A comprehensive review of methodologies and application to use the real-world data and analytics platform TriNetX by Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Matthew Anson, Matthew Anson, Henner Zirpel, Diamant Thaci, Henning Olbrich, Katja Bieber, Khalaf Kridin, Khalaf Kridin, Khalaf Kridin, Astrid Dempfle, Philip Curman, Philip Curman, Philip Curman, Philip Curman, Sizheng S. Zhao, Uazman Alam, Uazman Alam, Uazman Alam

“…TriNetX’s federated network architecture allows real-time, privacy-compliant data access, significantly enhancing the ability to conduct retrospective studies and refine clinical trial designs. With access to currently over 150 million EHRs, TriNetX has proven particularly effective in filling gaps left by RCTs, especially in the context of rare diseases, rare endpoints, and diverse patient populations. …”
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Reduction of Ascites Susceptibility in Broiler Chickens under Cold Stress by Guanidinoacetic Acid Supplementation by Mousa Ezatikia, parviz Farhoomand, Sina Payvastegan, Bahram Pirooz, Negin Delfani

“…Additionally, increasing the level of guanidinoacetic acid supplementation linearly increased breast muscle yield and decreased relative weights of the small intestine, duodenum, and ileum. …”
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Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of... by Bihua Wu, Shuangyan Su, Xianyu Wang, Yuwei Li, Zhenghao Mei, Fenglin Lou, Le Guo

“…BackgroundInflammatory bowel disease (IBD), characterized by chronic intestinal inflammation and epithelial barrier dysfunction, remains a therapeutic challenge due to the limitations of current treatments, including drug resistance and invasive surgical risks. …”
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Quantitative characterization of adsorbed and free shale oil microscopic distribution based on nuclear magnetic resonance: a case study of Chang 7 member of Triassic Yanchang Forma... by Fei LIU, Jinliang DU, Lin SUN, Ruiliang GUO, Bofei HAO, Peng LIU

“…Adsorbed oil mainly exist in micropores (< 100 nm), and the amount of free oil in micropores, mesopores, and macropores sequentially decreases. Organic-matter-rich shale generally contain higher amount of free oil and lower amount of adsorbed oil due to the existence of hydrocarbon generation-induced microfractures and less developed organic pores. …”
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Efficacy and Safety of Various Intravenous Thrombolytics for Acute Ischemic Stroke (AIS) at Various Dosages: A Systematic Review and Network Meta-Analysis by Yibin Hu, Shengxian Wu, Haixuan Zhang, Kangfeng Wang, Lijuan Zhang, Yizheng Ma, He Li

“…Abstract Background Currently, there is limited evidence on the efficacy and safety of various thrombolytic drugs at different dosages for the treatment of acute ischemic stroke (AIS). …”
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Optimizing in vitro slow-growth conservation media for garlic under ambient conditions: further implications for core set accessions by Ashwini Prashant Benke, DalasanuruChandregowda ManjunathaGowda, Vijay Mahajan, Digambar N. Mokat

“…Therefore, maintaining the crop’s genetic diversity in a suitable alternative form is crucial. The current study standardized the protocol for slow-growth conservation of garlic (in vitro) at an ambient temperature. …”
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Sustainable agriculture through nano-priming: Evaluating the role of biogenic manganese oxide nanoparticles in mitigating wastewater-induced stress in wheat (Triticum aestivum) by Aneeza ISHFAQ, Sabir HUSSAIN, Tanvir SHAHZAD, Muhammed SHAHID, Faisal MAHMOOD, Syed Raza HUSSAIN, Irfan HAIDRI, Imran KHAN, Mahmoud F. SELEIMAN, Muhammad Ahsan ASGHAR, Muhammad Fuad ANSHORI

“…Control included seeds without MnO-NP priming. The wastewater contained contaminants such as heavy metals and organic pollutants. …”
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Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes by Duc Tin Tran, Emily S. H. Yeung, Lisa Y. Q. Hong, Harmandeep Kaur, Suzanne L. Advani, Youan Liu, Madiha Zahra Syeda, Sri Nagarjun Batchu, Andrew Advani

“…After 26 weeks, mice were fed a high fat diet containing finerenone (100 mg/kg diet) or high fat diet alone for a further 2 weeks. …”
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Valorising mango, cashew apple, and papaya by-products for sustainable small ruminant production in low-income food deficit countries—a review by Antoinette Simpah Anim-Jnr, Salma Binta Yusif Ishaq, Prince Sasu, Sadat Gyimah, Henry Michael Rivers Greathead, Christine Boesch, Faith Philemon Mabiki, Mohammad Naushad Emmambux

“…It emphasizes the need for further research to determine their nutritional value in local contexts, establish optimal inclusion levels, and devise strategies for prolonging shelf life. …”
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Anticipating how spatial fishing restrictions in EU waters perform to protect marine species, habitats, and dependent fisheries by François Bastardie, Amaia Astarloa, Logan Binch, Isabella Bitetto, Dimitrios Damalas, Jochen Depestele, Pierre-Yves Hernvann, Sigrid Lehuta, Jonas Letschert, Irida Maina, Stéphanie Mahévas, Georgia Papantoniou, Miriam Püts, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Giovanni Romagnoni, Maria Teresa Spedicato, Klaas Sys, Irini Tsikopoulou, Gert Van Hoey, Walter Zupa, Anna Rindorf

“…As the proportion of closed regions increases, potential effects on marine ecosystems can even be damaging in the short term to some sensitive species (such as the endangered, threatened and protected species ETP) and vulnerable habitats (with currently high relative benthic status RBS). …”
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Development of a Correlation Model of Adherence to Sports With the Mental Health of Students Participating in Sports Leisure Time by Ahmad Mahmoudi, Mohammad Ghasemi, Reza Amin Zadeh, Danesh Zamani Rad

“…Informing people about the positive effects of physical activities on different body systems increased the tendency towards sports activities (Mostafavirad & Dehghan, 1397). …”
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The substance use profiles of adults who sought mental health and addiction services through a centralized intake process in Nova Scotia (2020–2021) by Matiwos Soboka, Philip G. Tibbo, Sherry H. Stewart, Sherry H. Stewart, Sherry H. Stewart, Patryk Simon, JianLi Wang, JianLi Wang

“…BackgroundDespite the increasing substance use in Canada, our understanding of how substance use varies based on the intersections of gender, ethnicity/race, and income sources among preclinical populations remains limited. …”
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MOTIVATIONAL COMPONENT AS A SUCCESS TO ORGANIZE AN INDEPENDENT WORK OF STUDENTS AT THE DEPATMENT OF THERAPEUTIC DENTISTRY by Yu. V. Sidash

“…The process of the study isto create a sincere atmosphere of communication in the audience, establish contact with students, achieve mutual understanding and form a sense of confidence in the student. …”
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Interior Point Algorithm in Multi-objective Portfolio Optimization: GlueVaR Approach by Elaheh Gohania, Gholamreza Mansourfar, Fahimeh Biglari

“…Conclusion Based on the current findings, it is evident that the internal point algorithm is effective in resolving stock portfolio optimization issues. …”
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Manganese for Whom? A Review on Manganese Mining Permits towards the Existence of Springs’ Sacred Forest in Manggarai Flores by Bernadinus Steni, Hariadi Kartodihardjo, Soeryo Adiwibowo, Ruchyat Deni Djakapermana

“…Both the spatial analysis and qualitative data are then analyzed alongside the legal framework of land use and spring used to distill the institutional barriers leading to the issuance of permits in such contexts. The analysis then briefly traces the current political economy of mining’s permits underlying the institutional interactions to better understand why the institutions behave as they do. …”
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Genomic Insights into and Lytic Potential of Native Bacteriophages M8-2 and M8-3 Against Clinically Relevant Multidrug-Resistant <i>Pseudomonas aeruginosa</i> by Francisco Ricardo Rodríguez-Recio, Javier Alberto Garza-Cervantes, Francisco de Jesús Balderas-Cisneros, José Rubén Morones-Ramírez

“…Their safety profile, high target specificity, and robust lytic activity underscore the feasibility of incorporating phage-based strategies into current antimicrobial protocols. This study contributes to the broader goal of developing sustainable and effective phage therapies for diverse clinical and environmental contexts.…”
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Development and evaluation of BDNF-loaded PCL/PVA two-layer nerve guidance conduit with enhanced biomechanical and biological properties for peripheral nerve regeneration by Massoumeh Jabbari Fakhr, Mohsen Eslami Farsani, Leyla Fath-Bayati, Reihaneh Seyedebrahimi, Mehdi Sadrjahani, Fatemeh Kavakebian, Alireza Rezapour

“…Hollow nerve conduits currently available do not align with the ideal human model. …”
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Medical embryology and regenerative medicine: research and applications in clinical practice by Julia Soczyńska, Julia Soczyńska, Wiktor Gawełczyk, Wiktor Gawełczyk, Patrycja Obrycka, Patrycja Obrycka, Mateusz Żołyniak, Mateusz Żołyniak, Adrian Muzyka, Adrian Muzyka, Krzysztof Majcherczyk, Krzysztof Majcherczyk, Julia Papierkowska, Julia Papierkowska, Sławomir Woźniak

“…Taking this progress a step further, the ability to introduce stem cells into damaged tissues, thereby facilitating the formation of functional structures, has led to the growing interest in organoids -three-dimensional models that replicate key functions of real organs. Organoids are currently applied not only in drug screening but are also gaining increasing attention for their role in cancer therapy research. …”
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Advancing life cycle assessment of bioenergy crops with global land use models by Anders Arvesen, Florian Humpenöder, Tomás Navarrete Gutierrez, Thomas Gibon, Paul Baustert, Jan Philipp Dietrich, Konstantin Stadler, Cristina-Maria Iordan, Gunnar Luderer, Alexander Popp, Francesco Cherubini

“…We find that land use-related CO _2 emission for bioenergy range from 2 to 35 tonne TJ ^−1 , depending on bioenergy demand, policy context, year and accounting method. GHG emissions per unit of bioenergy do not increase with bioenergy demand in presence of an emission tax. …”
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The Symbiotic Bacterial Profile of Laboratory-Reared and Field-Caught <i>Aedes albopictus</i> Mosquitoes from Greece by Elias Asimakis, Ioannis Galiatsatos, Georgia Apostolopoulou, Eleni C. Savvidou, Georgios Balatsos, Vasileios Karras, Vasiliki Evangelou, Eva Dionyssopoulou, Antonios Augustinos, Nikos T. Papadopoulos, Antonios Michaelakis, Panagiota Stathopoulou, George Tsiamis

“…The use of symbiotic bacteria to improve the application of SIT or design combined SIT/incompatible insect technique (IIT) approaches is currently considered. In this context, exploring the microbiota of local mosquito populations is crucial for identifying interesting components. …”
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