Combined and progestagen-only hormonal contraceptives and breast cancer risk: A UK nested case-control study and meta-analysis. by Danielle Fitzpatrick, Kirstin Pirie, Gillian Reeves, Jane Green, Valerie Beral

“…<h4>Background</h4>Current or recent use of combined oral contraceptives (containing oestrogen+progestagen) has been associated with a small increase in breast cancer risk. …”
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Fastest Prostate Cancer Prediction on Whole-Mount Pathological Slides Using Self-Reform Multilayer Transformer by Linjie Xu, Xiaotian Yu, Haoming Luo, Jili Wang, Wenjie Liang, Jing Zhang, Zunlei Feng, Cheng Lu, Xiuming Zhang

“…Moreover, pixels in each whole-mount slide of PCa are increased by approximately <inline-formula> <tex-math notation="LaTeX">$4\sim 9$ </tex-math></inline-formula> times, therefore containing more information for diagnosis. …”
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The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus by Zhang Mengjuan, Lin Guanglan, Pan Xiaohua, Song Weitao, Tan Can, Chen Xuan, Yang Yanling, Zhuang Zhenhong

“…Bioinformatics analysis showed Cti6 is conservative in Aspergillus spp., and mCherry mediated subcellular localization showed that most Cti6 accumulated in the nuclei, which reflected that Cti6 performed its important biological function in the nuclei in Aspergillus spp.. The results of the current study elucidate the roles of PHD domain containing proteins in the mechanism of the infection of crops by A. flavus, and provided a novel target for effectively controlling the contamination of Aspergillus spp. to crops.…”
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C18:0 GM3 ganglioside’s efficacy in LPS-induced parkinsonism: neuroprotection, inflammatory inhibition and gliosis mitigation by Tsung-Ta Liu, Cheng-Tsung Liu, I-Hsun Li, Yu-Chieh Chu, Hao-Yuan Hung, Chuang-Hsin Chiu, Ta-Kai Chou, Shiao-Yun Li, Tin-An Wang, Jui-Hu Shih

“…Abstract Background Parkinson’s disease (PD) is an incurable neurological disorder, and current pharmacological therapies primarily address symptoms without halting disease progression. …”
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Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extracts against TCDD-induced hepatocyte damage in Jian carp (Cyprinus carpio var. Jian) by Du Jinliang, Cao Liping, Jia Rui, Liu Yingjuan, Shen Yujin, Yin Guojun

“…Jian).Jian carp were fed with diet containing 3 doses of GGE (0.1, 0.5 and 1.0 g/kg diet) for 60 days before a single intraperitoneal injection of TCDD (0.6 μg/kg), 72 h after TCDD injection, blood and liver samples were taken for biochemical analysis.The results showed that GGE at 1.0 g/kg diet for 60 days prior to TCDD intoxication significantly reduced the elevated activities of ALT, AST, LDH, AKP and increased the reduced levels of total protein (TP), albumin (Alb) in the serum, markedly inhibited the reduction of the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), total antioxidant capacity (T-AOC), and reduced the malondialdehyde (MDA) formation in liver tissue. …”
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Sustainable agriculture through nano-priming: Evaluating the role of biogenic manganese oxide nanoparticles in mitigating wastewater-induced stress in wheat (Triticum aestivum) by Aneeza ISHFAQ, Sabir HUSSAIN, Tanvir SHAHZAD, Muhammed SHAHID, Faisal MAHMOOD, Syed Raza HUSSAIN, Irfan HAIDRI, Imran KHAN, Mahmoud F. SELEIMAN, Muhammad Ahsan ASGHAR, Muhammad Fuad ANSHORI

“…Control included seeds without MnO-NP priming. The wastewater contained contaminants such as heavy metals and organic pollutants. …”
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Anatomy and function of closing muscle complex of the vagina in health and pelvic organ prolapse by G. B. Dikke, A. D. Makatsariya, A. M. Ziganshin, E. A. Shaikhieva, V. O. Bitsadze

“…In modern literature, the pelvic floor muscles are presented by showing their anatomical location and indicating relevant attachment points, but their combined anatomical, topographic and functional significance is described insufficiently, which the current review was aimed at.Aim: to determine the physiological significance and anatomical units of the vagina occlusor muscle complex, topography and functions in health and in pelvic organ prolapse (POP).Materials and Methods. …”
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Evaluating and Enhancing Japanese Large Language Models for Genetic Counseling Support: Comparative Study of Domain Adaptation and the Development of an Expert-Evaluated Dataset by Takuya Fukushima, Masae Manabe, Shuntaro Yada, Shoko Wakamiya, Akiko Yoshida, Yusaku Urakawa, Akiko Maeda, Shigeyuki Kan, Masayo Takahashi, Eiji Aramaki

“…ObjectiveThis study aims to evaluate the current capabilities and identify challenges in developing a JGCLLM-based dialogue system for genetic counseling. …”
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Antiviral Therapeutics Discovery for Enterovirus D68. by Prof Justin Jang H Chu

“…To date, there are no effective antiviral successfully developed for enterovirus infection and the current understanding on pathogenesis is limited, which has resulted in the persistent circulation and outbreaks across the globe. …”
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Promising opportunities to improve polio vaccines by E. E. Evreinova, L. M. Khantimirova, V. A. Shevtsov, V. A. Merkulov, V. P. Bondarev

“…In order to meet the needs of global health, it is planned to increase the use of traditional and optimised inactivated polio vaccines and introduce new types of vaccines that are being developed based on the current understanding of RNA-containing viruses. …”
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Modern ideas about the role of the galaninergic system in the pathogenesis of heart failure and myocardial remodeling by A. A. Yafarova, A. R. Kiselev, A. F. Sheptulina, O. M. Drapkina

“…In this regard, the search for new molecules for therapeutic action aimed at preventing myocardial remodeling is of undoubted interest. In this context, the galaninergic system seems to be a promising target. …”
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Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge by Jitendra Maharana, Chun-Hsiung Wang, Li-An Tsai, Yi-Ting Liao, Cheng-Han Yang, Melvin C. Shen, Lourriel S. Macale, Thang Ngoc Tran, Joemark Narsico, Ronelito J. Perez, Sunil Kumar Tewary, Jian-Li Wu, Hong-You Lin, Shu-Wei Chang, Aaron Franklin, Patrick J. Moynihan, Deborah Jacobs-Sera, Krista G. Freeman, Graham F. Hatfull, Todd L. Lowary, Meng-Chiao Ho

“…Molecular insights into mycobacteriophage architecture and host interactions could allow structure-guided phage engineering to increase efficacy and broaden host range, but such information is currently unavailable. …”
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Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…We collected front-line national and international healthcare professional perspectives on best practice, current practice and explanations for implementation gaps between ‘best’ and ‘current’ practice (WP1, phase 2). …”
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SEED DORMANCY BREAKING OF AN ENDANGERED MEDICINAL TREE SPECIES (TAXUS BACCATA L.) USING EMBRYO CULTURE by Mohamed BEKHOUCHE, Abdelkader MORSLI, Majda KHELIFI-SLAOUI, Roukia BENYAMMI, Hayette ZAOUT, Lakhdar KHELIFI

“…These results indicated that the protocol developed during the current study will be useful to overcome seed dormancy and for multiplication and conservation of the species T. baccata L. …”
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Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice. by Ruinan Lu, Qian Wang, Yongli Han, Jianyong Li, Xiang-Jiao Yang, Dengshun Miao

“…The mice were treated with PTH1-34 (containing the first 34 residues of mature PTH), an anabolic drug currently used for treating osteoporosis, and compared with the vehicle-treated Bmi1-/- and wild-type littermates in terms of skeletal and haematopoietic phenotypes. …”
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Optimizing Antibiotic Use: Addressing Resistance Through Effective Strategies and Health Policies by Maurizio Capuozzo, Andrea Zovi, Roberto Langella, Alessandro Ottaiano, Marco Cascella, Manlio Scognamiglio, Francesco Ferrara

“…<b>Main text:</b> This review analyzes current strategies and health policies adopted in the European Union (EU) and Italy to manage AMR, presenting an in-depth examination of approaches for containment and mitigation. …”
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Making temporary homes by Marjolein Overtoom

“…The main finding was that the concept of home could benefit housing design. Current building guidelines do not include the user-perspective, which is of importance to residents. …”
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Evaluation of the applicability of the X-ray room technical passports in the medical facilities and approval of the X-ray department technical plans by the local radiological autho... by I. I. Berezin, S. S. Somov, К. V. Yakusheva

“…The purpose of this work was to assess the relevance and necessity of issuing a technical passport for the X-ray room and to coordinate the project of the X-ray room with the X-ray department in the light of the current sanitary legislation. Registration of a technical passport by organizations that have special permits for these types of work, and not only by the X-ray and radiological department, would increase the legal value of the technical passport. …”
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Hybrid closed-loop systems for managing blood glucose levels in type 1 diabetes: a systematic review and economic modelling by Asra Asgharzadeh, Mubarak Patel, Martin Connock, Sara Damery, Iman Ghosh, Mary Jordan, Karoline Freeman, Anna Brown, Rachel Court, Sharin Baldwin, Fatai Ogunlayi, Chris Stinton, Ewen Cummins, Lena Al-Khudairy

“…Current prices suggest that HCL is around an annual average of £1500 more expensive than CSII + CGM, although this may increase by around a further £500 for some systems. …”
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Research progress on nanotoxicity and detoxification of cobalt in metal-based implants by Wentao Fan, Mingxin Guo

“…While mechanisms are increasingly understood, further research is crucial to fully elucidate the long-term systemic consequences and to develop effective clinical detoxification and preventative strategies for patients with cobalt-containing implants.…”
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