Evolution of taxis responses in virtual bacteria: non-adaptive dynamics. by Richard A Goldstein, Orkun S Soyer

“…We currently lack a full understanding of the different pathway structures and dynamics and how this integration is achieved. …”
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Safety of a change of specifications of phytosterols/phytostanols as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Helle Katrine Knutsen, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Wolfgang Gelbmann, Harry J. McArdle

“…Regarding the maximum limit of the specification parameter ‘other sterols/stanols’, the applicant asks for an increase from currently less than 3% to less than 7% to better reflect and cover the natural composition and proportions of sunflower‐based phytosterols/phytostanols, noting that the existing specifications have been established largely based on the NF when sourced from soy. …”
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Optimizing enzyme thermostability by combining multiple mutations using protein language model by Jiahao Bian, Pan Tan, Ting Nie, Liang Hong, Guang‐Yu Yang

“…It showed a 10.19°C increase in the melting temperature and an ~655‐fold increase in the half‐life at 58°C. …”
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Ipomoea batatas (L.) Lam. cultivation in the conditions of light culture in vitro and ex vitro by E. A. Kalashnikova, R. N. Kirakosyan, A. V. Gushchin, K. G. Abubakarov, N. N. Sleptsov, S. K. Temirbekova, A. P. Glinushkin, O. V. Meleshina, N. Ya. Rebouh, M. M. Tareeva

“…Interest in this substance is justified by its valuable properties – it is a good immunomodulator, cleanses the body of toxins, radionuclides, "bad" cholesterol, promotes the assimilation of useful trace elements necessary for human life. Inulin is contained in plants such as jerusalem artichoke, chicory, as well as in sweet potatoes, the popularity of which is increasing every year. …”
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Are interventions for environmentally sustainable dietary behaviours effective? A review by Y Ran, U M Persson, T Lindahl, M Jonell, A Brons, B Macura, J Candel, A Abu Hatab, E Röös

“…In the face of growing environmental pressures, understanding how governance can promote more sustainable dietary behaviours is increasingly critical. However, a synthesis of available intervention strategies for behavioural change is currently missing. …”
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Clinical and laboratory assessment of the effect of hygiene products on the condition of periodontal tissues and hard tooth tissues in the treatment of caries by indirect method by I. A. Belenova, V. A. Mitronin, Z. A. Filippova, V. I. Khryachkov, M. S. Vasilyeva, N. A. Protsenko

“…According to statistics, the widespread use in modern dental practice of indirect restoration methods in the treatment of caries of the frontal group of teeth leads to an increase in the incidence of marginal periodontal disease. …”
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Efficiency and heat transport processes of low-temperature aquifer thermal energy storage systems: new insights from global sensitivity analyses by Luka Tas, Niels Hartog, Martin Bloemendal, David Simpson, Tanguy Robert, Robin Thibaut, Le Zhang, Thomas Hermans

“…Thick productive aquifer layers have been targeted first, as these are the most promising hydrogeological context for ATES. Regardless, there is currently an increasing trend to target more complex aquifers such as low-transmissivity and alluvial aquifers or fractured rock formations. …”
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iPSC models of mitochondrial diseases by Sonja Heiduschka, Alessandro Prigione

“…Consequently, most mitochondrial diseases are currently untreatable. Human induced pluripotent stem cells (iPSCs) represent a promising approach for developing human model systems and assessing therapeutic avenues in a patient- and tissue-specific context. iPSCs are being increasingly used to investigate mitochondrial diseases, either for dissecting mutation-specific defects within two-dimensional (2D) or three-dimensional (3D) progenies or for unveiling the impact of potential treatment options. …”
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In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington’s Disease by Luis C. Morales, Luv Modi, Saba Abbasi Dezfouli, Amarnath Praphakar Rajendran, Remant Kc, Vaibhavi Kadam, Simonetta Sipione, Hasan Uludağ

“…<b>Methods:</b> This study aims to investigate the efficacy of siRNA-containing nano-engineered lipopolymers in selectively silencing the <i>HTT</i> expression in a neuronal model expressing a chimeric protein formed by the human mutated exon 1 of the <i>HTT</i> gene, tagged with GFP. …”
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Development of an easy non‐destructive particle isolation protocol for quality control of red blood cell concentrates by Marine Ghodsi, Anne‐Sophie Cloos, Anaïs Lotens, Marine De Bueger, Patrick Van Der Smissen, Patrick Henriet, Nicolas Cellier, Christophe E. Pierreux, Tomé Najdovski, Donatienne Tyteca

“…Nevertheless, there is currently no standardized isolation protocol. In a previous publication, we developed a reproducible ultracentrifugation‐based protocol (20,000 × g protocol) that allows to classify red blood cell concentrates into three cohorts according to their vesiculation level. …”
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Selective Separation of Scandium in Acidic Water Using Carboxyl Functionalized Covalent Phosphonitrile Polymers by Yu BAI, Ayinuer WUSHUER, Lei OUYANG, Lijin HUANG, Qin SHUAI

“…As the acidity of the solution increases, the adsorption efficiency of CPF-T for Sc(III) significantly decreases, and at pH<3, the adsorption rate is below 60%. …”
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The implementation of safer drug consumption facilities in Scotland: a mixed methods needs assessment and feasibility study for the city of Edinburgh by James Nicholls, Wendy Masterton, Danilo Falzon, Andrew McAuley, Hannah Carver, Kathryn Skivington, Josh Dumbrell, Andy Perkins, Samantha Steele, Kirsten Trayner, Tessa Parkes

“…Abstract Background Scotland currently has amongst the highest rates of drug-related deaths in Europe, leading to increased advocacy for safer drug consumption facilities (SDCFs) to be piloted in the country. …”
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The challenges of reproducibility for research based on geodata web services by M. Cannata, M. Collombin, O. Ertz, G. Giuliani, J. Ingensand, C. Primerano, D. Strigaro

“…Additionally, we assess the currently available tools that support data versioning for databases, files and log-structured tables. …”
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Lipidomic markers of obesity and their dynamics after bariatric surgery by T. V. Saprina, A. S. Bashirova, V. V. Ivanov, S. I. Pekov, I. A. Popov, S. R. Bashirov, E. A. Vasilyeva, O. A. Pavlenko, D. V. Krinitskii, M. Chen

“…Currently available studies and their results suggest that we are only at the very start of studying this promising biomedical field.…”
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Physicians’ experiences of assessing and supporting fatigued patients in primary care: a focus group study by Conrad Samuelsson, Lisa Gunnarsson, Frank Svärdman, Christian Rück, Elin Lindsäter

“…Abstract Background Fatigue is a common symptom in primary healthcare, affecting 10–30% of patients, and is associated with increased healthcare consumption and functional disability. …”
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Standardization of the Pharmaceutical Substance of the Drug LCS-1208 by E. V. Ignateva, I. V. Yartseva, Z. S. Shprakh, A. P. Bud'ko, L. V. Ektova, D. A. Kozin, V. Yu. Reshetnyak, O. V. Nesterova, E. A. Pankratova

“…Indolocarbazole derivatives are of increasing scientific interest for practical oncology. …”
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A Transdisciplinary Framework to Bridge Science–Policy–Development Gaps in Global Land Management Initiatives by Nigussie Haregeweyn, Atsushi Tsunekawa, Ayele Almaw Fenta, Pasquale Borrelli, Panos Panagos, Ermias Aynekulu, Takeshi Abe, Peri Pablo, Simon West

“…Over 190 countries (81%) were found to be currently facing moderate or high risk of increased soil erosion from two or more erosion processes, and 182 countries (77%) were found to have a SPDI level that was lower than their soil erosion risk implying the urgent need for a transdisciplinary framework that supports the implementation of future soil erosion research and development projects. …”
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New perspectives on heterogeneity in astrocyte reactivity in neuroinflammation by Daniel Evangelista Santos, Sarah Alexandra Silva Lima, Leticia Santos Moreira, Silvia Lima Costa, Clarissa de Sampaio Schitine

“…Astrocyte reactivity, previously considered uniform and functionally inactive, is currently a very diverse event in different inflammatory processes. …”
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Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective by Karen Vanessa Fernandez-Muñoz, Cuauhtémoc Ángel Sánchez-Barrera, Marco Meraz-Ríos, Jose Luis Reyes, Eloy Andrés Pérez-Yépez, Maria Teresa Ortiz-Melo, Luis I. Terrazas, Monica Graciela Mendoza-Rodriguez

“…Curcumin, trimethylglycine, resveratrol, artemisinin, and some helminth-derived molecules, among others, are some natural compounds studied in the context of CRC. This review discusses the main benefits, mechanisms, advances, and dark side of conventional chemotherapeutics currently evaluated in CRC treatment. …”
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In silico identification of silent primycin biosynthetic gene clusters within the family Pseudonocardiaceae by Márk Kovács-Valasek, Csaba Fekete, Andrea Kovács-Valasek

“…In the global effort to discover or design new effective antibiotics to fight infectious diseases, the increasingly available multi-omics data with novel bioinformatics tools open up new horizons for the exploration of the genetic potential of bacteria to synthesize bioactive secondary metabolites. …”
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