Alpha Helices Are More Robust to Mutations than Beta Strands. by György Abrusán, Joseph A Marsh

“…The rapidly increasing amount of data on human genetic variation has resulted in a growing demand to identify pathogenic mutations computationally, as their experimental validation is currently beyond reach. …”
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Towards a sustainable rare disease and orphan drug ecosystem in Saudi Arabia: policy insights from a multi-stakeholder workshop by Ghada Mohammed Abozaid, Ghada Mohammed Abozaid, Hussain Abdulrahman Al-Omar, Abdulaziz Alrabiah, Asma AlMuaither, Amy Jayne McKnight

“…Through a series of presentations, educational sessions, and plenary discussions, participants examined the current landscape of RDs in SA, identified barriers to accessing ODs, and recommended strategies and initiatives to improve the accessibility, innovation, and sustainability of ODs.ResultsThe workshop highlighted key challenges recognized by a diverse group of 59 participants, including the absence of a national strategy, absent of local RDs and ODs definitions in the Saudi context, limited awareness and understanding of RDs among healthcare professionals, delayed diagnoses, scarcity of treatment and diagnosis centers for RDs, insufficient screening and prevention programs, regulatory hurdles in approving and importing ODs, and financial constraints. …”
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Trends in Research on Hypertrophic Cardiomyopathy and Mitochondria From 2003 to 2023: A Bibliometric Analysis by Lulu Yang, Heng Zhang, Zhiyang Zhu, Jianming Wang, Xiaojuan Liu, Lijie Lu, Jinliang Huang, Miaoran Wang, Zhengchuan Zhu

“…The investigation of mitochondria, particularly in the context of cardiovascular medicine and HCM, demonstrates an unstoppable momentum. …”
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Clinical applications and research progress of remifentanil by Xu Liu, Zhipeng Meng, Fei Tong

“…This review synthesizes current evidence on its clinical applications, pharmacological advantages, and emerging challenges, including Opioid-Induced Hyperalgesia (OIH) and labor analgesia.MethodsThis study is a systematic evidence review. …”
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Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. by Jamie T Griffin, T Deirdre Hollingsworth, Lucy C Okell, Thomas S Churcher, Michael White, Wes Hinsley, Teun Bousema, Chris J Drakeley, Neil M Ferguson, María-Gloria Basáñez, Azra C Ghani

“…However, it remains unclear what overall reduction in transmission is achievable using currently available tools.<h4>Methods and findings</h4>We developed an individual-based simulation model for Plasmodium falciparum transmission in an African context incorporating the three major vector species (Anopheles gambiae s.s., An. arabiensis, and An. funestus) with parameters obtained by fitting to parasite prevalence data from 34 transmission settings across Africa. …”
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CO2 methanation over low-loaded Ni-M, Ru-M (M = Co, Mn) catalysts supported on CeO2 and SiC by Chopendra G. Wasnik, Maki Nakamura, Taiki Shimada, Hiroshi Machida, Koyo Norinaga

“…An efficient circulation and utilization of CO2 is critical in the current environmental context. Methanation, an exothermic process, emerges as a critical strategy for effective CO2 utilization. …”
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MECHANISMS FOR ENSURING THE ECONOMIC DEVELOPMENT OF RURAL AREAS THROUGH THE FORMATION OF THEIR ENERGY DEPENDENCE BASED ON THE INTENSIFICATION OF BIOFUEL PRODUCTION by Yuliia Okhota, Denys Titov, Svitlana Dotsiuk

“…To achieve this goal, the article discusses the theoretical aspects of energy independence, analyzes current practices of biofuel production, and provides recommendations for their further implementation. …”
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Propagation Characteristics of Multi-Cluster Hydraulic Fracturing in Shale Reservoirs with Natural Fractures by Lianzhi Yang, Xinyue Wang, Tong Niu

“…Understanding the effects of reservoir and fracturing conditions on fracture propagation is of great significance for optimizing the hydraulic fracturing process and has not been adequately explored in the current literature. In the context of shale reservoirs in Yibin, Sichuan Province, China, the study selects outcrops to prepare samples for uniaxial compression and Brazilian splitting tests. …”
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Significant fundamental translational research on breast cancer in China: progress and prospects by LU Yufeng, WANG Han, XIE Yifan, JIANG Yizhou, SHAO Zhimin

“…Breast cancer is the most prevalent malignant tumor that poses a threat to women's health in China, with incidence and mortality rates persistently increasing. Given this critical situation, there is an urgent need to optimize therapeutic options through basic translational research to address current treatment challenges. …”
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Therapy, Pain &amp; Training by Jendrusch G, Henke T, Schnell D, Platen P

“…However, athletes are at increased risk for eye injuries caused by high-velocity objects e.g. balls or physical contact with opponents. …”
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Teaching English Oral Expressionand Listening Comprehension at the Department ofLetters and English Language, University of Constantine 1: Past and Present Ups and Downs by Youcef BEGHOUL

“…It also suggests some solutions for a more practical teaching of these two crucial skills in a pedagogical context characterized by ever decreasing linguistic and cultural levels and more and more overcrowded classes.…”
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Unlocking the potential of global greenhouse gas mitigation by reducing food loss and waste by Suraj Negi, Liang-Shih Fan, Hyunook Kim, Taira Hidaka, Aishwarya Rani, Shu-Yuan Pan

“…Food loss and waste (FLW) are significant yet under-addressed contributors to global greenhouse gas (GHG) emissions, and the effectiveness of current FLW mitigation policies and valorization technologies remains insufficiently explored. …”
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‘Just because something works doesn’t mean it can’t be improved’: an ethnographic analysis of the health system in Black Panther’s Wakanda by Jennifer Jackson, Carla Ferreira, Samantha Perry, Carla Ginn, Melissa Scott, Elke Jaibeeh Barah, Zahra Upal, Krista Phelps, Carol Mei, Haneul Woo, Megan Tung, Farida Gadimova, Alexandra Ewanyshyn, Twyla Ens

“…The emergence of COVID-19 (SARS-CoV-2) has introduced significant global challenges for healthcare systems, healthcare professionals and patients. This current climate creates an opportunity to learn from equitable health systems and move toward making fundamental changes to healthcare systems. …”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Understanding of the mechanisms underlying productive HEV infection remains incomplete and would benefit from technological advances improving current model systems. Methods: We exploited transposon-mediated random insertion and selection of viable clones to identify sites in the HEV open reading frame 2 (ORF2) protein, corresponding to the viral capsid, allowing for the insertion of reporter sequences in a functional context. …”
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Driving Factors of Urban–Rural Human Settlement Changes and a Multi-Scenario Simulation Based on SDGs by Yang Ye, Yantong Liu, Jingyi Liu, Zhiyi Weng, Ziyao Chang, Xiong Li

“…Human settlements are composed of “production–living–ecological” spaces (PLESs), where changes result from the combined influence of natural and socioeconomic factors. Currently, the spatiotemporal patterns of PLES and their driving factors, along with their compatibility with sustainable development goals (SDGs), remain unclear. …”
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Challenges in modelling the impact of frost and heat stress on the yield of cool-season annual grain crops by Jonathan Richetti, Victor Oscar Sadras, Victor Oscar Sadras, Victor Oscar Sadras, Di He, Brenton Leske, Pengcheng Hu, Yacob Beletse, C. Mariano Cossani, C. Mariano Cossani, C. Mariano Cossani, Ha Nguyen, Bangyou Zheng, David Matthews Deery, M. Fernanda Dreccer, Jeremy Whish, Julianne Lilley

“…These temperature extremes are increasing in frequency and intensity due to climate change in many parts of the broadacre cropping regions globally, presenting challenges to food production. …”
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OPPORTUNITIES IN ORGANIC BREEDING OF CAPON POULTRY AND SUSTAINABLE FARM MANAGEMENT by Elena BONCIU

“…The breeding of capons represents an opportunity for Romanian farmers who want a profitable business, especially since currently, in Romania, the number of such micro-farms is very limited.…”
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What Lies behind No-Confidence Motion on Indonesian Social Media? by Irfandi Pratama, Zuly Qodir

“…Social media is currently taking on a role as a mobilizing, organizing, and communication tool for social protest movements. …”
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Modern ideas about the role of the galaninergic system in the pathogenesis of heart failure and myocardial remodeling by A. A. Yafarova, A. R. Kiselev, A. F. Sheptulina, O. M. Drapkina

“…In this regard, the search for new molecules for therapeutic action aimed at preventing myocardial remodeling is of undoubted interest. In this context, the galaninergic system seems to be a promising target. …”
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Metagenomics approaches for studying the human microbiome by Biniam Moges, Degisew Yinur Mengistu

“…Thus, this review focuses on the advancement of metagenomics for exploring the human microbiome, human microbiome metagenomics data processing, and analysis strategies. Currently used bioinformatics tools and their approaches are also discussed in the context of human microbial metagenomics.…”
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