian Kang

“…By reviewing these articles, this review found that current research related to the soundscape study of wind farms is still lacking, with more researchers focussing on wind power noise and its effects on the physical and psychological health of residents rather than on the influence of the integrated acoustic environment and context of wind farms on residents' perception. …”
Get full text

Pregnancy-related acute kidney injury leads to hypertension, reduced kidney function and cognitive impairment in postpartum rats by Ashley Griffin, Jamie Szczepanski, Shauna-Kay Spencer, Shauna-Kay Spencer, Lucia Solis, Teylor Bowles, Reanna Robinson, Jan M. Williams, Patrick B. Kyle, Kedra Wallace, Kedra Wallace

“…Both hypertensive disorders of pregnancy and Acute Kidney Injury (AKI) outside the context of pregnancy have been associated with an increased risk of developing Chronic Kidney Disease (CKD) and cognitive impairment. …”
Get full text

Genome-Wide DNA Methylation Analysis during Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Yangyang Cao, Haoqing Yang, Luyuan Jin, Juan Du, Zhipeng Fan

“…We found that the majority of cytosines in a CpG context were methylated in induced BMSCs. Our results also revealed that, along with the induced osteogenic differentiation in BMSCs, the average genomic methylation levels and CpG methylation in transcriptional factor regions (TFs) were increased, the CpG methylation level of various genomic elements was mainly in the medium-high methylation section, and CpG methylation levels in the repeat element had highly methylated levels. …”
Get full text

Evaluating the Constructive Alignment of Learning Objectives Within Haptics Simulation in the Dental Undergraduate Curriculum by Susha Rajadurai, Tapan Hebballi, Zahra Sharif, Guneet Kaur Kukreja, Ithar Derdour

“…This study seeks to explore whether the current learning objectives constructively align with our current haptics simulation curriculum – in the specific context of how well they are being met by year 1 undergraduate dental students. …”
Get full text

Impacts of climatology error on evapotranspiration data merging over the intensively irrigated Haihe river basin, China by Yuxi Li, Xi Chen, Jianzhi Dong, Jianhong Zhou, Xin Tian, Man Gao

“…New hydrological insights for the region: Results demonstrate that current RS and reanalysis datasets of ERA5, PML, and ALEXI contain strong intra and inter-annual biases. …”
Get full text

Self-generated temperature gradient under uniform heating in p–i–n junction carbon nanotube thermoelectric generators by Oga Norimasa, Ryota Tamai, Hiroto Nakayama, Yoshiyuki Shinozaki, Masayuki Takashiri

“…The output voltage and current of the SWCNT-TEG increased with increasing temperature. …”
Get full text

Absence of progression risk of chronic kidney disease in patients with urine protein-creatinine ratio below 500 mg/g: a cohort study with competing risk analysis by Jiang Bai, Lijuan Zhang, Jingkai Di, Wenyu Wang, Yawen Wu, Yun Zhou, Yun Zhou, Yun Zhou

“…The results of the Fine and Gray competing risk survival regression model showed the same trend.ConclusionIn patients with CKD and UPCR levels below 500 mg/g, there was no increased risk of CKD progression associated with the higher proteinuria levels.…”
Get full text

Validation of the Mild Behavioral Impairment Scale (MBI-S) for brief self-assessment of Mild Behavioral Impairment in people without dementia by Paula Hinkl, Elmar Graessel, Nicolas Rohleder, Peter Landendoerfer, Thomas Kuehlein, Natascha Lauer, Anna Pendergrass

“…It has high test economy and measures current neuropsychiatric symptoms and their intensity as a state criterion. …”
Get full text

Knowledge of Preconception Healthcare and Associated Factors: A Study among Mothers in Jinka Town, Southern Region, Ethiopia by Kassahun Fikadu Tesema, Tamirat Cheneka, Alemayehu Alemu, Mekonen Feyissa, Birhanu Birkaye, Hafiza Mohammed, Eleni Kidu, Getahun Wegaso, Biresaw Wasihun

“…Preconception healthcare is promising to improve the reproductive health status of women and couples if they receive care three months to two years before conception. In the current context of Ethiopia, however, preconception healthcare is overlooked in the continuum of care. …”
Get full text

A Novel CTC-Binding Probe: Enzymatic vs. Shear Stress-Based Detachment Approaches by Sophia Krakowski, Sara Campos, Henri Wolff, Gabi Bondzio, Felix Hehnen, Michael Lommel, Ulrich Kertzscher, Paul Friedrich Geus

“…The additional flow treatment did not increase the CTC detachment efficiency. <b>Conclusions</b>: It is feasible that the detachment efficiency can be further increased by a longer enzymatic incubation time or higher shear stress. …”
Get full text

Spiritual space: Hearing and experiencing the voice of God by Walter Firth

“…As scrutiny increases of what and how, such material is shared, used and taught, creating a space where the voice of God can speak into our current settings becomes increasingly vital. …”
Get full text

A critical analysis of the policy potential for sustainable agriculture in India by Neha Chauhan, Henrik von Wehrden

“…As per last census conducted (in 2011), 54.6% of India’s total population depends on agriculture as their primary livelihood. In this context, the current study emphases on ascertaining the major themes of the current policies being implemented in agriculture in India, while evaluating the potential of these policies in restructuring the agriculture into a more sustainable sector. …”
Get full text

Indonesian Nursing Educators’ Experiences with Developing Student-Centered Learning Methods by Vigdis Abrahamsen Grøndahl, Kirsti Lauvli Andersen, Ann Karin Helgesen, Asniar Asniar, Randi Martinsen, Riza Septiani, Dharina Baharuddin, Signe Rasch Woersaa, Anna Willman, Liv Berit Olsen

“…A three-year educational program for nursing educators in Indonesia was developed. The current study used a qualitative, descriptive design with a questionnaire containing four open-ended questions focusing on the educators’ experiences with developing student-active methods and conditions affecting this process. …”
Get full text

Holiday Weight Change in a US College Student Sample: A Prospective Observational Cohort Study by Hannah B. Yoo, Casen Bigham, Tanisha Basu, Sharmin Akter, Tiffany Tsai, Alexis Brown, Sara Kiros, Shruthi Durai, Claire Brown, Martin Binks

“…Weight gain occurred alongside increases in lean mass but not body fat. Results provide important context to previous findings observing weight gain in college students and adults over the holiday season. …”
Get full text