HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis by Jie Yu, Bing Guo, Fan Zhang, Miao Liu, Ying Xie, Hui-mei Zou, Yuan-yuan Ruan, Xiao-min An, Pei-lei Chen, Ying-qin Luo, Ming-jun Shi, Li-fen Xu

“…Objective The current study aims to elucidate the critical function of hepatocyte nuclear factor 1-beta (HNF1-β) in lupus nephritis (LN) by investigating its modulation of the Derlin-1/valosin-containing protein (VCP)/VCP-interacting membrane selenoprotein (VIMP) complex, endoplasmic reticulum (ER) stress and podocyte apoptosis.Methods In vitro and in vivo models of LN were established using glomerular podocytes treated with LN serum and MRL/lpr mice, respectively. …”
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The impact of electronic cigarette smoking on periodontal status and proinflammatory cytokine levels: a cross-sectional study by Banna Alnufaiy, Hanadi Ghurmallah Alzahrani, Rhodanne A. Lambarte, Mohannad Abdullah Alghamdi, Abdulelah Saad Alali, Wael Farhan Alanazi, Mohammad Hamad Alkanhal, Abdulrahman Farhan Almukhalfi

“…Abstract Background E-cigs(E-cigs) use is increasing worldwide. Recent studies suggest that E-cigs contain harmful elements that could lead to adverse oral health outcomes. …”
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Bionomics of Aedes mosquito species in three eco-epidemiological settings of Cameroon and their susceptibilities profiles to insecticides by Ms Bertille Djapoum, Ms Gisele Aurelie Foko Dadji, Mr Borel DJIAPPI-TCHAMEN, Mr Christophe ANTONIO-NKONDJIO

“…After emergence and morphological identification, F0 and F1 of Aedes aegypti and Aedes albopictus progeny will be used to assess the current phenotypic resistance status to the commonly used insecticides using WHO bioassays and mortality rates were assess according to the different insecticides tested. …”
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Improved Mechanical Performances of Hastelloy C276 Composite Coatings Reinforced with SiC by Laser Cladding by Yuqing Tang, Zheng Lu, Xuan Zhang, Xihuai Wang, Shengbin Zhao, Mingdi Wang

“…The self-corrosion potential measured at 315 mV, with a self-corrosion current density of 6.884 × 10⁻⁶ A/cm², and the electrochemical charge-transfer resistance was approximately 25 times that of the substrate and 1.26 times that of the 0 wt%. …”
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Intelligent beehive monitoring system based on internet of things and colony state analysis by Yiyao Zheng, Xiaoyan Cao, Shaocong Xu, Shihui Guo, Rencai Huang, Yingjiao Li, Yijie Chen, Liulin Yang, Xiaoyu Cao, Zainura Idrus, Hongting Sun

“…Moreover, our counting algorithm also achieved excellent results, with root mean square error (RMSE) of 1.3 ± 0.1, 0.2 ± 0.0, and 1.6 ± 0.1 in counting the number of bees current, entry, and out scene in an episode, respectively. …”
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Aortic Aneurysm Inflammatory Cell Detection with Deep Learning methods by Kristóf-Gergö Nagy, Csaba Szferle, Attila Fintha

“…INTRODUCTION: In digital pathology, neural networks such as the Multilayer Perceptron (MLP) and Residual Neural Network (ResNet) are becoming increasingly prevalent for the analysis of tissue structure. …”
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Construction of Modified Mesoporous Graphite Phase Carbon Nitride Material and Its Photocatalytic U(Ⅵ) Reduction Performance by YU Mingyue1, HAO Shuai1, HUANG Wenlong1, JIANG Dongmei2, XIA Liangshu1

“…Consequently, the uranium-containing wastewater produced poses significant and substantial threats to environmental safety and public health. …”
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Integrating quantum synchronization in future generation networks by Swaraj Shekhar Nande, Muhammad Idham Habibie, Milad Ghadimi, Andrea Garbugli, Koteswararao Kondepu, Riccardo Bassoli, Frank H. P. Fitzek

“…However, existing standards, such as the precision time protocol, are unreliable due to jitters, datagram losses, and complexity. Increasing the synchronization error from the ideal tens of nanoseconds to hundreds of microseconds is unacceptable in future-generation networks. …”
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Why a strong global plastics treaty is essential for agricultural systems, food safety, food security and human health by Marie-France Dignac, Melissa Bakhos, Susanne Brander, Gabin Colombini, Megan Deeney, Etienne Dufour, Violette Geissen, Asta Hooge, Esperanza Huerta Lwanga, Baptiste Monsaingeon, Kristian Syberg, Joe Yates

“…An ambitious global plastics treaty is urgently needed to decrease soil pollution from microplastics and nanoplastics (MNPs), originating both from intentional uses of agricultural plastics and from composts and sludges applied to soils, contaminated due to the increasing plastic production and use. The current narrative, biased by vested interests, overemphasizes short-term benefits of agricultural plastics, while ignoring their adverse effects. …”
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M.A.R.V.E.L.S. "Medical Students Advancing Research, Visibility, Education, Leadership, and Support." A Student-Driven Initiative by Molly Mehta, Kayvon Yazdanbakhsh, Elizabeth Hsu, Olga Gomeniouk, Kayla Nenninger, Devin P. Asher

“…METHODS: A committee of six second-year medical students and four faculty advisors established three networks to increase medical student involvement in research. The first is a Microsoft systems database containing contact, field of study, productivity, and project information of research faculty open to mentoring students aimed to facilitate meaningful collaboration between faculty seeking help with research projects and medical students eager to conduct research. …”
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NECROSIS AS A COMPLICATION OF LOCAL ANESTHESIA IN DENTISTRY by V.V. Lepsky, C. V. Osik

“…However, as a rule, most of the groups of painkillers contain vasoconstrictors of the cartridge, such as adrenaline hydrochloride, noradrenaline, although the last one is currently banned for use because of the complications that it can cause. …”
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Rapid public health genomics capacity building during the COVID-19 Delta crisis driven by a transnational private, public, and social alliance by Mehul Champaklal Mehta, Mehul Champaklal Mehta, Mehul Champaklal Mehta, Gayatri Nair Lobo, Gayatri Nair Lobo, Gretchen Weightman, Gretchen Weightman, Vidushi Chitalia, Vidushi Chitalia, Jayanthi Shastri, Jayanthi Shastri, Jayanthi Shastri

“…This has transformed Mumbai’s ability to expeditiously identify and contain infectious outbreaks, thus better protecting its citizens. …”
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Contribution of the TRPM4 Channel to Osteogenic Differentiation of Human Aortic Valve Interstitial Cells by Margaux Aize, Arthur Boilève, Benoit D. Roussel, Laura Brard, Harlyne Mpweme Bangando, Corentin Kerevel, Alexandre Lebrun, Hind Messaoudi, Vladimir Saplacan, Alain Manrique, Romain Guinamard, Christophe Simard

“…Results Western blot on VICs revealed TRPM4 protein expression and channel functionality was confirmed by patch‐clamp recordings exhibiting a cationic current sensitive to voltage and internal Ca2+. VICs maintained in pro‐calcifying media exhibited a higher mineralization than in standard media, with an increase in osteogenic markers. …”
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Study on the Preparation and Corrosion Properties of Hydrotalcite Composite Permeation Layer via Plasma Electrolytic Carbonitriding by YANG Zhuolin, ZHAI Yanbo, CENG Shunke, PENG He, LE Chunpeng, WEI Ziwei

“…In order to improve the corrosion resistance of steel materials treated by plasma electrolytic infiltration，annealed 20 steel was used as the experimental substrate.Micro-nanopores formed during the plasma electrolytic carbonitriding process were utilized as containers to load magnesium-iron layered double hydroxides (Mg-Fe-LDHs) as a corrosion inhibitor，and the effects of Mg-Fe-LDHs on the corrosion performance of 20 steel were investigated.First，formamide was used as the carbon and nitrogen source，and KCl was used as the conductive salt.These components were mixed with deionized water to form an electrolyte.Then，the samples were treated at a constant DC pulse voltage of 220 V for 9 min to produce a carbonitrided layer (denoted as PEC/N samples).Subsequently，the PEC/N samples were immersed in a Mg-Fe-LDHs precursor solution containing urea，MgSO4 and Na2CO3，and hydrothermally crystallized at 140 ℃for 10 h to obtain a composite infiltration layer (denoted as PEC/N-LDHs samples).The performance of the composite infiltration layers was analyzed using a microhardness tester，scanning electron microscopy (SEM)，X-ray diffraction (XRD) and electrochemical testing.Results showed that the microhardness of the composite infiltration layer reached approximately 900 HV，which was 4.6 times higher than that of the substrate.The carbonitrided layer of the PEC/N samples was about 20 μm，with a smooth and flat cross-section but a rough，porous and honeycomb-like surface.After hydrothermal synthesis of LDHs，the surface became smooth，lacking a visible honeycomb structure，and a large number of flake-like crystalline deposits appeared on the surface.The XRD spectra of the PEC/N samples showed absorption peaks corresponding to Fe3C，Fe5C2，α-Fe and Fe3N phases.After the in-situ loading of Mg-Fe-LDHs，new absorption peaks corresponding to the (003)，(006) and (009) crystal planes of Mg-Fe-LDHs appeared in the XRD spectra of the PEC/N-LDHs samples.Combined with SEM morphology analysis，it was confirmed that Mg-Fe-LDHs were successfully loaded，presenting a flake-like structure.Compared with 20 steel，the PEC/N samples exhibited improved corrosion potential (Ecorr) and corrosion current density (Jcorr)，reaching－0.451 V and 75.22 μA/cm2，respectively，although the lowfrequency impedance modulus (｜Z ｜0.01 Hz) showed no significant increase，reaching only 998.5 Ω·cm2.After loading Mg-Fe-LDHs，the PEC/N-LDHs samples demonstrated further improvements，with Ecorr，Jcorr and ｜Z ｜0.01 Hz reaching－0.355 V，39.11 μA/cm2 and 6 586.0 Ω·cm2，respectively，showing significant enhancement compared to both 20 steel and PEC/N samples.These results indicated that plasma electrolytic carbonitriding treatment of 20 steel could produce a carbonitrided layer with high hardness.Additionally，the hydrothermal loading of LDHs further improved the corrosion resistance of the composite infiltration layer without affecting its hardness.The PEC/N-LDHs composite infiltration layer thus achieved both high hardness and superior corrosion resistance.…”
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Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence by N. G. Barannik, S. D. Varzhapetyan, A. V. Sidoryako, Yu. S. Karabinova

“…Serum IL4 concentration was increased only in patient with pyoinflammatory changes in more than one area. …”
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The possibility of using the DKS-AT1123 dosimeter for radiation monitoring of medical electron accelerators with the energy of more than 10 MeV by A. N. Barkovsky, S. A. Ogorodnikov

“…Over the past 4 years, their number has increased 2.5 times. These installations contain pulsed electron accelerators that generate pulsed bremsstrahlung radiation with a maximum energy from 6 to 21 MeV. …”
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Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…The antibacterial efficiency of the MO-HPA1.0 group on E. coli and S. aureus increased by about 40.1% and 55.6% respectively, compared to the MO-HPA0.5 group. …”
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Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway by Xiao Li, Mengna Cui, Long Xu, Qie Guo

“…ObjectiveSorafenib, a multikinase inhibitor, is currently the standard treatment for advanced liver cancer. …”
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Neutralizing Antibody Spectrum in COVID-19 Patients who Became Ill During the Circulation of Different SARS-CoV-2 Variants by S. K. Pylaeva, L. I. Kozlovskaya, A. A. Erovichenkov, D. I. Sirazova, E. Y. Shustova, E. A. Artamonova, A. A. Sinyugina, I. V. Gordeychuk, D. V. Troshyanskiy, E. V. Kosareva, O. N. Solodovnikova, R. K. Kogotyzhev, A. U. Berestovskaia, I. N. Tyurin, D. N. Protsenko, A. A. Ishmukhametov

“…Thus, a fraction of people, regardless of age, who became infected in 2020-2021 have an antibody spectrum capable of neutralizing current and possibly related SARS-CoV-2 variants that will emerge in the near future. …”
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Assessment of the phenolic profile and biological activities of aqueous date seed extracts: A comparative analysis by Tareq M. Osaili, Aseel Swaidan, Anas Al-Nabulsi, Amin Olaimat, Susanne Neugart, Layla Engelhardt, Tuba Esatbeyoglu, Mutamed Ayyash, Leila Cheikh Ismail, Maher M Al-Dabbas, Reyad S. Obaid, Nada El Darra

“…Date palm fruit (Phoenix dactylifera L.) is a well-known fruit that has become increasingly popular among consumers due to its pleasant flavor, nutrient-dense content, and nutraceutical characteristics. …”
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