A novel therapeutic approach targeting PD-L1 in HNSCC and bone marrow-derived mesenchymal stem cells hampers pro-metastatic features in vitro: perspectives for blocking tumor-strom... by Ylenia Ferrara, Debora Latino, Angela Costagliola di Polidoro, Angela Oliver, Annachiara Sarnella, Maria Grazia Caprio, Laura Cerchia, Menotti Ruvo, Annamaria Sandomenico, Antonella Zannetti

“…Abstract Background Current conventional treatment regimens for head and neck squamous cell carcinoma (HNSCC), are poorly effective because of the emergence of resistance mechanisms. …”
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MODERN APPROACHES TO DIAGNOSTICS AND TREATMENT OF DENTAL TRAUMA by O.S. Ivanytska

“…The current approach to the treatment of dental trauma is focused on less invasive and more biologically oriented methods of treatment of hard dental tissues, pulp, periodontal ligament and alveolar bone. …”
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Advances and applications of empirical mode decomposition and its variants in hydrology: A review by CHEN Yunfei, LIU Zuyu, LIU Xiuhua, HE Junqi, ZHENG Ce, MA Yandong

“…Empirical Mode Decomposition (EMD) has garnered increasing attention due to its ability to analyze non-linear and non-stationary data. …”
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Immunological and physiological changes of exercise-released lactate on tumors: an important and new research window by Amir Hossein Ahmadi Hekmatikar, Arsham Entesari, Hossein Shirvani

“…In the cancer immune cycle, the immune checkpoint PD-1 and its ligand PD-L1 collaborate to facilitate immune escape and promote tumor progression (Keir et al., 2008). In this context, a study revealed that lactate can enhance the expression of PD-L1 on tumor cells, suggesting that lactate may have a protective effect against tumors by increasing PD-L1 expression (Feng et al., 2017). …”
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Presentation of Financial Assets in Russian Macroeconomic Statistics by V. N. Salin, M. V. Vakhrameeva, O. Yu. Sitnikova

“…The purpose of the study. Currently, much attention is paid to the collection, presentation and analysis of data on the volume, structure and dynamics of economic assets. …”
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Materials and Structures Used in Aeronautics: Present and Future Perspectives by Mihai FLOREA, Vlad-Stefan CONSTANTIN, Andrei-Christian BUCUR, Raluca FAUR, Denis PREDU, Alexandru CAZACU

“…Trial and error can be costly in this context, necessitating well-planned design and engineering to ensure resistance to aerodynamic forces during flight. …”
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Linking weather and climate information services (WCIS) to Climate-Smart Agriculture (CSA) practices by Tafadzwanashe Mabhaudhi, Tinashe Lindel Dirwai, Cuthbert Taguta, Aidan Senzanje, Wuletawu Abera, Ajit Govid, Elliott Ronald Dossou-Yovo, Ermias Aynekulu, Vimbayi Grace Petrova Chimonyo

“…Specifically, it addresses the following questions: (1) What is the current status of knowledge on WCIS and CSA in the global south, specifically the African continent?…”
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Tracking development assistance for health from China, 2007–2017 by Angela E Micah, Catherine S Chen, Abigail Chapin, Joseph L Dieleman, Paul H Lee, Michael R Phillips, Kun Tang, Shenglan Tang, Jost Jonas, Shiwei Liu, Yingxi Zhao, Bianca S. Zlavog, Golsum Tsakalos, Stephen Gloyd, Man Tat Alexander Ng, Enrico Rubagotti, Mustafa Younis, Yunquan Zhang

“…However, relative to population size and government spending, China’s contributions are modest.Conclusion In the current context of plateauing in the growth rate of DAH contributions, China has the potential to contribute to future global health financing, especially financing for health system strengthening.…”
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Implementation of a digital nurse to improve the use of digital health applications (DiGA) for older people with depressive disorders (DiGA4Aged): a randomized proof of concept stu... by Anna Mai, Magdalena Pape, Theresa Sophie Busse, Katharina Kunde, Jennifer Bosompem, Chantal Giehl, Ina Carola Otte, Stephan Herpertz, Georg Juckel, Ida Haussleiter, Rainer Wirth, Horst Christian Vollmar, Nina Timmesfeld, Jan Dieris-Hirche

“…Discussion In Germany, the approved DiGA are currently little used, especially by people with a low digital affinity. …”
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High-risk pregnancy and risk of breastfeeding failure by Eman S. Salama, Mostafa Hussein, Ahmed N. Fetih, Azza M. A. Abul-Fadl, Shimaa A. Elghazally

“…A pretested and validated questionnaire was used to collect detailed epidemiological, personal, health-related status, medications, hospitalizations, reproductive history, current delivery, and previous breastfeeding experiences. …”
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Web-Based Respondent-Driven Sampling to Assess Biobehavioral Factors Among Men Who Have Sex With Men in Thailand: Cross-Sectional Study by Watcharapol Srinor, Suvimon Tanpradech, Panupit Thiengtham, Samart Karuchit, Charif Naksuk, Thitipong Yingyong, Thananda Naiwatanakul, Sanny Northbrook, Wolfgang Hladik

“… Abstract BackgroundRespondent-driven sampling (RDS) is the current standard for sampling key populations at risk for HIV infections but is usually limited to local implementation in single towns or cities. …”
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Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic by Peter F M Choong, Michelle M Dowsey, Samantha Bunzli, Michelle Ghert, Ajay Puri, Robert Turcotte, Penny O'Brien, Peter Rose, Will Aston, Miguel A Ayerza, Lester Chan, Stephane Cherix, Jorge de las Heras, Davide Donati, Uwale Eyesan, Nicola Fabbri, Thomas Hilton, Oluwaseyi Kayode Idowu, Jungo Imanishi, Dundar Sabah, Kristy Weber

“…Common to ‘unique’ decisions about patient care was uncertainty about what was going on and what would happen in the future (theme 1: the context of uncertainty), the impact of the pandemic on resources or threat of the pandemic to overwhelm resources (theme 2: limited resources), perceived increased risk to self (theme 3: duty of care) and least-worst decision making, in which none of the options were perceived as ideal and participants settled on the least-worst option at that point in time (theme 4: least-worst decision making).Conclusions In the context of rapidly changing standards of justice and beneficence in patient care, traditional decision-making frameworks may no longer apply. …”
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Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy? by Georgios Tsioulos, Natalia G. Vallianou, Alexandros Skourtis, Maria Dalamaga, Evangelia Kotsi, Sofia Kargioti, Nikolaos Adamidis, Irene Karampela, Iordanis Mourouzis, Dimitris Kounatidis

“…Consequently, immunomodulatory strategies have gained increasing attention, though none have yet reached widespread clinical adoption. …”
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Use of ICT to Confront COVID-19 by Yousry Saber El Gamal

“…Supporting a digitized world and staying current in the latest technology will be essential for any country to remain competitive in a post COVID-19 world. …”
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Potential therapeutic effects of IL28RA inhibition on acute myocardial infarction through phosphorylated JAK1/STAT1 signaling pathways by Ge Gong, Xiangxuan Chen, Xinghu Zhang, Jian Yin, Wenhui Wan

“…Abstract While current coronary intervention therapies and surgical bypass procedures are widely utilized, the treatment of acute myocardial infarction (AMI) in the elderly continues to pose significant challenges. …”
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Reporting quality of systematic review protocols in environmental and occupational toxicology: a meta-epidemiology study protocol by Milica D. Pavlovic, Malgorzata Lagisz, Natália B. Videira, Julia M. L. Menon, Gunn E. Vist, Elma Omeragic, Rebecca L. Morgan, Sebastian Hoffmann, Evidence-Based Toxicology Collaboration

“…Background Systematic reviews (SR), an evidence-synthesis tool, have been increasingly used in toxicology, for regulatory decision-making and allocation of research funding resources. …”
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Characteristics, outcomes, and maternity care experiences of women with children’s social care involvement who subsequently died: national cohort study and confidential enquiry by Marian Knight, Abigail Easter, Jane Sandall, Elsa Montgomery, Nicola Vousden, Emma Rose, Claire Mason, Kirsty Kitchen, Kaat De Backer, Allison Marjorie Felker, Caroline Bull, Oluwaseun Labisi

“…A critical review of current care pathways and policy changes is urgently needed to tailor care to the needs of this group of women and to look at the inequalities that disproportionately affect them.…”
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Analysis of the demand for “Internet + nursing services” and its influencing factors among orthopaedic patients in Zhejiang, a developed area of China by Hui Li, Yuyu Chen, Jia Cao, Danlei Zheng, Bingbing Wu, Lifang Shao, Xiaoli Zhong, Chengli Yan

“…Abstract Background The “Internet + nursing services” model has been applied to various diseases and has been accepted by an increasing number of people, especially in the context of chronic disease management. …”
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Boosting Blood Donations Through Facebook Engagement: Randomized Controlled Field Trial by Steven Ramondt, Peter Kerkhof, Eva-Maria Merz

“…Blood collection agencies increasingly rely on social media not only for donor recruitment and retention but also for promoting donation-related behaviors. …”
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Integrating CEN ISO/TS 82304-2 in the Catalan Health App Assessment Framework: Comparative Case Study by Berta Llebot Casajuana, Petra Hoogendoorn, Maria Villalobos-Quesada, Carme Pratdepàdua Bufill

“… Abstract BackgroundHealth apps are increasingly being used to promote health, manage diseases, and deliver health care services. …”
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