Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Understanding of the mechanisms underlying productive HEV infection remains incomplete and would benefit from technological advances improving current model systems. Methods: We exploited transposon-mediated random insertion and selection of viable clones to identify sites in the HEV open reading frame 2 (ORF2) protein, corresponding to the viral capsid, allowing for the insertion of reporter sequences in a functional context. …”
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Unlocking the potential of global greenhouse gas mitigation by reducing food loss and waste by Suraj Negi, Liang-Shih Fan, Hyunook Kim, Taira Hidaka, Aishwarya Rani, Shu-Yuan Pan

“…Food loss and waste (FLW) are significant yet under-addressed contributors to global greenhouse gas (GHG) emissions, and the effectiveness of current FLW mitigation policies and valorization technologies remains insufficiently explored. …”
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Temporal and Spatial Evolution and Driving Force Analysis of Water Conservation Function in Yunnan Province Based on Climate and Land Use Change by LIU Fengru, ZHAO Junsan, LIN Yilin, CHEN Guoping, ZHANG Longjiang, PENG Sufen

“…The framework can predict land use change and assess water conservation in the context of future climate change and different economic developments. …”
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Climate change reduces warming potential of nitrous oxide by an enhanced Brewer‐Dobson circulation by Daniela Kracher, Christian H. Reick, Elisa Manzini, Martin G. Schultz, Olaf Stein

“…N2O is a potent greenhouse gas and the most relevant currently emitted ozone‐depleting substance. Here we examine the implications of a reduced N2O lifetime in the context of climate change. …”
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Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection by Carrie L. Butler, Nicole M. Valenzuela, Kimberly A. Thomas, Elaine F. Reed

“…This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR).…”
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Research on precision shaping technology of CVT for fairway cBN grinding wheel by Xiangguo QIN, Ziying ZHANG, Dongsheng TANG

“…When adjusting the program, the contact angle is adjusted to a negative difference, and the allowable wear amount of the tool grinding wheel is increased to prolong the service time of the tool grinding wheel. …”
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Removal of microplastics by electrocoagulation by Alex Pilco-Nuñez, Edilberto Hinostroza-Antonio, Pablo Diaz-Bravo, Wendy Palacios-Salvador, Richard Solis-Toledo, Jhanover Baldeon-Romero

“…With the gradual increase of microplastics in water bodies, it is essential to understand the current treatment processes for their removal. …”
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The impacts of climate variability on conflict risk in conflict-prone regions worldwide by Xiaolan Xie, Fangyu Ding, Mengmeng Hao, Jun Zhuo, Shuai Chen, Jiajie Wu, Jiping Dong, Kai Sun, Qian Wang, Dong Jiang

“…The meta-analysis shows that one standard positive temperature deviation (1σ), increased extreme precipitation, and decreased precipitation induce 0.81 %, 2.53 %, and 1.04 % increment respectively in the risk of conflict incidence, as well as 1.12 %, 2.55 %, and 1.15 % decrement respectively in the risk of conflict onset. …”
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Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins by Georgy Berezhnoy, Gyuntae Bae, Leonie Wüst, Claudia Schulte, Claire Cannet, Isabel Wurster, Milan Zimmermann, Alexander Jäck, Eike Jakob Spruth, Julian Hellmann-Regen, Sandra Roeske, Dominik Pürner, Wenzel Glanz, Fabian Maass, Felix Hufschmidt, Ingo Kilimann, Elisabeth Dinter, Okka Kimmich, Anna Gamez, Johannes Levin, Josef Priller, Oliver Peters, Michael Wagner, Alexander Storch, Paul Lingor, Emrah Düzel, Christoph van Riesen, Ullrich Wüllner, Stefan Teipel, Björn Falkenburger, Mathias Bähr, Inga Zerr, Gabor C. Petzold, Annika Spottke, Patricia Rizzu, Frederic Brosseron, Hartmut Schäfer, Thomas Gasser, Christoph Trautwein

“…Abstract The challenge of early detection and stratification in Parkinson’s disease (PD) is urgent due to the current emergence of mechanism-based disease-modifying treatments. …”
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Alpha Helices Are More Robust to Mutations than Beta Strands. by György Abrusán, Joseph A Marsh

“…The rapidly increasing amount of data on human genetic variation has resulted in a growing demand to identify pathogenic mutations computationally, as their experimental validation is currently beyond reach. …”
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Insomnia, Cognitive Impairment, or a Combination of Both, Alter Lipid Metabolism Due to Changes in Acylcarnitine Concentration in Older Persons by Selma Karime Castillo-Vazquez, Berenice Palacios-González, Marcela Vela-Amieva, Isabel Ibarra-González, Ricardo Morales, Paola García-delaTorre, Sergio Sánchez-García, Carmen García-Peña, Ricardo Reyes-Chilpa, Raúl Hernán Medina-Campos, Jessica Hernández-Pineda, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura

“…Results: Our results show that insomnia increases the concentration of acylcarnitines (C10, C8, C14, C12:1, C18:1 and C18) as compared to CI group, while older persons with CI show a decrease the concentration of the acylcarnitines C16, C10 and C8. …”
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Compost from the food waste for organic production of cabbage, cauliflower, and radish under sub-tropical conditions by Neha Kumari, Anit Sharma, Mamta Devi, Atif Zargar, Sunny Kumar, Umesh Thakur, Ajay Bhatia, Khushboo Badhan, Sunaina Chandel, Arpana Devi, Kriti Sharma, Shweta Kumari, Mussarat Choudhary, Arup Giri

“…Purpose In the current scenario, food wastage is a significant concern throughout the world. …”
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Domestic Violence, Mental Health, and COVID-19: A Community-based Study of Women in Delhi by Ajit Kumar Lenka, Neha Sharawat, Smritima Diksha Lama, Sanghmitra S Acharya

“…Several factors led to an increase in the number of domestic violence cases including loss of livelihoods, restriction of social contact within informal and informal networks, and limited access to services and community support. …”
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Acute effects of single-bout isometric handgrip exercise on selected cardiovascular parameters in young normotensive adults at a tertiary care center of West Bengal by Anisha Dutta, Anish Bhowmik

“…Context: Hypertension is currently prevalent along with other lifestyle disorders, which further adds up to cardiovascular morbidity. …”
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"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts. by Chi-Ping Day, John Carter, Zoe Weaver Ohler, Carrie Bonomi, Rajaa El Meskini, Philip Martin, Cari Graff-Cherry, Lionel Feigenbaum, Thomas Tüting, Terry Van Dyke, Melinda Hollingshead, Glenn Merlino

“…Preclinical therapeutic assessment currently relies on the growth response of established human cell lines xenografted into immunocompromised mice, a strategy that is generally not predictive of clinical outcomes. …”
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Protocol for a randomized controlled trial of patient–portal–based screening for substance use among people with HIV by Eric Roessler, Daniela Zimmer, Jon Grant, Harold Pollack, Basmattee Boodram, Jessica Schmitt, Jessica Schmitt, Eleanor Friedman, Jade Pagkas-Bather, Jade Pagkas-Bather, Russell A. Brewer, Jessica Ridgway, Neda Laiteerapong, Neda Laiteerapong

“…BackgroundAchieving Equity in Patient Outcome Reporting for Timely Assessments of Life with HIV and Substance Use (ePORTAL HIV-S) is a research project funded by the National Institute for Drug Abuse to implement and evaluate multi-level interventions to decrease barriers to substance use screening and treatment for PLWH. …”
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Dynamics of educational activity of students under the influence of digitalisation by D. Yu. Narkhov, E. N. Narkhova, D. V. Shkurin

“…This study is based on the use of specific approaches to industry-specific sociological knowledge (youth and education): community, system, structural-functional, institutional, temporal, thesaurus, network, panoramic (pedagogical science). The current research employs the results of a mass survey conducted among students (N = 1825, 19 universities of the Sverdlovsk region) according to the authors’ method. …”
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Complementary Strategy of Maternal Immunization with RSVpreF Vaccine and Monoclonal Antibodies for the Prevention of Respiratory Syncytial Virus Among Italian Infants: A Cost-Effec... by Barbara Polistena, Fabio Midulla, Giovanni Sotgiu, Daniela d’Angela, Roberto Di Virgilio, Federico Spandonaro

“…The strategy results cost-saving: the complementary strategy saves € 6.0 mil and € 8.4 mil per year in the NHS and in the Societal perspective, respectively; the complementary strategies of maternal vaccination plus nirsevimab also prove to have significant benefits versus the monoclonal antibody alone, providing a decrease equal to 941 annual hospitalizations (−9.0%), 6 years of life recovered, and an increase of 20 QALYs. …”
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Increasing day three parasitaemia is observed after treatment of patients with artemether-lumefantrine and single dose of primaquine for uncomplicated Plasmodium falciparum malaria... by Bontu Abate, Bokretsion Gidey Brhane, Tsegahun Manyazewal, Hussien Mohammed, Yonas Wuletaw, Moges Kassa, Mesay Hailu, Getachew Tollera, Geremew Tasew, Ashenafi Assefa, Eyasu Makonnen

“…These findings support the ongoing use of AL with a single dose of PQ as the primary treatment option for uncomplicated P. falciparum infections in the study area. In the context of the emergence and spread of partial artemisinin-based combination therapy(ACT) resistance in Africa, regular monitoring of the efficacy of current artemisinin-based combinations is recommended for the early detection of emerging drug resistance in the study setting and beyond.…”
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Impact of Climate Change on the Narrow Endemic Herb Psilopeganum sinense (Rutaceae) in China by Ruixiong Deng, Kaitong Xiao, Xin Chen, Beibei Huang, Haoran Li, Lin Wu, Hang Ning, Hui Chen

“…Future climate scenarios indicated a projected 32.84% decrease in suitable areas under RCP4.5–2050s. In northern Chongqing, the ecological corridors established in highly suitable habitats would fragment and gradually separate. …”
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