Coordinated regulation of timing and strength of synaptic outputs by adrenergic receptors through control of action potentials in Purkinje cells by Kei Furukawa, Kei Furukawa, Shin-ya Kawaguchi

“…We demonstrate that Purkinje cell axons exhibit negative control of action potentials in amplitude and conduction velocity by β-adrenergic receptors in a manner dependent on the axonal length through specific reduction of axonal Na+ currents. On the other hand, β-adrenergic receptors increased presynaptic release probability without changing the amount of readily releasable vesicles in axon terminals of Purkinje cells. …”
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Memory-Based Navigation in Elephants: Implications for Survival Strategies and Conservation by Margot Morel, Robert Guldemond, Melissa A. de la Garza, Jaco Bakker

“…This review synthesises current literature on elephant navigation and decision-making, exploring how their behavioural strategies contribute to resilience amid increasing anthropogenic pressures. …”
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Leishmaniases in Ethiopia: a scoping review by Ermias Diro, Fiona Wallace, Mezgebu Silamsaw Asres, Richard Wamai, Hugh Shirley, Grace Grifferty, Eleni Ayele, Katherine O’Brien, Adriana Totten, Philip Coombs, Adrienne M Orriols, Shreyas Mosurkal, Ellie Krulwich, Leah Oruko, Isabel C Roman, Prapti Shah, Riley Fanning-Hughes, Abigail L Williams, Morgan G Wong, Sophia Roe, Khushi Gandhi, Laith Matari, Sara Shaikh, Abigail Binkley, Benjamin J D Boutselis, Amer Chaudhry, Mahlet Haile

“…The identified studies were analysed using an extensive codebook, which was previously developed by this team and adapted to the Ethiopian context to classify the research into different categories.Results A total of 8698 articles were identified. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Study 1B: we undertook six focus-group discussions (FGDs) with MSM to increase understanding of accessibility and feasibility of HIV self-testing among MSM and identify barriers and facilitators in a range of models and contexts to inform development of the intervention. …”
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Do we need urine drug screens in opioid addiction treatment: An observational study on self-report versus urine drug screens by Alannah McEvoy, Myanca Rodrigues, Brittany B Dennis, Jacqueline Hudson, David C. Marsh, Andrew Worster, Lehana Thabane, Zainab Samaan

“…It is therefore important to consider the context of the patient, and the type of the co-substance used to select patient-centred testing as indicated. …”
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Harnessing stromal vascular fraction-based therapies for wound healing: Mechanisms, synergies, and clinical translation by Jing Wu, Yao Wang, Wenjie Chen, Min Lin, Jinwen Jiang, Hongde Jiang, Zehuan Li, Kailei Xu, Bin Zhang

“…Wound healing remains a major challenge in contemporary medicine, particularly with the increasing incidence of chronic wounds, such as those associated with diabetes and thermal injuries. …”
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An analysis of data quality and population characteristics of the SIGN online surgical database: A 20 year review by Matthew Roces, Ericka von Kaeppler, Claire Donnelley, Mayur Urva, Abigail Cortez, Kelsey Brown, Michael Flores, Patricia Rodarte, Kian Niknam, Francisco Gomez-Alvarado, Babapelumi Adejuyigbe, Lewis Zirkle, David Shearer

“…However, the quality of data contained in the SOSD is largely unknown. The aim of the current study was to analyze the trend in data quality and follow-up rate of the SOSD over the past two decades. …”
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Platelet glycoprotein VI promotes folic acid-induced acute kidney injury through interaction with tubular epithelial cell-derived galectin-3 by Ya-Wei Guo, Qi Luo, Meng Lu, Xiang-Bin Zeng, Yu-Min Zhang, Yue-Ling Lin, Xu-Ran Guo, Rong Ma, Zhang-Yin Ming

“…Additionally, we utilized platelet GPVI-specific knockout mice in conjunction with TD139, a small-molecule inhibitor of galectin-3, to explore the effects of inhibiting the galectin-3-GPVI interaction on FA-AKI. Results In the current study, we observed that mouse platelets displayed hyperactivity in the context of functional acute kidney injury (FA-AKI). …”
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Knowledge and Practice Regarding Pressure Injury Prevention among Nurses at King Abdul-Aziz Specialist Hospital by Afnan Sahrah, Wafaa Althobaiti, Sahar Albalawi, Ensherah Althobiti, Turki Alfattah, Abdulellah Almalki, Ahlam Alotaibi, Maha Alkhaldi, Talal Alqurashi, Faten Sahrah, Munirah Alfifi, Rami Alnemari, Alaa Alzahrani

“… Context: Preventing hospital-acquired pressure injuries (HAPI) poses a significant challenge within tertiary service hospitals. …”
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Mixed-methods assessment of health and mental health characteristics and barriers to healthcare for Ebola survivors in Beni, Butembo and Katwa health zones of the Democratic Republ... by Lynn Lieberman Lawry, Nancy Stroupe Kannappan, Covadonga Canteli, William Clemmer

“…Trouble sleeping and anger were the strongest predictors of post-traumatic stress disorder, major depressive disorder (MDD), anxiety and suicide attempts with 3-fold to 16-fold increases in the odds of these disorders. There was a 71% decrease in the odds of MDD if current substance abuse (aOR 0.29; 95% CI 0.13 to 0.67; p<0.01) was reported.Conclusions Specialised mental health services were limited. …”
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Immunisation of young children against influenza — evidence review by V. A. Bulgakova, L. R. Selimzyanova, T. E. Privalova, D. A. Yusupova

“…Influenza is a highly contagious viral infection and poses a serious burden, especially for children under 5 years of age due to an increased risk of severe illness and hospitalization. …”
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Influence of fruit stages on chemical compositions, phytochemicals, and antioxidant activity of wood apple (Feronia limonia (L.) Swingle) by Rashmi Srivastava, Neha Mishra, Arshi, Shraddha Tripathi, Smriti, Neha Taslim Fatima, Neetu Mishra

“…Swingle is an underappreciated tropical fruit, contains several vitamins, minerals, and bioactive substances, yet it has received significantly less attention. …”
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Age of tobacco, nicotine and cannabis use initiation in Switzerland: a sequence analysis among adolescents and young adults by Diana Fernandes, Lorraine Chok, Jérémy Cros, Luc Lebon, Karin Zurcher, Alexandre Dubuis, Cathy Berthouzoz, André Berchtold, Yara Barrense-Dias

“…Conclusions Cigarettes remain the first product to be used, but the younger the respondents, the earlier they start using e-cigarettes, and very close to cigarettes. Regarding current consumption patterns, e-cigarettes are becoming increasingly prominent.…”
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Optimization of Distillation Conditions for Improved Recovery of Phthalides from Celery (Apium graveolens L.) Seeds by Adam Kokotkiewicz, Anna Badura, Żaneta Tabaczyńska, Andżelika Lorenc, Adam Buciński, Maria Luczkiewicz

“…The change of distillation mode from HD to SDE significantly increased the oil yield of whole seeds (from 2.8 to 5.8% for 6 h processing) while maintaining its high phthalide content (62.5%), which translated to an increase in the total phthalide yield from 19.4 to 36.0 g/kg.…”
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Understanding the political economy of reforming global health initiatives – insights from global and country levels by Sophie Witter, Natasha Palmer, Rosemary Jouhaud, Shehla Zaidi, Severine Carillon, Rene English, Giulia Loffreda, Emilie Venables, Shifa Salman Habib, Jeff Tan, Fatouma Hane, Maria Paola Bertone, Seyed-Moeen Hosseinalipour, Valery Ridde, Asad Shoaib, Adama Faye, Lilian Dudley, Karen Daniels, Karl Blanchet

“…For this paper, data were analysed using a political economy framework which focused on actors, context (especially governance and financing) and framing. …”
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Disease progression & treatment need in sub-genotype C4 hepatitis B infection: a retrospective cohort study in the Northern Territory, Australia by Genevieve E. Martin, Kelly Hosking, Kelly Banz, Catherine Gargan, Geoff Stewart, Belinda Greenwood-Smith, Penelope Ramsay, Jaclyn Tate-Baker, Christine Connors, Paula Binks, Melita McKinnon, Prashanti Manchikanti, George Garambaka Gurruwiwi, Nicole Allard, Ashleigh Qama, Jessica Michaels, Emily Vintour-Cesar, Robert Batey, Catherine Marshall, Peter Nihill, Tammy-Allyn Fernandes, Karen Fuller, Steven Y. C. Tong, David Boettiger, Benjamin Cowie, Joshua S. Davis, Sarah Mariyalawuy Bukulatjpi, Jane Davies, on behalf of the Hep B PAST Partnership

“…Only 6·7% of untreated individuals were treatment eligible under current guidelines. Using the 2024 World Health Organisation guidelines, this increased to 50% due mostly to fibrosis and population prevalence of diabetes. …”
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Modelling of biological age in stable and acute exacerbations of chronic obstructive pulmonary disease by Yujiao Wang, Ting Mu, Yufen Fu, Yuxin Wang, Guoping Li

“…Biological age (BA), a novel metric for gauging the extent of aging, has rarely been investigated in the context of acute exacerbation of COPD (AECOPD). Our study aimed to elucidate the association between BA and AECOPD, thereby highlighting the potential of BA as a predictive tool in clinical practice. …”
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Changes in tree-ring wood density of European beech (Fagus sylvatica L.), silver fir (Abies alba Mill.), and Norway spruce (Picea abies (L.) H. Karst.) in European mountain forests... by Chiara Torresan, Torben Hilmers, Admir Avdagić, Edmondo Di Giuseppe, Matija Klopčič, Mathieu Lévesque, Florian Motte, Enno Uhl, Tzvetan Zlatanov, Hans Pretzsch

“…Abstract Key message We found a significant increase in the latewood density of European beech, and a decrease in the latewood and mean wood density of silver fir and Norway spruce in European mountain forests over the period 1901–2016. …”
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Molecular Layering Synthesis and Investigation of Nanostructured Oxide Layers in High Aspect Ratio Substrates by A. P. Baraban, V. A. Dmitriev, A. V. Drozd, V. A. Moshnikov

“…Comparative tests of MCP samples containing the synthesized films were carried out.Conclusion. …”
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The Concept of Sovereignty Through Space and Time by Ksenia Radchenkova

“…This phenomenon is especially evident in contexts where Westernization is perceived as a potential threat to the “sovereign equality” of nations. …”
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