Physician experiences of electronic health record interoperability and its practical impact on care delivery in the English NHS: a cross-sectional survey study by Ara Darzi, Jonathan Clarke, Hutan Ashrafian, Ana Luísa Neves, Edmond Li, Olivia Lounsbury, Mujtaba Hasnain

“…Recruitment was performed via convenience sampling and snowballing in collaboration with contacts at Health Education England deaneries and the Royal College of General Practitioners. …”
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Improved effectiveness of vaccination campaigns against rabies by reducing spatial heterogeneity in coverage. by Elaine A Ferguson, Ahmed Lugelo, Anna Czupryna, Danni Anderson, Felix Lankester, Lwitiko Sikana, Jonathan Dushoff, Katie Hampson

“…Using generalized linear mixed models, we find that current focal (village-level) dog rabies incidence decreases with increasing recent focal vaccination coverage. …”
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Financial security of Ukraine in debt burden: Assessment and forecasting by Fedir Zhuravka, Yuriy Petrushenko, Svitlana Chorna, Bohdana Huriy, Inessa Yarova, Olga Pankiv, Wojciech Duranowski

“…This study aims to comprehensively assess the state’s financial security of Ukraine in the context of mounting debt and economic instability. …”
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ISSUES AND TRENDS OF PROGRESS TOWARDS SUSTAINABLE DEVELOPMENT GOALS IN ROMANIA by Dumitru Florin FRONE, Simona FRONE

“…Monitoring SDG 12 in an EU context focuses on progress made in decoupling environmental impacts from economic growth, in decreasing energy consumption and in tackling waste generation and management. …”
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Ramadan fasting and exercise combination therapy: A novel approach for osteoporosis prevention in ovariectomized rats by Tarfa Albrahim, Raghad Alangry, Raghad Alotaibi, Leen Almandil, Sara Alburikan, Hisham S. Aloudah, Mohammed Alahmed, Mohammed Alahmed, Mona Alonazi

“…This could be recommended as a lifestyle modification that is protective against osteoporosis, especially in the context of depleted estrogen hormone after menopause.…”
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An experimental study on the effects of electronic medicinal product information on vaccine hesitancy by Jim Ingebretsen Carlson, Federico Puppo, Ana Roca-Umbert, Frans Folkvord, Francisco Lupiáñez-Villanueva

“…We conclude, by relating the current study to the relevant literature, that salience and information overload could be the main driver of vaccine hesitancy in the context of this study.…”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Understanding of the mechanisms underlying productive HEV infection remains incomplete and would benefit from technological advances improving current model systems. Methods: We exploited transposon-mediated random insertion and selection of viable clones to identify sites in the HEV open reading frame 2 (ORF2) protein, corresponding to the viral capsid, allowing for the insertion of reporter sequences in a functional context. …”
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Unlocking the potential of global greenhouse gas mitigation by reducing food loss and waste by Suraj Negi, Liang-Shih Fan, Hyunook Kim, Taira Hidaka, Aishwarya Rani, Shu-Yuan Pan

“…Food loss and waste (FLW) are significant yet under-addressed contributors to global greenhouse gas (GHG) emissions, and the effectiveness of current FLW mitigation policies and valorization technologies remains insufficiently explored. …”
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Climate change reduces warming potential of nitrous oxide by an enhanced Brewer‐Dobson circulation by Daniela Kracher, Christian H. Reick, Elisa Manzini, Martin G. Schultz, Olaf Stein

“…N2O is a potent greenhouse gas and the most relevant currently emitted ozone‐depleting substance. Here we examine the implications of a reduced N2O lifetime in the context of climate change. …”
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Ashwagandha and Its Role in Stress Reduction, Hormonal Balance, and Athletic Recovery: An Evidence-Based Review by Weronika Ossowska, Maksymilian Czarnota, Wiktoria Ösztreicher

“…Given the increasing use of herbal supplements among athletes and active individuals, this review aims to critically examine clinical evidence regarding the effects of ashwagandha supplementation on stress reduction, regulation of cortisol and testosterone levels, and enhancement of physical recovery.                                                                                                      State of Knowledge: Current clinical studies suggest that ashwagandha may effectively lower cortisol levels, thereby supporting stress resilience in both mentally and physically demanding contexts. …”
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Exploring the barriers to, and importance of, participant diversity in early-phase clinical trials: an interview-based qualitative study of professionals and patient and public rep... by Cindy Cooper, Katie Biggs, Alexander Rothman, Christina Yap, Fiona Thistlethwaite, Della Ogunleye, Munyaradzi Dimairo, Robin Chatters, Shamila Ditta, Jonathan Woodward

“…Participants were identified via their institutional web page, existing contacts or social media (eg, X, formerly known as Twitter).Results Professionals viewed that diversity is not currently considered in all early-phase clinical trials but felt that it should always be taken into account. …”
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Leasing impact on transformation processes in the Russian agricultural sector under sanctions pressure by A. A. Kiritsa, Yu. V. Chutcheva

“…With consideration to  the current situation in   the domestic market, decreased prices for agricultural products and rapid growth of   prices for agricultural machinery, the most promising areas for the use of  leasing mechanisms have been proposed to   help accelerate technical re-equipment in   the agricultural sector: application of   leasing solutions in   the agricultural industry that have already been tested and proven successful in   other market segments (for example, subscription, agrocarsharing, etc.); combination of   leasing mechanisms with trade-in programmes which make it  possible to  comprehensively solve issues not only of   updating machinery and tractor fleet, but also of  recycling worn-out agricultural equipment; use of   leasing mechanisms for the development of  machine and technological complexes as a   modern form of  joint use of   machinery in  agriculture which allows accelerating technical equipment of   the industry. …”
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The Palliative Care in Patients with Oncological Diseases - a New Medical and Therapeutic Approach by Catalina FLORESCU, Octavian VASILIU, Dan PRELIPCEANU

“…A new notion, created by the first author, is supported by this research, i.e., “long-term oncological survivorship care,” which will replace the former concept of palliative care, which refers to “end-of-life care,” or “comfort care,” in relation to the oncological context.…”
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Alpha Helices Are More Robust to Mutations than Beta Strands. by György Abrusán, Joseph A Marsh

“…The rapidly increasing amount of data on human genetic variation has resulted in a growing demand to identify pathogenic mutations computationally, as their experimental validation is currently beyond reach. …”
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Therapy, Pain & Training by Jendrusch G, Henke T, Schnell D, Platen P

“…However, athletes are at increased risk for eye injuries caused by high-velocity objects e.g. balls or physical contact with opponents. …”
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Sustainable agricultural mechanization in Timor-Leste: status, challenges and further action by Jelle Van Loon, Mayling Flores Rojas

“…Beyond this, a reform of the current government mechanization hire schemes is needed: integrated approaches, as found from business model analyses and training exercises during field missions, are needed, that entail context-specific solutions for targeted rural communities, with special attention given to participatory extension, inclusive co-validation of technologies, and private sector-led business model development around mechanization service delivery. …”
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The role of anifrolumab in reshaping the treatment landscape of extra-renal systemic lupus erythematosus by Fulvia Ceccarelli, Matteo Piga, Alessandra Bortoluzzi, Laura Coladonato, Micaela Fredi, Daniele Mauro, Chiara Tani, Luca Iaccarino

“…Hypothetical scenarios derived from clinical practice were examined to identify real-life contexts suitable for the early initiation of anifrolumab treatment. …”
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Acute effects of single-bout isometric handgrip exercise on selected cardiovascular parameters in young normotensive adults at a tertiary care center of West Bengal by Anisha Dutta, Anish Bhowmik

“…Context: Hypertension is currently prevalent along with other lifestyle disorders, which further adds up to cardiovascular morbidity. …”
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"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts. by Chi-Ping Day, John Carter, Zoe Weaver Ohler, Carrie Bonomi, Rajaa El Meskini, Philip Martin, Cari Graff-Cherry, Lionel Feigenbaum, Thomas Tüting, Terry Van Dyke, Melinda Hollingshead, Glenn Merlino

“…Preclinical therapeutic assessment currently relies on the growth response of established human cell lines xenografted into immunocompromised mice, a strategy that is generally not predictive of clinical outcomes. …”
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Insomnia, Cognitive Impairment, or a Combination of Both, Alter Lipid Metabolism Due to Changes in Acylcarnitine Concentration in Older Persons by Selma Karime Castillo-Vazquez, Berenice Palacios-González, Marcela Vela-Amieva, Isabel Ibarra-González, Ricardo Morales, Paola García-delaTorre, Sergio Sánchez-García, Carmen García-Peña, Ricardo Reyes-Chilpa, Raúl Hernán Medina-Campos, Jessica Hernández-Pineda, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura

“…However, the relationship between the two entities (insomnia and CI) is poorly understood. In this context, adults with insomnia show metabolic changes, including alterations in the catabolism of branched-chain amino acids, glycerophospholipids, and glutathione and glutamate biosynthesis. …”
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