Unraveling the complex role of microglia in Alzheimer’s disease: amyloid β metabolism and plaque formation by Sho Takatori, Mayuna Kondo, Taisuke Tomita

“…Conversely, we explore findings that challenge this view, such as microglial depletion experiments resulting in unchanged or decreased Aβ accumulation. We propose that the contribution of microglia to Aβ metabolism is context-dependent, varying with disease progression, genetic background, and experimental conditions. …”
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Social Skills Training Program and its Effect on Quality of Life and Stigma among Patients with Schizophrenia by Samah Ali, Amal Awad, Hanaa Ewise, Shimaa Adam

“… Context: Schizophrenia is a severe mental disorder that significantly disrupts an individual's social interactions, work performance, and overall quality of life. …”
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Therapeutic potential of microRNAs in neurological disorders: mechanisms, biomarkers, and emerging therapeutic strategies by Sourav Pal, Subhajit Mandal

“…This review explores the biogenesis of miRNAs and their dysregulation in neurological disorders, highlighting specific miRNAs that serve as potential biomarkers and therapeutic targets. For instance, decreased levels of miR-125b-5p and miR-26b-5p in cerebrospinal fluid have been associated with Alzheimer’s disease progression. …”
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Overcoming immunosuppression in cancer: how ketogenic diets boost immune checkpoint blockade by Victoria E. Stefan, Daniela D. Weber, Roland Lang, Barbara Kofler

“…., high-fat low-carbohydrate diets, have been shown to have antiproliferative and immunomodulatory effects in various preclinical cancer studies. Here, we review current knowledge of the complex interplay of KDs and the anti-tumor immune response in the context of ICB therapy, to update our understanding of diet-induced immunometabolic reprogramming in cancer. …”
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Horticultural performance and QTL mapping of snap bean (Phaseolus vulgaris L.) populations with organic and conventional breeding histories by Hayley E. P. Richardson, Ryan M. King, Joel Davis, James R. Myers

“…IntroductionImproving crop cultivars for use on organic farms is pertinent, as current elite germplasm is less resilient within the more variable context of organic farm environments. …”
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Stacked-cup multiwall carbon nanotubes as components of energy-intensive suspension jet fuels by L. S. Karpushenkava, G. Ya. Kabo, A. V. Blokhin

“…The addition of high-density carbon materials to jet fuels can lead to a significant increase in the volumetric energy of the fuel combustion. …”
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Assessment of Socio-Economic Impacts of Hyperloop Technology on European Trade Routes by Aleksejs Vesjolijs, Yulia Stukalina, Olga Zervina

“…In this paper, twelve different scenarios are constructed and compared; these scenarios contain the description of current EU trade routes that could be influenced by Hyperloop and those that could be introduced given the improved delivery times and sustainable business opportunities. …”
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Cryo-EM and cryo-ET reveal the molecular architecture and host interactions of mycobacteriophage Douge by Jitendra Maharana, Chun-Hsiung Wang, Li-An Tsai, Yi-Ting Liao, Cheng-Han Yang, Melvin C. Shen, Lourriel S. Macale, Thang Ngoc Tran, Joemark Narsico, Ronelito J. Perez, Sunil Kumar Tewary, Jian-Li Wu, Hong-You Lin, Shu-Wei Chang, Aaron Franklin, Patrick J. Moynihan, Deborah Jacobs-Sera, Krista G. Freeman, Graham F. Hatfull, Todd L. Lowary, Meng-Chiao Ho

“…Molecular insights into mycobacteriophage architecture and host interactions could allow structure-guided phage engineering to increase efficacy and broaden host range, but such information is currently unavailable. …”
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Legal Challenges of Marine Insurance Laws in the Use of Unmanned Ships by Mahsa Bahadoran- Baghbaderani, Masoud Shirani, Reza Soltani

“…While such defects can lead to severe incidents, most current insurance policies do not cover these risks. …”
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Harnessing stromal vascular fraction-based therapies for wound healing: Mechanisms, synergies, and clinical translation by Jing Wu, Yao Wang, Wenjie Chen, Min Lin, Jinwen Jiang, Hongde Jiang, Zehuan Li, Kailei Xu, Bin Zhang

“…Wound healing remains a major challenge in contemporary medicine, particularly with the increasing incidence of chronic wounds, such as those associated with diabetes and thermal injuries. …”
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Impact of Sustainable Environmental Expenditures Policy on Air Pollution Reduction, During European Integration Framework by Ionel Bostan, Mihaela Onofrei, Elena-Doina Dascălu, Bogdan Fîrtescu, Carmen Toderascu

“…These are the total investments made in the mining sector; when these expenses were raised by 1% of the GDP value, there was a decrease of 11 628.3 thousand tons Cot at the level of the European countries analysed, according to the result of the OLS analysis, based on the robust M estimation.…”
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Phenotypic and functional changes of NK cells in patients with myelodysplastic syndrome and acute myeloid leukemia treated with hypomethylating drugs by D. I. Zhigarev, M. V. Khoreva, L. V. Gankovskaya

“…Meanwhile, the origin of this change and its role are important in the context of the disease pathogenesis. Ultimately, a simple description of an increase or decrease in a single receptor expression is not illustrative, since it can lead to uncertain consequences. …”
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RELEVANT CONCEPTS OF A TEACHER’S STATE WHEN EXPERIENCING PROFESSIONAL IDENTITY CRISIS by N. O. Sadovnikova, A. M. Mirzaahmedov

“…Recently, a professional activity and development of a teacher has been carried out in the context of permanent changes in the education system. …”
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Enhanced differentiation between 3‐hydroxyglutaric and 2‐hydroxyglutaric acids facilitates diagnostic testing for glutaric aciduria type 1 by Denis Cyr, Michel Boutin, Bruno Maranda, Paula J. Waters

“…Accurate quantitation of urinary 3‐HG is crucial in diagnostic workup for GA1, but in this context, current gas chromatography–mass spectrometry (GC–MS) methods have inherent analytical challenges. …”
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Assessment of Sexual Functions among Infertile Women by Azza A. Mohamed, Aziza A. Attia, Hanan A. Mahjoub

“… Context: Sexual function plays a vital role in the quality of life and is determined by both biological and psychosocial factors. …”
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Advancing Energy Transition: A Circular Economy Framework for Co-Optimizing Energy, Water, and Emissions in Low-Carbon Systems by Mohamed Elsir, Ameena Saad Al-Sumaiti, Mohamed Shawky El Moursi

“…This integrated methodology allows us to achieve unprecedented results: a 9% reduction in peak load, 4% cost savings, and a 6.6% decrease in CO2 emissions in benchmark IEEE test systems. …”
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An analysis of data quality and population characteristics of the SIGN online surgical database: A 20 year review by Matthew Roces, Ericka von Kaeppler, Claire Donnelley, Mayur Urva, Abigail Cortez, Kelsey Brown, Michael Flores, Patricia Rodarte, Kian Niknam, Francisco Gomez-Alvarado, Babapelumi Adejuyigbe, Lewis Zirkle, David Shearer

“…However, the quality of data contained in the SOSD is largely unknown. The aim of the current study was to analyze the trend in data quality and follow-up rate of the SOSD over the past two decades. …”
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Immunisation of young children against influenza — evidence review by V. A. Bulgakova, L. R. Selimzyanova, T. E. Privalova, D. A. Yusupova

“…Influenza is a highly contagious viral infection and poses a serious burden, especially for children under 5 years of age due to an increased risk of severe illness and hospitalization. …”
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Influence of fruit stages on chemical compositions, phytochemicals, and antioxidant activity of wood apple (Feronia limonia (L.) Swingle) by Rashmi Srivastava, Neha Mishra, Arshi, Shraddha Tripathi, Smriti, Neha Taslim Fatima, Neetu Mishra

“…Swingle is an underappreciated tropical fruit, contains several vitamins, minerals, and bioactive substances, yet it has received significantly less attention. …”
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Age of tobacco, nicotine and cannabis use initiation in Switzerland: a sequence analysis among adolescents and young adults by Diana Fernandes, Lorraine Chok, Jérémy Cros, Luc Lebon, Karin Zurcher, Alexandre Dubuis, Cathy Berthouzoz, André Berchtold, Yara Barrense-Dias

“…Conclusions Cigarettes remain the first product to be used, but the younger the respondents, the earlier they start using e-cigarettes, and very close to cigarettes. Regarding current consumption patterns, e-cigarettes are becoming increasingly prominent.…”
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