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2861
The Validity of Cryptocurrency Transactions and the Analysis of Associated Disputes
Published 2025-03-01“…Introduction The complex economic relations in the current era increasingly demand the provision of efficient, rational, and comprehensive legal norms. …”
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2862
Evaluation of biokinetics and dosimetry in [131I]-NaI therapies: whole-body images quantification versus lower limb region
Published 2020-06-01“…As the current dosimetric protocol can be performed by delimiting a region of interest (ROI) in whole body images to evaluate the biokinetics and absorbed dose by the patient, the objective of this study was to analyze the possibility that this measurement was restricted to only one thigh region. …”
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2863
Coordinated regulation of timing and strength of synaptic outputs by adrenergic receptors through control of action potentials in Purkinje cells
Published 2025-07-01“…We demonstrate that Purkinje cell axons exhibit negative control of action potentials in amplitude and conduction velocity by β-adrenergic receptors in a manner dependent on the axonal length through specific reduction of axonal Na+ currents. On the other hand, β-adrenergic receptors increased presynaptic release probability without changing the amount of readily releasable vesicles in axon terminals of Purkinje cells. …”
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2864
The Association Between Traumatic Brain Injury and the Risk of Cognitive Decline: An Umbrella Systematic Review and Meta-Analysis
Published 2024-11-01“…Background: There is currently increasing interest in the implication of traumatic brain injury (TBI) as a potential risk factor for long-term neurodegenerative conditions, such as dementia and Alzheimer’s disease (AD). …”
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2865
Reassessing immediate coal phase-out: Dual imperatives of capacity control and renewables expansion in China’s net-zero strategy
Published 2025-09-01“…Broader context: Reducing CO2 emissions in power systems is crucial for China in achieving its net-zero emission target. …”
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2866
Medical triage as an AI ethics benchmark
Published 2025-08-01“…Adversarial prompts significantly decreased accuracy. By demonstrating the influence of context and ethical framing on the performance of LLMs, we provide critical insights into the current capabilities and limitations of AI in high-stakes ethical decision making in medicine.…”
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2867
La política de ordenación y desarrollo del País Vasco norte
Published 2020-08-01“…The current context is characterized at the same time by the exacerbation of the territorial tensions with the metropolization of regional capitals, the rise of the periurban phenomenum and the depopulation of rural areas where public services and employments are decreasing, and by the exhaustion of a model of development based on the clustering of productive activity, exploitation of natural resources and the growth of social inequalities. …”
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2868
ANALYSIS OF THE DYNAMICS AND TRENDS IN THE DEVELOPMENT OF MODERN INTERNATIONAL TOURIST MARKET
Published 2021-02-01“…Based on the statistical data of international organizations, the author studied indicators of international tourist flows, identified the main trends in the development of international tourism at the current stage, assessed the impact on the tourism sector of the COVID-19 pandemic and determined possibilities for its development in the context of the economic crisis, showed prospects for the development of the industry.…”
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2869
OPTIMIZATION OF IMID-BASED THERAPIES
Published 2024-12-01“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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2870
Trends and Prospects in Educational Modernisation: A Hermeneutic Approach
Published 2018-12-01“…To overcome this situation and to break this deadlock, a profound reconsideration of the values underlying mechanisms of reform is required, taking into account multifaceted personal, social, national and universal relations, as well as unity of content, forms and means of education.The aims of the research were identified as follows: to analyse the current trends of modernisation in comprehensive schools and higher educational establishments; to justify humanistic mechanisms for improving the modernisation in the context of language education, which performs personally developing and socialising functions under ideological pluralism and opposition of value systems.Methodology and research methods. …”
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2871
Sala de aula invertida com Tecnologias Digitais e Ferramenta Metacognitiva para potencializar as aulas do Ensino Superior / Flipped classroom with digital technologies and metacogn...
Published 2020-12-01“…A utilização do material autossuficiente baseado nas tecnologias digitais auxiliou os alunos na apreensão dos conceitos de fibromialgia, pois oferecia o conteúdo de modo organizado, atendendo as necessidades dos estudantes. /// In the current digital context, students are increasingly involved by digital technologies in their daily lives, which drives their insertion in the educational field, at different levels of education, in order to make classes more attractive, interesting and dynamic. …”
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2872
Optimizing a Novel Smartphone App to Prevent Postpartum Depression Adapted From an Evidence-Based Cognitive Behavioral Therapy Program: Qualitative Study
Published 2024-12-01“…Participants’ suggestions to improve MBapp were categorized within the FRAME as adaptations that improved either content or context to optimize reach, retention, engagement, and fit for end users. …”
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2873
Early detection to improve outcome in people with undiagnosed psoriatic arthritis: the PROMPT research programme including RCT
Published 2025-06-01“…We had two main study aims: To understand experiences of diagnosis in the current healthcare context from the perspective of patients newly diagnosed with PsA. …”
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2874
Enhancing digital literacy in primary education through augmented reality
Published 2024-11-01“…Currently, there is a need to develop digital competencies already because they are included in the new curriculum. …”
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2875
Integrating the international medical graduate
Published 2025-03-01“…Introduction: The growing utilisation of international medical graduate (IMG) doctors in the UK has uncovered a need for hospitals to establish induction programmes that harness supportive environments for these doctors to learn within the specific context of the NHS. Currently, IMGs are under-supported at local and national levels. …”
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2876
New Developments in the EU Internal Market – Harmonisation vs. Mutual Recognition
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2877
Flood Risk Mitigation by Spatial Planning—Lessons Learned From Municipal Consultation
Published 2025-06-01“…The flood event that hit the German states of Rhineland‐Palatinate and North Rhine‐Westphalia in mid‐July 2021 increased municipal awareness for flood‐sensitive planning. …”
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2878
THE WEEKEND TOUR AS THE PROSPECTIVE TREND OF RURAL DEVELOPMENT
Published 2024-03-01“…The authors of the article are convinced that the study and adopting the best practices of European countries in the context of a weekend tour will contribute to an increase in income from domestic tourism. …”
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2879
Assessing the impact of cryptocurrency usage on cybersecurity: the European Union experience
Published 2023-12-01“…Therefore, researching the impact of cryptocurrency usage on cybersecurity is currently a relevant issue. The purpose of this study is to investigate the impact of cryptocurrency usage on cybersecurity in European Union countries. …”
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2880
Reporting Together: Transactional Sociability, Digital Communities and Alternate Embodiments on the Road through the Use of Waze
Published 2017-11-01“…The paper seeks to fill a gap in digital spatial theory by upholding that apps are made at a fast pace to help increase their commercial value, but their development, design, and research currently lacks critical study. …”
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