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4801
What Were Bulletin Board Systems? Looking Back At Pre-Internet Online Communication in Turkey
Published 2024-03-01“…It then introduces the HitNet archive, currently the only publicly accessible Turkish language BBS archive in the world. …”
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4802
The Ukraine-Russia conflict: An international humanitarian law review of the involvement of foreign fighters
Published 2025-01-01“…Their involvement on both sides of the conflict between those supporting either Ukrainian forces or Russian-backed groups, presents a complex issue that requires careful consideration within the context of IHL, which currently lacks clear provisions for addressing their legal status. …”
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4803
Review of the hydrological effects of the extreme event Hurricane Eta in the Chiriquí Viejo River basin, November 2020
Published 2025-06-01“…The maximum rainfall recorded on November 4, 2020, reached 223.8 mm, while the flow in Paso Canoa reached 638.03 m³/s, demonstrating the magnitude of the event and the inability of the basin to handle such high volumes of water.Through a detailed analysis, it was observed that soil saturation resulted in direct runoff of up to 70.0 mm that same day, which shows that the infiltration capacity of the soil was quickly exceeded.Despite the damage observed, there are currently no advanced hydrological studies on extreme events in critical basins such as the Chiriquí Viejo River.This lack of research reflects a serious lack of planning and assessment of the risks associated with phenomena of this magnitude.One of the most critical problems found is the lack of specialized hydrology professionals, who are essential to carry out detailed studies and ensure sustainable management of water resources.In a context where climate change increases the frequency and intensity of extreme events, the absence of hydrologists in the region puts the resilience of the basin to future disasters at risk.The basin's hydraulic system demonstrated its inability to handle high flows, underscoring the need to improve flood control and water retention infrastructure.In addition, the lack of effective hydrological planning and coordination in the management of hydraulic infrastructures compromises both the safety of downstream communities and the sustainability of hydroelectric reservoirs, vital for the region.…”
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4804
Promising areas and megatrends in the development of logistics technologies in the future
Published 2025-05-01“…The authors have determined that the key trend is increasing the flexibility of the logistics process, improving its ability to adapt to changing external conditions and continuously improve. …”
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4805
RETRACTED: Recent trends in the use of bacteriophages as replacement of antimicrobials against food-animal pathogens
Published 2023-05-01“…Additionally, bacteria are becoming more resistant to antibiotics, which pose a global threat. Currently, many scientific efforts have been made to develop and implement new technologies to combat bacteria considering the increasing emergence of multidrug-resistant bacteria. …”
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4806
Experience in implementing a patient-centered approach in a private medical organization
Published 2022-09-01“…Currently, taking into account the pronounced competition among modern medical organizations, attracting patients and forming a high degree of their loyalty requires significant efforts both in the field of ensuring the quality of medical services provided, and in the field of full implementation of legally enshrined patient rights, compliance with ethical and deontological norms, the formation of effective communication and integration processes between employees of a medical organization and patients and/ or their relatives, and in the context of the activities of a private medical organization, special work is also largely required to optimize the main business processes. …”
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4807
PO54 | FATTY INFILTRATION AND POTENTIAL ADIPOGENIC SHIFT OF SKELETAL MUSCLE CELLS: MULTIPARAMETRIC HISTOLOGICAL ANALYSIS OF MYOSTEATOSIS
Published 2025-08-01“… Myosteatosis, defined as an ectopic fat accumulation within skeletal muscle, has gained increasing clinical relevance as it fits within the context of metabolic disorders and aging. …”
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4808
Refinement of the Reference Viral Database (RVDB) for improving bioinformatics analysis of virus detection by high-throughput sequencing (HTS)
Published 2025-07-01“…ABSTRACT All biological products are required to demonstrate the absence of adventitious viruses (AVs), which may be inadvertently introduced at different steps involved in the manufacturing process. The currently recommended in vitro and in vivo virus detection assays have limitations for broad detection and are lengthy and laborious. …”
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4809
Identification, Evolution and Expression Analyses of the Hox Family in Procambarus clarkii
Published 2025-08-01“…Homeobox genes are ubiquitous in eukaryotic genomes and can be transcribed into a homeodomain of approximately 60 amino acids. Hox genes are currently the most studied class of homeobox genes. …”
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4810
Biooxidation of Arsenopyrite by <i>Acidithiobacillus ferriphilus</i> QBS 3 Exhibits Arsenic Resistance Under Extremely Acidic Bioleaching Conditions
Published 2025-05-01“…As described in this paper, through arsenic acclimation, the maximum arsenic tolerance concentration of <i>Acidithiobacillus ferriphilus</i> QBS 3 isolated from arsenic-containing acid mine drainage was increased to 80 mM As(Ⅲ) and 100 mM As(V). …”
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4811
Effect of acid modification of natural zeolites on the adsorption of some pharmacopollutants
Published 2022-12-01“…Treatment of these waters is carried out comprehensively by various methods, which significantly increases costs. Currently, the problem of a large amount of drugs entering the wastewater is very relevant. …”
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4812
Smart Packet Delivery in Mobile Underwater Sensors Networks (M-CTSP)
Published 2025-01-01“…This research is focused on leveraging the Travelling Salesman Problem (TSP) to establish the optimal route of getting from a source node to a destination node in an underwater dynamic location. In this context, all nodes are mobile and slightly adjust their positions due to water currents. …”
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4813
Digital Transformation Strategy of Aerospace Industry
Published 2025-04-01“…The aerospace industry, as an important representative of high-end manufacturing, plays an irreplaceable role in the development of new-quality productivity. In the context of increasingly complex projects and rapid iteration of new technologies, the development model of the aerospace industry is facing significant challenges and urgently requires digital transformation to promote high-quality development of the industry. …”
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4814
Supply Chain Model for Mini Wind Power Systems in Urban Areas
Published 2025-02-01“…The pursuit of energy security has become one of the most important challenges facing modern societies worldwide. The increase in energy consumption and the need to promote sustainability puts pressure on power generation systems. …”
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4815
Standardized Outcomes for Randomized Controlled Trials Targeting Early Interventions in Patients With Moderate-to-Severe Traumatic Brain Injury: Protocol for the Development of a C...
Published 2025-01-01“…In the last 20 years, there has been an increase in clinical trials in neurocritical care, leading mostly to negative results. …”
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4816
Exercise Promotes Hippocampal Neurogenesis in T2DM Mice via Irisin/TLR4/MyD88/NF-κB-Mediated Neuroinflammation Pathway
Published 2024-10-01“…Moreover, exercise markedly increased the levels of fibronectin type III domain-containing protein 5 (FNDC5)/irisin protein while decreasing the expression of Toll-like receptor 4 (TLR4), myeloid differential protein-88 (MyD88), and nuclear factor kappa-B (NF-κB) in the hippocampus of T2DM mice. …”
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4817
Test, Modeling, and Vibration Control of a Novel Viscoelastic Multi-Dimensional Earthquake Isolation and Mitigation Device
Published 2024-11-01“…Earthquakes contain complex components in both the horizontal and vertical directions. …”
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4818
Oral vs. Outpatient Parenteral Antimicrobial Treatment for Infective Endocarditis: Study Protocol for the Spanish OraPAT-IE GAMES Trial
Published 2025-03-01“…Conclusion In a global context of limited healthcare resources and a sustained increase in elderly and frail patients, it is of great importance to demonstrate the effectiveness and safety of outpatient management strategies that could reduce the duration of conventional hospitalizations with their potential complications and inherent costs. …”
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4819
OPTIMIZATION OF IMID-BASED THERAPIES
Published 2024-12-01“…In this case, it is clear that multiple myeloma treatment optimization cannot be achieved by considering multiple myeloma treatment only as applying the appropriate drug combination.In order to ensure the optimization of IMID-based therapies, it is necessary to take a broad perspective.This perspective should include the correct selection of the patient to be treated with IMID, the development and implementation of IMID forms that will increase patient compliance, the use of techniques to predict the development of resistance, side effect management during treatment, preventing the increase in disease burden with appropriate maneuvers by following the disease burden after treatment, and drug-free follow-up.It is recommended to avoid thalidomide in the presence of peripheral neuropathy, to prefer other agents instead of lenalidomide in the presence of renal function loss, and to avoid pomalidomide in patients with COPD.Nex-20, a once-monthly subcutaneous formulation of lenalidomide, is expected to be an important breakthrough in improving patient compliance.Prediction of which patients will develop resistance will be very useful in order to have the best treatment outcomes.Calculation of miRNA risk scores, measurement of lenalidomide metabolite levels in urine, measurement of cereblon levels in blood, or immunohistochemical detection of cereblon levels are some of the methods currently being tried to predict disease resistance.Patients who develop anemia should be treated with erythropoietin, skin reactions should be treated with steroids and antihistamines, diarrhea should be treated with loperamide and colestyramine, and in general, the drug should be discontinued and the same dose or a lower dose should be insisted upon.An important part of treatment is maintenance therapy with lenalidomide. …”
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4820
Justification of military neutrality of the Republic of Serbia at a time of erosion of neutrality in Europe
Published 2023-01-01“…Increase of NATO members, as well as abandoning neutrality under the influence of globalization and negative experiences of neutral countries in the 20th century, strengthens this assertion. …”
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