Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype. by Ruthiran Kugathasan, Ksenia Sukhova, Maya Moshe, Paul Kellam, Wendy Barclay

“…New variants of SARS-CoV-2 are continually emerging with mutations in spike associated with increased transmissibility and immune escape. Phenotypic maps can inform the prediction of concerning mutations from genomic surveillance, however most of these maps currently derive from studies using monomeric RBD, while spike is trimeric, and contains additional domains. …”
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Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus. by Guillaume Osterstock, Pauline Escobar, Violeta Mitutsova, Laurie-Anne Gouty-Colomer, Pierre Fontanaud, François Molino, Jean-Alain Fehrentz, Danielle Carmignac, Jean Martinez, Nathalie C Guerineau, Iain C A F Robinson, Patrice Mollard, Pierre-François Méry

“…Indeed, ghrelin does not modify synaptic currents of GHRH neurons. However, ghrelin exerts a strong and direct depolarizing effect on GHRH neurons, which supports their increased firing rate.…”
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IAE-CDNet: A Remote Sensing Change Detection Network for Buildings With Interactive Attention-Enhanced by Zhaoyang Han, Linlin Zhang, Qingyan Meng, Chongchang Wang, Wenxu Shi, Maofan Zhao

“…Currently, the development of deep learning has had a positive impact on remote sensing image change detection tasks, but many current methods still face challenges in effectively processing global and local features, especially in the task of building change detection in high-resolution images containing complex scenes. …”
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Variation and prognostic potential of the gut antibiotic resistome in the FINRISK 2002 cohort by Katariina Pärnänen, Matti O. Ruuskanen, Guilhem Sommeria-Klein, Ville Laitinen, Pyry Kantanen, Guillaume Méric, Camila Gazolla Volpiano, Michael Inouye, Rob Knight, Veikko Salomaa, Aki S. Havulinna, Teemu Niiranen, Leo Lahti

“…Resistance was linked not only to prior use of antibiotics, as anticipated, but also to frequent consumption of fresh vegetables and poultry, two food groups previously reported to contain antibiotic-resistant bacteria. Interestingly, resistance was not linked to the consumption of high-fat and high-sugar foods, but was consistently higher in females and urban high-income individuals, who currently have generally lower mortality rates. …”
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Establishing priorities for future land conservation to maximise biodiversity conservation and other ecosystem services in the Tilarán Mountains of Costa Rica by Lindsay Stallcup, Matthew D. Moran, Doris Rojas, Erich Mata

“…The opportunity to connect currently protected areas to one another through effective biological corridors still remains, possibly through conservation partnerships with landowners or direct land purchase, but time could be short as increasing development and changing land-use patterns threaten to further isolate habitats in the MAB.…”
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Exposure to secondhand smoke from cigarettes and secondhand aerosol from tobacco and nicotine products in indoor and outdoor public spaces in the European Union: a cross-sectional... by Anthony A Laverty, Ariadna Feliu, Filippos T Filippidis, Constantine I Vardavas, Cristina Martínez, Charis Girvalaki, Armando Peruga, Charlotte Xin Li, Pin-Chun Wang, Cornel Radu Loghin

“…Introduction In December 2024, the Council of the European Union (EU) adopted a recommendation to expand regulations on the use of nicotine-containing products both in indoor settings and specific outdoor areas. …”
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Standalone ultrasound-based highly visualized volumetric spine imaging for surgical navigation by Xinben Hu, Tianjian Liu, Zhengyuan Zhang, Xuan Xiao, Lin Chen, Gao Wei, Yunjiang Wang, Keji Yang, Haoran Jin, Yongjian Zhu

“…Abstract Current navigation systems employing intraoperative CT have been applied in spinal interventions for accurate and visualized guidance. …”
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Post-pandemic patient safety: have the characteristics of incidents with harm changed? Comparative observational study in primary care via review of medical records with a trigger... by Gerardo Garzón González, Tamara Alonso Safont, Oscar Aguado Arroyo, Cristina Villanueva Sanz, Arancha Luaces Gayán, Esther Zamarrón Fraile, Juan José Jurado Balbuena, Inmaculada Mediavilla Herrera, Research Team “TriggerPrim®”

“…Conclusions No differences were found in the avoidability, severity, place of occurrence, or contributory factors of PSIHs before the pandemic and currently. In terms of the nature of these incidents, the outcomes revealed an increase in diagnostic errors (excluding diagnostic tests), which could be attributed to a greater frequency of remote consultations and a decrease in the longitudinality of care resulting from the shortage of professionals.…”
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A mixed-methods nutrition, water, sanitation and hygiene knowledge, attitudes, and practices survey of IDPs, returnees, and host community members in four counties of Jonglei state... by Lynn Lieberman Lawry, Rachel Gabor, Jacques Katele, Lazarus Baak Madut, Katina Sommers, David Manuel, Claire Nadolski, Mounir Lado, Tracey Perez Koehlmoos, William Clemmer

“…Improved flood resistant sources for clean water, clean covered water storage container distribution, improved sanitation, oral rehydration solution (ORS) and zinc distribution and education are necessary to decrease diarrheal rates.…”
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Digital currency: features of regulation in the Russian Federation by T. E. Rozhdestvenskaya, A. G. Guznov

“…The article examines the main approaches to the regulation of digital currencies, studies the phenomenon of digital currency itself, assesses the circumstances that aroused massive interest and enthusiasm for cryptocurrencies. An analysis of current positive legal material is presented, in particular, the approach to the regulation of digital currency contained in the Russian Federal Law of July 31, 2020 No. 259- FZ "On digital financial assets, digital currency and on amendments to certain legislative acts of the Russian Federation". …”
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Screen-printed Carbon Electrode from Coconut Shell Activated Carbon Modified with Ferrocene for Cobalt Detection by Muhammad Farhan, Eddy Heraldy, Abu Masykur, Muhammad A. Munir, Fitria Rahmawati

“…The cyclic voltammetry analysis found that 10% Fc on SPCE provides the highest current density compared to 20% and 30%. Meanwhile, the 2 mV s-1 scanning rate reveals a more defined anodic and cathodic peak than 3 mV s-1 and 5 mV s‑1. …”
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Beyond the brain: early autonomic dysfunction in Alzheimer’s disease by Carmen Nanclares, Inés Colmena, Alicia Muñoz-Montero, Andrés M. Baraibar, Ricardo de Pascual, Aneta Wojnicz, Ana Ruiz-Nuño, Antonio G. García, Adrián Gironda-Martínez, Luis Gandía

“…These changes were accompanied by diminished sodium (INa), calcium (ICa), and nicotinic (IACh) currents, compromising CC excitability. With age, a shift toward increased potassium (IK) currents and enhanced catecholamine secretion may reflect compensatory adaptations aimed at preserving output. …”
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What type of leadership is more effective for managing change during force majeure? Achieving organizational effectiveness during the pandemic by Nazia Habib, Shaheryar Naveed, Muhammad Mumtaz, Rabia Sultana, Shoaib Akhtar

“…Hence, it was important to identify effective leadership styles to successfully manage the transformational process during the period. Therefore, the current study aims to explore and compare the effectiveness of transformational and ethical leadership (EL) in terms of achieving organizational goals during COVID-19 in public and private sector organizations in Pakistan. …”
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THE IMPACT OF THE USE OF BIOFUELS ON CO2 EMISSIONS AT THE LEVEL OF EUROPEAN COUNTRIES FROM THE PERSPECTIVE OF ABSOLUTE DECOUPLING by Valentina SIMION, Liviu MARCUTA, Maricel CAZACU, Nicolae MINEA, Camelia HODOAȘAN

“…Decoupling economic growth from CO2 emissions completely is still a key goal of sustainability programs. According to the current research, nations with faster energy transitions and advanced technologies typically see a sharper decoupling, meaning that real GDP growth is attained without a rise in greenhouse gas emissions. …”
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Adverse birth outcome research case definitions associated with maternal HIV and antiretroviral drug use in pregnancy: a scoping review by Kopano R. Dube, Shani T. de Beer, Kathleen M. Powis, Michael McCaul, Amy L. Slogrove

“…In conjunction with good reporting, variation in adverse birth outcome definitions can be decreased to facilitate comparability of studies as well as pooling of data for enhanced evidence synthesis.…”
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Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing by Gökmen Aktas, Felix Keller, Justyna Siwy, Agnieszka Latosinska, Harald Mischak, Jorge Mayor, Jan Clausen, Michaela Wilhelmi, Vesta Brauckmann, Stephan Sehmisch, Tarek Omar Pacha

“…Preemptive personalized treatment aimed at preventing these events is a crucial objective of patient management; however, the currently available scoring systems provide only moderate guidance. …”
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Genetic Diversity and Mutation Frequency Databases in Ethnic Populations: Systematic Review by Shumaila Khan, Mahmood Alam, Iqbal Qasim, Shahnaz Khan, Wahab Khan, Orken Mamyrbayev, Ainur Akhmediyarova, Nurzhan Mukazhanov, Zhibek Alibiyeva

“…The review also addressed standardization and data quality challenges prevalent in current NEMDBs. ResultsThe analysis of 42 NEMDBs revealed significant issues, with 70% (29/42) lacking standardized data formats and 60% (25/42) having notable gaps in the cross-comparison of genetic variations, and 50% (21/42) of the databases contained incomplete or outdated data, limiting their clinical utility. …”
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Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior. by Henry H Jerng, Jay M Patel, Tamor A Khan, Benjamin R Arenkiel, Paul J Pfaffinger

“…We also find that an Opto-Kv1 construct containing a dominant-negative pore mutation (Opto-Kv1(V400D)) can be used to down-regulate Kv1 currents in a blue light-dependent manner. …”
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Investigation of the content of unsaturated hydrocarbons in transformer oils using IR spectroscopy by M. Sh. Garifullin, Y. N. Slobodina, A. R. Bikzinurov, R. A. Giniatullin, V. A. Chernyshov

“…THE  PURPOSE. To  analyze  the  current  understanding  of  unsaturated  hydrocarbons with  double  C=C  bonds  in  mineral  transformer  oils  and  evaluate  the  effectiveness  of  modern methods of controlling the content of these compounds in oils. …”
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The development of a beneficiation process to remove carbonates from lithium sedimentary claystones by Sabinus Essel Arthur, Emmanuel Atta Mends, Angela Manka Tita, Pengbo Chu

“…These carbonates not only increase acid consumption during leaching but also result in the generation of pure carbon dioxide. …”
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