Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease by Elisa Rubino, Maria Italia, Elisa Giorgio, Silvia Boschi, Paola Dimartino, Tommaso Pippucci, Fausto Roveta, Clara Maria Cambria, Gabriella Elia, Andrea Marcinnò, Salvatore Gallone, Ekaterina Rogaeva, Flavia Antonucci, Alfredo Brusco, Fabrizio Gardoni, Innocenzo Rainero

“…Primary rat hippocampal neurons overexpressing GluN2CA1072V showed an increase in NMDAR-induced currents, suggesting altered glutamatergic transmission. …”
Get full text

Automated Mapping of the Freshwater Ecosystem Functional Groups of the International Union for Conservation of Nature Global Ecosystem Typology in a Large Region of Arid Australia by Roxane J. Francis, Hedley S. Grantham, David A. Keith, Jose R. Ferrer-Paris, Richard T. Kingsford

“…The classification of freshwater ecosystems is essential for effective biodiversity conservation and ecosystem management, particularly with increasing threats. We developed an automated approach to mapping and classifying freshwater ecosystem functional groups based on the IUCN Global Ecosystem Typology (GET), offering a scalable, dynamic and efficient alternative to current manual methods. …”
Get full text

Life cycle assessment of polyethylene packaging and alternatives on the European market by Manfred Tacker, Tasja Hafner-Kuhn, Andrin Gstöhl, Experience Nduagu, Eric Vozzola, Timothee W. Roux, Rafael Auras

“…The assessment covered the material and production phase to end-of-life (EoL), based on current conditions in Europe (EU27 + UK). The potential impacts from the packaged product's production and usage phase were excluded. …”
Get full text

M.A.R.V.E.L.S. "Medical Students Advancing Research, Visibility, Education, Leadership, and Support." A Student-Driven Initiative by Molly Mehta, Kayvon Yazdanbakhsh, Elizabeth Hsu, Olga Gomeniouk, Kayla Nenninger, Devin P. Asher

“…METHODS: A committee of six second-year medical students and four faculty advisors established three networks to increase medical student involvement in research. The first is a Microsoft systems database containing contact, field of study, productivity, and project information of research faculty open to mentoring students aimed to facilitate meaningful collaboration between faculty seeking help with research projects and medical students eager to conduct research. …”
Get full text

The water level regime of periglacial lakes during the growth stage (the lakes of the Tavan-Bogdo-Ola mountain massif, South-Eastern Altai) by V. A. Rasputina, G. V. Pryakhina, D. A. Ganyushkin, D. V. Bantcev, N. A. Paniutin

“…Assessment of the dynamics of high-altitude glacial lakes is becoming increasingly important in the context of modern climate instability. …”
Get full text

Stunting Super App as an Effort Toward Stunting Management in Indonesia: Delphi and Pilot Study by Kadek Ayu Erika, Nur Fadilah, Aulia Insani Latif, Nurhikmawaty Hasbiah, Aidah Juliaty, Harun Achmad, Anugrayani Bustamin

“… Abstract BackgroundCurrently, 30 million children are experiencing acute malnutrition, and 8 million children are severely underweight. …”
Get full text

Development of recipes for combined products with functional properties by O. A. Ogneva, N. S. Bezverkhaya

“…Currently, products with functional properties are becoming more and more important, therefore, it is relevant to expand the range of these products and increase their production. …”
Get full text

Contrasting Effect of Curcumin on Hepatitis B Virus Replication According to the Hepatoma Cell Line by María Mercedes Elizalde, Pedro Fuentes, Diego Chiappetta, Diego Martín Flichman

“…In recent decades, considerable advances have been achieved in the treatment of chronic hepatitis B. However, the currently available drugs have shortcomings. In this context, several natural compounds have been proposed as potential agents to improve either the outcome of antiviral treatment or the progression of chronic infection, with curcumin being one of the most evaluated compounds due to its pleiotropic antiviral activity. …”
Get full text

A review on the synergism between corrosion and fatigue of magnesium alloys: Mechanisms and processes on the micro-scale by Mara Cristina Lopes de Oliveira, Rejane Maria Pereira da Silva, Ricardo M. Souto, Renato Altobelli Antunes

“…Understanding the interaction between cyclic stresses and corrosion of magnesium (Mg) and its alloys is increasingly in demand due to the continuous expansion of structural applications of these materials. …”
Get full text

Climate Change and Malaria in Canada: A Systems Approach by L. Berrang-Ford, J. D. MacLean, Theresa W. Gyorkos, J. D. Ford, N. H. Ogden

“…Competent malaria vectors currently exist in southern Canada, including within this range several major urban centres, and conditions here have historically supported endemic malaria transmission. …”
Get full text

Differences between the European and Eurasian Good Pharmacovigilance Practices by A. V. Matveev, A. E. Krasheninnikov, E. A. Matveeva, B. K. Romanov

“…However, the number of differences between the documents increases, as changes are made to the EU GVP. A more comprehensive harmonisation of the EAEU GVP with the current version of the EU GVP will make it possible to develop and use uniform pharmacovigilance documents in the EU and EAEU, and will facilitate the introduction of EAEU medicines into the global pharmaceutical market.…”
Get full text

Surface modification of aluminum on a silicon chip by citric acid treatment by Moataz Mekawy, Kazuya Iida, Akitsu Shigetou, Jin Kawakita

“…In situ electrical current measurements from arrays of aluminum wires located on the silicon chip were performed during the treatment. …”
Get full text

Broadband Chirped InAs Quantum-Dot Superluminescent Light-Emitting Diodes With In_xAl_1-xAs Strain-Reducing Layers by Ruizhe Yao, Nicholas Weir, Chi-Sen Lee, Wei Guo

“…In the SLED devices, a broad and uniform spectrum with a linewidth of 100 nm at 3 dB is realized at an injection current level of 100 mA, and no significant spectrum dip is observed in the entire injection current window ranging from 50 <inline-formula> <tex-math notation="LaTeX">$\mu\text{A}$</tex-math></inline-formula> to 100 mA.…”
Get full text

Adenosine A2A receptor agonist polydeoxyribonucleotide ameliorates short-term memory impairment by suppressing cerebral ischemia-induced inflammation via MAPK pathway. by Il-Gyu Ko, Jun-Jang Jin, Lakkyong Hwang, Sang-Hoon Kim, Chang-Ju Kim, Jung Won Jeon, Jun-Young Chung, Jin Hee Han

“…In order to confirm the participation of the adenosine A2A receptor in the effects mediated by PDRN, 8 mg/kg 7-dimethyl-1-propargylxanthine (DMPX), adenosine A2A receptor antagonist, was treated with PDRN. In the current study, induction of ischemia enhanced the levels of pro-inflammatory cytokines and increased phosphorylation of MAPK signaling factors in the hippocampus and basolateral amygdala. …”
Get full text

Prospective Interventions for reducing the vulnerability of communities in post-disaster resettlement, a case of Bunambutye camp, Eastern Uganda by Harriet Cherotich, Frank Mugagga, Fredrick Tumwine, Henry Musoke Ssemakula

“…We recommend the establishment of a skills-based training institution within the resettlement that should train survivors using content customized to address current and future needs hence ensuring self-sufficiency, reliance, and livelihood sustainability through outcomes like increased disposable incomes and wellbeing of the survivors in the resettlement. …”
Get full text

Microbiological examination of aerosols and sprays by O. V. Gunar, N. G. Sakhno

“…The current regulatory standards for microbiological testing of medicines provide little information on the quality control of metereddose aerosols. …”
Get full text

The Involvement of Ser1898 of the Human L-Type Calcium Channel in Evoked Secretion by Niv Bachnoff, Moshe Cohen-Kutner, Daphne Atlas

“…This mutation does not alter basal CaV1.2 current properties or regulation of CaV1.2 current by PKA and the beta-adrenergic receptor, but abolishes CaV1.2 phosphorylation by PKA. …”
Get full text

Productivity and nutritional value of aboveground biomass of annual crops in companion sowings by Т. V. Rodina, V. I. Zhuzhukin, А. N. Astashov

“…Siberian and Italian millet formed mean productivity of 16.13 and 15.60 t/ha, respectively. The current paper has presented data on productivity and has studied feed advantages of single-species and two-species sowings. …”
Get full text

Insect farming: A bioeconomy-based opportunity to revalorize plastic wastes by Juan C. Sanchez-Hernandez, Mallavarapu Megharaj

“…Managing plastic waste is one of the greatest challenges humanity faces in the coming years. Current strategies—landfilling, incineration, and recycling—remain insufficient or pose significant environmental concerns, failing to address the growing volume of plastic residues discharged into the environment. …”
Get full text

Mesenchymal stem cell- derived exosomes as cell-free therapeutics for sensorineural hearing loss by Maria Perde-Schrepler, Ioana Brie, Alma Maniu

“…This paper aims to review current knowledge on the use of MSCs and MSC-derived exosomes for inner ear sensory cell regeneration and explore their potential for clinical applications. …”
Get full text