Neutrophil-to-Lymphocyte ratio as surrogate for JAK2V617F suppression and event-free survival in polycythemia vera by Tiziano Barbui, Arianna Ghirardi, Victoria Empson, Francesca Fenili, Giuseppe Gaetano Loscocco, Annalisa Condorelli, Alessandra Iurlo, Daniele Cattaneo, Elena Rossi, Valerio De Stefano, Paola Guglielmelli, Christoph Klade, Heinz Gisslinger, Alessandro Rambaldi, Joseph M. Scandura, Alessandro Maria Vannucchi

“…Abstract Chronic systemic inflammation is a key driver of polycythemia vera (PV) progression, but the immunomodulatory effects of current treatments remain poorly defined. The neutrophil-to-lymphocyte ratio (NLR) is an accessible biomarker of systemic inflammation proven in other contexts, but its role in monitoring PV disease activity has not been established. …”
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About Our 24th Issue

“…We have determined the themes of our journal for 2024 as Discourse and Reality and Social Memory in order to analyze the sociocultural, political economic, and technological order and system that people are experiencing currently. In this context, we are proud to publish the first issue of the year under the theme of Discourse and Reality. …”
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Effect of Chloride Ions on Electrochemical Behavior of Canister Materials by Gha-Young Kim, Junhyuk Jang, Minsoo Lee, Jin-Seop Kim

“…The polarization measurements revealed that the addition of chloride ions was detrimental to the SS316L and Cu materials by increasing corrosion current, which is an indicator of corrosion rate. …”
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TIM-3 expression on monocyte-derived dendritic cells by T. V. Tyrinova, O. Yu. Leplina, E. R. Chernykh

“…Further studies of the regulation of TIM-3 expression by monocyte-derived dendritic cells will expand the understanding of the biological significance of inhibitory receptors on DCs from the point of view of the immune response, as well as, in the future, increase the effectiveness of current approaches in cancer immunotherapy using IFN-DCs and inhibitors of checkpoint molecules.…”
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Prophylactic Treatment of Probiotic and Metformin Mitigates Ethanol-Induced Intestinal Barrier Injury: In Vitro, In Vivo, and In Silico Approaches by Farhin Patel, Kirti Parwani, Priyashi Rao, Dhara Patel, Rakesh Rawal, Palash Mandal

“…Rats fed with ethanol-containing Lieber-DeCarli liquid diet showed decreased expression of TJ proteins, and increased intestinal barrier injury resulting in pro-inflammatory response and oxidative stress in the colon. …”
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Impact of imported COVID-19 cases on South Korea’s response: variant transitions and regional patterns (2020–2023) by Haram Seo, Minchan Choi, Gerardo Chowell, Hyosun Lee, Byul Nim Kim, Sunmi Lee

“…Results The findings reveal a significant increase in imported cases during the transition from the Delta to Omicron variants, highlighting the increased transmissibility of Omicron and its impact on imported case numbers. …”
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Enhanced weathering of kimberlite residues in a field experiment: implications for carbon removal quantification and mine waste valorization by Zivi R. Schaffer, Kwon Rausis, Ian M. Power, Carlos Paulo

“…Coinciding with increases in Mg and Si, dissolved inorganic carbon increased in porewaters with kimberlite dosage (amended: 64–118 mg C/L, control: 56 ± 14 mg C/L), demonstrating CO2 solubility trapping. …”
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Physical and chemical characterization of experimental newly formulated polymer infiltrated lithium disilicate ceramic network versus polymer infiltrated feldspathic ceramic networ... by Alaa Hussein, Moustafa Aboushlieb, Nour A. Habib

“…A porous lithium disilicate ceramic networks containing 25% (PILN-25) and 20% (PILN-20) porosity were produced by firing at 820OC and 830OC respectively. …”
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Effect of plasma-activated water on body weight, behavior, biochemical profile, intestinal microbiota, and liver and kidney histopathology in mice by Ghada Abd El-Reda, Usama T. Mahmoud, Manal A. M. Mahmoud, Fatma Abo Zakaib Ali, Fatma M. Abdel-Maksoud, Fayez M. El-Hossary

“…However, its safety and long-term effects require further investigation. Therefore, the current study was designed to evaluate the impact of PAW oral gavage on body weight, food intake, behavior (tail suspension test and open field test), internal organs relative weight, blood biochemical indicators, intestinal microbiota and liver and kidney histopathology in 10-week-old female mice (n = 30). …”
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Results of Using Different Modes of Presentation of Stereostimuli in the Study of Stereo Vision in Normal Children and in Children with Non-Paralytic Strabismus without Functional... by S. I. Rychkova, V. G. Likhvantseva

“…The work is devoted to one of the actual problems of current ophthalmology — creating effective methods of studying stereovision.The purpose — comparative analysis of the capability of stereoperception under conditions of using different regimes of alternating presentation of stereo stimuli with different characteristics in children with strabismus and in children without ophthalmopathology.Patients and methods. 294 school children — 167 children of the control group (without ophthalmopathology) and 127 children with non-paralytic strabismus without functional scotoma (FSS) were observed. …”
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Performance and emission prediction using ANN (artificial neural network) on H2-assisted Garcinia gummi-gutta biofuel doped with nano additives by Harish Venu, Manzoore Elahi M. Soudagar, Tiong Sieh Kiong, N. M. Razali, Hua-Rong Wei, T. M. Yunus Khan, Naif Almakayeel, M. A. Kalam, Erdem Cuce

“…Abstract The current work focuses on utilization of ANN (artificial neural network) for the prediction of performance and tailpipe emissions of Garcinia gummigutta methyl ester (GGME) enriched with H2 and TiO2 nano additives. …”
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A novel therapeutic approach targeting PD-L1 in HNSCC and bone marrow-derived mesenchymal stem cells hampers pro-metastatic features in vitro: perspectives for blocking tumor-strom... by Ylenia Ferrara, Debora Latino, Angela Costagliola di Polidoro, Angela Oliver, Annachiara Sarnella, Maria Grazia Caprio, Laura Cerchia, Menotti Ruvo, Annamaria Sandomenico, Antonella Zannetti

“…Abstract Background Current conventional treatment regimens for head and neck squamous cell carcinoma (HNSCC), are poorly effective because of the emergence of resistance mechanisms. …”
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MODERN APPROACHES TO DIAGNOSTICS AND TREATMENT OF DENTAL TRAUMA by O.S. Ivanytska

“…To diagnose dental traumas and, accordingly, to determine the ways to eliminate their consequences, its classification is of great importance. In this context, the classification by Andreason gained the strongest support in the world dental community. …”
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European orthopaedic trauma registries: perspectives from Belgium, Greece, Germany, the Netherlands, Spain, and the United Kingdom by Lynn Hutchings, DPhil, FRCS, Guy Putzeys, MD, FIOTA, Christina Arnaoutoglou, Zoe Dailiana, Kees Jan Ponsen, MD, PhD, Pieter Joosse, Frank Bloemers, Francisco Chana-Rodriguez, Jesus Gomez-Vallejo, Hector Aguado-Hernández

“…Member countries of the International Orthopaedic Trauma Association were contacted to provide information on the development, current position, and future plans for trauma registries within their countries. …”
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The State and the Prospects of the Development of Innovative Activity in the Russian Federation in the XXI Century by A. A. Varushchenko, N. A. Vladimirov

“…Global spending on innovation continues to grow, and the share of business in it is increasing. The relevance of this topic is also due to the acceleration of the processes of digital transformation of the Russian and international economy, which is why the need to create conditions for innovation, information and communication technologies is increasing. …”
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Cost-effective screening strategy to prevent venous thromboembolism in combined oral contraceptive users by Jonathan Douxfils, Jonathan Douxfils, Jonathan Douxfils

“…Combined oral contraceptives (COCs) increase VTE risk by 2- to 6-fold, resulting in approximately 22,925 cases annually in the European Economic Area (EEA). …”
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Presentation of Financial Assets in the Statistics of Foreign Economic Relations by V. N. Salin, L. Yu. Arhangelskaya, O. G. Tretyakova

“…Together with the financial account, account figures for other changes in financial assets and liabilities explain the total amount of changes: increases or decreases in the value of financial assets / liabilities, their occurrence or disposal, resulting from transactions, revaluation and other changes in volume.The issues of theory and practice of presenting indexes of financial assets in the considered sections of macrostatistics and their analysis are a relevant and promising direction for improving national statistical accounting, incl. due to the spread of remote work, the collection of information via the Internet, the emergence of a large number of new financial instruments and operations.The authors of the article have repeatedly referred to the problems of macroeconomic financial statistics in their studies, which gave them the opportunity to comprehensively consider the topical issues of representing financial assets in the statistics of foreign economic relations.…”
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Incorporation of amoxicillin-loaded microspheres in mineral trioxide aggregate cement: an in vitro study by Fábio Rocha Bohns, Vicente Castelo Branco Leitune, Isadora Martini Garcia, Bruna Genari, Nélio Bairros Dornelles, Silvia Stanisçuaski Guterres, Fabrício Aulo Ogliari, Mary Anne Sampaio de Melo, Fabrício Mezzomo Collares

“…When mixed with amoxicillin-loaded microspheres, the setting times of both test materials significantly increased. The diametral tensile strength of cement containing microspheres at 5% was similar to control. …”
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Characterization, Conservation, and Breeding of Winter Squash (<i>Cucurbita moschata</i> Duchesne): Case Study of the Collection Maintained at the Federal University of Viçosa Vege... by Derly José Henriques da Silva, Ronaldo Silva Gomes, Ronaldo Machado Júnior, Cleverson Freitas de Almeida, Rebeca Lourenço de Oliveira, Dalcirlei Pinheiro Albuquerque, Santina Rodrigues Santana

“…Studies on <i>C. moschata</i> germplasm have reported high variability, particularly in Brazil. Currently, Brazil maintains six <i>Cucurbita</i> germplasm collections, kept in research and teaching institutions. …”
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Hydrogen Loss on Venus Driven by Photochemistry by Hao Gu, Jun Cui, Xiaoshu Wu, Xu Huang, Shiqi Wu, Wenlong Li, Jinjin Zhao, Haoyu Lu, Lei Li

“…Venus has experienced substantial H loss through hydrodynamic outflow in its early history, transforming from a warm and wet state to the current arid and scorching state. While Venus continues to lose H today, no consensus has been reached regarding the present dominant escape mechanisms. …”
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