STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma by Dingheng Lu, Yuxiao Li, Xinyang Niu, Jiazhu Sun, Weitao Zhan, Yuchen Shi, Kai Yu, Suyuelin Huang, Xiaoyan Liu, Liping Xie, Xueyou Ma, Ben Liu

“…While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. …”
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Climate and human activities alter coupling of soil macro- and micronutrients: Evidence from a long-term experiment in typical steppes by Yi Zhou, Shenghua Chang, Xiaojuan Huang, Wenjun Wang, Fujiang Hou, Yanrong Wang, Zhibiao Nan

“…Our results showed decreases in soil Zn and Fe stocks, alongside increases in Cu, SOC, and STN stocks over time. …”
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The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in e... by Biao Peng, Mu-Yun Yan, Yun-Rong Chen, Fei Sun, Xu-Dong Xiang, Da Liu

“…Objective The prognosis for severe asthma is poor, and the current treatment options are limited. The methyl-CpG binding domain protein 2 (MBD2) participates in neutrophil-mediated severe asthma through epigenetic regulation. …”
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Food Application of Orange Seed Powder through Incorporation in Wheat Flour to Boost Vitamin and Mineral Profiles of Formulated Biscuits by Ashiq Hussain, Salah Laaraj, Tusneem Kausar, Aziz Tikent, Hanane Azzouzi, Samina Kauser, Qurat Ul An, Aqsa Iqbal, Saima Akram, Rizwan Nisar, Ayesha Najam, Haya Fatima, Shazia Yaqub, Kaoutar Elfazazi

“…In the current work, orange seed powder replaced wheat flour at 0, 2.5, 5, 7.5, and 10% levels, to observe changes in physicochemical features of developed biscuits. …”
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Improvement of the perovskite photodiodes performance via advanced interface engineering with polymer dielectric by Andrey P. Morozov, Lev O. Luchnikov, Sergey Yu. Yurchuk, Artur R. Ishteev, Pavel A. Gostishchev, Sergey I. Didenko, Nikita S. Saratovsky, Dmitry O. Balakirev, Ivan V. Dyadishchev, Andrey A. Romanov, Ekaterina A. Ilicheva, Anton A. Vasilev, Sergey S. Kozlov, Dmitry S. Muratov, Yuriy N. Luponosov, Danila S. Saranin

“…IV curve analysis and 2-diode model calculations showed enhanced shunt properties, a decreased non-ideality factor, and reduced saturation dark current. …”
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Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT by Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger

“…Modelling suggested that provision of oral tenofovir/emtricitabine pre-exposure prophylaxis increased human immunodeficiency virus testing, with anti-retroviral therapy initiation at diagnosis, and reductions in the level of condom-less sex, that each played an important role in decreasing human immunodeficiency virus incidence among men who have sex with men, and that the current human immunodeficiency virus incidence would have been double what it is if any one of them had not occurred. …”
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Effects of temporary erosion control blanket and grass cover on the rates of runoff and sediment in the cut and fill slopes of forest roads using a rainfall simulation test by Behnaz Askari, Mehran Nasiri, Majid Lotfalian

“…The use of erosion control blankets is a soil bio-engineering method that can effectively reduce runoff and sediment and increase slope stability. Therefore, the current research aimed to temporarily stabilize soil using protective covering treatments, such as jute, straw, wood chips, Festuca grass cover, and nano zeolite super absorbent, to reduce the amount of runoff and sediment. …”
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MHD analysis of couple stress nanofluid through a tapered non-uniform channel with porous media and slip-convective boundary effects by P. Deepalakshmi, G. Shankar, E.P. Siva, D. Tripathi, O. Anwar Bég

“…The current research addresses the peristaltic transport mechanism that propels fluid through a conduit through rhythmic contraction and relaxation of the conduit walls, a phenomenon evident in numerous biological systems, including the gastrointestinal tract. …”
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components by Marion Henderson, Anja Wittkowski, Katie Buston, Karen Crawford, Alice MacLachlan, Alex McConnachie, Emma McIntosh, Claudia-Martina Messow, Catherine Nixon, Rosaleen O’Brien, Shona Shinwell, Daniel Wight, Yiqiao Xin, Rachel Calam, Ruth Dundas, James Law, Helen Minnis, Lucy Thompson, Philip Wilson

“…Trial registration This trial is registered as Current Controlled Trials ISRCTN21656568 (www.isrctn.com/ISRCTN21656568). …”
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Smart green ports: a sustainable solution for the maritime industry in a changing climate by Mohamed Elhussieny

“…Such basic analysis offers lessons on what current practices are, along with the challenges to be faced within the maritime sector. …”
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Social Networks Link Prediction Based on Incremental Learning by Jian SHU, Zhichen CHEN

“…However, the prediction performance of IL−SNLP on Ask Ubuntu and Super User decreases by only 4.54% and 5.25%, respectively, compared to its performance on Math Overflow. …”
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Effects of Conditioning Temperature on Pellet Quality, Nutrients Digestibility, and Metabolizable Energy of Broilers Diet by Seyedeh Vajiheh Shakhese Emampour, Abolghasem Golian, Heydar Zarghi, Ali Reza Hesabi Nameghi

“…So that the amount of electricity usage decreased (quadratic, p< 0.001), and increased pellet PDI (quadratic, p<0.001) and pellet hardness (linear, p<0.002) by increasing in conditioning temperature. …”
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Experimental study on tensile performance of horizontal joint bolted connections in fully assembled modular construction reinforced concrete by RAN Mingming, KOU Guangyun, XIONG Feng, ZHANG Dongdong, LI Wei

“…Larger bolt-hole diameters and smaller steel washer dimensions led to a reduction in the contact area between the washer and concrete, thereby decreasing the peak load-carrying capacity and initial stiffness. …”
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Mortality impact, risks, and benefits of general population screening for ovarian cancer: the UKCTOCS randomised controlled trial by Usha Menon, Aleksandra Gentry-Maharaj, Matthew Burnell, Andy Ryan, Jatinderpal K Kalsi, Naveena Singh, Anne Dawnay, Lesley Fallowfield, Alistair J McGuire, Stuart Campbell, Steven J Skates, Mahesh Parmar, Ian J Jacobs

“…The no-screening group contained 101,359 women. Those in the blood and scan groups had screening every year until December 2011. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…This paper describes the current transplant system’s use of subjective evaluation criteria, particularly psychosocial support and compliance. …”
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Protecting the Autonomy of Patients with Severe Mental Illness Through Psychiatric Advance Directive Peer-Facilitation by Nicholas Karasik

“…Guiding Distributive Justice: Capability Theory Capability theory is an account of justice opportunity that places a fundamental moral significance on individuals' ability to reach proper functioning and well-being.[52] Whether or not an individual can make use of a particular set of resources and convert them into a state of functioning depends on personal, sociopolitical, and environmental conditions ("conversion factors").[53] In this sense, liberty is not the absence of restraint from others or institutions but the freedom achieved through capability-enhancing relationships.[54] Within the context of bioethics, capability theory shifts focus toward creating circumstances by which individuals can direct their lives as they choose.[55] Acting in accordance with the principle of beneficence, peer-support specialists could enhance the capability of patients to be self-determined and autonomous, which would promote patient well-being and empowerment.[56] Those living with SMI, such as schizophrenia and bipolar disorder, are among the most disadvantaged in society, experiencing social and economic hardship related to their illness.[57] These individuals are often feared and rejected by others, which increases depression, lowers self-esteem, and engenders feelings of social isolation.[58] Compounding their challenges, especially for those facing structural inequalities, is insufficient access to appropriate mental health services supporting recovery.[59] Capability theory provides a sound justification for the resource distribution necessary to create and sustain a thriving network of peer-support specialists, to which those with SMI currently do not have access. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…This article examines the alignment of current predominant payment models of fee-for-service, capitation, and value-based payments with patient care ethics. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…This article examines the alignment of current predominant payment models of fee-for-service, capitation, and value-based payments with patient care ethics. …”
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Application of biomedical cell products in the treatment of congenital epidermolysis bullosa by Arfenya E. Karamova, Kseniya M. Aulova, Vadim V. Chikin, Аlexey A. Kubanov

“…Congenital epidermolysis bullosa is a phenotypically and genetically heterogeneous group of genodermatoses, which are characterized by decreasing of skin’s structural protein production up to complete absence or violation of the structure as a result of mutation. …”
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Effect of partial substitution of wheat flour (Triticum spp) with vetch flour (Vicia sativa) on the technological and sensory properties of bread by Lucía Buitrón, Cecilia Dini, Pedro Gustavo Maldonado-Alvarado

“…Vicia sativa (common vetch) seeds contain valuable nutrients but are currently unsafe for human consumption. …”
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