EstablishINg the best STEp-up treatments for children with uncontrolled asthma despite INhaled corticosteroids (EINSTEIN): protocol for a systematic review, network meta-analysis a... by Ian Sinha, Dyfrig A Hughes, Michelle Maden, Stephen Turner, Sofia Cividini, Sarah Donegan, Giovanna Culeddu, Katie Rose, Olive Fulton, Catrin Tudur Smith

“…Treatment with a low-dose ICS, however, fails to control asthma symptoms in around 10%–15% of children and this places the individual at increased risk for an asthma attack. At present, there is no clear preferred treatment option for a child whose asthma is not controlled by low-dose ICS and international guidelines currently recommend at least three treatment options. …”
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Sustainable Design of a Tiny House: Using a Life Cycle Assessment Approach to Compare the Environmental Performance of Industrial and Earth-Based Building Systems by Letizia Dipasquale, Giada Giuffrida, Natalia Jorquera Silva, Riccardo Maria Pulselli, Rosa Caponetto

“…The increased concerns about climate change, diminishing natural resources, and environmental degradation call for deep research into new environmentally friendly building systems that use natural or recycled materials. …”
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Prevention of tumors in treating fibrocystic breast diseases using <i>Vitex agnus-castus</i>-based herbal remedy by N. A. Omarbayeva, D. R. Kaidarova, D. Kh. Omarov, A. Askandirova, Kh. Keskin, A. Zh. Abdrakhmanova, S. A. Yessenkulova, T. G. Goncharova, A. K. Jakipbayeva

“…Oncologists notice an increasing prevalence of female reproductive system pathological conditions that lead to benign and malignant diseases of mammary glands. …”
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Innovation activity in European Union service sector: Similarities or differences? by Kamil Decyk

“…On the other hand, it could contain instruments and tools specific to a given industry. …”
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Effect of fermentation on the constituents in the branches and leaves of Taxus media and non-small cell lung cancer by Xing Guo, Rui-Sheng Wang, Zhen-Ling Zhang, Zhen-Ling Zhang, Zhen-Ling Zhang, Zhen-Ling Zhang, Hong-Wei Zhang, Sheng-Chao Wang, Shuai Zhang, Ya-Ning Wu, Ya-Jing Li, Jun Yuan

“…IntroductionNon-small cell lung cancer (NSCLC) is a prominent lung cancer disease worldwide. Currently, commonly used methods, such as surgery and radiotherapy, have significant side effects. …”
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Rapid public health genomics capacity building during the COVID-19 Delta crisis driven by a transnational private, public, and social alliance by Mehul Champaklal Mehta, Mehul Champaklal Mehta, Mehul Champaklal Mehta, Gayatri Nair Lobo, Gayatri Nair Lobo, Gretchen Weightman, Gretchen Weightman, Vidushi Chitalia, Vidushi Chitalia, Jayanthi Shastri, Jayanthi Shastri, Jayanthi Shastri

“…This has transformed Mumbai’s ability to expeditiously identify and contain infectious outbreaks, thus better protecting its citizens. …”
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Combined TNF-α and OX40L targeting as a new treatment option for hidradenitis suppurativa by Thomas Leeuw, PhD, Deimantė Šimaitė, PhD, Karen Heyninck, PhD, Clement Levin, PhD, Sigrid Cornelis, PhD, Youssef Hijazi, PhD, Heidi Rommelaere, PhD, Thomas Kreutzberg, PhD, Peter Florian, DVM, Markus Kohlmann, PhD, Theresa-Charlotte Brembach, PhD, Frank Nestle, MD, FmedSci, Kerstin Wolk, PhD, Robert Sabat, MD, PhD, Matthias Herrmann, PhD

“…Conclusion: OX40-OX40L interaction is a key pathogenetic feature in HS, and patients with HS might benefit from combined TNF-α/OX40L blockade by SAR442970, which is currently investigated in a clinical phase 2 trial.…”
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Effectiveness of virtual fencing in a mountain environment and its impact on heifer behaviour and welfare by P. Fuchs, C.M. Pauler, M.K. Schneider, C. Umstätter, C. Rufener, B. Wechsler, R.M. Bruckmaier, M. Probo

“…Video cameras recorded animal reactions upon virtual fence contact. Grass height was measured to estimate forage availability in the currently grazed paddocks. …”
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Prevalence and associated factors of tuberculosis among diabetic patients attending public health facilities in Ethiopia: a multicenter study by Ayinalem Alemu, Getachew Seid, Getu Diriba, Michael Hailu, Biniyam Dange, Shewki Moga, Daniel Melese, Gemechu Tadesse, Solomon H Mariam, Nega Berhe, Balako Gumi

“…Abstract Background Individuals with diabetes mellitus (DM) have high tuberculosis (TB) prevalence. Currently, the incidence of DM is increasing in low and middle-income countries including Ethiopia where TB is also endemic, which may complicate TB prevention and control efforts. …”
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Epigenetic therapeutics to overcome resistance against immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC): a proof-of-concept clinical trial by Stephen Chan, Alfred Cheng, Nick La Thangue, David Kerr

“…However, resistance to ICI is increasingly encountered in clinical practice in HCC patients. …”
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Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…The antibacterial efficiency of the MO-HPA1.0 group on E. coli and S. aureus increased by about 40.1% and 55.6% respectively, compared to the MO-HPA0.5 group. …”
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Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway by Xiao Li, Mengna Cui, Long Xu, Qie Guo

“…ObjectiveSorafenib, a multikinase inhibitor, is currently the standard treatment for advanced liver cancer. …”
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A Comparative Study of the Extraction Methods for the Simultaneous Detection of NPS Groups from Urine by M. Kuloglu Genc, S. Mercan, C. Bulut, Z. Turkmen

“…A total of 1,127 NPS have been reported worldwide as of 2022. The increasing chemical diversity and unprecedented substance numbers of NPS make this phenomenon even more difficult to detect, monitor and understand analytically. …”
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Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale County, coastal Kenya by Tobias Odongo, Isaiah Omondi, Caroline Wanjiku, Miguel Okoko, Caroline Kiuru, Mercy Kariuki, Isaac Ringera, Bruno Otieno, Festus Mure, Joanna Furnival-Adams, Almudena Sanz Gutierrez, Rachel Otuko, Nelly Regina Rabinovich, Joseph Mwangangi, Carlos Chaccour, Marta Ferreira Maia

“…Ivermectin, an endectocide known to impact various neglected tropical diseases and hematophagous arthropods, is currently being assessed for malaria vector control. …”
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Hermetia illucens oil vs. hydrogenated palm fat in dairy cow nutrition: effects on digestive parameters, oxidative stress, and milk production performance by Lara Rastello, Laura Gasco, Mauro Coppa, Mathieu Gerbelle, Stefania Colombini, Marco Battelli, Paola Badino, Luca Vernetti-Prot, Pablo G. Toral, Alberto Brugiapaglia, Giulia Gardini, Vanda Malfatto, Isabelle Constant, Alessandro Galli, Christophe Trespeuch, Manuela Renna

“…Abstract Background Scant information is currently available on the use of insect oils in ruminant diets. …”
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Analysis of the influence of the microbial load of poultry facilities on the development of keel “mins” in turkeys by R. I. Fedyniak, R. A. Peleno

“…Instead, an imbalance can lead to the development of specific pathologies in the bird. Currently, in the conditions of industrial poultry farming, studying the influence of the microbial environment of poultry houses on the health and development of birds is a relevant and important topic of scientific research. …”
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Presentation of Financial Assets in the Monetary Statistics by V. N. Salin, O. Y. Sitnikova, L. Y. Arhangelskaya

“…The purpose of the study. Currently, the issues of determining, presenting and analyzing indicators of economic assets, in particular, financial ones, are relevant, since financial assets, along with nonfinancial ones, constitute the most important characteristic of national wealth as a level of development of the country and are the basis for constructing national accounts, indicators of monetary statistics and other sections of macroeconomic statistics. …”
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Progress of researches on the internalization of Escherichia coli O157:H7 in plant tissues by Yang Li, Wang Haizhen, Yao Zhiyuan, Wu Jianjun

“…Whether human pathogen currently carries the effector proteins is yet to be determined. …”
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A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses by Roxanne Fouillé, Eloi R. Verrier, Amse De Meyer, Lieven Verhoye, Maud Michelet, Romain Barnault, Caroline Pons, Olivier Diaz, Michel Rivoire, Guillaume Passot, Eike Steinmann, Heiner Wedemeyer, Anna Salvetti, Nicole Pavio, Virginie Doceul, Raphaël Darteil, Philip Meuleman, David Durantel, Julie Lucifora

“…Results: We observed increased expression of liver specific transcripts and production of ApoB containing VLDL in dHuH7.5-NTCP cells and replication of HBV, HDV, HCV and HEV for at least 4 weeks after mono or multiple infections. …”
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Studying the Possibility of Application ir Spectroscopy for Raw Material Identification <I>Valeriana wolgensis</I> Kazak. and <I>Valeriana dudia</I> L. by O. A. Kolosova, O. V. Trineeva

“…Recently, IR spectroscopy has been increasingly used to identify various groups of biologically active substances (BAS) in plant objects. …”
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