Transcriptomic analysis on pancreatic adenocarcinoma patients uncovers KRAS-mediated PPAR pathway alteration by Giuseppe Defazio, Federico Scolari, Sara Fancelli, Simone Polvani, Daniele Lavacchi, Lucia Picariello, Alessandro Tubita, Michaela Luconi, Lorenzo Antonuzzo, Lorenzo Antonuzzo, Andrea Galli, Serena Pillozzi

“…The incidence and mortality of pancreatic adenocarcinoma (PC) are expected to increase in the coming years, with survival rates remaining poor due to limited treatment options. …”
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Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances by Qiu Jiang, Jie Liu, Shan Huang, Xuan-Yue Wang, Xiaowei Chen, Guang-Hui Liu, Keqiang Ye, Weihong Song, Colin L. Masters, Jun Wang, Yan-Jiang Wang

“…Abstract In the context of global ageing, the prevalence of neurodegenerative diseases and dementia, such as Alzheimer’s disease (AD), is increasing. …”
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TRANSFORMING MUSIC EDUCATION IN UKRAINE: OPPORTUNITIES AND CHALLENGES IN CULTURAL AND ARTISTIC EDUCATION REFORM by Ihor ZAKUS, Nataliia LEBEDIEVA, Irma GVINIASHVILI, Viktoriya KORZHENOK, Dennis ADU

“… The article discusses the current challenges and prospects for developing music education in Ukraine while reforming the cultural and artistic sphere. …”
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Electrochemical performance and interfacial stability in Ni-rich NCM/ halide solid state batteries by Jing Wang, Yi Zhang, Yingchun Lyu, Tu Lan, Bing Han, Yitong Guo, Zexi Yang, Jingjing Zhou, Shangqian Zhao, Rong Yang, Shigang Lu

“…AC impedance analysis reveals increased interfacial impedance at high potentials, particularly during constant-current/constant-voltage charging, indicating interfacial instability. …”
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Effects of Deposition Power and Annealing Temperature on Indium Zinc Oxide (IZO) Film’s Properties and Their Applications to the Source–Drain Electrodes of Amorphous Indium Gallium... by Yih-Shing Lee, Chih-Hsiang Chang, Bing-Shin Le, Vo-Truong Thao Nguyen, Tsung-Cheng Tien, Horng-Chih Lin

“…Both resistances decreased significantly as the annealing temperature increased from 200 °C to 300 °C.…”
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A computational fluid dynamics (CFD) study on extraction of geothermal energy in Bangladesh by Prodeepta Neogi, Md Tauhidur Rahman, Khairul Habib, Md. Sayeedur Rahman Sakib, Fardin Islam, Khandakar Fahim Anjum, SM Shakhawat Hossain, Md․Aliur Rahman

“…Due to Bangladesh’s elevated geothermal gradients for its tectonic position, geothermal energy can be harnessed through directionally drilled U-shaped wells, enhancing current designs by removing internal pipes and optimizing contact with elevated subsurface temperatures. …”
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ENHANCING ACCOUNTABILITY FOR MAKING CITIES RESILIENT AND ROLE OF SUPREME AUDIT INSTITUTIONS by Arife Coşkun, Latif Gürkan Kaya

“…Currently,more and more people are settling in cities, located in disaster prone areas. …”
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Formation of Innovative Infrastructure of the Industrial Sphere by M. Ya. Veselovsky

“…The purpose of article is increase in efficiency of innovative infrastructure of the industrial sphere. …”
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Assessment of Reader Technologies for Over-the-Counter Diagnostic Testing by Mia Cirrincione, Maren Downing, Kevin Leite, Samuel Dolphin, Adam Samuta, Mack Schermer, Kimberly Noble, Brian Walsh

“…Reader technology type, which is predictive of core reader attributes, should be considered when selecting a reader technology for a specific LFA test within the context of regulatory guidance. As diagnostics increase in complexity, readers provide solutions to accessibility challenges, facilitate public health reporting, and ease the transition to multiplex testing, therefore increasing market availability.…”
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Defining, assessing, and implementing organizational health literacy: barriers, facilitators, and tools – a systematic review by Nicola Pelizzari, Loredana Covolo, Elisabetta Ceretti, Carlotta Fiammenghi, Umberto Gelatti

“…This systematic review synthesizes current research on OHL, focusing on its definitions, assessment tools, implemented practices, outcomes, and the factors influencing successful OHL integration within healthcare settings. …”
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Relevance of reporting leprosy related disability at the completion of multi drug therapy: A 5-year retrospective analysis of disability in persons affected by leprosy at ALERT Hos... by Bereket Abebayehu Tegene, Thomas Asfaw Atnafu

“…WHO should make some changes in the way it counts disability as the current definitions are prone to interpretation bias and lacks uniformity among various programmes and health workers. …”
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Co-benefits of resilience planning: a review of analysis tools and methods by Jennifer F. Helgeson, Azin Al Kajbaf, Juan F. Fung

“…Fung and Helgeson reviewed the literature on co-benefits with a specific focus on the definition of co-benefits, areas where co-benefits are used the most (considering the literature related to climate change), and co-benefit measurement and assessment methodologies in the context of resilience planning. The current study further explores these areas by focusing on the development of the literature on co-benefits published since 2017. …”
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Target image detection algorithm of complex road scene based on improved multi-scale adaptive feature fusion technology by Xu Zhaosheng, Liao Zhongming, Xiao Xiaoyong, Ahmad Suzana, Mat Diah Norizan, Ismail Azlan

“…Understanding road scenes is crucial to the safe driving of autonomous vehicles, and object detection in road scenes is necessary to develop driving assistance systems. Current object detection algorithms are not very good at handling complex road scenes, and public datasets do not always adequately represent city traffic. …”
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The science behind the lifesum app: an intervention design analysis by Signe Svanfeldt, Chris Seth, Marcus Gners, Andreas Blomqvist

“…This was an intervention design analysis, designed to describe the theoretical model and intervention theory used to create the Lifesum app in its current embodiment. A pragmatic theoretical model describing behaviour change in the context of healthy eating was devised based on findings in literature. …”
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CMIP6 multi-model ensemble projection of reference evapotranspiration using machine learning algorithms by Milad Nouri, Shadman Veysi

“…This highlights the critical necessity for adaptive strategies in agricultural water management to mitigate the adverse CC effects. In this context, the current findings can assist decision-makers in identifying hotspots and quantifying CC impacts, thereby enabling the design of crucial adaptations.…”
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Insurtech innovations and telematics as «drivers» of change in the insurance industry by A.Yu. Polchanov, K.O. Halatiuk

“…The purpose of the article is to analyze the impact of the introduction of innovative technologies (Insurtech) and telematics on the development of the insurance market in the context of increasing globalization trends. Results. …”
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Modelling the supply and need for health professionals for primary health care in Ghana: Implications for health professions education and employment planning. by James Avoka Asamani, Christmal Dela Christmals, Gerda Marie Reitsma

“…By 2035, US$ 2.374 billion must be planned for the employment of those that would have to be trained to fill the need-based shortages and for sustaining the employment of those currently available.…”
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From bench to bedside: nanomedicine development for intracerebral hemorrhage – exploring microenvironment, innovation, and translation by Gui Wan, Lingui Gu, Yangyang Chen, Yiqing Wang, Ye Sun, Zhenwei Li, Wenbin Ma, Xinjie Bao, Renzhi Wang

“…Finally, the progress of nanomedicines in clinical translation is analyzed, highlighting the challenges, opportunities, and future prospects for their application in the context of ICH. Graphical abstract…”
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Reducing long‐term use of benzodiazepine receptor agonists: In‐depth interview study with primary care stakeholders by Kristien Coteur, Sanne Peters, Pieter Jansen, Birgitte Schoenmakers, Marc Van Nuland

“…Although primary care professionals in this study found discontinuation of long‐term BZRA use relevant to the patient's health, many organisational and personal barriers were reported. Moreover, the current social and healthcare context is not empowering patients and professionals to reduce long‐term BZRA use for insomnia. …”
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Extraterritorial Human Rights Obligations in the Area of Climate Change: Why the European Union Should Take Them Seriously by Chiara Tea Antoniazzi

“…After exploring the wide array of EU climate measures and their extensive impacts on third countries and persons living therein, the Article offers an overview of the historical evolution and current state of ex-traterritorial human rights obligations in general and in the context of climate change specifically, pay-ing special attention to recent judicial and quasi-judicial developments. …”
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