Рreventive efficacy of interferon -2b in the COVID-19 pandemic by Zh. B. Ponezheva, A. A. Grishaeva, I. V. Mannanova, A. N. Kupchenko, S. B. Yatsyshina, S. V. Krasnova, V. V. Malynovskaya, V. G. Akimkin

“…The amount of infected people has already exceeded 48 million, and more than 1 million deaths have been registered. A steady increase of new cases of COVID-19 is currently observed on the territory of the Russian Federation. …”
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Effects of ibrutinib and venetoclax on the expression of immune checkpoint molecules in leukemic blasts of patients with acute lymphoblastic leukemia by Armin Dozandeh-Jouybari, Fatemeh Mousavi-Mirkalaei, Saeid Taghiloo, Hossein Karami, Mohammad Naderisorki, Ehsan Zaboli, Mohammad Eslami-Jouybari, Tohid Kazemi, Hossein Asgarian-Omran

“…By elucidating the precise underlying mechanisms, these drugs could emerge as promising therapeutic options, particularly in the context of combination therapy for ALL.…”
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A novel therapeutic approach targeting PD-L1 in HNSCC and bone marrow-derived mesenchymal stem cells hampers pro-metastatic features in vitro: perspectives for blocking tumor-strom... by Ylenia Ferrara, Debora Latino, Angela Costagliola di Polidoro, Angela Oliver, Annachiara Sarnella, Maria Grazia Caprio, Laura Cerchia, Menotti Ruvo, Annamaria Sandomenico, Antonella Zannetti

“…Abstract Background Current conventional treatment regimens for head and neck squamous cell carcinoma (HNSCC), are poorly effective because of the emergence of resistance mechanisms. …”
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MODERN APPROACHES TO DIAGNOSTICS AND TREATMENT OF DENTAL TRAUMA by O.S. Ivanytska

“…The current approach to the treatment of dental trauma is focused on less invasive and more biologically oriented methods of treatment of hard dental tissues, pulp, periodontal ligament and alveolar bone. …”
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Advances and applications of empirical mode decomposition and its variants in hydrology: A review by CHEN Yunfei, LIU Zuyu, LIU Xiuhua, HE Junqi, ZHENG Ce, MA Yandong

“…Empirical Mode Decomposition (EMD) has garnered increasing attention due to its ability to analyze non-linear and non-stationary data. …”
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Effects of coix seed polyphenol extract on rumen fermentation, milk production, fatty acid profile, antioxidant activity, and polyphenol content in dairy goats by X.Z. Tian, Y.Q. Xu, J.X. Qin, X. Wang, S.L. Xie, R. Chen, Q. Lu, X. Chen

“…Overall, the appropriate supplemental level of CSE was 1.5 g/kg in dairy goats under the conditions of the current experiment.…”
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STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. …”
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Advancing the therapeutic effectiveness of paclitaxel in chronic lymphocytic leukemia through the simultaneous inhibition of NOTCH1 and SF3B1 by Shiva Abolhasani, Armin Mahmoud salehi Khesht, Atefeh Khodakarami, Ali Masjedi, Bentolhoda Rashidi, Sepideh Izadi, Fatemeh Karimian Noukabadi, Vahid Karpisheh, Khatereh Torabi Poudeh, Pooya Jalali, Zahra Salehi, Rafieh Bagherifar, Seyyed Sina Hejazian, AliAkbar Movassaghpour, Abbas Ali Hosseinpour Feizi, Farhad Jadidi

“…Overexpression of the splicing factor 3b subunit 1 (SF3B1) and neurogenic locus notch homolog protein 1 (NOTCH1) factors is typically found in chronic lymphocytic leukemia (CLL), leading to the development of chemotherapy resistance. Objective The current investigation aims to evaluate the chemosensitivity of CLL cells by blocking NOTCH1 and SF3B1 using chitosan lactate (CL) nanoparticles (NPs). …”
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Immunological and physiological changes of exercise-released lactate on tumors: an important and new research window by Amir Hossein Ahmadi Hekmatikar, Arsham Entesari, Hossein Shirvani

“…In the cancer immune cycle, the immune checkpoint PD-1 and its ligand PD-L1 collaborate to facilitate immune escape and promote tumor progression (Keir et al., 2008). In this context, a study revealed that lactate can enhance the expression of PD-L1 on tumor cells, suggesting that lactate may have a protective effect against tumors by increasing PD-L1 expression (Feng et al., 2017). …”
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Presentation of Financial Assets in Russian Macroeconomic Statistics by V. N. Salin, M. V. Vakhrameeva, O. Yu. Sitnikova

“…The purpose of the study. Currently, much attention is paid to the collection, presentation and analysis of data on the volume, structure and dynamics of economic assets. …”
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Materials and Structures Used in Aeronautics: Present and Future Perspectives by Mihai FLOREA, Vlad-Stefan CONSTANTIN, Andrei-Christian BUCUR, Raluca FAUR, Denis PREDU, Alexandru CAZACU

“…Trial and error can be costly in this context, necessitating well-planned design and engineering to ensure resistance to aerodynamic forces during flight. …”
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Linking weather and climate information services (WCIS) to Climate-Smart Agriculture (CSA) practices by Tafadzwanashe Mabhaudhi, Tinashe Lindel Dirwai, Cuthbert Taguta, Aidan Senzanje, Wuletawu Abera, Ajit Govid, Elliott Ronald Dossou-Yovo, Ermias Aynekulu, Vimbayi Grace Petrova Chimonyo

“…Specifically, it addresses the following questions: (1) What is the current status of knowledge on WCIS and CSA in the global south, specifically the African continent?…”
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Tracking development assistance for health from China, 2007–2017 by Angela E Micah, Catherine S Chen, Abigail Chapin, Joseph L Dieleman, Paul H Lee, Michael R Phillips, Kun Tang, Shenglan Tang, Jost Jonas, Shiwei Liu, Yingxi Zhao, Bianca S. Zlavog, Golsum Tsakalos, Stephen Gloyd, Man Tat Alexander Ng, Enrico Rubagotti, Mustafa Younis, Yunquan Zhang

“…However, relative to population size and government spending, China’s contributions are modest.Conclusion In the current context of plateauing in the growth rate of DAH contributions, China has the potential to contribute to future global health financing, especially financing for health system strengthening.…”
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Outcomes following single level posterior lumbar fusion in patients with systemic and discoid lupus: A retrospective national database study by Meera M. Dhodapkar, MD, MHS, Scott J. Halperin, MD, MHS, Wesley Day, BA, Comron Saifi, MD, Daniel R. Rubio, MD, Fotios Koumpouras, MD, Jonathan N. Grauer, MD, Arya Varthi, MD

“…ABSTRACT: Background context: Posterior lumbar fusion (PLF) is a common procedure, for which patients with systemic conditions may be considered. …”
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The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in e... by Biao Peng, Mu-Yun Yan, Yun-Rong Chen, Fei Sun, Xu-Dong Xiang, Da Liu

“…Objective The prognosis for severe asthma is poor, and the current treatment options are limited. The methyl-CpG binding domain protein 2 (MBD2) participates in neutrophil-mediated severe asthma through epigenetic regulation. …”
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Food Application of Orange Seed Powder through Incorporation in Wheat Flour to Boost Vitamin and Mineral Profiles of Formulated Biscuits by Ashiq Hussain, Salah Laaraj, Tusneem Kausar, Aziz Tikent, Hanane Azzouzi, Samina Kauser, Qurat Ul An, Aqsa Iqbal, Saima Akram, Rizwan Nisar, Ayesha Najam, Haya Fatima, Shazia Yaqub, Kaoutar Elfazazi

“…In the current work, orange seed powder replaced wheat flour at 0, 2.5, 5, 7.5, and 10% levels, to observe changes in physicochemical features of developed biscuits. …”
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Implementation of a digital nurse to improve the use of digital health applications (DiGA) for older people with depressive disorders (DiGA4Aged): a randomized proof of concept stu... by Anna Mai, Magdalena Pape, Theresa Sophie Busse, Katharina Kunde, Jennifer Bosompem, Chantal Giehl, Ina Carola Otte, Stephan Herpertz, Georg Juckel, Ida Haussleiter, Rainer Wirth, Horst Christian Vollmar, Nina Timmesfeld, Jan Dieris-Hirche

“…Discussion In Germany, the approved DiGA are currently little used, especially by people with a low digital affinity. …”
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High-risk pregnancy and risk of breastfeeding failure by Eman S. Salama, Mostafa Hussein, Ahmed N. Fetih, Azza M. A. Abul-Fadl, Shimaa A. Elghazally

“…A pretested and validated questionnaire was used to collect detailed epidemiological, personal, health-related status, medications, hospitalizations, reproductive history, current delivery, and previous breastfeeding experiences. …”
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Web-Based Respondent-Driven Sampling to Assess Biobehavioral Factors Among Men Who Have Sex With Men in Thailand: Cross-Sectional Study by Watcharapol Srinor, Suvimon Tanpradech, Panupit Thiengtham, Samart Karuchit, Charif Naksuk, Thitipong Yingyong, Thananda Naiwatanakul, Sanny Northbrook, Wolfgang Hladik

“… Abstract BackgroundRespondent-driven sampling (RDS) is the current standard for sampling key populations at risk for HIV infections but is usually limited to local implementation in single towns or cities. …”
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Life or limb: an international qualitative study on decision making in sarcoma surgery during the COVID-19 pandemic by Peter F M Choong, Michelle M Dowsey, Samantha Bunzli, Michelle Ghert, Ajay Puri, Robert Turcotte, Penny O'Brien, Peter Rose, Will Aston, Miguel A Ayerza, Lester Chan, Stephane Cherix, Jorge de las Heras, Davide Donati, Uwale Eyesan, Nicola Fabbri, Thomas Hilton, Oluwaseyi Kayode Idowu, Jungo Imanishi, Dundar Sabah, Kristy Weber

“…Common to ‘unique’ decisions about patient care was uncertainty about what was going on and what would happen in the future (theme 1: the context of uncertainty), the impact of the pandemic on resources or threat of the pandemic to overwhelm resources (theme 2: limited resources), perceived increased risk to self (theme 3: duty of care) and least-worst decision making, in which none of the options were perceived as ideal and participants settled on the least-worst option at that point in time (theme 4: least-worst decision making).Conclusions In the context of rapidly changing standards of justice and beneficence in patient care, traditional decision-making frameworks may no longer apply. …”
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