Efficiency and heat transport processes of low-temperature aquifer thermal energy storage systems: new insights from global sensitivity analyses by Luka Tas, Niels Hartog, Martin Bloemendal, David Simpson, Tanguy Robert, Robin Thibaut, Le Zhang, Thomas Hermans

“…Thick productive aquifer layers have been targeted first, as these are the most promising hydrogeological context for ATES. Regardless, there is currently an increasing trend to target more complex aquifers such as low-transmissivity and alluvial aquifers or fractured rock formations. …”
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iPSC models of mitochondrial diseases by Sonja Heiduschka, Alessandro Prigione

“…Consequently, most mitochondrial diseases are currently untreatable. Human induced pluripotent stem cells (iPSCs) represent a promising approach for developing human model systems and assessing therapeutic avenues in a patient- and tissue-specific context. iPSCs are being increasingly used to investigate mitochondrial diseases, either for dissecting mutation-specific defects within two-dimensional (2D) or three-dimensional (3D) progenies or for unveiling the impact of potential treatment options. …”
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The implementation of safer drug consumption facilities in Scotland: a mixed methods needs assessment and feasibility study for the city of Edinburgh by James Nicholls, Wendy Masterton, Danilo Falzon, Andrew McAuley, Hannah Carver, Kathryn Skivington, Josh Dumbrell, Andy Perkins, Samantha Steele, Kirsten Trayner, Tessa Parkes

“…Abstract Background Scotland currently has amongst the highest rates of drug-related deaths in Europe, leading to increased advocacy for safer drug consumption facilities (SDCFs) to be piloted in the country. …”
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The challenges of reproducibility for research based on geodata web services by M. Cannata, M. Collombin, O. Ertz, G. Giuliani, J. Ingensand, C. Primerano, D. Strigaro

“…Additionally, we assess the currently available tools that support data versioning for databases, files and log-structured tables. …”
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Lipidomic markers of obesity and their dynamics after bariatric surgery by T. V. Saprina, A. S. Bashirova, V. V. Ivanov, S. I. Pekov, I. A. Popov, S. R. Bashirov, E. A. Vasilyeva, O. A. Pavlenko, D. V. Krinitskii, M. Chen

“…Currently available studies and their results suggest that we are only at the very start of studying this promising biomedical field.…”
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Physicians’ experiences of assessing and supporting fatigued patients in primary care: a focus group study by Conrad Samuelsson, Lisa Gunnarsson, Frank Svärdman, Christian Rück, Elin Lindsäter

“…Abstract Background Fatigue is a common symptom in primary healthcare, affecting 10–30% of patients, and is associated with increased healthcare consumption and functional disability. …”
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Mapping the status of global taxonomic knowledge of Orthoptera (Arthropoda, Insecta) by Rodrigo Antônio Castro-Souza, Juliana Stropp, Luiz Felipe Moretti Iniesta, Richard J. Ladle, Neucir Szinwelski, Geiziane Tessarolo, José Alexandre Diniz-Filho, Thadeu Sobral-Souza, Joaquín Hortal

“…Our analyses show that the descriptions of currently valid species increased exponentially since the 19th century, with a temporary decline following World War II, while synonyms outpaced the number of valid species until the 1980s. …”
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A Transdisciplinary Framework to Bridge Science–Policy–Development Gaps in Global Land Management Initiatives by Nigussie Haregeweyn, Atsushi Tsunekawa, Ayele Almaw Fenta, Pasquale Borrelli, Panos Panagos, Ermias Aynekulu, Takeshi Abe, Peri Pablo, Simon West

“…Over 190 countries (81%) were found to be currently facing moderate or high risk of increased soil erosion from two or more erosion processes, and 182 countries (77%) were found to have a SPDI level that was lower than their soil erosion risk implying the urgent need for a transdisciplinary framework that supports the implementation of future soil erosion research and development projects. …”
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New perspectives on heterogeneity in astrocyte reactivity in neuroinflammation by Daniel Evangelista Santos, Sarah Alexandra Silva Lima, Leticia Santos Moreira, Silvia Lima Costa, Clarissa de Sampaio Schitine

“…Astrocyte reactivity, previously considered uniform and functionally inactive, is currently a very diverse event in different inflammatory processes. …”
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Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective by Karen Vanessa Fernandez-Muñoz, Cuauhtémoc Ángel Sánchez-Barrera, Marco Meraz-Ríos, Jose Luis Reyes, Eloy Andrés Pérez-Yépez, Maria Teresa Ortiz-Melo, Luis I. Terrazas, Monica Graciela Mendoza-Rodriguez

“…Curcumin, trimethylglycine, resveratrol, artemisinin, and some helminth-derived molecules, among others, are some natural compounds studied in the context of CRC. This review discusses the main benefits, mechanisms, advances, and dark side of conventional chemotherapeutics currently evaluated in CRC treatment. …”
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In silico identification of silent primycin biosynthetic gene clusters within the family Pseudonocardiaceae by Márk Kovács-Valasek, Csaba Fekete, Andrea Kovács-Valasek

“…In the global effort to discover or design new effective antibiotics to fight infectious diseases, the increasingly available multi-omics data with novel bioinformatics tools open up new horizons for the exploration of the genetic potential of bacteria to synthesize bioactive secondary metabolites. …”
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Flavonoid intake in European adults (18 to 64 years). by Anna Vogiatzoglou, Angela A Mulligan, Marleen A H Lentjes, Robert N Luben, Jeremy P E Spencer, Hagen Schroeter, Kay-Tee Khaw, Gunter G C Kuhnle

“…For this reason, there is an increasing interest in investigating the potential health effects of these compounds. …”
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Mengkriminalisasi Greenwashing: Menjawab Tantangan Perlindungan Konsumen di Era Keberlanjutan by Zentoni, Budi Santoso, David M. L. Tobing

“…This phenomenon has grown alongside increasing public awareness of the importance of environmental sustainability. …”
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The convergence of climate, recreation and health: La Niña, crab catching and necrotising fasciitis, a case series by Daniel Bermingham, Bruno De Vidal Chaves, Anamika Ganju, Arifuzzaman Khan, Angela Ratsch

“… Context: Necrotising fasciitis is a rapidly progressing, life-threatening soft tissue infection that carries a high morbidity and mortality, especially in susceptible populations. …”
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Public Private Partnership in the European Union: Experiences in the UK, Germany and Austria by Ronald W. McQuaid, Walter Scherrer

“…The political context of governments differs between the UK, Germany and Austria, but each government currently has a positive view of Public private Partnership (PPP). …”
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The evolution and scope of Article 38 of the Convention on the Rights of the Child in a globalizing world by Dawid Stadniczeńko

“…Observational method, document examination method, method of analysis and criticism of literature Results The scope of contemporary research on childhood within the context of international discourse reveals the necessity of revising the approach to children and their issues. …”
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Climate science for 2050 by Guy Brasseur, Guy Brasseur, Detlef Stammer, Pierre Friedlingstein, Pierre Friedlingstein, Gabriele Hegerl, Tiffany Shaw, Kevin Trenberth, Kevin Trenberth, Jadwiga Richter, Carolina Vera, André Berger, Helen Cleugh, Steve Easterbrook, Paul Edwards, Daniela Jacob, Michael Mann, Valérie Masson-Delmotte, Gavin Schmidt, Mary Scholes, Thomas Stocker, Martin Visbeck, Guoxiong Wu

“…Finally, we speculate about the values and ethics of climate science and the nature of climate research in a world that will be increasingly affected by global warming in a geopolitical context very different from that of recent decades.…”
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Innovative Thermosensitive Composite Materials: Merging Poloxamer PF‐127 and Polysaccharides for Enhanced Functional Properties by Marcos Blanco‐López, Inmaculada deDios‐Pérez, Álvaro González‐Garcinuño, Antonio Tabernero, Eva Martín del Valle

“…Abstract Currently, new cancer treatment options are being developed following tumor resection surgery, with a focus on minimizing invasiveness and reducing systemic toxicity to lower the risk of recurrence. …”
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Assessing coupled human-flood interactions using LiDAR geostatistics and neighbourhood analyses by Morgan J. Breen, Abiy S. Kebede, Carola S. König

“…The paper integrates well-established methods from other spheres of flood risk assessment in a novel way to explore the currently poorly understood Safe Development Paradox (SDP) phenomenon in coastal settings. …”
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A Methodological Proposal for Determining Environmental Risk Within Territorial Transformation Processes by Marco Locurcio, Felicia Di Liddo, Pierluigi Morano, Francesco Tajani, Laura Tatulli

“…The built assets and the real estate sector play a key role in this context; indeed, being among the first ones to be exposed to the effects of climate change, they serve as a crucial tool for the implementation of governance strategies that are more focused on environmental issues. …”
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