Treatment Methods Dry Form of Age Macular Degeneration — History and Prospects. Review by A. N. Kulikov, M. V. Zakharov, A. A. Volozhev

“…The main treatment for wet AMD is the injection of medications called anti-VEGF agents. Currently, treatment of dry age-related macular degeneration includes modification of risk factors (stop smoking, healthy life style and etc) and dietary supplements containing a combination of certain ingredients (vitamin C, vitamin E, zinc, copper, and lutein with zeaxanthin or beta-carotene) may be able to slow the progression of the disease. …”
Get full text

Leasing impact on transformation processes in the Russian agricultural sector under sanctions pressure by A. A. Kiritsa, Yu. V. Chutcheva

“…With consideration to  the current situation in   the domestic market, decreased prices for agricultural products and rapid growth of   prices for agricultural machinery, the most promising areas for the use of  leasing mechanisms have been proposed to   help accelerate technical re-equipment in   the agricultural sector: application of   leasing solutions in   the agricultural industry that have already been tested and proven successful in   other market segments (for example, subscription, agrocarsharing, etc.); combination of   leasing mechanisms with trade-in programmes which make it  possible to  comprehensively solve issues not only of   updating machinery and tractor fleet, but also of  recycling worn-out agricultural equipment; use of   leasing mechanisms for the development of  machine and technological complexes as a   modern form of  joint use of   machinery in  agriculture which allows accelerating technical equipment of   the industry. …”
Get full text

Combined and progestagen-only hormonal contraceptives and breast cancer risk: A UK nested case-control study and meta-analysis. by Danielle Fitzpatrick, Kirstin Pirie, Gillian Reeves, Jane Green, Valerie Beral

“…<h4>Background</h4>Current or recent use of combined oral contraceptives (containing oestrogen+progestagen) has been associated with a small increase in breast cancer risk. …”
Get full text

Defining the Optimal Ranges of Tourist Visits in UNESCO World Heritage Caves with Rock Art: The Case of El Castillo and Covalanas (Cantabria, Spain) by Angel Fernandez-Cortes, Eduardo Palacio-Perez, Tamara Martin-Pozas, Soledad Cuezva, Roberto Ontañon, Javier Lario, Sergio Sanchez-Moral

“…These two caves are currently open to tourism and boast an exceptional archaeological heritage that includes magnificent examples of Palaeolithic cave art. …”
Get full text

Trusted Energy-Aware Hierarchical Routing (TEAHR) for Wireless Sensor Networks by Vikas, Charu Wahi, Bharat Bhushan Sagar, Manisha Manjul

“…Moreover, we explore the scalability of TEAHR across large networks as well as its performance in computationally constrained contexts. We have verified through our detailed investigation that the energy metrics used uniquely in TEAHR extend the life of the network while increasing data routing trust and trustworthiness. …”
Get full text

Fastest Prostate Cancer Prediction on Whole-Mount Pathological Slides Using Self-Reform Multilayer Transformer by Linjie Xu, Xiaotian Yu, Haoming Luo, Jili Wang, Wenjie Liang, Jing Zhang, Zunlei Feng, Cheng Lu, Xiuming Zhang

“…Moreover, pixels in each whole-mount slide of PCa are increased by approximately <inline-formula> <tex-math notation="LaTeX">$4\sim 9$ </tex-math></inline-formula> times, therefore containing more information for diagnosis. …”
Get full text

Traditional Chinese medicine (Shenqinlong Qingfei Peiyuan) alleviate pulmonary infection in immunodeficient mice by suppressing HMGB1 and reversing macrophage polarization by Meijun Liu, Xiyuan Song, Xiaoli Chen, Pengfei Meng, Qian Yu, Liran Xu, Aiping Lyu, Kenneth CP Cheung

“…Results: QFPY treatment showed efficacy comparable to the current standard treatment for lung infections, levofloxacin tablets (LEV). …”
Get full text

Influence of Health Expenditure on COVID-19 Contraction: Theoretical and Empirical Analysis by Alina Vysochyna, Agnieszka Jakubowska

“…A more in-depth analysis using panel regression modelling in Stata 12/SE revealed the positive impact of public, private and external health expenditures on reducing mortality, as well as the positive impact of increasing current health expenditures on life expectancy. …”
Get full text

The PHD transcription factor Cti6 is involved in the fungal colonization and aflatoxin B1 biological synthesis of Aspergillus flavus by Zhang Mengjuan, Lin Guanglan, Pan Xiaohua, Song Weitao, Tan Can, Chen Xuan, Yang Yanling, Zhuang Zhenhong

“…Bioinformatics analysis showed Cti6 is conservative in Aspergillus spp., and mCherry mediated subcellular localization showed that most Cti6 accumulated in the nuclei, which reflected that Cti6 performed its important biological function in the nuclei in Aspergillus spp.. The results of the current study elucidate the roles of PHD domain containing proteins in the mechanism of the infection of crops by A. flavus, and provided a novel target for effectively controlling the contamination of Aspergillus spp. to crops.…”
Get full text

C18:0 GM3 ganglioside’s efficacy in LPS-induced parkinsonism: neuroprotection, inflammatory inhibition and gliosis mitigation by Tsung-Ta Liu, Cheng-Tsung Liu, I-Hsun Li, Yu-Chieh Chu, Hao-Yuan Hung, Chuang-Hsin Chiu, Ta-Kai Chou, Shiao-Yun Li, Tin-An Wang, Jui-Hu Shih

“…Abstract Background Parkinson’s disease (PD) is an incurable neurological disorder, and current pharmacological therapies primarily address symptoms without halting disease progression. …”
Get full text

Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extracts against TCDD-induced hepatocyte damage in Jian carp (Cyprinus carpio var. Jian) by Du Jinliang, Cao Liping, Jia Rui, Liu Yingjuan, Shen Yujin, Yin Guojun

“…Jian).Jian carp were fed with diet containing 3 doses of GGE (0.1, 0.5 and 1.0 g/kg diet) for 60 days before a single intraperitoneal injection of TCDD (0.6 μg/kg), 72 h after TCDD injection, blood and liver samples were taken for biochemical analysis.The results showed that GGE at 1.0 g/kg diet for 60 days prior to TCDD intoxication significantly reduced the elevated activities of ALT, AST, LDH, AKP and increased the reduced levels of total protein (TP), albumin (Alb) in the serum, markedly inhibited the reduction of the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), total antioxidant capacity (T-AOC), and reduced the malondialdehyde (MDA) formation in liver tissue. …”
Get full text

Sustainable agriculture through nano-priming: Evaluating the role of biogenic manganese oxide nanoparticles in mitigating wastewater-induced stress in wheat (Triticum aestivum) by Aneeza ISHFAQ, Sabir HUSSAIN, Tanvir SHAHZAD, Muhammed SHAHID, Faisal MAHMOOD, Syed Raza HUSSAIN, Irfan HAIDRI, Imran KHAN, Mahmoud F. SELEIMAN, Muhammad Ahsan ASGHAR, Muhammad Fuad ANSHORI

“…Control included seeds without MnO-NP priming. The wastewater contained contaminants such as heavy metals and organic pollutants. …”
Get full text

Anatomy and function of closing muscle complex of the vagina in health and pelvic organ prolapse by G. B. Dikke, A. D. Makatsariya, A. M. Ziganshin, E. A. Shaikhieva, V. O. Bitsadze

“…In modern literature, the pelvic floor muscles are presented by showing their anatomical location and indicating relevant attachment points, but their combined anatomical, topographic and functional significance is described insufficiently, which the current review was aimed at.Aim: to determine the physiological significance and anatomical units of the vagina occlusor muscle complex, topography and functions in health and in pelvic organ prolapse (POP).Materials and Methods. …”
Get full text

Antiviral Therapeutics Discovery for Enterovirus D68. by Prof Justin Jang H Chu

“…To date, there are no effective antiviral successfully developed for enterovirus infection and the current understanding on pathogenesis is limited, which has resulted in the persistent circulation and outbreaks across the globe. …”
Get full text

Entrepreneurial bricolage: A systematic literature network analysis and TCCM approach by Brahim Aaouid, Abdellah Elboussadi, Omar Boubker, Zakaria Nejjari

“…In recent years, bricolage, often considered an alternative approach to traditional methods of entrepreneurial action, has attracted increasing interest from researchers. This article aims to provide an in-depth overview of the current state of bricolage research and to illuminate the historical development of knowledge in this area. …”
Get full text

Promising opportunities to improve polio vaccines by E. E. Evreinova, L. M. Khantimirova, V. A. Shevtsov, V. A. Merkulov, V. P. Bondarev

“…In order to meet the needs of global health, it is planned to increase the use of traditional and optimised inactivated polio vaccines and introduce new types of vaccines that are being developed based on the current understanding of RNA-containing viruses. …”
Get full text

Protection of forest lands in the Russian Federation: Problems and solutions by Serebryakov Oleg, Yakovenko Natalia, Komov Igor, Kolotushkin Andrey

“…The main attention is paid to the analysis of the current forest legislation, its shortcomings and potential for improvement in order to increase the effectiveness of protection measures. …”
Get full text

Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge by Jitendra Maharana, Chun-Hsiung Wang, Li-An Tsai, Yi-Ting Liao, Cheng-Han Yang, Melvin C. Shen, Lourriel S. Macale, Thang Ngoc Tran, Joemark Narsico, Ronelito J. Perez, Sunil Kumar Tewary, Jian-Li Wu, Hong-You Lin, Shu-Wei Chang, Aaron Franklin, Patrick J. Moynihan, Deborah Jacobs-Sera, Krista G. Freeman, Graham F. Hatfull, Todd L. Lowary, Meng-Chiao Ho

“…Molecular insights into mycobacteriophage architecture and host interactions could allow structure-guided phage engineering to increase efficacy and broaden host range, but such information is currently unavailable. …”
Get full text

SEED DORMANCY BREAKING OF AN ENDANGERED MEDICINAL TREE SPECIES (TAXUS BACCATA L.) USING EMBRYO CULTURE by Mohamed BEKHOUCHE, Abdelkader MORSLI, Majda KHELIFI-SLAOUI, Roukia BENYAMMI, Hayette ZAOUT, Lakhdar KHELIFI

“…These results indicated that the protocol developed during the current study will be useful to overcome seed dormancy and for multiplication and conservation of the species T. baccata L. …”
Get full text

HORMONE IMBALANCE AS A MANIFESTATION OF STRESS IN THE FORMATION OF OLIGOMENORRHEA IN TEENAGE GIRLS by В. Диннік, О. Диннік, С. Новохатська

“…At OM onset, nearly 20% of participants exhibited low E2 levels. With increased disease duration (years 2–3), the proportion of adolescents with low E2 decreased while those with elevated E2 increased. …”
Get full text