Anti-tumor activity of a novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancer. by Bin Bao, Shadan Ali, Dejuan Kong, Sanila H Sarkar, Zhiwei Wang, Sanjeev Banerjee, Amro Aboukameel, Subhash Padhye, Philip A Philip, Fazlul H Sarkar

“…<h4>Methodology/principal findings</h4>In the current study we showed, for the first time, that CDF could significantly inhibit the sphere-forming ability (pancreatospheres) of PC cells consistent with increased disintegration of pancreatospheres, which was associated with attenuation of CSC markers (CD44 and EpCAM), especially in gemcitabine-resistant (MIAPaCa-2) PC cells containing high proportion of CSCs consistent with increased miR-21 and decreased miR-200. …”
Get full text

Flavor Quality of Scomberomorus niphonius by Shanyu WANG, Chong JIAN, Yong XUE, Ling ZHAO, Huihui SUN, Rong CAO

“…In addition, seafood contains essential nutritional lipids, including phospholipids, triglycerides, and essential fatty acids, which is an important feature distinguishing it from other species. …”
Get full text

Impaired plasma membrane calcium ATPase activity and mitochondrial dysfunction contribute to calcium dysregulation in Fabry disease-related painful neuropathy by Francesco Formaggio, Asia Pizzi, Cecilia Delprete, Davide Pasqualini, Isabella Mataloni, Roberto Rimondini, Ludovica Campolongo, Vincenzo Donadio, Anna Maria Ghelli, Rocco Liguori, Marco Caprini

“…The reduced activity was associated with a decrease of cytosolic pH which weakened the PMCA-dependent calcium extrusion. …”
Get full text

Getting Blood out of a Stone: Vascularization via Spheroids and Organoids in 3D Bioprinting by Daria Revokatova, Polina Bikmulina, Zahra Heydari, Anna Solovieva, Massoud Vosough, Anastasia Shpichka, Peter Timashev

“…It is also responsible for inductive biochemical exchange, and provides a structural pattern for organ growth. In vitro systems, containing no perfusable vessels, suffer from the quick formation of a necrotic core of organoids, and further development does not occur due to increased metabolic demands. …”
Get full text

Facilitation as Attenuating of Environmental Stress among Structured Microbial Populations by Suzana Cláudia Silveira Martins, Sandra Tédde Santaella, Claudia Miranda Martins, Rogério Parentoni Martins

“…There is currently an intense debate in microbial societies on whether evolution in complex communities is driven by competition or cooperation. …”
Get full text

Comprehensive analysis of kampo medicine utilization across all outpatient departments with a focus on anesthesiology department/pain clinic at Kyoto university hospital over 12 ye... by Karin Kato, Kaori Tsuyuki, Takuma Ohsuga, Akihiko Ueda, Miho Egawa, Masashi Ikuno, Neiko Ozasa, Kiyoaki Tanikawa

“…The usage rate of Processed Aconite Root-containing formulations increased with increasing patient age, reaching 3.3% in individuals in their teens, 6.6% in their twenties, 13.3% in their thirties, and over 30% in their eighties and nineties. …”
Get full text

Optimizing Green Spaces Significantly Improves Wind Environment and Accessibility in County Towns by Dan-Yin Zhang, Ling Yang, Li-Yi Feng, Jiang Liu, Xin-Chen Hong

“…With the increasing frequency of extreme disasters, effectively utilizing park green spaces in both daily life and disaster scenarios has emerged as a new challenge, particularly in county-level cities. In this context, the core planning area of Anxi County in Quanzhou was selected as the study site. …”
Get full text

The Effect of Sodium Dodecyl Sulphate Additives on the Electrochemical Performance of Aqueous Zinc Ion Batteries by Na Chen, Ying Huang, Yuan Lv, Wenju Wang

“…The cycling stability of NVP/Zn batteries was greatly enhanced by using a battery containing 1% SDS that still had a discharge specific capacity of 71 mAh/g after 100 cycles at a charging current density of 1 C, with a capacity retention rate of 89%. …”
Get full text

Investigation of Anti-Mycobacterial Activity of Orientin and Vitexin on the Six Mycobacterium tuberculosis Strains by Tülin Aşkun

“…Orientin and vitexin have not been tested on current clinical strains of M. tuberculosis before. …”
Get full text

A Computational Model of Attention-Guided Visual Learning in a High-Performance Computing Software System by Alice Ahmed, Md. Tanim Hossain

“…It reveals how attention increases responses to attentive stimuli, thereby normalizing activity across the population. …”
Get full text

Glycosphingolipids and their impact on platelet activity in a murine model of fabry disease by Adam J. Kanack, Eve Prodoehl, Mayumi Ishihara-Aoki, Kazuhiro Aoki, Nancy M. Dahms

“…Notably, treatment of platelets from wild-type animals with globotriaosylceramide (Gb3) increased baseline platelet activation and aggregation. …”
Get full text

Analiza znowelizowanego listu apostolskiego papieża Franciszka Vos estis lux mundi by Dariusz Mazurkiewicz

“…It seems that the current legislation in this matter still requires unification and simplification, which will allow for more effective application of the law.…”
Get full text

Assessment of consumer perspectives on the use of paper packaging in Trinidad. by Farrah Mathura, Rohanie Maharaj

“…<h4>Background</h4>Paper packaging is increasingly being used to replace single use plastics to mitigate the negative effects of plastic pollution on the environment. …”
Get full text

Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems. by Takuto Nosaka, Tatsushi Naito, Yu Akazawa, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

“…Knockdown of STAT1 increased viral products in HBV-transfected HepG2 cells, but decreased in HBV-infected PXB cells. …”
Get full text

A congestion prediction method based on trajectory mining algorithm by Liu Dongjiang, Li Leixiao, Li Jie

“…Abstract Nowadays, number of private cars is increasing rapidly. Traffic congestion becomes a serious problem in urban region. …”
Get full text

Perceptions and Beliefs on Vaccination for COVID-19 in Delhi: A Cross-Sectional Study by Abha Sharma, Anshuman Srivastava

“…Hence, this study may help the administrators to understand the community concerns, tweaking current policies, and increasing the awareness campaign so that people gather more knowledge about vaccine benefits and community trust is built.…”
Get full text

18F-FDG PET/CT revealed primary malignant giant cell tumor of the sacrum: a case report by Zelong Feng, Ronghua Yu, Xianwen Hu

“…Primary malignant giant cell tumor of bone (PMGCTB), which is usually confirmed to contain a high-grade sarcomatous component at the time of initial diagnosis, accounts for 1.6% of giant cell tumors of bone (GCTB). …”
Get full text

From Ocean to Market: Technical Applications of Fish Protein Hydrolysates in Human Functional Food, Pet Wellness, Aquaculture and Agricultural Bio-Stimulant Product Sectors by Dolly Bhati, Maria Hayes

“…Food producers need to increasingly adopt sustainable practices to reduce negative environmental impacts and food waste. …”
Get full text

Correlation of disease severity with body weight and high fat diet in the FATZO/Pco mouse. by Brian A Droz, Bria L Sneed, Charles V Jackson, Karen M Zimmerman, M Dodson Michael, Paul J Emmerson, Tamer Coskun, Richard G Peterson

“…Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic mutations; these are rarely associated with the development of human obesity. …”
Get full text

Fabrication of Sol Gel Solution-Based Zinc–Tin Oxide/Carbon Nanotube Hybrid Thin-Film for Thin-Film Transistors by Yong-Jae Kim, Woon-Seop Choi

“…Among the samples, the ZTO TFT with an SWNT concentration of 0.07 wt.% showed a field-effect mobility (μsat) of 13.12 cm²/Vs (increased by a factor of 3) and an I_on/I_off current ratio of 7.66 × 10⁷ with a lower threshold voltage. …”
Get full text