Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype. by Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, Paul Kellam, Wendy Barclay

“…New variants of SARS-CoV-2 are continually emerging with mutations in spike associated with increased transmissibility and immune escape. Phenotypic maps can inform the prediction of concerning mutations from genomic surveillance, however most of these maps currently derive from studies using monomeric RBD, while spike is trimeric, and contains additional domains. …”
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Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. by Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry

“…Indeed, ghrelin does not modify synaptic currents of GHRH neurons. However, ghrelin exerts a strong and direct depolarizing effect on GHRH neurons, which supports their increased firing rate.…”
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Cranberry Leaves as Feed Additive in Poultry Nutrition: Effects on Performance and Oxidative Stability by Arabela Elena Untea, Iulia Varzaru, Mihaela Saracila, Petru Alexandru Vlaicu, Alexandra-Gabriela Oancea, Tatiana Dumitra Panaite

“…The leaves belonging to that species can be considered a cost-effective alternative in the context of reducing antibiotics strategy in animal nutrition. …”
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Cost-effectiveness of atezolizumab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in the US and Chinese setting: a modelling compa... by Lei Wang, Lulu Liu, Yiling Ding, Qilin Zhang, Yamin Shu

“…In scenario analyses, the atezolizumab plus bevacizumab treatment becomes favourable when the cost of atezolizumab decreases to 67.85% and 18.45% of its original price in the USA and China, respectively.Conclusions The atezolizumab plus bevacizumab is unlikely to be cost-effective compared with sorafenib for patients with unresectable HCC in the context of the USA and China. …”
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IAE-CDNet: A Remote Sensing Change Detection Network for Buildings With Interactive Attention-Enhanced by Zhaoyang Han, Linlin Zhang, Qingyan Meng, Chongchang Wang, Wenxu Shi, Maofan Zhao

“…Currently, the development of deep learning has had a positive impact on remote sensing image change detection tasks, but many current methods still face challenges in effectively processing global and local features, especially in the task of building change detection in high-resolution images containing complex scenes. …”
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Variation and prognostic potential of the gut antibiotic resistome in the FINRISK 2002 cohort by Katariina Pärnänen, Matti O. Ruuskanen, Guilhem Sommeria-Klein, Ville Laitinen, Pyry Kantanen, Guillaume Méric, Camila Gazolla Volpiano, Michael Inouye, Rob Knight, Veikko Salomaa, Aki S. Havulinna, Teemu Niiranen, Leo Lahti

“…Resistance was linked not only to prior use of antibiotics, as anticipated, but also to frequent consumption of fresh vegetables and poultry, two food groups previously reported to contain antibiotic-resistant bacteria. Interestingly, resistance was not linked to the consumption of high-fat and high-sugar foods, but was consistently higher in females and urban high-income individuals, who currently have generally lower mortality rates. …”
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Establishing priorities for future land conservation to maximise biodiversity conservation and other ecosystem services in the Tilarán Mountains of Costa Rica by Lindsay Stallcup, Matthew D. Moran, Doris Rojas, Erich Mata

“…The opportunity to connect currently protected areas to one another through effective biological corridors still remains, possibly through conservation partnerships with landowners or direct land purchase, but time could be short as increasing development and changing land-use patterns threaten to further isolate habitats in the MAB.…”
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Exposure to secondhand smoke from cigarettes and secondhand aerosol from tobacco and nicotine products in indoor and outdoor public spaces in the European Union: a cross-sectional... by Anthony A Laverty, Ariadna Feliu, Filippos T Filippidis, Constantine I Vardavas, Cristina Martínez, Charis Girvalaki, Armando Peruga, Charlotte Xin Li, Pin-Chun Wang, Cornel Radu Loghin

“…Introduction In December 2024, the Council of the European Union (EU) adopted a recommendation to expand regulations on the use of nicotine-containing products both in indoor settings and specific outdoor areas. …”
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Effect of temperature on corrosion behaviors of copper in high-level nuclear waste disposal environment by Tianyu Wang, Chengtao Li, Lijun Song, Xiang Cai, Jian Chen, Zhilin Chen, Qichao Zhang, Yishan Jiang, Yanxin Qiao

“…The results showed that the increase in temperature can accelerate both cathodic and anodic reactions, thereby increasing the corrosion current density. …”
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Standalone ultrasound-based highly visualized volumetric spine imaging for surgical navigation by Xinben Hu, Tianjian Liu, Zhengyuan Zhang, Xuan Xiao, Lin Chen, Gao Wei, Yunjiang Wang, Keji Yang, Haoran Jin, Yongjian Zhu

“…Abstract Current navigation systems employing intraoperative CT have been applied in spinal interventions for accurate and visualized guidance. …”
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Screen-printed Carbon Electrode from Coconut Shell Activated Carbon Modified with Ferrocene for Cobalt Detection by Muhammad Farhan, Eddy Heraldy, Abu Masykur, Muhammad A. Munir, Fitria Rahmawati

“…The cyclic voltammetry analysis found that 10% Fc on SPCE provides the highest current density compared to 20% and 30%. Meanwhile, the 2 mV s-1 scanning rate reveals a more defined anodic and cathodic peak than 3 mV s-1 and 5 mV s‑1. …”
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Genetic Diversity and Mutation Frequency Databases in Ethnic Populations: Systematic Review by Shumaila Khan, Mahmood Alam, Iqbal Qasim, Shahnaz Khan, Wahab Khan, Orken Mamyrbayev, Ainur Akhmediyarova, Nurzhan Mukazhanov, Zhibek Alibiyeva

“…The review also addressed standardization and data quality challenges prevalent in current NEMDBs. ResultsThe analysis of 42 NEMDBs revealed significant issues, with 70% (29/42) lacking standardized data formats and 60% (25/42) having notable gaps in the cross-comparison of genetic variations, and 50% (21/42) of the databases contained incomplete or outdated data, limiting their clinical utility. …”
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Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels. by Chunfang Gu, Miranda S C Wilson, Henning J Jessen, Adolfo Saiardi, Stephen B Shears

“…The HCT116 cell line, which has a pseudo-diploid karotype, is a popular model in the fields of cancer cell biology, intestinal immunity, and inflammation. In the current study, we describe two batches of diverged HCT116 cells, which we designate as HCT116NIH and HCT116UCL. …”
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Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior. by Henry H Jerng, Jay M Patel, Tamor A Khan, Benjamin R Arenkiel, Paul J Pfaffinger

“…We also find that an Opto-Kv1 construct containing a dominant-negative pore mutation (Opto-Kv1(V400D)) can be used to down-regulate Kv1 currents in a blue light-dependent manner. …”
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Investigation of the content of unsaturated hydrocarbons in transformer oils using IR spectroscopy by M. Sh. Garifullin, Y. N. Slobodina, A. R. Bikzinurov, R. A. Giniatullin, V. A. Chernyshov

“…THE  PURPOSE. To  analyze  the  current  understanding  of  unsaturated  hydrocarbons with  double  C=C  bonds  in  mineral  transformer  oils  and  evaluate  the  effectiveness  of  modern methods of controlling the content of these compounds in oils. …”
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The development of a beneficiation process to remove carbonates from lithium sedimentary claystones by Sabinus Essel Arthur, Emmanuel Atta Mends, Angela Manka Tita, Pengbo Chu

“…These carbonates not only increase acid consumption during leaching but also result in the generation of pure carbon dioxide. …”
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Sensitivity Approach for Blood Glucose Impedance Data Using the Geselowitz Theorem by Bruna Gabriela Pedro, John Alexander Gomez Sanchez, Pedro Bertemes-Filho

“…The article presents a preclinical study focused on developing a non-invasive blood glucose monitoring device. Current glucose monitoring methods, such as capillary or venous tests, are inconvenient for frequent use, making continuous monitoring challenging. …”
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Is Brazil reaching malaria elimination? A time series analysis of malaria cases from 2011 to 2023. by Klauss Kleydmann Sabino Garcia, Seyi Soremekun, Amanda Amaral Abrahão, Paola Barbosa Marchesini, Chris Drakeley, Walter Massa Ramalho, André M Siqueira

“…Pf infections remain a persistent challenge to control in the country and may require novel measures for containment. Current government supporting actions towards combating illegal goldmining activities and protecting indigenous populations may help malaria control indicators for the following years.…”
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STUDY ON THE PERCEPTION OF STUDENTS OF THE FACULTY OF MANAGEMENT AND RURAL DEVELOPMENT REGARDING THE TEACHING - LEARNING-ASSESSMENT ACTIVITY CARRIED OUT ONLINE DURING THE COVID-19... by Ramona Elena ANGHEL, Alina MARCUTA, Cristiana TINDECHE, Mihaela ROSU, Constantin TRAISTARU, Liviu MARCUTA

“…The Faculty of Management and Rural Development is one of the 7 faculties of the University of Agronomic Sciences and Veterinary Medicine in Bucharest and which, through the mission and objective, it has proposed as the university curriculum to increase the quality of the didactic act with the aim of training specialists who can integrate into the current knowledge-based society, specialists who can assume responsibilities, be creative, original, flexible, adaptable, with an analytical thinking, innovative and able to run businesses, so that the motto of the faculty is "Preparing to lead!". …”
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Nanoindentation Simulation of Hardening Caused by Cr Precipitates in FeCr Alloy by WANG Shumin, HE Xinfu, CAO Jinli

“…By analyzing the dislocations, it is found that the dislocation length in Fe matrix containing Cr clusters decreases obviously, while the nucleation time of dislocations and the depth of indenter when dislocations nucleate slightly increase, indicating that the addition of Cr clusters slightly slows down the nucleation of dislocations and significantly hinders the expansion of dislocations in the matrix. …”