Fexuprazan safeguards the esophagus from hydrochloric acid-induced damage by suppressing NLRP1/Caspase-1/GSDMD pyroptotic pathway by Seo Yeon Kim, Seo Yeon Kim, Jung-Ho Yoon, Da Hyun Jung, Ga Hee Kim, Chul Hoon Kim, Chul Hoon Kim, Sang Kil Lee

“…Esomeprazole, a representative PPI, and three currently marketed P-CABs (vonoprazan, tegoprazan, and fexuprazan) were used for pretreatment. …”
Get full text

Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes by Anushka Deshpande, Leo Weirauch, Tapan Kumar Baral, Marco Steier, Ankush Borlepawar, Manju Kumari, Lucia S. Kilian, Karsten Richter, Elke Hammer, Derk Frank, Constanze Schmidt, Norbert Frey, Ashraf Y. Rangrez

“…Electrophysiologically, Letm1 reduced L-type Ca2+ current density and significantly shortened action potential duration, leading to impaired contractility. …”
Get full text

Artificial Intelligent Model to Enhance Thermal Conductivity of TiO₂-Al₂O₃/Water-Ethylene Glycol-Based Hybrid Nanofluid for Automotive Radiator by Md. Munirul Hasan, Md. Mustafizur Rahman, Md. Arafatur Rahman, Suraya Abu Bakar, Mohammad Saiful Islam, Tarek Khalifa

“…Vehicular cooling system is one of the priorities for the automobile industry, aiming to achieve sustainability and energy efficiency. Currently, coolants are being utilized in cooling systems that exhibit super heat transfer capabilities. …”
Get full text

Vertical distribution of ¹³⁷Cs in soddy-podzolic sandy soil in grasslands and forests of the Bryansk region in 2015–2016 by V. P. Ramzaev, A. N. Barkovsky, K V. Varfolomeeva

“…In practical terms, it indicates that the depth of soil sampling equal to 20 cm is currently quite sufficient to estimate the dose rate of gamma radiation in the air in virgin grasslands and in forests.…”
Get full text

Transmission network and phylogenetic analysis reveal older male-centered transmission of CRF01_AE and CRF07_BC in Guangxi, China by Fei Zhang, Yao Yang, Na Liang, Huayue Liang, Yongzheng Chen, Zhaosen Lin, Tongbi Chen, Wenling Tan, Yuan Yang, Rongye Huang, Lin Yao, Fuling Chen, Xingzhen Huang, Li Ye, Hao Liang, Bingyu Liang

“…In China, the number of newly reported HIV infections in older people is increasing rapidly. However, clear information on the impact of older people on HIV transmission is limited. …”
Get full text

Synergistic Effects of Mannan Oligosaccharides and Onion Peels on In Vitro Batch Culture Fermentation of High Concentrate and Forage Diets by Lydia K. Olagunju, Oludotun O. Adelusi, Peter A. Dele, Yasmine Shaw, Rosetta M. Brice, Oluteru E. Orimaye, Jorge A. Villarreal-González, Hye Won Kang, Ahmed E. Kholif, Uchenna Y. Anele

“…Administration of MOS:2OP to the HC diet increased GP at 24 h of incubation, while the lowest GP was observed with the OP in the HF diet. …”
Get full text

MHD analysis of couple stress nanofluid through a tapered non-uniform channel with porous media and slip-convective boundary effects by P. Deepalakshmi, G. Shankar, E.P. Siva, D. Tripathi, O. Anwar Bég

“…The current research addresses the peristaltic transport mechanism that propels fluid through a conduit through rhythmic contraction and relaxation of the conduit walls, a phenomenon evident in numerous biological systems, including the gastrointestinal tract. …”
Get full text

Multi-method evaluation of volatile flavor compounds in five kiwifruit varieties by ZENG Shuo, GUO Xinyu, NIU Dongsheng, LI Feng

“…[Objective] Fruit wine, as a food of fruit processing, not only enhances the flavor diversity of kiwifruit but also increases its biological activity, leading to the production of kiwifruit wine with a unique flavor, combined fruit with wine aromas, and rich nutrition. …”
Get full text

Microvesicles Derived from Human Embryonic Neural Stem Cells Inhibit the Apoptosis of HL-1 Cardiomyocytes by Promoting Autophagy and Regulating AKT and mTOR via Transporting HSP-70 by Lei Zhang, Jianyi Gao, Tianyan Chen, Xiang Chen, Xianyan Ji, Kai Ye, Jiahong Yu, Bin Tang, Yusheng Wei, Hong Xu, Jiabo Hu

“…Additionally, hESC-NSC-derived MVs contained high levels of heat shock protein 70 (HSP-70), which can increase the level of HSP-70 in cells. …”
Get full text

In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives by Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete

“…Exposure to melanoma murine supernatants also promotes M1 polarization. Supernatants containing traces of 1,2,4-oxadiazole derivative 2 (Supernatants B, C, and D) increased the percentage of M1 cells compared to Supernatant A, as well as elevated levels of nitrite, TNF-α, and IL-12. 1,2,4-oxadiazole derivative 2 combined with Supernatant A and 1,2,4-oxadiazole derivative 2 combined with LPS also resulted in higher M1 polarization, suggesting a synergistic effect on M1 polarization and TNF-α production. …”
Get full text

PANCAKE: A Python-based Numerical Color–Magnitude Diagram Analysis Package by Yun Zheng, Yujiao Yang, Yong-Kun Zhang, Zheng Zheng, Jing Wang, Lister Staveley-Smith, Chao-Wei Tsai, Di Li, Chao Liu, Jingjing Hu, Huaxi Chen, Donghui Quan, Yinghui Zheng, Hangyuan Li

“…The color–magnitude diagram (CMD) stands out as the most accurate tool currently available for inferring the star formation histories (SFHs) of nearby galaxies with stellar-resolved multiband data. …”
Get full text

Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
Get full text

Dealing with Complexity – Knowledge, design, and management of the built environment by Cesare Sposito, Francesca Scalisi

“…How do we place knowledge and learning into a system to better understand the current era’s multidimensional, fundamental, and global issues in their irreducible complexity? …”
Get full text

Comparative chromium adsorptive capacity of different low-cost materials using fixed bed column by Asma Shakeel, Inayat Mustafa Khan, Faheem Jeelani, Mukhtar Iderawumi Abdulraheem, Salma Imam Sulaiman, Mohmad Auyoub Bhat, Javid Ahmad Bhat, Tahir Sheikh, Rakshanda Anayat, Syed Andleeba Jan, Mehnaz Shakeel, Mohd. Tariq, Arifullah Mohammed, Tabarak Malik

“…Abstract The accessibility of pure water is crucial for various human activities and is increasingly in demand due to the growing global population. …”
Get full text

Application of dry electrodes in supercapacitors and lithium-ion batteries by Guolei ZHANG, Keliang ZHANG, Yabin AN, Chen LI, Guanwei LIU, Xianzhong SUN, Changzhou YUAN, Kai WANG, Xiong ZHANG, Yanwei MA

“…Finally, the challenges and issues in the current use of dry electrodes in supercapacitors and lithium-ion batteries are summarized, along with proposed future directions. …”
Get full text

Exploring Scientific Outputs about Globalization: A Conceptual Framework Study by Saleh Rahimi, Faramarz Soheili

“…The extracted data spanned 25 years (1999–2023) and included 1,281 documents containing 4,502 author keywords. After standardization, 2,169 unique keywords remained. …”
Get full text

Рreventive efficacy of interferon -2b in the COVID-19 pandemic by Zh. B. Ponezheva, A. A. Grishaeva, I. V. Mannanova, A. N. Kupchenko, S. B. Yatsyshina, S. V. Krasnova, V. V. Malynovskaya, V. G. Akimkin

“…The amount of infected people has already exceeded 48 million, and more than 1 million deaths have been registered. A steady increase of new cases of COVID-19 is currently observed on the territory of the Russian Federation. …”
Get full text

Solid waste management service chain and sanitation safety: a case study of existing practice in Addis Ababa, Ethiopia by Shegaw Fentaye Sisay, Sirak Robele Gari, Sirak Robele Gari, Argaw Ambelu

“…Additionally, 85% of households used storage and transport containers that had leaks, potentially leading to contamination and infection. …”
Get full text

Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…Trial registration This trial is registered as Current Controlled Trials ISRCTN21656568 (www.isrctn.com/ISRCTN21656568). …”
Get full text

HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia by James Soka Moses, Alice K. Pau, Safia Kuriakose, Greg Grandits, Cavan Reilly, Brad T. Sherman, Weizhong Chang, Lisheng Dai, Muhammad A. Khan, Helene Highbarger, Moses Mannah, Johnathan McCullough, Carla Chorley, Isaac Morlu, Joseph Dorbor, Ophelia Talweh Bongolee, Rebecca Slewion, Esther Akpa, Barthalomew Wilson, April L. Poole, Stacy L. Kopka, Tracey Miller, Cecelia J. Nuta, Christina Lindan, David Glidden, Jeffrey N. Martin, Kumblytee L. Johnson, Robin L. Dewar, Ian Wachekwa, Stephen A. Migueles

“…Abstract Background Increasingly, persons with HIV in Liberia are receiving antiretroviral therapy containing the integrase strand-transfer inhibitor (InSTI) dolutegravir (DTG), but the prevalence of and factors associated with virologic failure and HIV drug resistance (HIVDR) remain unknown. …”
Get full text