Pharmacometric in silico studies used to facilitate a national dose standardisation process in neonatology – application to amikacin by Verena Gotta, Julia Anna Bielicki, Paolo Paioni, Chantal Csajka, Dominic Stefan Bräm, Christoph Berger, Elisabeth Giger, Michael Buettcher, Klara M. Posfay-Barbe, John van den Anker, Marc Pfister

“…Simulations showed that extending the dosing interval to ≥36 h in the subpopulation of clinical concern increased the frequency of a desirable Ctrough below 5 mg/l to >80%. …”
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THE CONTRIBUTION OF THE BIBLIOMETRIC ANALYSIS TO THE UNDERSTANDING OF TRENDS IN THE SUSTAINABLE DEVELOPMENT OF TOURISM by Andrei Ștefan VASILE, Liviu MARCUTA, Alina MARCUTA, Valentina Constanța TUDOR, Cornelia Marilena DAMIAN (BADEA)

“…In the contemporary context of economic development and environmental conservation, sustainable tourism is an important field of research that significantly impacts local communities and natural resource management. …”
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PATHWAYS TO ENHANCING THE EFFICIENCY OF BUSINESS MANAGEMENT MECHANISMS IN HEALTHCARE by Nataliia Letunovska, Liliia Khomenko, Yevhen Chvankin

“…The proposed measures aim to address current challenges in the blood supply sector, improve population access to safe, high-quality blood components, and enhance overall satisfaction with blood services. …”
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Stress and influencing factor among children diagnosed with cancer at hospitals in Nepal: a cross-sectional study by Surya Kamal Shahi, Panpan Wang, Jinjin Gu, Rajendra Man Shrestha, Peng Wang

“…The study’s finding showed a remarkable association between stress and factors like sex, education level, the duration of diagnosis, current health status, reasons for hospital visits including pain (P < 0.05). …”
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The Effectiveness of Collaborative Centralized Information Systems in Project Management: A Pilot Demonstration of a Multifunctional Building in Africa by Fábio Oliveira Santos, Nuno Lacerda Lopes

“…In the current context of transformation within the Architecture, Engineering, and Construction (AEC) sector, and the growing adoption of interdisciplinary collaboration processes such as Integrated Project Delivery (IPD) and Building Information Modeling (BIM), information management systems are crucial to ensure both the security and reliability of data, and its effective distribution among project stakeholders. …”
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Combined effects of conditional cash transfer program and environmental health interventions on diarrhea and malnutrition morbidity in children less than five years of age in Brazi... by Anelise Andrade de Souza, Sueli Aparecida Mingoti, Rômulo Paes-Sousa, Léo Heller

“…The concomitant presence of these measures with environmental sanitation interventions may increase their positive effect. The context of simultaneous improvement of social protection and environmental sanitation is found in Brazil since 2007 and an assessment of the combined effects of both programs has not been performed so far.…”
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The state and prospects of the development of small and medium business in the conditions of war in Ukraine by Viktoriia M. Orlova, Olena R. Serhieieva, Oksana V. Kuzmenko

“…This paper investigates the current state of small and medium business in Ukraine. …”
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Testosterone-induced erythrocytosis: addressing the challenge of metabolic syndrome and widely prescribed SGLT2-inhibitor drugs by Federica Tramontana, Azmi Mohammed, Yaasir H Mamoojee, Richard Quinton

“…Crucially, they also increase haematocrit by promoting haematopoiesis. This review focuses on the current best evidence for managing erythrocytosis, in the context of more prevalent obesity and prescriptions of testosterone and SGLT2i in this population. …”
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Regulation and governance for the implementation and management of point-of-care testing in Australia: a scoping review by Jacqueline Prestedge, Claire Kaufman, Deborah A. Williamson

“…Of the grey literature sources, fifteen current PoCT governance documents comprising of six standards, five guidelines and four frameworks at the international, national and jurisdictional level were included with an increasing number of grey literature sources since the onset of the COVID-19 pandemic in 2020. …”
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Socio-economic problems of hydrogen energy development by M. A. Pletnev, A. N. Kopysov

“…To solve this problem, the method of analyzing the regulatory framework, monographic, scientific and analytical literature, program documents of various levels, real steps of the authorities in the implementation of the fourth energy transition was used. DISCUSSIONS. The current economic model of energy production and consumption is based on an increase in entropy, which leads to irreversible changes in the global ecosystem. …”
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The Impact of Decentralized Finance on the Activities of Traditional Financial Intermediaries by M. T. Belova, I. A. Rizvanova

“…Focus on minimizing risks should facilitate the use of DeFi services by traditional financial intermediaries in the context of creating and developing innovative projects. …”
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The New Normal? by O. A. Donskikh

“…The article discusses the preliminary results of the forced transition to entire online learning in the higher education system in the context of the general growth trend of the corresponding form of education in various universities around the world. …”
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Can we adapt fairly? Scoping review of health equity implications of flood risk in coastal communities by Sari Kovats, Grace Turner, Sally Brown, Owen Landeg, Rachel Brisley, Louise O’Connor

“…Policies and practices like household insurance and property resilience measures may increase inequalities, while community engagement, planning and structural solutions can reduce disparities, depending on local context and implementation.Conclusions Adaptation to UK coastal flood risk requires both short-term and long-term strategies. …”
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Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole by Caroline Silveira Martinez, Ancheng Zheng, Qingzhong Xiao

“…In this review, we will provide an overview and discussion of the recent findings on mtROS production, its threshold for imbalance, and the subsequent dysfunction that leads to related cardiac and systemic phenotypes in the context of HFpEF. We will also focus on newly discovered cellular and molecular mechanisms underlying ROS dysregulation, current therapeutic options, and future perspectives for treating HFpEF by targeting mtROS and the associated signal molecules.…”
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Introduction by Faidra Filippidou

“…At the same time, the current world population, of 7.6 billion, is predicted to reach 8.6 billion in 2030 and 9.8 billion in 2050 (UN 2017). …”
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The prevalence of posttraumatic stress disorder and its correlation with health beliefs among medical students by Mohammad Amiri, Zahra Mehmannavaz Mikal, Elham Sadeghi, Ahmad Khosravi

“…Furthermore, the variables of educational level, impoverished economic status, and anxiety induced by the COVID-19 pandemic emerged as significant predictors of elevated scores on the PTSD scale. In order to increase psychological health and reduce PTSD in students, this research suggests teaching health principles in the context of COVID-19.…”
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Production and characterization of a promising microbial-derived lipase enzyme targeting BCL-2 gene expression in hepatocellular carcinoma by Amal M. Abo-Kamer, Ahmed A. Abdelaziz, Esraa S. Elkotb, Lamiaa A. Al-Madboly

“…These findings suggest that lipase from P. aeruginosa holds promise as a novel therapeutic agent for hepatocellular carcinoma, addressing the limitations of current treatments.…”
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Mapping and visualization of global research progress on autophagy in metabolic dysfunction-associated steatotic liver disease and metabolic syndrome: a bibliometric analysis (2009... by Xing Liu, Xiang Li

“…ObjectiveThis study aimed to delineate the current trends and hotspots in autophagy research related to metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD), with the aim of guiding future investigations in this area.MethodsThis study extracted research on autophagy in MetS and MASLD from the Web of Science Core Collection (WoSCC) database. …”
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Study on the Leakage Diagnosis of a Chilled Water Pipeline Network System Based on Pressure Variation Rate Analysis for Climate Change Mitigation by Xuan Zhou, Fei Liu, Lisheng Luo, Shiman Peng, Junlong Xie

“…In the context of increasing climate variability and extreme weather, chilled water systems face mounting challenges due to amplified heating and cooling demands and prevalent pipe leakages. …”
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A Hydrological–Energy Balance Model to Assess Land Surface Temperature at the Urban Scale: The Case Study of Milano, Italy by Sonia Morgese, Wenchuang Zhang, Francesca Casale, Daniele Bocchiola

“…ABSTRACT This paper provides a physically based approach to assess Land Surface Temperature (LST) in an urban context, to analyze the Surface Urban Heat Island Intensity (SUHII). …”
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