Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs. by Bryan T Davis, Xiao-Jun Wang, Judy A Rohret, Jason T Struzynski, Elizabeth P Merricks, Dwight A Bellinger, Frank A Rohret, Timothy C Nichols, Christopher S Rogers

“…Recent progress in engineering the genomes of large animals has spurred increased interest in developing better animal models for diseases where current options are inadequate. …”
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Methylchloroisothiazolinone/Methylisothiazolinone and Methylisothiazolinone Sensitivity in Hungary by Györgyi Pónyai, Ilona Németh, Erzsébet Temesvári

“…A further increase of MI hypersensitivity might be expected in the future as products containing MI are still widely available.…”
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Tim-3 is dispensable for allergic inflammation and respiratory tolerance in experimental asthma. by Carolin Boehne, Ann-Kathrin Behrendt, Almut Meyer-Bahlburg, Martin Boettcher, Sebastian Drube, Thomas Kamradt, Gesine Hansen

“…T cell immunoglobulin and mucin domain-containing molecule-3 (Tim-3) has been described as a transmembrane protein, expressed on the surface of various T cells as well as different cells of innate immunity. …”
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Coinhibitory Effects of Resveratrol- and Protopanaxadiol-Enriched Rice Seed Extracts Against Melanogenic Activities in Melan-a Cells by Chaiwat Monmai, Yong-In Kuk, So-Hyeon Baek

“…In the current study, we aimed to evaluate the combined antimelanogenic effects of resveratrol- and protopanaxadiol (PPD)-enriched rice seed extracts (DJ526 and DJ-PPD) in melan-a cells. …”
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Activity of combinations of bactericidal and bacteriostatic compounds in Mycobacterium abscessus-infected mice: an overview by Alessio Lanni, Elisabetta Iona, Lanfranco Fattorini, Federico Giannoni, Angelo Iacobino

“…Overall, these data suggest that there is an urgent need for systematic in vivo investigations on anti-MAB activity of combinations containing bactericidal drugs that are part of current treatment guidelines or of new, preferably oral compounds, to ultimately eradicate non-replicating persisters at the sites of disease.…”
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Investigation of the Impact of Chemical Modifications on the Photostability of Polymethyl Methacrylate by Hanan A. Ibraheem, Gamal A. El-Hiti, Emad Yousif, Dina S. Ahmed, Hassan Hashim, Benson M. Kariuki

“…Polymeric chain modifications have proved to be efficient in increasing the photostability of materials. The current work deals with the surface functionalization of polymethyl methacrylate (PMMA) by incorporating organotin moieties on the polymer backbone. …”
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Job insecurity, work passion, and work–life balance in diverse work arrangements by Chantell Ribas, Gerhard H. Rabie, Karina Mostert, Leon De Beer

“…Orientation: The coronavirus disease 2019 (COVID-19) pandemic shifted work settings, revealing gaps in current literature on how work arrangements affect employee experiences and well-being. …”
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On the Issue of Improving Remuneration System in Budget Organizations of the Republic of Kazakhstan by S. K. Baidybekova

“…The problems of accounting and analysis at enterprises in the context of international financial reporting standards are currently relevant, consequently it is necessary to work further to improve the organization of accounting and analysis of staff remuneration in budget organizations.…”
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Network pharmacology-based prediction and “gut microbiota-inflammation-brain axis” validation of the active ingredients and potential mechanisms of Plantagins Herba for treating di... by Zhixuan Huang, Zhixuan Huang, Jian Liu, Jian Liu, Hui Li, Hui Li, Hui Li, Yangwen Ai, Yangwen Ai, Dongyue Zhou, Dongyue Zhou

“…BackgroundDiabetes-related cognitive dysfunction (DRCD) is increasingly recognized as a common complication. However, there are currently no specific remedies for DRCD. …”
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Liquid CO phase transition fracturing technology and its application in enhancing gas drainage of coal mines by Yingchun Fan, Botao Qin, Qun Zhou, Quanlin Shi, Dong Ma, Jiahao Wu

“…It utilized phase transition equipment (PTE) consisting of a liquid gas container, control unit for the current and gas volume, heating tube, and other components. …”
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Amphicutis stygobita (Echinodermata, Ophiuroidea, Amphilepidida, Amphilepididae), a brooding brittle star from anchialine caves in The Bahamas: feeding, reproduction, morphology, p... by Jerry H. Carpenter

“…It has been found only in two anchialine caves: Bernier Cave (type locality and current study area) and Lighthouse Cave on San Salvador Island, The Bahamas. …”
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Case Report: Locally invasive thyroid metastases from renal cell carcinoma: surgery after neoadjuvant therapy by Dana M. Hartl, Mohamed-Amine Bani, Abir Al Ghuzlan, Andreea-Elena Simonescu, Ingrid Breuskin, Alix Marhic, Laurence Albiges, Laurence Albiges, Livia Lamartina, Livia Lamartina, Julien Hadoux, Julien Hadoux

“…Patient 1 received lenvatinib and a bispecific anti–Programmed cell Death protein 1/ cytotoxic T-lymphocyte-associated protein 4 (PD-1/CTLA-4) antibody in the context of a clinical trial. The second patient received nivolumab and cabozantinib.ResultsThe observed tumor response in patient 1 showed a decrease in mean surgical complexity score from unresectable (prevertebral fascia invasion) to severe (risk of recurrent nerve paralysis) and in patient 2 from unresectable (prevertebral fascia) to moderate (superficial esophageal invasion). …”
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Evaluating inhaled corticosteroids' impact on osteoporosis and fracture risk in COPD patients: a real-world evidence-based systematic review and meta-analysis by Hsiao-Feng Huang, Chin-Wei Hsu, Chin-Wei Hsu, Chin-Wei Hsu, Fei-Ting Hsieh, Kuang-Ming Liao, Kuang-Ming Liao

“…Subgroup analyses indicated a potential increased risk in Asian and European populations but not in North America. …”
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The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications by Alaa A. A. Aljabali, Kenneth Lundstrom, Altijana Hromić-Jahjefendić, Nawal Abd El-Baky, Debaleena Nawn, Sk. Sarif Hassan, Alberto Rubio-Casillas, Elrashdy M. Redwan, Vladimir N. Uversky

“…The XEC strain of SARS-CoV-2 has drawn particular attention due to its increasing prevalence in multiple regions and its potential to displace other Omicron subvariants, although direct evidence of enhanced replicative fitness is currently lacking. …”
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The Effect of Gamified Physical Activities on the Quality of Students' Leisure Time (Case Study: Female Secondary School Students in Ardabil City) by aylar sefidgar, Hamed Kheirollahi Meidani, Mehrdad Moharramzadeh

“…Its reliability was also established, achieving a Cronbach's alpha coefficient of 0.95, which demonstrates the high reliability of the questionnaire used in the current study. The questionnaire contains 64 items divided into four components: decision-making skills, leisure awareness skills, social relations skills, and self-awareness skills. …”
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Laparoscopic sleeve gastrectomy performed in a morbidly obese patient with gastrointestinal stromal tumor: a case report and literature review by Kenkichi Hashimoto, Yoshihisa Sakaguchi, Sho Nambara, Kensuke Kudou, Eiji Kusumoto, Keiji Yoshinaga, Tetsuya Kusumoto, Koji Ikejiri

“…Abstract Background Gastrointestinal stromal tumor (GIST) is the most frequent submucosal tumor, and with advancements of diagnostic modalities, the incidence of GIST cases diagnosed have increased. Similarly, prevalence of morbid obesity has also rapidly increased over the past decade. …”
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Unraveling the dynamics of dengue in Metahara town, East Shewa, Oromia, Ethiopia, 2023. by Bikila Negesa Gobena, Teshome Kabeta Dadi, Gemechu Chemeda Feyisa, Birhanu Kenate, Gemechu Shumi, Fantahun Workie, Haimanot Workie, Ebise Djirata, Dabesa Gobena

“…<h4>Background</h4>Since 2013, dengue cases have shown a marked increase in Ethiopia. The current suspected outbreak occurring in Metahara town, Oromia Regional State, began in July 2023. …”
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Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system. by Preciosa M Coloma, Martijn J Schuemie, Gianluca Trifirò, Laura Furlong, Erik van Mulligen, Anna Bauer-Mehren, Paul Avillach, Jan Kors, Ferran Sanz, Jordi Mestres, José Luis Oliveira, Scott Boyer, Ernst Ahlberg Helgee, Mariam Molokhia, Justin Matthews, David Prieto-Merino, Rosa Gini, Ron Herings, Giampiero Mazzaglia, Gino Picelli, Lorenza Scotti, Lars Pedersen, Johan van der Lei, Miriam Sturkenboom, EU-ADR consortium

“…Outcome of interest was statistically significant increased risk of AMI during drug exposure that has not been previously described in current literature and is biologically plausible.…”
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EXTREME WINTERS IN XX–XXI CENTURIES AS INDICATORS OF SNOWINESS AND AVALANCHE HAZARD IN THE PAST AND EXPECTED CLIMATE CHANGE CONDITIONS by A. D. Oleynikov, N. A. Volodicheva

“…Currently, due to the global climate change and increasing frequency of weather events focus is on prediction of climate extremes. …”
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Incidence and trends of limb amputation in first nations and general population in Saskatchewan, 2006-2019. by Samuel Kwaku Essien, Gary Linassi, Margaret Larocque, Audrey Zucker-Levin

“…Overall and primary LA rates for the GP Group declined 0.7% and 1.0%, while subsequent LA increased 0.1%. An increased LA rate for all categories (overall 4.9%, primary 5.1%, and subsequent 4.6%) was identified in the RI group. …”
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