Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation by Sho Takatori, Mayuna Kondo, Taisuke Tomita

“…Conversely, we explore findings that challenge this view, such as microglial depletion experiments resulting in unchanged or decreased Aβ accumulation. We propose that the contribution of microglia to Aβ metabolism is context-dependent, varying with disease progression, genetic background, and experimental conditions. …”
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CIS Countries Foreign Economic Activity — from Challenges to New Opportunities by M. S. Goncharov

“…Aim and tasks. To identify current trends and issues in foreign trade, the international financial system, and the investment activity of CIS member states, and to provide recommendations that contribute to sustainable economic development and strengthened mutual cooperation.Methods. …”
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Unlocking the hidden forces: deformation and associated stress distribution in the present-day Geneva Basin and Jura fold-and-thrust belt by Sandra Borderie, Jon Mosar, Adeline Marro, Louis Hauvette

“…If current seismicity indicates that the Geneva Basin is tectonically active, few data regarding the state of stress in the area are currently available. …”
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Social Skills Training Program and its Effect on Quality of Life and Stigma among Patients with Schizophrenia by Samah Ali, Amal Awad, Hanaa Ewise, Shimaa Adam

“… Context: Schizophrenia is a severe mental disorder that significantly disrupts an individual's social interactions, work performance, and overall quality of life. …”
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Therapeutic potential of microRNAs in neurological disorders: mechanisms, biomarkers, and emerging therapeutic strategies by Sourav Pal, Subhajit Mandal

“…We also explore the future of miRNA research in the context of precision medicine, highlighting the importance of targeted delivery, safety optimization, and integration of patient-specific molecular profiles. …”
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MODELLING THE IMPACT OF INTELLECTUALIZATION ON ECONOMIC GROWTH IN UKRAINE by Iryna Kalenyuk, Larysa Antoniuk, Oleg Kuklin, Liudmyla Tsymbal, Olena Tsyrkun

“…An important task in the context of economic development research is to find out strong relations between individual indicators. …”
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The Anthropocene is shifting the paradigm of geosciences and science by Coudrain, Anne, Le Duff, Matthieu, Mitja, Danielle

“…Noting that humans are affecting the Earth’s envelopes, with geosciences becoming inseparable from social sciences and humanities, and acknowledging the increasing use of the word Anthropocene, the authors of this paper explore the possibility of a scientific paradigm shift. (1) Since the 17th century, modern science has developed in a context of naturalist worlding that favors its hegemony over other modes of existence and its paradigm of a quest to define the laws of nature. (2) Various manifestations attest to the emergence of a paradigm of knowledge diversity and the unravelling of the naturalist worlding. (3) The current boom in participatory science is a sign of this paradigm shift: through the fundamental changes to the Earth System that refer to it, the Anthropocene forces science to move towards action and interact with a society involved in adapting to changes and concerned with the threats to its territory’s habitability.…”
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Modeling Customer Purchase Behavior in the Insurance Industry Using System Dynamics by Shabnam Jalalat, Kambiz Shahroodi, Mehdi Fadaei, Mahdi Homayounfar

“…The first scenario showed that of continuing the current conditions would lead to an increase in the gap between life insurance expenses and revenue. …”
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Regulation and governance for the implementation and management of point-of-care testing in Australia: a scoping review by Jacqueline Prestedge, Claire Kaufman, Deborah A. Williamson

“…Of the grey literature sources, fifteen current PoCT governance documents comprising of six standards, five guidelines and four frameworks at the international, national and jurisdictional level were included with an increasing number of grey literature sources since the onset of the COVID-19 pandemic in 2020. …”
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Study on the Leakage Diagnosis of a Chilled Water Pipeline Network System Based on Pressure Variation Rate Analysis for Climate Change Mitigation by Xuan Zhou, Fei Liu, Lisheng Luo, Shiman Peng, Junlong Xie

“…In the context of increasing climate variability and extreme weather, chilled water systems face mounting challenges due to amplified heating and cooling demands and prevalent pipe leakages. …”
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Value added medicines: what value repurposed medicines might bring to society? by Mondher Toumi, Cécile Rémuzat

“…Discussion & conclusions: There is currently a gap between increasing regulatory authority interest in capturing value added medicines’ benefits and the resistance of HTA bodies/payers, who tend to ignore this important segment of the pharmaceutical field. …”
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Requests for physician-assisted suicide in German general practice: frequency, content, and motives– a qualitative analysis of GPs’ experiences by Luise Farr, Juliane Poeck, Claudia Bozzaro, Jutta Bleidorn

“…Methods We conducted 19 guideline-based interviews with GPs currently or formerly practicing in Germany (study period: 03/22–12/22). …”
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Contrasting Effect of Curcumin on Hepatitis B Virus Replication According to the Hepatoma Cell Line by María Mercedes Elizalde, Pedro Fuentes, Diego Chiappetta, Diego Martín Flichman

“…In recent decades, considerable advances have been achieved in the treatment of chronic hepatitis B. However, the currently available drugs have shortcomings. In this context, several natural compounds have been proposed as potential agents to improve either the outcome of antiviral treatment or the progression of chronic infection, with curcumin being one of the most evaluated compounds due to its pleiotropic antiviral activity. …”
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Short Research Report: A universal socio-emotional learning programme for child adjustment and peer relationships by Sofia Moreira, Vera Coelho, Carla Peixoto, Andreia Espain, Helena Azevedo

“…Measures comprised the Strengths and Difficulties Questionnaire, completed by teachers, and the Classroom Peer Context Questionnaire, completed by students. Students attended a 32-week classroom-based universal SEL intervention during one school year. …”
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ENHANCING ACCOUNTABILITY FOR MAKING CITIES RESILIENT AND ROLE OF SUPREME AUDIT INSTITUTIONS by Arife Coşkun, Latif Gürkan Kaya

“…Currently,more and more people are settling in cities, located in disaster prone areas. …”
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Studying and Characterization of Coating of Zein–CaSiO3 Composite on Polyetheretherketone Implant Material by Sama Abdulrazzaq, Thekra Ismael Hamad

“…Each group was characterized by atomic force microscopy, field emission scanning electron microscope, Fourier-transform infrared spectroscopy, water contact angle, and adhesion strength. The lowest water contact angle was obtained for Group 1: 10% wt and 90% wt were (26.64° and 27.13°, respectively), and increasing amounts of zein in comparison to quantities of CaSiO3 resulted in increased adhesion strength of the composite material to the substrate. …”
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A methodological framework for assessing development solutions: application to wood fuel challenges in Nigeria by Jamie A. Carr, Aliyu Salisu Barau, Eleanor K. K. Jew, Joshua D. Kirshner, Robert A. Marchant, Abubakar Tanimu Salisu, Gillian Petrokofsky, Julia Tomei, Lindsay C. Stringer

“…Abstract Development interventions often yield co-benefits and trade-offs across multiple Sustainable Development Goals (SDGs). However, current approaches typically assess progress towards specific SDG targets, such as increasing access to clean energy or improving health outcomes, rather than evaluating the co-benefits and trade-offs of the solutions used to achieve these targets. …”
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The Design and Analysis of a Proportional Solenoid with Experimental Validation of Static and Dynamic Behavior by Ercan Düzgün, Gürsel Şefkat

“…The solenoid achieved a constant magnetic force of 45 ± 3 N with a current of 1.3 A over a working range of 1–3 mm. The dynamic model, incorporating data from ANSYS, yielded results that closely matched the experimental findings.…”
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Nested case-control study investigating factors affecting initial adoption of HIV self-testing among men who have sex with men in Guangzhou, China: amidst comprehensive service cov... by Yuzhou Gu, JiaLi Yang, Yefei Luo, Lishan Zhan, Fanghua Liu, Wenting Zeng, Huifang Xu, Huifang Xu, Yongheng Lu, Yanshan Cai, Zhigang Han

“…Multivariate logistic regression analysis revealed that individuals who primarily sought sexual partners through offline venues in the past 6 months (aOR = 5.28, 95% CI: 1.01–27.79), had more than one sexual partner in the past 6 months (aOR = 2.76, 95% CI: 1.33–5.74), engaged with more than two casual partners in the past 6 months (aOR = 3.02, 95% CI: 1.35–6.78), or had more than one regular partner (aOR = 3.37, 95% CI: 1.51–7.51) exhibited an increased likelihood of initiating HIVST.ConclusionIn the context of comprehensive promotion and coverage of HIVST service, the development of personalized, adaptable, and innovative HIVST strategies for MSM with a higher number of sexual partners, particularly those in regular partnerships and those seeking partners offline, may further increase the adoption of HIVST among MSM.…”
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Reduction of uncertainties in rice yield response to elevated CO2 by experiment-model integration: A case study in East China by Zihao Wang, Yu Zhang, Xueni Wang, Yanfeng Ding, Songhan Wang

“…This study thus highlights the large CFE uncertainties of current crop models and provides us with a method to reduce this uncertainty, which is beneficial for the accurate prediction of future global rice yield in the context of climate change.…”
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