Chlorpromazine directly inhibits Kv1.3 channels by facilitating the inactivation of channels by Seo-In Park, Soobeen Hwang, Young Lee, Hee-Yoon Lee, Soohyun Kim, Junseo Hong, Su-Hyun Jo, Se-Young Choi

“…The antipsychotic chlorpromazine (CPZ) demonstrates anti-inflammatory effects by decreasing Kv1.3 activity in mPFC microglia. However, the precise mechanism of CPZ’s effect in the mPFC remains unclear, given that CPZ is known to inhibit dopamine receptors and the mPFC contains various cell types with dopamine receptors. …”
Get full text

Persistent anti-NY-ESO-1-specific T cells and expression of differential biomarkers in a patient with metastatic gastric cancer benefiting from combined radioimmunotherapy treatmen... by Deepak Kumar, Said Dermime, Maysaloun Merhi, Afsheen Raza, Varghese Philipose Inchakalody, Kodappully S Siveen, Fairooz Sahir, Sarra Mestiri, Shereena Hydrose, Niloofar Allahverdi, Munir Jalis, Allan Relecom, Lobna Al Zaidan, Mohamed Sir Elkhatim Hamid, Mai Mostafa, Abdul Rehman Zar Gul, Shahab Uddin, Mohammed Al Homsi

“…Combined radioimmunotherapy is currently being investigated to treat patients with cancer. …”
Get full text

Nutritional management of pediatric nephrotic syndrome regarding oxidative stress and antioxidant balance by Elena Jechel, Alin Horatiu Nedelcu, Felicia Dragan, Vasile Valeriu Lupu, Iuliana Magdalena Starcea, Adriana Mocanu, Solange Tamara Rosu, Violeta Streanga, Ruxandra Russu, Ginel Baciu, Ciprian Danielescu, Delia Lidia Salaru, Ionela Daniela Morariu, Olga Cirstea, Emil Anton, Ancuta Lupu

“…The analysis focuses on the molecular mechanisms by which oxidative stress contributes to the progression of renal dysfunction, the role of oxidative biomarkers in disease monitoring, and the ability of antioxidants to reduce the need for immunosuppressants and corticosteroids, thus contributing to the decrease in associated morbidity. The translational perspectives of antioxidant therapy are also discussed, in the context of the urgent need for effective adjuvant strategies with a safety profile superior to conventional therapies. …”
Get full text

Improved lubricating and corrosion resistance of MAO coatings on ZK61 Mg alloy by co-doping with graphite and nano-zirconia by Chao Yang, Liyuan Sheng, Chaochao Zhao, Pinghu Chen, Wentai Ouyang, Daokui Xu, Yufeng Zheng, Paul K. Chu

“…Graphite doping decreases the friction coefficient, while ZrO2 doping decreases the wear rate. …”
Get full text

Resolution on the results of the first working meeting of the scientific advisory board «Actual problems of glycemic variability as a new criterion of glycemic control and safety o... by Mikhail B. Antsiferov, Gagik R. Galstyan, Alexey V. Zilov, Alexander Y. Mayorov, Tatyana N. Markova, Nikolay A. Demidov, Olga M. Koteshkova, Dmitry N. Laptev, Alisa V. Vitebskaya

“…The aims of the working meeting were to conduct a comprehensive data analysis of the relationship between GV and hypoglycaemia; to gather and analyse published data and the experience of decrease in GV and improved outcomes of diabetes against the background of different types of insulin therapy; to compare existing methods of glycaemia monitoring and GV assessment and examine their validity and availability in real practice in the context of limited budget and to analyse the informativeness and clinical and prognostic significance of various parameters of GV assessment and to determine their reasonable ‘minimum’ for a comprehensive assessment of GV as a criterion for evaluating the effectiveness of DM treatment and the predictors of negative diabetes outcomes. …”
Get full text

Latest trends on interplay of autophagy, adipose tissue, and gut microbiota in obesity-related metabolic disorders by Claudette Butoyi, Muhammad Asad Iqbal, Isaac Duah Boateng

“…Purpose of review: This review aims to synthesize current research on the intricate relationships among visceral obesity (VO), autophagy (Atg), gut microbiota, and adipose tissue dysfunction, all of which contribute significantly to insulin resistance (IR) and associated metabolic disorders. …”
Get full text

Mapping evidence of spinal manipulation therapy for headaches in South Africa: a scoping review of grey literature by Keseri Padayachy, Ismail Fatima, Morris Kahere, Alister du Rose, Katherine A. Pohlman

“…Abstract Objective Spinal manipulative therapy (SMT) has been demonstrated to be an effective management approach for primary headaches; however, current literature often excludes data from South Africa (SA). …”
Get full text

“They tossed me up like a ball”: informal settlement residents’ experiences in accessing healthcare in Kampala, Uganda by Julia Dickson-Gomez, Kirsten Beyer, Arthur Kiconco, Ronald Anguzu, Agnes Nyabigambo

“…The focus group interviews indicated that private healthcare systems have created incentives to draw resources away from already depleted public healthcare systems, further decreasing access to the most vulnerable. Conclusions Our study reveals important and substantial gaps in the current healthcare system in Uganda. …”
Get full text

Comparison of Bone Mineral Density in Lumbar Spine and Fracture Rate among Eight Drugs in Treatments of Osteoporosis in Men: A Network Meta-Analysis. by Ling-Xiao Chen, Zhi-Rui Zhou, Yu-Lin Li, Guang-Zhi Ning, Tian-Song Zhang, Di Zhang, Shi-Qing Feng

“…<h4>Context</h4>The preferred treatment for osteoporosis in men is debated, and pairwise meta-analysis cannot obtain hierarchies of these treatments.…”
Get full text

A comprehensive review of the genetic control of cooking time in dry beans (Phaseolus vulgaris L.) by Hannah R. Jeffery, Marcelo Efrén Murillo‐Quesada, Luis Barboza‐Barquero, Karen Cichy

“…The current evidence suggests that cooking time is increased by genetic factors that decrease the amount of soluble compounds in the cotyledons, including but not limited to 1) genes that increase the abundance of calcium‐binding storage proteins and/or de‐methylesterfied pectins paired with high inter‐ or intra‐cellular calcium levels (higher calcium levels can be caused by reduced levels of phytate) and 2) genes that increase insoluble condensed tannin/lignin content in the cotyledon cell walls. …”
Get full text

Azov-type spits: long-term monitoring of morphodynamics and vegetation in response to changing environment by Oksana Tyshchenko, Volodymyr Tyshchenko, Svitlana Boychenko, Andrii Tarieiev, Vasyl Tkachenko

“…The study provides a complex evaluation of the current anthropogenic impacts on the spits and their vegetation.…”
Get full text

Average nutrient and chlorophyll distributions in the western Mediterranean: RADMED project by María del Carmen García-Martínez, Manuel Vargas-Yáñez, Francina Moya, Rocío Santiago, María Muñoz, Andreas Reul, Teodoro Ramírez, Rosa Balbín

“…The present work analyses nutrient, chlorophyll and oxygen time series from 2007 to 2015 in some cases and from 1992 in other cases. The current analyses show a clear trophic gradient in the RADMED area. …”
Get full text

Optimal Decision-Making in a Green Supply Chain Duopoly: A Comparative Analysis of Subsidy Strategies with Data-Driven Marketing by Yao Yao, Shaoqing Geng, Jianhui Chen, Feng Shen, Huajun Tang

“…In the current context of severe environmental challenges and climate change, the low-carbon green development model has become an international consensus. …”
Get full text

INTERNATIONAL EXPERIENCE AND TRENDS OF INNOVATIVE DEVELOPMENT OF ARCTIC TERRITORIES by M. Dudin, N. Ivashchenko

“…As a consequence of that, it is expected that in the XXI century the Arctic region will be the focus of attention as an official Arctic 45, and a number of states whose territory is quite removed from it; For Russia, given the current, acute political conditions (sanctions, confrontation with the West, Ukrainian crisis and war in the Middle East) development of Arctic territories, some moved away, moved on tomorrow and the day after tomorrow on the agenda. …”
Get full text

Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy by Chao Lv, Chao Lv, Chao Lv, Chao Lv, Chao Lv, Lei Zhao, Jiani Hou, Hongyin Sun, Hongyin Sun, Hongyin Sun, Zhongsha Li, Zhongsha Li, Zhongsha Li, Zhongsha Li, Yuesong Wu, Yuesong Wu, Yuesong Wu, Yuesong Wu, Peizheng Shi, Yaping Xiao, Yunjin Xie, Yunjin Xie, Yunjin Xie, Yunjin Xie, Wei Su, Wei Su, Wei Su, Wei Su, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin, Mingzhu Yin

“…(Malvaceae), abbreviated as TFA, in the context of MAFLD. Ultra-high-performance liquid chromatography-quadrupole orbitrap mass spectrometry (UHPLC-QTOF-MS) was used to identify the metabolites in TFA. …”
Get full text

C18:0 GM3 ganglioside’s efficacy in LPS-induced parkinsonism: neuroprotection, inflammatory inhibition and gliosis mitigation by Tsung-Ta Liu, Cheng-Tsung Liu, I-Hsun Li, Yu-Chieh Chu, Hao-Yuan Hung, Chuang-Hsin Chiu, Ta-Kai Chou, Shiao-Yun Li, Tin-An Wang, Jui-Hu Shih

“…Abstract Background Parkinson’s disease (PD) is an incurable neurological disorder, and current pharmacological therapies primarily address symptoms without halting disease progression. …”
Get full text

Low drying temperature has negligible impact but defatting increases in vitro rumen digestibility of insect meals, with minor changes on fatty acid biohydrogenation by Manuela Renna, Mauro Coppa, Carola Lussiana, Aline Le Morvan, Laura Gasco, Lara Rastello, Jonas Claeys, Gaëlle Maxin

“…Abstract Background Insect meals have been identified as innovative and sustainable feedstuffs that could be used in ruminant nutrition. However, current research on the effects that their processing may have on rumen digestibility and fatty acid (FA) biohydrogenation is scant. …”
Get full text

Effect of increasing supplementation of dietary glycine on growth performance, meat quality, liver characteristics, and intestinal health in broiler chickens raised under heat stre... by Sung Hoon Kwon, Ji Hye Lee, Hyun Woo Kim, Deok Yun Kim, Dong Yong Kil

“…ABSTRACT: The current study aimed to investigate the effect of increasing supplementation of dietary glycine (Gly) on growth performance, meat quality, liver characteristics, and intestinal health in broiler chickens raised under heat stress (HS) conditions. …”
Get full text

A mixed-methods nutrition, water, sanitation and hygiene knowledge, attitudes, and practices survey of IDPs, returnees, and host community members in four counties of Jonglei state... by Lynn Lieberman Lawry, Rachel Gabor, Jacques Katele, Lazarus Baak Madut, Katina Sommers, David Manuel, Claire Nadolski, Mounir Lado, Tracey Perez Koehlmoos, William Clemmer

“…Improved flood resistant sources for clean water, clean covered water storage container distribution, improved sanitation, oral rehydration solution (ORS) and zinc distribution and education are necessary to decrease diarrheal rates.…”
Get full text

Digital currency: features of regulation in the Russian Federation by T. E. Rozhdestvenskaya, A. G. Guznov

“…The article examines the main approaches to the regulation of digital currencies, studies the phenomenon of digital currency itself, assesses the circumstances that aroused massive interest and enthusiasm for cryptocurrencies. An analysis of current positive legal material is presented, in particular, the approach to the regulation of digital currency contained in the Russian Federal Law of July 31, 2020 No. 259- FZ "On digital financial assets, digital currency and on amendments to certain legislative acts of the Russian Federation". …”
Get full text